JP6153874B2 - 非侵襲的出生前倍数性呼び出しのための方法 - Google Patents
非侵襲的出生前倍数性呼び出しのための方法 Download PDFInfo
- Publication number
- JP6153874B2 JP6153874B2 JP2013553423A JP2013553423A JP6153874B2 JP 6153874 B2 JP6153874 B2 JP 6153874B2 JP 2013553423 A JP2013553423 A JP 2013553423A JP 2013553423 A JP2013553423 A JP 2013553423A JP 6153874 B2 JP6153874 B2 JP 6153874B2
- Authority
- JP
- Japan
- Prior art keywords
- dna
- chromosome
- sample
- primer
- ploidy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N7/00—Computing arrangements based on specific mathematical models
- G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/40—Population genetics; Linkage disequilibrium
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/179—Modifications characterised by incorporating arbitrary or random nucleotide sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/113—Time
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/143—Concentration of primer or probe
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/149—Sequential reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Physiology (AREA)
- Ecology (AREA)
- General Physics & Mathematics (AREA)
- Software Systems (AREA)
- Data Mining & Analysis (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161462972P | 2011-02-09 | 2011-02-09 | |
| US61/462,972 | 2011-02-09 | ||
| US201161448547P | 2011-03-02 | 2011-03-02 | |
| US61/448,547 | 2011-03-02 | ||
| US201161516996P | 2011-04-12 | 2011-04-12 | |
| US61/516,996 | 2011-04-12 | ||
| US13/110,685 | 2011-05-18 | ||
| US13/110,685 US8825412B2 (en) | 2010-05-18 | 2011-05-18 | Methods for non-invasive prenatal ploidy calling |
| US201161571248P | 2011-06-23 | 2011-06-23 | |
| US61/571,248 | 2011-06-23 | ||
| US201161542508P | 2011-10-03 | 2011-10-03 | |
| US61/542,508 | 2011-10-03 | ||
| PCT/US2011/061506 WO2012108920A1 (en) | 2011-02-09 | 2011-11-18 | Methods for non-invasive prenatal ploidy calling |
| US13/300,235 | 2011-11-18 | ||
| US13/300,235 US10017812B2 (en) | 2010-05-18 | 2011-11-18 | Methods for non-invasive prenatal ploidy calling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507141A JP2014507141A (ja) | 2014-03-27 |
| JP2014507141A5 JP2014507141A5 (enExample) | 2015-01-15 |
| JP6153874B2 true JP6153874B2 (ja) | 2017-06-28 |
Family
ID=46638881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553423A Active JP6153874B2 (ja) | 2011-02-09 | 2011-11-18 | 非侵襲的出生前倍数性呼び出しのための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (16) | US10017812B2 (enExample) |
| EP (1) | EP2673729B1 (enExample) |
| JP (1) | JP6153874B2 (enExample) |
| CN (1) | CN103608818B (enExample) |
| AU (1) | AU2011358564B9 (enExample) |
| BR (1) | BR112013020220B1 (enExample) |
| CA (1) | CA2824387C (enExample) |
| IL (1) | IL227842A0 (enExample) |
| RU (1) | RU2671980C2 (enExample) |
| WO (1) | WO2012108920A1 (enExample) |
Families Citing this family (195)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070178501A1 (en) * | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US8532930B2 (en) * | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US8515679B2 (en) * | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070027636A1 (en) * | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| WO2009105531A1 (en) * | 2008-02-19 | 2009-08-27 | Gene Security Network, Inc. | Methods for cell genotyping |
| US20110092763A1 (en) * | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
| US20110178719A1 (en) * | 2008-08-04 | 2011-07-21 | Gene Security Network, Inc. | Methods for Allele Calling and Ploidy Calling |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| CA2760439A1 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| ES2640776T3 (es) | 2009-09-30 | 2017-11-06 | Natera, Inc. | Métodos para denominar de forma no invasiva ploidía prenatal |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| GB2479471B (en) | 2010-01-19 | 2012-02-08 | Verinata Health Inc | Method for determining copy number variations |
| US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| WO2011091046A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
| EP2526415B1 (en) | 2010-01-19 | 2017-05-03 | Verinata Health, Inc | Partition defined detection methods |
| US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| EP2854058A3 (en) | 2010-05-18 | 2015-10-28 | Natera, Inc. | Methods for non-invasive pre-natal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| RU2620959C2 (ru) | 2010-12-22 | 2017-05-30 | Натера, Инк. | Способы неинвазивного пренатального установления отцовства |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| EP2670863B1 (en) | 2011-01-31 | 2018-06-27 | H. Hoffnabb-La Roche Ag | Methods of identifying multiple epitopes in cells |
| WO2016100976A2 (en) * | 2014-12-19 | 2016-06-23 | Apprise Bio, Inc. | Methods for identifying multiple epitopes in selected sub-populations of cells |
| US11560585B2 (en) | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| EP2860265B1 (en) | 2011-02-24 | 2016-10-26 | The Chinese University of Hong Kong | Determining fetal DNA percentage for twins |
| AU2012242698C1 (en) | 2011-04-12 | 2015-06-04 | Verinata Health, Inc. | Resolving genome fractions using polymorphism counts |
| US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US20140235474A1 (en) | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140242588A1 (en) | 2011-10-06 | 2014-08-28 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| US9206418B2 (en) | 2011-10-19 | 2015-12-08 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| LT2805280T (lt) | 2012-01-20 | 2022-12-27 | Sequenom, Inc. | Diagnostikos būdai, kurie atsižvelgia į eksperimentines sąlygas |
| US9650628B2 (en) | 2012-01-26 | 2017-05-16 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library regeneration |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| CA3209140A1 (en) | 2012-04-19 | 2013-10-24 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| RU2014152211A (ru) * | 2012-05-23 | 2016-07-20 | БГИ Диагносис Ко., Лтд. | Способ и система идентификации типов близнецов |
| US9193992B2 (en) * | 2012-06-05 | 2015-11-24 | Agilent Technologies, Inc. | Method for determining ploidy of a cell |
| CN104619894B (zh) | 2012-06-18 | 2017-06-06 | 纽亘技术公司 | 用于非期望核酸序列的阴性选择的组合物和方法 |
| US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| HK1211058A1 (en) | 2012-07-24 | 2016-05-13 | 纳特拉公司 | Highly multiplex pcr methods and compositions |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| DE202013012824U1 (de) | 2012-09-04 | 2020-03-10 | Guardant Health, Inc. | Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9932576B2 (en) | 2012-12-10 | 2018-04-03 | Resolution Bioscience, Inc. | Methods for targeted genomic analysis |
| US9128861B2 (en) | 2013-01-17 | 2015-09-08 | Personalis, Inc. | Methods and systems for genetic analysis |
| EP2958574A4 (en) * | 2013-01-23 | 2016-11-02 | Reproductive Genetics And Technology Solutions Llc | COMPOSITIONS AND METHODS FOR GENETIC ANALYSIS OF EMBRYOS |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10844424B2 (en) | 2013-02-20 | 2020-11-24 | Bionano Genomics, Inc. | Reduction of bias in genomic coverage measurements |
| EP2959015B1 (en) | 2013-02-20 | 2020-11-04 | Bionano Genomics, Inc. | Characterization of molecules in nanofluidics |
| US9235808B2 (en) | 2013-03-14 | 2016-01-12 | International Business Machines Corporation | Evaluation of predictions in the absence of a known ground truth |
| WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| WO2014143989A1 (en) * | 2013-03-15 | 2014-09-18 | Medical College Of Wisconsin, Inc. | Fetal well being surveillance using fetal specific cell free dna |
| WO2014144092A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| WO2014165596A1 (en) | 2013-04-03 | 2014-10-09 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| JP6561046B2 (ja) | 2013-05-24 | 2019-08-14 | セクエノム, インコーポレイテッド | 遺伝子の変動の非侵襲性評価のための方法および処理 |
