MX2021003435A - Moleculas inmunomoduladoras localizadas en el colageno y metodos de las mismas. - Google Patents

Moleculas inmunomoduladoras localizadas en el colageno y metodos de las mismas.

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Publication number
MX2021003435A
MX2021003435A MX2021003435A MX2021003435A MX2021003435A MX 2021003435 A MX2021003435 A MX 2021003435A MX 2021003435 A MX2021003435 A MX 2021003435A MX 2021003435 A MX2021003435 A MX 2021003435A MX 2021003435 A MX2021003435 A MX 2021003435A
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Mexico
Prior art keywords
collagen
methods
localized
immunomodulatory molecules
immunomodulatory
Prior art date
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MX2021003435A
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English (en)
Inventor
Karl Dane Wittrup
Noor Momin
Joseph Palmeri
Magnolia Chinn
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Massachusetts Inst Technology
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Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2021003435A publication Critical patent/MX2021003435A/es

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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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Abstract

La presente invención proporciona proteínas de fusión inmunomoduladoras que comprenden un dominio de unión a colágeno ligado operablemente a un dominio de fusión inmunomodulador. La descripción también presenta composiciones y métodos para utilizar las mismas, por ejemplo, para tratar cáncer.
MX2021003435A 2018-09-28 2019-07-26 Moleculas inmunomoduladoras localizadas en el colageno y metodos de las mismas. MX2021003435A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862738981P 2018-09-28 2018-09-28
PCT/US2019/043805 WO2020068261A1 (en) 2018-09-28 2019-07-26 Collagen-localized immunomodulatory molecules and methods thereof

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MX2021003435A true MX2021003435A (es) 2021-06-15

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BR112021004383A2 (pt) 2021-08-03
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