JP6873097B2 - 選択的ペプチド二重ｇｌｐ−１／グルカゴン受容体アゴニストとしての新しいエキセンジン−４誘導体 - Google Patents

選択的ペプチド二重ｇｌｐ−１／グルカゴン受容体アゴニストとしての新しいエキセンジン−４誘導体 Download PDF

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JP6873097B2
JP6873097B2 JP2018500700A JP2018500700A JP6873097B2 JP 6873097 B2 JP6873097 B2 JP 6873097B2 JP 2018500700 A JP2018500700 A JP 2018500700A JP 2018500700 A JP2018500700 A JP 2018500700A JP 6873097 B2 JP6873097 B2 JP 6873097B2
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JP2018528931A5 (enExample
JP2018528931A (ja
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マルティン・ボッサート
アンドレアス・エヴァース
トーシュテン・ハーク
カトリン・ローレンツ
ディーター・カーデライト
ミヒャエル・ワーグナー
ベルント・ヘンケル
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018500700A 2015-07-10 2016-07-08 選択的ペプチド二重ｇｌｐ−１／グルカゴン受容体アゴニストとしての新しいエキセンジン−４誘導体 Active JP6873097B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306141.1 2015-07-10
EP15306141 2015-07-10
PCT/EP2016/066299 WO2017009236A2 (en) 2015-07-10 2016-07-08 New exendin-4 derivatives as selective peptidic dual glp-1 / glucagon receptor agonists

Publications (3)

Publication Number Publication Date
JP2018528931A JP2018528931A (ja) 2018-10-04
JP2018528931A5 JP2018528931A5 (enExample) 2019-07-25
JP6873097B2 true JP6873097B2 (ja) 2021-05-19

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JP2018500700A Active JP6873097B2 (ja) 2015-07-10 2016-07-08 選択的ペプチド二重ｇｌｐ−１／グルカゴン受容体アゴニストとしての新しいエキセンジン−４誘導体

Country Status (13)

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US (1) US9982029B2 (enExample)
EP (1) EP3319982B1 (enExample)
JP (1) JP6873097B2 (enExample)
KR (1) KR20180025966A (enExample)
CN (1) CN108026153B (enExample)
AR (1) AR105284A1 (enExample)
AU (1) AU2016292747A1 (enExample)
CA (1) CA2991367A1 (enExample)
IL (1) IL256748A (enExample)
MX (1) MX2018000362A (enExample)
TW (1) TW201706291A (enExample)
UY (1) UY36779A (enExample)
WO (1) WO2017009236A2 (enExample)

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CN115298206A (zh) * 2020-02-13 2022-11-04 菲尔若国际公司 眼科药物组合物及其用途
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CN114349828B (zh) * 2020-11-27 2023-12-08 江苏师范大学 Glp-1/胰高血糖素受体双重激动剂及其应用
CN116710462A (zh) 2021-01-20 2023-09-05 维京治疗公司 用于治疗代谢病症和肝病的组合物和方法
CN115448978A (zh) * 2021-06-09 2022-12-09 中国科学院上海药物研究所 Tgr5-dpp4双重活性化合物及其制备方法、药物组合物和用途
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WO2025168049A1 (zh) * 2024-02-07 2025-08-14 江苏恒瑞医药股份有限公司 胰岛淀粉样多肽类似物及其医药用途
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US20170008944A1 (en) 2017-01-12
UY36779A (es) 2017-01-31
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