| AU2014281635B2 (en) * | 2013-06-17 | 2020-05-28 | Verinata Health, Inc. | Method for determining copy number variations in sex chromosomes |
| EP3540076B1 (en) | 2013-06-21 | 2025-05-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2015026967A1 (en) * | 2013-08-20 | 2015-02-26 | Natera, Inc. | Methods of using low fetal fraction detection |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| JP6525434B2 (ja) | 2013-10-04 | 2019-06-05 | セクエノム, インコーポレイテッド | 遺伝子の変異の非侵襲的な評価のための方法および処理 |
| EP3495496B1 (en) | 2013-10-07 | 2020-11-25 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| SG10201804519RA (en) | 2013-12-28 | 2018-07-30 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| CN104745679B (zh) * | 2013-12-31 | 2018-06-15 | 杭州贝瑞和康基因诊断技术有限公司 | 一种无创检测egfr基因突变的方法及试剂盒 |
| EP4219744A3 (en) | 2014-01-27 | 2023-08-30 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
| CN106164295B (zh) * | 2014-02-25 | 2020-08-11 | 生物纳米基因公司 | 减小基因组覆盖测量中的偏差 |
| US9745614B2 (en) | 2014-02-28 | 2017-08-29 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| CN103901217A (zh) * | 2014-03-21 | 2014-07-02 | 靖江市人民医院 | 大豆过氧化物酶免疫生物芯片及在唐氏综合症产前筛查血清学标志物检测中的应用 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CN106460070B (zh) * | 2014-04-21 | 2021-10-08 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
| CN106661620B (zh) * | 2014-05-06 | 2021-11-23 | 贝勒医学院 | 单细胞全基因组线性扩增法 |
| US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US20160145684A1 (en) * | 2014-06-27 | 2016-05-26 | Genotox Laboratories | Methods of detecting synthetic urine and matching a urine sample to a subject |
| CN104156631B (zh) * | 2014-07-14 | 2017-07-18 | 天津华大基因科技有限公司 | 染色体三倍体检验方法 |
| EP3656875B1 (en) * | 2014-07-18 | 2021-09-22 | Illumina, Inc. | Non-invasive prenatal diagnosis |
| EP3760739B1 (en) | 2014-07-30 | 2025-09-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| SG11201700765WA (en) * | 2014-08-01 | 2017-02-27 | Ariosa Diagnostics Inc | Detection of target nucleic acids using hybridization |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US20160053301A1 (en) * | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
| EP3192879A4 (en) * | 2014-09-11 | 2017-07-19 | Fujifilm Corporation | Method for detecting presence/absence of fetal chromosomal aneuploidy |
| WO2016042830A1 (ja) * | 2014-09-16 | 2016-03-24 | 富士フイルム株式会社 | 胎児染色体の解析方法 |
| CN107002121B (zh) * | 2014-09-18 | 2020-11-13 | 亿明达股份有限公司 | 用于分析核酸测序数据的方法和系统 |
| US10612080B2 (en) | 2014-09-22 | 2020-04-07 | Roche Molecular Systems, Inc. | Digital PCR for non-invasive prenatal testing |
| EP3224595A4 (en) | 2014-09-24 | 2018-06-13 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
| JP2016067268A (ja) * | 2014-09-29 | 2016-05-09 | 富士フイルム株式会社 | 胎児の染色体異数性の非侵襲的判別方法 |
| JP2017530720A (ja) * | 2014-10-17 | 2017-10-19 | グッド スタート ジェネティクス, インコーポレイテッド | 着床前遺伝子スクリーニングおよび異数性検出 |
| WO2016068245A1 (ja) * | 2014-10-30 | 2016-05-06 | 株式会社 東芝 | 遺伝子型推定装置、方法、及びプログラム |
| WO2016070131A1 (en) | 2014-10-30 | 2016-05-06 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| US10066259B2 (en) | 2015-01-06 | 2018-09-04 | Good Start Genetics, Inc. | Screening for structural variants |
| GB201502447D0 (en) | 2015-02-13 | 2015-04-01 | Univ Liverpool | Method and apparatus for sample analysis |
| JP6502477B2 (ja) | 2015-03-31 | 2019-04-17 | 富士フイルム株式会社 | 胎児の遺伝子状態を判定する方法 |
| CN106148323B (zh) * | 2015-04-22 | 2021-03-05 | 北京贝瑞和康生物技术有限公司 | 一种用于构建alk基因融合突变检测文库的方法和试剂盒 |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| CA3004435A1 (en) | 2015-11-11 | 2017-05-18 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
| HK1259478A1 (zh) * | 2016-02-12 | 2019-11-29 | Regeneron Pharmaceuticals, Inc. | 用於检测异常核型的方法和系统 |
| ES2913468T3 (es) | 2016-04-15 | 2022-06-02 | Natera Inc | Métodos para la detección del cáncer de pulmón. |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| EP3510171A4 (en) * | 2016-07-01 | 2020-04-29 | Natera, Inc. | COMPOSITIONS AND METHODS FOR DETECTION OF NUCLEIC ACID MUTATIONS |
| US11200963B2 (en) | 2016-07-27 | 2021-12-14 | Sequenom, Inc. | Genetic copy number alteration classifications |
| EP4667584A2 (en) | 2016-08-25 | 2025-12-24 | Resolution Bioscience, Inc. | Methods for quantitative genetic analysis of dna fragments using adaptors with unique molecular identifiers and sample tags |
| EP3518974A4 (en) * | 2016-09-29 | 2020-05-27 | Myriad Women's Health, Inc. | NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION |
| CN109790570B (zh) * | 2016-09-30 | 2023-09-15 | 富士胶片株式会社 | 获取来源于脊椎动物的单细胞的碱基序列信息的方法 |
| EP3461274B1 (en) | 2016-09-30 | 2020-11-04 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| US10451544B2 (en) | 2016-10-11 | 2019-10-22 | Genotox Laboratories | Methods of characterizing a urine sample |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| IL267913B2 (en) | 2017-01-24 | 2025-08-01 | Sequenom Inc | Methods and processes for assessing genetic variations |
| CN110520045A (zh) * | 2017-02-03 | 2019-11-29 | 斯特里克公司 | 带防腐剂的采样管 |
| US10894976B2 (en) | 2017-02-21 | 2021-01-19 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| US12421550B2 (en) | 2017-03-17 | 2025-09-23 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| RU2657769C1 (ru) * | 2017-05-31 | 2018-06-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Способ прогнозирования наличия хромосомных аномалий в эмбрионах удовлетворительного и плохого качества на основании оценки транскрипционного профиля в кумулюсных клетках в программе экстракорпорального оплодотворения |
| CN110945136A (zh) | 2017-06-20 | 2020-03-31 | 威斯康星州立大学医学院 | 使用总无细胞dna评估移植并发症风险 |
| EP4116432A1 (en) * | 2017-07-07 | 2023-01-11 | Nipd Genetics Public Company Limited | Target-enriched multiplexed parallel analysis for assessment of fetal dna samples |
| WO2019016289A1 (en) * | 2017-07-18 | 2019-01-24 | Congenica Ltd. | SYSTEM AND METHOD FOR SCREENING |
| EP3658689B1 (en) * | 2017-07-26 | 2021-03-24 | Trisomytest, s.r.o. | A method for non-invasive prenatal detection of fetal chromosome aneuploidy from maternal blood based on bayesian network |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| CA3080117A1 (en) | 2017-10-27 | 2019-05-02 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| US12462935B2 (en) | 2018-03-30 | 2025-11-04 | Nucleix Ltd. | Deep learning-based methods, devices, and systems for prenatal testing |
| JP7573443B2 (ja) | 2018-04-14 | 2024-10-25 | ナテラ, インコーポレイテッド | 循環腫瘍dnaの個別化された検出を用いる癌検出およびモニタリングの方法 |
| EP3818177A1 (en) | 2018-07-03 | 2021-05-12 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN109493919B (zh) * | 2018-10-31 | 2023-04-14 | 中国石油大学(华东) | 基于条件概率的基因型指派方法 |
| CN113366119A (zh) * | 2018-12-05 | 2021-09-07 | 威廉马歇莱思大学 | 使用snp谱分析对少量血液样品中的外源dna进行定量 |
| CA3123847A1 (en) | 2018-12-17 | 2020-06-25 | Natera, Inc. | Methods for analysis of circulating cells |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| WO2020214547A1 (en) | 2019-04-15 | 2020-10-22 | Natera, Inc. | Improved liquid biopsy using size selection |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| US12176069B2 (en) | 2019-06-21 | 2024-12-24 | Coopersurgical, Inc. | Systems and methods for determining pattern of inheritance in embryos |
| AU2020296110B2 (en) * | 2019-06-21 | 2023-07-27 | Coopersurgical, Inc. | Systems and methods for determining genome ploidy |
| CN114945987A (zh) | 2019-11-05 | 2022-08-26 | 佩索纳里斯公司 | 从单一样品预估肿瘤纯度 |
| CN113275053A (zh) | 2020-02-03 | 2021-08-20 | 帝肯基因组学公司 | 试剂存储系统 |
| US12305242B2 (en) | 2020-04-24 | 2025-05-20 | The Johns Hopkins University | Methods and related aspects for quantitative polymerase chain reaction to determine fractional abundance |
| CA3180334A1 (en) | 2020-05-29 | 2021-12-02 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| EP4165184A4 (en) * | 2020-06-10 | 2024-09-04 | Bonadea Diagnostics, LLC | SEQUENCE CONVERSION REACTION |
| CN111951890B (zh) * | 2020-08-13 | 2022-03-22 | 北京博昊云天科技有限公司 | 染色体和单基因病同步产前筛查的设备、试剂盒和分析系统 |
| US20220106590A1 (en) * | 2020-10-05 | 2022-04-07 | Twist Bioscience Corporation | Hybridization methods and reagents |
| US20220170010A1 (en) * | 2020-12-02 | 2022-06-02 | Illumina Software, Inc. | System and method for detection of genetic alterations |
| CN116964223A (zh) | 2021-02-25 | 2023-10-27 | 纳特拉公司 | 用于检测多个器官的移植受体中的供体源性游离dna的方法 |
| JP2024511980A (ja) | 2021-03-18 | 2024-03-18 | ナテラ, インコーポレイテッド | 移植拒絶反応の判定方法 |
| WO2022225933A1 (en) | 2021-04-22 | 2022-10-27 | Natera, Inc. | Methods for determining velocity of tumor growth |
| CA3225014A1 (en) | 2021-08-02 | 2023-02-09 | Georgina GOLDRING | Methods for detecting neoplasm in pregnant women |
| EP4396378A1 (en) | 2021-09-01 | 2024-07-10 | Natera, Inc. | Methods for non-invasive prenatal testing |
| US12297508B2 (en) | 2021-10-05 | 2025-05-13 | Personalis, Inc. | Customized assays for personalized cancer monitoring |
| US11935627B2 (en) * | 2021-12-29 | 2024-03-19 | Mujin, Inc. | System and method for text-based biological information processing with analysis refinement |
| WO2023133131A1 (en) | 2022-01-04 | 2023-07-13 | Natera, Inc. | Methods for cancer detection and monitoring |
| WO2023244735A2 (en) | 2022-06-15 | 2023-12-21 | Natera, Inc. | Methods for determination and monitoring of transplant rejection by measuring rna |
| US20250388956A1 (en) | 2022-06-29 | 2025-12-25 | Natera, Inc. | Compositions and methods for identification of chromosomal microdeletions |
| CN120344675A (zh) | 2022-10-06 | 2025-07-18 | 纳特拉公司 | 评定怀孕移植受体的移植排斥的非侵入性方法 |
| CN120225694A (zh) | 2022-10-06 | 2025-06-27 | 纳特拉公司 | 用于通过测量来源于异种移植的核酸或蛋白质来确定和监测异种移植排斥的方法 |
| CN120283064A (zh) | 2022-10-06 | 2025-07-08 | 纳特拉公司 | 灌注或冲洗液的核酸分析 |
| CN116240274A (zh) * | 2022-11-10 | 2023-06-09 | 武汉蓝沙医学检验实验室有限公司 | 无需父本对妊娠胎儿进行亲子鉴定的方法 |
| WO2024168038A2 (en) | 2023-02-07 | 2024-08-15 | Natera, Inc. | Method for identifying kidney allograft rejection genes in urine and utility of making those measurements |
| CN117965744B (zh) * | 2023-12-12 | 2024-10-11 | 东莞博奥木华基因科技有限公司 | 一种基于多重pcr捕获技术检测胎儿样本倍性和母源细胞污染的试剂盒、引物和方法 |
| WO2026006620A1 (en) | 2024-06-28 | 2026-01-02 | Natera, Inc. | Methods for determination and treatment of rhesus incompatibilty |
Family Cites Families (625)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957654A (en) | 1974-02-27 | 1976-05-18 | Becton, Dickinson And Company | Plasma separator with barrier to eject sealant |
| US4040785A (en) | 1976-10-18 | 1977-08-09 | Technicon Instruments Corporation | Lysable blood preservative composition |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4935342A (en) | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
| US5319071A (en) | 1987-11-25 | 1994-06-07 | Immunex Corporation | Soluble interleukin-1 receptors |
| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5153117A (en) | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5645988A (en) | 1991-05-08 | 1997-07-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of identifying drugs with selective effects against cancer cells |
| US5262329A (en) | 1991-06-13 | 1993-11-16 | Carver Jr Edward L | Method for improved multiple species blood analysis |
| DE69213112T2 (de) | 1991-06-20 | 1997-04-03 | Hoffmann La Roche | Verbesserte Methoden zur Nukleinsäure-Amplifizierung |
| US5569582A (en) | 1991-07-15 | 1996-10-29 | Institute Of Molecular Biology & Technology | Rapid amplification and detection of nucleic acids |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| US5965362A (en) | 1992-03-04 | 1999-10-12 | The Regents Of The University Of California | Comparative genomic hybridization (CGH) |
| GB9305984D0 (en) | 1993-03-23 | 1993-05-12 | Royal Free Hosp School Med | Predictive assay |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| DE69432751T2 (de) | 1993-07-05 | 2004-04-29 | Sheffield Teaching Hospitals National Health Service Trust | Präparation und stabilisation von zellen |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5716776A (en) | 1994-03-04 | 1998-02-10 | Mark H. Bogart | Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample |
| US5891734A (en) | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
| US6025128A (en) | 1994-09-29 | 2000-02-15 | The University Of Tulsa | Prediction of prostate cancer progression by analysis of selected predictive parameters |
| US6479235B1 (en) | 1994-09-30 | 2002-11-12 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| US5648220A (en) | 1995-02-14 | 1997-07-15 | New England Medical Center Hospitals, Inc. | Methods for labeling intracytoplasmic molecules |
| CA2221454A1 (en) | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Wide dynamic range nucleic acid detection using an aggregate primer series |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5736033A (en) | 1995-12-13 | 1998-04-07 | Coleman; Charles M. | Separator float for blood collection tubes with water swellable material |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| EP0929694A4 (en) | 1996-03-15 | 2002-05-02 | Penn State Res Found | DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS |
| PT938320E (pt) | 1996-03-26 | 2010-09-22 | Michael S Kopreski | Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro |
| US6108635A (en) | 1996-05-22 | 2000-08-22 | Interleukin Genetics, Inc. | Integrated disease information system |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| US5860917A (en) | 1997-01-15 | 1999-01-19 | Chiron Corporation | Method and apparatus for predicting therapeutic outcomes |
| US5824467A (en) | 1997-02-25 | 1998-10-20 | Celtrix Pharmaceuticals | Methods for predicting drug response |
| US20010051341A1 (en) | 1997-03-04 | 2001-12-13 | Isis Innovation Limited | Non-invasive prenatal diagnosis |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| DE69827060T2 (de) | 1997-03-20 | 2005-03-24 | F. Hoffmann-La Roche Ag | Modifizierte Primer |
| ES2563643T3 (es) | 1997-04-01 | 2016-03-15 | Illumina Cambridge Limited | Método de secuenciación de ácido nucleico |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US20020119478A1 (en) | 1997-05-30 | 2002-08-29 | Diagen Corporation | Methods for detection of nucleic acid sequences in urine |
| US5994148A (en) | 1997-06-23 | 1999-11-30 | The Regents Of University Of California | Method of predicting and enhancing success of IVF/ET pregnancy |
| US6013444A (en) * | 1997-09-18 | 2000-01-11 | Oligotrail, Llc | DNA bracketing locus compatible standards for electrophoresis |
| US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| ES2245085T3 (es) | 1998-01-23 | 2005-12-16 | Immunex Corporation | Adn y polipeptidos acpl. |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6406671B1 (en) | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
| DE60041442D1 (de) | 1999-04-30 | 2009-03-12 | Cyclops Genome Sciences Ltd | Isolierung von nukleinsäuren |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| US7058517B1 (en) | 1999-06-25 | 2006-06-06 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
| US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
| AU782170B2 (en) | 1999-07-23 | 2005-07-07 | Forensic Science Service Ltd. | Improvements in and relating to analysis of DNA |
| GB9917307D0 (en) | 1999-07-23 | 1999-09-22 | Sec Dep Of The Home Department | Improvements in and relating to analysis of DNA |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6251604B1 (en) | 1999-08-13 | 2001-06-26 | Genopsys, Inc. | Random mutagenesis and amplification of nucleic acid |
| WO2001034844A1 (en) | 1999-11-10 | 2001-05-17 | Ligochem, Inc. | Method for isolating dna from a proteinaceous medium and kit for performing method |
| US20030148301A1 (en) | 1999-12-10 | 2003-08-07 | Toshiya Aono | Method of detecting nucleotide polymorphism |
| US6221603B1 (en) | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
| DK1259643T3 (da) | 2000-02-07 | 2009-02-23 | Illumina Inc | Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming |
| US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| GB0009179D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Non-invasive prenatal diagnosis |
| US7510834B2 (en) | 2000-04-13 | 2009-03-31 | Hidetoshi Inoko | Gene mapping method using microsatellite genetic polymorphism markers |
| EP1290225A4 (en) | 2000-05-20 | 2004-09-15 | Univ Michigan | METHOD FOR PRODUCING A DNA BANK BY POSITIONAL REPRODUCTION |
| AU2001264811A1 (en) | 2000-05-23 | 2001-12-03 | Vincent P. Stanton Jr. | Methods for genetic analysis of dna to detect sequence variances |
| US20030009295A1 (en) | 2001-03-14 | 2003-01-09 | Victor Markowitz | System and method for retrieving and using gene expression data from multiple sources |
| US7087414B2 (en) | 2000-06-06 | 2006-08-08 | Applera Corporation | Methods and devices for multiplexing amplification reactions |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| WO2001094630A2 (en) | 2000-06-07 | 2001-12-13 | Baylor College Of Medicine | Compositions and methods for array-based nucleic acid hybridization |
| US7058616B1 (en) | 2000-06-08 | 2006-06-06 | Virco Bvba | Method and system for predicting resistance of a disease to a therapeutic agent using a neural network |
| GB0016742D0 (en) | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| WO2002057491A2 (en) | 2000-10-24 | 2002-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic dna |
| US20020107640A1 (en) | 2000-11-14 | 2002-08-08 | Ideker Trey E. | Methods for determining the true signal of an analyte |
| CA2428757A1 (en) | 2000-11-15 | 2002-07-18 | Roche Diagnostics Corporation | Methods and reagents for identifying rare fetal cells in the maternal circulation |
| WO2002044411A1 (en) | 2000-12-01 | 2002-06-06 | Rosetta Inpharmatics, Inc. | Use of profiling for detecting aneuploidy |
| US7218764B2 (en) | 2000-12-04 | 2007-05-15 | Cytokinetics, Inc. | Ploidy classification method |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| JP2002300894A (ja) | 2001-02-01 | 2002-10-15 | Inst Of Physical & Chemical Res | 一塩基多型タイピング方法 |
| US20020182622A1 (en) | 2001-02-01 | 2002-12-05 | Yusuke Nakamura | Method for SNP (single nucleotide polymorphism) typing |
| CN100523216C (zh) | 2001-03-02 | 2009-08-05 | 匹兹堡大学 | Pcr方法 |
| US6489135B1 (en) | 2001-04-17 | 2002-12-03 | Atairgintechnologies, Inc. | Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media |
| FR2824144B1 (fr) | 2001-04-30 | 2004-09-17 | Metagenex S A R L | Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel |
| US7392199B2 (en) | 2001-05-01 | 2008-06-24 | Quest Diagnostics Investments Incorporated | Diagnosing inapparent diseases from common clinical tests using Bayesian analysis |
| WO2002090505A2 (en) | 2001-05-09 | 2002-11-14 | Virginia Commonwealth University | Multiple sequencible and ligatible structures for genomic analysis |
| US20040126760A1 (en) | 2001-05-17 | 2004-07-01 | Natalia Broude | Novel compositions and methods for carrying out multple pcr reactions on a single sample |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| JP2004531271A (ja) | 2001-06-22 | 2004-10-14 | ユニバーシティ オブ ジュネーブ | 染色体不均衡により引き起こされる疾患を検出する方法 |
| WO2003010537A1 (en) | 2001-07-24 | 2003-02-06 | Curagen Corporation | Family based tests of association using pooled dna and snp markers |
| US7297778B2 (en) | 2001-07-25 | 2007-11-20 | Affymetrix, Inc. | Complexity management of genomic DNA |
| ATE502119T1 (de) | 2001-07-25 | 2011-04-15 | Oncomedx Inc | Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| ATE401574T1 (de) | 2001-08-23 | 2008-08-15 | Immunivest Corp | Analyse zirkulierender tumorzellen, fragmente und trümmer |
| US6807491B2 (en) | 2001-08-30 | 2004-10-19 | Hewlett-Packard Development Company, L.P. | Method and apparatus for combining gene predictions using bayesian networks |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| AUPR749901A0 (en) | 2001-09-06 | 2001-09-27 | Monash University | Method of identifying chromosomal abnormalities and prenatal diagnosis |
| US7153656B2 (en) | 2001-09-11 | 2006-12-26 | Los Alamos National Security, Llc | Nucleic acid sequence detection using multiplexed oligonucleotide PCR |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US20040014067A1 (en) | 2001-10-12 | 2004-01-22 | Third Wave Technologies, Inc. | Amplification methods and compositions |
| WO2003031646A1 (en) | 2001-10-12 | 2003-04-17 | The University Of Queensland | Multiple genetic marker selection and amplification |
| US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| CN100468058C (zh) | 2001-12-11 | 2009-03-11 | 株式会社奈特克 | 血细胞分离体系 |
| US7198897B2 (en) | 2001-12-19 | 2007-04-03 | Brandeis University | Late-PCR |
| EP1325963B1 (en) | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| US20040115629A1 (en) | 2002-01-09 | 2004-06-17 | Panzer Scott R | Molecules for diagnostics and therapeutics |
| US20030211522A1 (en) | 2002-01-18 | 2003-11-13 | Landes Gregory M. | Methods for fetal DNA detection and allele quantitation |
| EP1483720A1 (en) | 2002-02-01 | 2004-12-08 | Rosetta Inpharmactis LLC. | Computer systems and methods for identifying genes and determining pathways associated with traits |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US7208274B2 (en) | 2002-03-01 | 2007-04-24 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US20060229823A1 (en) | 2002-03-28 | 2006-10-12 | Affymetrix, Inc. | Methods and computer software products for analyzing genotyping data |
| US7211191B2 (en) | 2004-09-30 | 2007-05-01 | Thermogenesis Corp. | Blood component separation method and apparatus |
| US7241281B2 (en) | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
| US20040096874A1 (en) | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
| US20030235848A1 (en) | 2002-04-11 | 2003-12-25 | Matt Neville | Characterization of CYP 2D6 alleles |
| US7208317B2 (en) | 2002-05-02 | 2007-04-24 | The University Of North Carolina At Chapel Hill | In Vitro mutagenesis, phenotyping, and gene mapping |
| US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20070178478A1 (en) | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040009518A1 (en) | 2002-05-14 | 2004-01-15 | The Chinese University Of Hong Kong | Methods for evaluating a disease condition by nucleic acid detection and fractionation |
| US20040229231A1 (en) | 2002-05-28 | 2004-11-18 | Frudakis Tony N. | Compositions and methods for inferring ancestry |
| EP1532453B1 (en) | 2002-05-31 | 2013-08-21 | Genetic Technologies Limited | Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood |
| AU2003243475A1 (en) | 2002-06-13 | 2003-12-31 | New York University | Early noninvasive prenatal test for aneuploidies and heritable conditions |
| US7108976B2 (en) | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| US7097976B2 (en) | 2002-06-17 | 2006-08-29 | Affymetrix, Inc. | Methods of analysis of allelic imbalance |
| US20050009069A1 (en) | 2002-06-25 | 2005-01-13 | Affymetrix, Inc. | Computer software products for analyzing genotyping |
| AU2003247715B8 (en) | 2002-06-28 | 2008-06-05 | Orchid Cellmark Inc. | Methods and compositions for analyzing compromised samples using single nucleotide polymorphism panels |
| EP1388812A1 (en) | 2002-07-04 | 2004-02-11 | Ronald E. Dr. Kates | Method for training a learning-capable system |
| JP4116856B2 (ja) | 2002-10-02 | 2008-07-09 | 富士フイルム株式会社 | 1塩基多型の検出方法 |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| WO2004033649A2 (en) | 2002-10-07 | 2004-04-22 | University Of Medicine And Dentistry Of New Jersey | High throughput multiplex dna sequence amplifications |
| WO2004044225A2 (en) | 2002-11-11 | 2004-05-27 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
| JP2006508662A (ja) | 2002-12-04 | 2006-03-16 | アプレラ コーポレイション | ポリヌクレオチドの多重増幅 |
| KR20080022602A (ko) | 2003-01-02 | 2008-03-11 | 알로이즈 워벤 | 풍력 발전 플랜트를 위한 회전자 날개 |
| US20040224331A1 (en) | 2003-01-17 | 2004-11-11 | The Trustees Of Boston University | Haplotype analysis |
| WO2004065628A1 (en) | 2003-01-21 | 2004-08-05 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| EP1594981B1 (en) | 2003-01-29 | 2010-03-17 | 454 Corporation | Double ended sequencing |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
| US20040197832A1 (en) | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| WO2004099439A1 (en) | 2003-05-09 | 2004-11-18 | Tsinghua University | Methods and compositions for optimizing multiplex pcr primers |
| CA2525956A1 (en) | 2003-05-28 | 2005-01-06 | Pioneer Hi-Bred International, Inc. | Plant breeding method |
| US20040259100A1 (en) | 2003-06-20 | 2004-12-23 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| EP1660680B1 (en) | 2003-07-31 | 2009-03-11 | Sequenom, Inc. | Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| AU2003263660A1 (en) | 2003-08-29 | 2005-03-16 | Pantarhei Bioscience B.V. | Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood |
| AU2004270220B2 (en) | 2003-09-05 | 2009-03-05 | The Chinese University Of Hong Kong | Method for non-invasive prenatal diagnosis |
| US20050053950A1 (en) | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
| EP1668154B1 (en) * | 2003-09-22 | 2008-11-26 | Trisogen Biotechnology Limited Partnership | Methods useful for detecting an alteration in a locus copy number |
| JPWO2005028645A1 (ja) | 2003-09-24 | 2007-11-15 | 株式会社産学連携機構九州 | MDR1遺伝子の5’制御領域におけるSNPs |
| WO2005030999A1 (en) | 2003-09-25 | 2005-04-07 | Dana-Farber Cancer Institute, Inc | Methods to detect lineage-specific cells |
| WO2005035725A2 (en) | 2003-10-08 | 2005-04-21 | The Trustees Of Boston University | Methods for prenatal diagnosis of chromosomal abnormalities |
| CA2482097C (en) | 2003-10-13 | 2012-02-21 | F. Hoffmann-La Roche Ag | Methods for isolating nucleic acids |
| ATE435301T1 (de) | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
| US20050221341A1 (en) | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
| US20070212689A1 (en) | 2003-10-30 | 2007-09-13 | Bianchi Diana W | Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid |
| US20050164252A1 (en) | 2003-12-04 | 2005-07-28 | Yeung Wah Hin A. | Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell |
| EP1706488B1 (en) | 2004-01-12 | 2013-07-24 | Roche NimbleGen, Inc. | Method of performing pcr amplification on a microarray |
| US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20100216151A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US7035740B2 (en) | 2004-03-24 | 2006-04-25 | Illumina, Inc. | Artificial intelligence and global normalization methods for genotyping |
| JP4437050B2 (ja) | 2004-03-26 | 2010-03-24 | 株式会社日立製作所 | 診断支援システム、診断支援方法および診断支援サービスの提供方法 |
| WO2005094363A2 (en) | 2004-03-30 | 2005-10-13 | New York University | System, method and software arrangement for bi-allele haplotype phasing |
| ATE450549T1 (de) | 2004-03-31 | 2009-12-15 | Adnagen Ag | Monoklonale antikörper mit spezifität für fetale erythroidzellen |
| US7414118B1 (en) | 2004-04-14 | 2008-08-19 | Applied Biosystems Inc. | Modified oligonucleotides and applications thereof |
| US7468249B2 (en) | 2004-05-05 | 2008-12-23 | Biocept, Inc. | Detection of chromosomal disorders |
| EP1754141A4 (en) | 2004-06-02 | 2008-01-02 | New England Biolabs Inc | INFERENCE FUNCTION FROM BLIND SEQUENCING DATA |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| KR20070034588A (ko) | 2004-06-14 | 2007-03-28 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | Cd34+/cd36+ 태아 세포에는 결합하지만 성체세포에는 결합하지 않는 항체 |
| US20080102455A1 (en) | 2004-07-06 | 2008-05-01 | Genera Biosystems Pty Ltd | Method Of Detecting Aneuploidy |
| BRPI0513382A (pt) | 2004-07-14 | 2008-05-06 | Wyeth Corp | composições e processos de purificação de glicoproteìna associada à mielina (mag) |
| DE102004036285A1 (de) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe |
| JP5249581B2 (ja) | 2004-08-09 | 2013-07-31 | ジェネレイション バイオテック リミテッド ライアビリティ カンパニー | 核酸の単離および増幅方法 |
| WO2006023769A2 (en) | 2004-08-18 | 2006-03-02 | Abbott Molecular, Inc. | Determining data quality and/or segmental aneusomy using a computer system |
| JP4810164B2 (ja) | 2004-09-03 | 2011-11-09 | 富士フイルム株式会社 | 核酸分離精製方法 |
| US8024128B2 (en) | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
| US20060088574A1 (en) | 2004-10-25 | 2006-04-27 | Manning Paul B | Nutritional supplements |
| WO2006047481A2 (en) | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US20060134662A1 (en) | 2004-10-25 | 2006-06-22 | Pratt Mark R | Method and system for genotyping samples in a normalized allelic space |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| WO2006055761A1 (en) | 2004-11-17 | 2006-05-26 | Mosaic Reproductive Health And Genetics, Llc | Methods of determining human egg competency |
| CA2588296A1 (en) | 2004-11-24 | 2006-06-01 | Neuromolecular Pharmaceuticals, Inc. | Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease |
| US20070042384A1 (en) | 2004-12-01 | 2007-02-22 | Weiwei Li | Method for isolating and modifying DNA from blood and body fluids |
| ATE406621T1 (de) * | 2005-02-11 | 2008-09-15 | Smartgene Gmbh | Computerimplementiertes verfahren und computergestütztes system zur validierung von dna-sequenzierungsdaten |
| US20090098534A1 (en) | 2005-02-25 | 2009-04-16 | The Regents Of The University Of California | Full Karyotype Single Cell Chromosome Analysis |
| US20060234264A1 (en) | 2005-03-14 | 2006-10-19 | Affymetrix, Inc. | Multiplex polynucleotide synthesis |
| US7618777B2 (en) | 2005-03-16 | 2009-11-17 | Agilent Technologies, Inc. | Composition and method for array hybridization |
| CN102010902B (zh) | 2005-03-18 | 2012-05-23 | 香港中文大学 | 产前诊断和监测的标记 |
| JP5219516B2 (ja) | 2005-03-18 | 2013-06-26 | ザ チャイニーズ ユニバーシティー オブ ホンコン | 染色体異数性の検出方法 |
| AU2006226873B2 (en) * | 2005-03-24 | 2009-09-24 | Zoragen Biotechnologies Llp | Nucleic acid detection |
| WO2006110855A2 (en) | 2005-04-12 | 2006-10-19 | 454 Life Sciences Corporation | Methods for determining sequence variants using ultra-deep sequencing |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| US20090280479A1 (en) | 2005-05-27 | 2009-11-12 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding |
| US20070077570A1 (en) | 2005-05-31 | 2007-04-05 | Applera Corporation | Multiplexed amplification of short nucleic acids |
| EP2477029A1 (en) | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| US7601499B2 (en) | 2005-06-06 | 2009-10-13 | 454 Life Sciences Corporation | Paired end sequencing |
| DK1907571T3 (en) | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
| ATE489473T1 (de) | 2005-07-15 | 2010-12-15 | Life Technologies Corp | Analyse von boten-rna und mikro-rna im gleichen reaktionsansatz |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| RU2290078C1 (ru) | 2005-07-25 | 2006-12-27 | Евгений Владимирович Новичков | Способ прогнозирования рецидива серозного рака яичников |
| US8532930B2 (en) * | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US11111543B2 (en) * | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070178501A1 (en) | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US20070027636A1 (en) | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US8515679B2 (en) | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| EP1924704B1 (en) | 2005-08-02 | 2011-05-25 | Rubicon Genomics, Inc. | Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction |
| US7884119B2 (en) | 2005-09-07 | 2011-02-08 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as Axl inhibitors |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| GB0523276D0 (en) | 2005-11-15 | 2005-12-21 | London Bridge Fertility | Chromosomal analysis by molecular karyotyping |
| EP3012760A1 (en) | 2005-11-26 | 2016-04-27 | Natera, Inc. | System and method for cleaning noisy genetic data and using data to make predictions |
| US20070172853A1 (en) | 2005-12-02 | 2007-07-26 | The General Hospital Corporation | Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility |
| WO2007070482A2 (en) | 2005-12-14 | 2007-06-21 | Xueliang Xia | Microarray-based preimplantation genetic diagnosis of chromosomal abnormalities |
| EP1966394B1 (en) | 2005-12-22 | 2012-07-25 | Keygene N.V. | Improved strategies for transcript profiling using high throughput sequencing technologies |
| PT2385143T (pt) * | 2006-02-02 | 2016-10-18 | Univ Leland Stanford Junior | Rastreio genético fetal não-invasivo por análise digital |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| EP1991675B1 (en) | 2006-02-08 | 2011-06-29 | Illumina Cambridge Limited | End modification to prevent over-representation of fragments |
| US20100184043A1 (en) | 2006-02-28 | 2010-07-22 | University Of Louisville Research Foundation | Detecting Genetic Abnormalities |
| DK2351858T3 (da) | 2006-02-28 | 2015-04-07 | Univ Louisville Res Found | Påvisning af føtale kromosomabnormiteter ved anvendelse af tandem-enkeltnukleotid-polymorfismer |
| US8609338B2 (en) | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2007106545A2 (en) | 2006-03-13 | 2007-09-20 | Veridex, Llc | Propagation of primary cells |
| WO2007111937A1 (en) | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
| US20080038733A1 (en) | 2006-03-28 | 2008-02-14 | Baylor College Of Medicine | Screening for down syndrome |
| JP2009072062A (ja) | 2006-04-07 | 2009-04-09 | Institute Of Physical & Chemical Research | 核酸の5’末端を単離するための方法およびその適用 |
| US20070243549A1 (en) | 2006-04-12 | 2007-10-18 | Biocept, Inc. | Enrichment of circulating fetal dna |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US7901884B2 (en) | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| EP3260556B1 (en) | 2006-05-31 | 2019-07-31 | Sequenom, Inc. | Methods for the extraction of nucleic acid from a sample |
| WO2007146819A2 (en) | 2006-06-09 | 2007-12-21 | Brigham And Women's Hospital, Inc. | Methods for identifying and using snp panels |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| EP2024512A4 (en) | 2006-06-14 | 2009-12-09 | Artemis Health Inc | METHOD FOR DIAGNOSIS OF FEDERAL ANOMALIES |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US20080026390A1 (en) | 2006-06-14 | 2008-01-31 | Roland Stoughton | Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis |
| WO2007147073A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| AU2007260676A1 (en) | 2006-06-14 | 2007-12-21 | Artemis Health, Inc. | Rare cell analysis using sample splitting and DNA tags |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| WO2008111990A1 (en) | 2006-06-14 | 2008-09-18 | Cellpoint Diagnostics, Inc. | Rare cell analysis using sample splitting and dna tags |
| US20080026451A1 (en) | 2006-06-15 | 2008-01-31 | Braman Jeffrey C | System for isolating biomolecules from a sample |
| CN101501251A (zh) | 2006-06-16 | 2009-08-05 | 塞昆纳姆股份有限公司 | 扩增、检测和定量样品中核酸的方法和组合物 |
| US20080182244A1 (en) | 2006-08-04 | 2008-07-31 | Ikonisys, Inc. | Pre-Implantation Genetic Diagnosis Test |
| KR101205619B1 (ko) * | 2006-08-22 | 2012-11-27 | 미합중국 (관리부서 : 미합중국 해군성) | 서열 분석된 유기체의 검출 및 동정을 위한 유전자 표적의 디자인 및 선별 |
| WO2008024473A2 (en) | 2006-08-24 | 2008-02-28 | University Of Massachusetts Medical School | Mapping of genomic interactions |
| WO2008143627A2 (en) | 2006-09-14 | 2008-11-27 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US20080085836A1 (en) | 2006-09-22 | 2008-04-10 | Kearns William G | Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy |
| EP2094838A1 (en) | 2006-10-16 | 2009-09-02 | Cellula, Inc. | Methods and compositions for differential expansion of fetal cells in maternal blood and their use |
| US20100184152A1 (en) | 2006-10-23 | 2010-07-22 | Vladislav Sandler | Target-oriented whole genome amplification of nucleic acids |
| KR100825367B1 (ko) | 2006-11-07 | 2008-04-28 | 전남대학교산학협력단 | 표지자로서 미토콘드리아 유전자 과변이부위를 이용하는조혈모세포이식 후 생착능 평가방법 및 키트 |
| WO2008069906A2 (en) | 2006-11-14 | 2008-06-12 | The Regents Of The University Of California | Digital expression of gene analysis |
| WO2008059578A1 (en) | 2006-11-16 | 2008-05-22 | Olympus Corporation | Multiplex pcr method |
| WO2008061213A2 (en) | 2006-11-16 | 2008-05-22 | Genentech, Inc. | Genetic variations associated with tumors |
| WO2008079374A2 (en) | 2006-12-21 | 2008-07-03 | Wang Eric T | Methods and compositions for selecting and using single nucleotide polymorphisms |
| WO2008081451A2 (en) | 2007-01-03 | 2008-07-10 | Monaliza Medical Ltd. | Methods and kits for analyzing genetic material of a fetus |
| US20080164204A1 (en) | 2007-01-08 | 2008-07-10 | Mehdi Hatamian | Valve for facilitating and maintaining separation of fluids and materials |
| EP2121977B1 (en) | 2007-01-11 | 2017-06-21 | Erasmus University Medical Center | Circular chromosome conformation capture (4c) |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| US20100129792A1 (en) | 2007-02-06 | 2010-05-27 | Gerassimos Makrigiorgos | Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions |
| CA2677517C (en) | 2007-02-08 | 2015-11-03 | Sequenom, Inc. | Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification |
| WO2008115497A2 (en) | 2007-03-16 | 2008-09-25 | Gene Security Network | System and method for cleaning noisy genetic data and determining chromsome copy number |
| CA2679511A1 (en) | 2007-03-16 | 2008-09-25 | 454 Life Sciences Corporation | System and method for detection of hiv drug resistant variants |
| EP2140031A4 (en) | 2007-03-26 | 2011-04-20 | Sequenom Inc | RESTRICTION ENDONUCLEASE REINFORCED POLYMORPHIC SEQUENCE DETECTION |
| JP5262230B2 (ja) | 2007-03-28 | 2013-08-14 | 独立行政法人理化学研究所 | 新規多型検出法 |
| ITTO20070307A1 (it) | 2007-05-04 | 2008-11-05 | Silicon Biosystems Spa | Metodo e dispositivo per la diagnosi prenatale non-invasiva |
| US20080293589A1 (en) | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
| CA2688155C (en) | 2007-05-31 | 2020-02-11 | The Regents Of The University Of California | High specificity and high sensitivity detection based on steric hindrance & enzyme-related signal amplification |
| US8822153B2 (en) | 2007-06-01 | 2014-09-02 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| WO2008157264A2 (en) | 2007-06-15 | 2008-12-24 | Sequenom, Inc. | Combined methods for the detection of chromosomal aneuploidy |
| WO2008155599A1 (en) | 2007-06-20 | 2008-12-24 | Taag-Genetics Sa | Nested multiplex amplification method for identification of multiple biological entities |
| US20090023190A1 (en) | 2007-06-20 | 2009-01-22 | Kai Qin Lao | Sequence amplification with loopable primers |
| WO2009004630A1 (en) | 2007-07-03 | 2009-01-08 | Genaphora Ltd. | Chimeric primers for improved nucleic acid amplification reactions |
| WO2009009769A2 (en) | 2007-07-11 | 2009-01-15 | Artemis Health, Inc. | Diagnosis of fetal abnormalities using nucleated red blood cells |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| KR102339760B1 (ko) | 2007-07-23 | 2021-12-14 | 더 차이니즈 유니버시티 오브 홍콩 | 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법 |
| CN101815789B (zh) | 2007-08-01 | 2013-06-12 | 达纳-法伯癌症研究院有限公司 | 靶序列的富集 |
| WO2009019215A1 (en) | 2007-08-03 | 2009-02-12 | Dkfz Deutsches Krebsforschungszentrum | Method for prenatal diagnosis using exosomes and cd24 as a marker |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| WO2009032779A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for the size-specific seperation of nucleic acid from a sample |
| WO2009032781A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US8748100B2 (en) | 2007-08-30 | 2014-06-10 | The Chinese University Of Hong Kong | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences |
| EA018555B1 (ru) | 2007-09-07 | 2013-08-30 | Флуидигм Корпорейшн | Определение вариаций количества копий, способы и системы |
| EP2201143B2 (en) | 2007-09-21 | 2016-08-24 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| US20090081678A1 (en) | 2007-09-21 | 2009-03-26 | Streck, Inc. | Nucleic acid isolation in preserved whole blood |
| WO2009042198A1 (en) | 2007-09-27 | 2009-04-02 | Fred Hutchinson Cancer Research Center | Identifying a subject with an increased risk of invasive mold infection |
| JP2011500041A (ja) | 2007-10-16 | 2011-01-06 | エフ.ホフマン−ラ ロシュ アーゲー | クローナルシークエンシングによる高分解能かつ高効率のhla遺伝子型決定法 |
| US20100086914A1 (en) | 2008-10-03 | 2010-04-08 | Roche Molecular Systems, Inc. | High resolution, high throughput hla genotyping by clonal sequencing |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| WO2009064897A2 (en) | 2007-11-14 | 2009-05-22 | Chronix Biomedical | Detection of nucleic acid sequence variations in circulating nucleic acid in bovine spongiform encephalopathy |
| US8748113B2 (en) | 2007-11-15 | 2014-06-10 | The Johns Hopkins University | Methods for detecting and monitoring circulating cancer stem cells |
| JP5726529B2 (ja) | 2007-11-30 | 2015-06-03 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 単一試料からのゲノムdna、rnaおよびタンパク質の単離方法 |
| EP2227565A2 (en) | 2007-12-10 | 2010-09-15 | Ben Gurion University Of The Negev Research And Development Authority | Assay for detecting circulating free nucleic acids |
| FR2925480B1 (fr) | 2007-12-21 | 2011-07-01 | Gervais Danone Sa | Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations |
| EP2077337A1 (en) | 2007-12-26 | 2009-07-08 | Eppendorf Array Technologies SA | Amplification and detection composition, method and kit |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| EP2620511B1 (en) | 2008-01-17 | 2018-02-28 | Sequenom, Inc. | Single molecule nucleic acid sequence analysis processes |
| EP3708682B1 (en) | 2008-02-01 | 2022-11-23 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of medical diseases and conditions |
| WO2009099602A1 (en) | 2008-02-04 | 2009-08-13 | Massachusetts Institute Of Technology | Selection of nucleic acids by solution hybridization to oligonucleotide baits |
| WO2009105531A1 (en) | 2008-02-19 | 2009-08-27 | Gene Security Network, Inc. | Methods for cell genotyping |
| US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| EP2271772B1 (en) | 2008-03-11 | 2014-07-16 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| US20090307181A1 (en) | 2008-03-19 | 2009-12-10 | Brandon Colby | Genetic analysis |
| EP2276858A4 (en) | 2008-03-26 | 2011-10-05 | Sequenom Inc | RESTRICTED ENDONUCLEASE AMPLIFIED POLYMORPHIC SEQUENCE DETECTION |
| WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| SI2271767T1 (sl) | 2008-04-03 | 2016-12-30 | Cb Biotechnologies, Inc. | Osvoboditev amplikona multipla verižna reakcija s polimerazo za pomnoževanje multiplih tarč |
| US20110092763A1 (en) | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
| EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
| ES2754033T3 (es) | 2008-07-21 | 2020-04-15 | Becton Dickinson Co | Dispositivo de separación de fase de densidad |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| US20110178719A1 (en) | 2008-08-04 | 2011-07-21 | Gene Security Network, Inc. | Methods for Allele Calling and Ploidy Calling |
| US8697363B2 (en) | 2008-08-26 | 2014-04-15 | Fluidigm Corporation | Methods for detecting multiple target nucleic acids in multiple samples by use nucleotide tags |
| DE102008045705A1 (de) | 2008-09-04 | 2010-04-22 | Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft | Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| JP5727375B2 (ja) | 2008-09-16 | 2015-06-03 | セクエノム, インコーポレイテッド | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2012502632A (ja) | 2008-09-17 | 2012-02-02 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | スモールrnaの単離法 |
| EP2562268B1 (en) | 2008-09-20 | 2016-12-21 | The Board of Trustees of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US20110301221A1 (en) | 2008-10-10 | 2011-12-08 | Swedish Health Services | Diagnosis, prognosis and treatment of glioblastoma multiforme |
| WO2010045617A2 (en) | 2008-10-17 | 2010-04-22 | University Of Louisville Research Foundation | Detecting genetic abnormalities |
| US8236503B2 (en) | 2008-11-07 | 2012-08-07 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| SG10201501804WA (en) | 2008-12-22 | 2015-05-28 | Celula Inc | Methods and genotyping panels for detecting alleles, genomes, and transcriptomes |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| US8450063B2 (en) | 2009-01-28 | 2013-05-28 | Fluidigm Corporation | Determination of copy number differences by amplification |
| WO2010087985A2 (en) | 2009-01-28 | 2010-08-05 | Yale University | Novel markers for detection of complications resulting from in utero encounters |
| US8304187B2 (en) | 2009-02-18 | 2012-11-06 | Streck, Inc. | Preservation of cell-free RNA in blood samples |
| EP2411543B1 (en) | 2009-03-27 | 2017-04-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| US20100285537A1 (en) | 2009-04-02 | 2010-11-11 | Fluidigm Corporation | Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation |
| EP2414547B1 (en) | 2009-04-02 | 2014-03-12 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
| EP3211095B1 (en) | 2009-04-03 | 2019-01-02 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| EP2417270B1 (en) | 2009-04-06 | 2017-09-20 | The Johns Hopkins University | Digital quantification of dna methylation |
| US20120115140A1 (en) | 2009-04-29 | 2012-05-10 | Js Genetics Inc. | Molecular Diagnosis of Fragile X Syndrome Associated with FMR1 Gene |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US8481699B2 (en) | 2009-07-14 | 2013-07-09 | Academia Sinica | Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| US8563242B2 (en) | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| CN101643904B (zh) | 2009-08-27 | 2011-04-27 | 北京北方微电子基地设备工艺研究中心有限责任公司 | 深硅刻蚀装置和深硅刻蚀设备的进气系统 |
| WO2011032078A1 (en) | 2009-09-11 | 2011-03-17 | Health Reseach Inc. | Detection of x4 strains of hiv-1 by heteroduplex tracking assay |
| US9005894B2 (en) | 2009-09-22 | 2015-04-14 | Roche Molecular Systems, Inc. | Determination of KIR haplotypes associated with disease |
| EP2480666B1 (en) | 2009-09-24 | 2017-03-08 | QIAGEN Gaithersburg, Inc. | Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material |
| ES2640776T3 (es) | 2009-09-30 | 2017-11-06 | Natera, Inc. | Métodos para denominar de forma no invasiva ploidía prenatal |
| US9784742B2 (en) | 2009-10-26 | 2017-10-10 | Lifecodexx | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
| US8467976B2 (en) | 2009-11-05 | 2013-06-18 | The Chinese University Of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| EP3719140A1 (en) | 2009-11-06 | 2020-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive diagnosis of graft rejection in organ transplant patients |
| CA2780536C (en) | 2009-11-09 | 2018-01-02 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
| JP2013511991A (ja) | 2009-11-25 | 2013-04-11 | クアンタライフ, インコーポレイテッド | 遺伝子材料を検出する方法および組成物 |
| US20120251411A1 (en) | 2009-12-07 | 2012-10-04 | Min-Yong Jeon | Centrifuge tube |
| MA33899B1 (fr) | 2009-12-08 | 2013-01-02 | Hemaquest Pharmaceuticals Inc | Procedes et regimes a faible dose pour des troubles des globules rouges |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| EP3088532B1 (en) | 2009-12-22 | 2019-10-30 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| US8574842B2 (en) | 2009-12-22 | 2013-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Direct molecular diagnosis of fetal aneuploidy |
| CN102782158A (zh) | 2010-01-15 | 2012-11-14 | 不列颠哥伦比亚大学 | 用于检测核酸变异的多重扩增 |
| GB2479471B (en) | 2010-01-19 | 2012-02-08 | Verinata Health Inc | Method for determining copy number variations |
| US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
| US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US20120270739A1 (en) | 2010-01-19 | 2012-10-25 | Verinata Health, Inc. | Method for sample analysis of aneuploidies in maternal samples |
| US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| US20130143219A1 (en) | 2010-01-28 | 2013-06-06 | Medical College of Wisconsin Inc. | Methods and compositions for high yield, specific amplification |
| US8574832B2 (en) | 2010-02-03 | 2013-11-05 | Massachusetts Institute Of Technology | Methods for preparing sequencing libraries |
| WO2011100057A2 (en) | 2010-02-09 | 2011-08-18 | Eugene Spier | Methods and compositions for universal detection of nucleic acids |
| PT2539472E (pt) | 2010-02-26 | 2015-09-24 | Life Technologies Corp | Pcr rápida para genotipagem de str |
| US9128101B2 (en) | 2010-03-01 | 2015-09-08 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| CN102892901B (zh) | 2010-03-24 | 2015-11-25 | 凸版印刷株式会社 | 利用竞争性引物的目标碱基序列的检测方法 |
| US9255291B2 (en) | 2010-05-06 | 2016-02-09 | Bioo Scientific Corporation | Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing |
| US9234240B2 (en) | 2010-05-07 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| EP2569453B1 (en) | 2010-05-14 | 2015-12-16 | Fluidigm Corporation | Nucleic acid isolation methods |
| WO2011142836A2 (en) | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Assays for the detection of genotype, mutations, and/or aneuploidy |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190309358A1 (en) | 2010-05-18 | 2019-10-10 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190284623A1 (en) | 2010-05-18 | 2019-09-19 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2013052557A2 (en) | 2011-10-03 | 2013-04-11 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| US20140206552A1 (en) | 2010-05-18 | 2014-07-24 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| US20130196862A1 (en) | 2010-05-18 | 2013-08-01 | Natera, Inc. | Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20130123120A1 (en) | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20220356526A1 (en) | 2010-05-18 | 2022-11-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| EP2854058A3 (en) | 2010-05-18 | 2015-10-28 | Natera, Inc. | Methods for non-invasive pre-natal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20110301854A1 (en) | 2010-06-08 | 2011-12-08 | Curry Bo U | Method of Determining Allele-Specific Copy Number of a SNP |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20120190557A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
| JP2012085556A (ja) | 2010-10-18 | 2012-05-10 | Shinya Watanabe | 乳がんの診断方法 |
| WO2012058316A1 (en) | 2010-10-26 | 2012-05-03 | Stanford University | Non-invasive fetal genetic screening by sequencing analysis |
| DK2633071T3 (en) | 2010-10-27 | 2017-01-30 | Harvard College | COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE |
| US9163329B2 (en) | 2010-11-12 | 2015-10-20 | Agilent Technologies, Inc. | RNA labeling method |
| KR102185244B1 (ko) | 2010-11-30 | 2020-12-02 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| WO2012078792A2 (en) | 2010-12-07 | 2012-06-14 | Stanford University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
| EP3564392B1 (en) | 2010-12-17 | 2021-11-24 | Life Technologies Corporation | Methods for nucleic acid amplification |
| US20150064695A1 (en) | 2010-12-17 | 2015-03-05 | Celula Inc. | Methods for screening and diagnosing genetic conditions |
| RU2620959C2 (ru) | 2010-12-22 | 2017-05-30 | Натера, Инк. | Способы неинвазивного пренатального установления отцовства |
| BR112013016708B1 (pt) | 2010-12-30 | 2021-08-17 | Foundation Medicine, Inc | Otimização de análise multigene de amostras de tumor |
| US20120190020A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Detection of genetic abnormalities |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| EP2902500B1 (en) | 2011-02-09 | 2017-01-11 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| WO2012113780A1 (en) | 2011-02-21 | 2012-08-30 | Qiagen Gmbh | Method for quantifying human dna |
| GB2488358A (en) | 2011-02-25 | 2012-08-29 | Univ Plymouth | Enrichment of foetal DNA in maternal plasma |
| WO2012122374A2 (en) | 2011-03-08 | 2012-09-13 | Children's Medical Center Corporation | Non-invasive methods for diagnosing chronic organ transplant rejection |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| AU2012242698C1 (en) | 2011-04-12 | 2015-06-04 | Verinata Health, Inc. | Resolving genome fractions using polymorphism counts |
| WO2012142531A2 (en) | 2011-04-14 | 2012-10-18 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
| US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| WO2012142213A2 (en) | 2011-04-15 | 2012-10-18 | The Johns Hopkins University | Safe sequencing system |
| WO2012149438A1 (en) | 2011-04-28 | 2012-11-01 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| WO2012149339A2 (en) | 2011-04-29 | 2012-11-01 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| CN102876660A (zh) | 2011-07-11 | 2013-01-16 | 三星电子株式会社 | 扩增靶核酸的方法和测定样品中的靶核酸的相对量的方法 |
| US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| EP2753715A4 (en) | 2011-09-09 | 2015-05-20 | Univ Leland Stanford Junior | METHOD FOR OBTAINING A SEQUENCE |
| JP5536729B2 (ja) | 2011-09-20 | 2014-07-02 | 株式会社ソニー・コンピュータエンタテインメント | 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法 |
| CN113388605A (zh) | 2011-09-26 | 2021-09-14 | 凯杰有限公司 | 用于分离细胞外核酸的快速方法 |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US20140242588A1 (en) | 2011-10-06 | 2014-08-28 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
| US20140234273A1 (en) | 2011-10-07 | 2014-08-21 | Muroch Children Research Institute | Diagnostic assay for tissue transplantation status |
| WO2013078470A2 (en) | 2011-11-22 | 2013-05-30 | MOTIF, Active | Multiplex isolation of protein-associated nucleic acids |
| WO2013086464A1 (en) | 2011-12-07 | 2013-06-13 | The Broad Institute, Inc. | Markers associated with chronic lymphocytic leukemia prognosis and progression |
| WO2013086352A1 (en) | 2011-12-07 | 2013-06-13 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| UA115321C2 (uk) | 2011-12-16 | 2017-10-25 | Басф Агрокемікал Продактс Б.В. | Спосіб та комплект для аналізу ahasl генів у рослин |
| US20130190653A1 (en) | 2012-01-25 | 2013-07-25 | Angel Gabriel Alvarez Ramos | Device for blood collection from the placenta and the umbilical cord |
| CN104204228A (zh) | 2012-02-14 | 2014-12-10 | 康奈尔大学 | 使用组合的核酸酶、连接和聚合酶反应用于核酸序列的相对定量、表达或拷贝变化的方法 |
| US9670529B2 (en) | 2012-02-28 | 2017-06-06 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
| WO2013130848A1 (en) | 2012-02-29 | 2013-09-06 | Natera, Inc. | Informatics enhanced analysis of fetal samples subject to maternal contamination |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US9862995B2 (en) | 2012-03-13 | 2018-01-09 | Abhijit Ajit Patel | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| CA3209140A1 (en) | 2012-04-19 | 2013-10-24 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| EP2653562A1 (en) | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| CA2873176C (en) | 2012-05-10 | 2024-02-27 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| CN104736722B (zh) | 2012-05-21 | 2018-08-07 | 斯克利普斯研究所 | 样品制备方法 |
| US10077474B2 (en) | 2012-05-29 | 2018-09-18 | Abbott Molecular, Inc. | Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits |
| CN104350152B (zh) | 2012-06-01 | 2017-08-11 | 欧米伽生物技术公司 | 选择性核酸片段回收 |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| EP2877594B1 (en) | 2012-07-20 | 2019-12-04 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
| HK1211058A1 (en) | 2012-07-24 | 2016-05-13 | 纳特拉公司 | Highly multiplex pcr methods and compositions |
| JP6285436B2 (ja) | 2012-08-03 | 2018-02-28 | フェリング ベスローテン フェンノートシャップ | 雌性不妊症のための治療標的および診断マーカーとしての無細胞dna |
| US10993418B2 (en) | 2012-08-13 | 2021-05-04 | Life Genetics Lab, Llc | Method for measuring tumor burden in patient derived xenograft (PDX) mice |
| EP2867252B1 (en) | 2012-08-15 | 2019-12-04 | Université de Montréal | Method for identifying novel minor histocompatibility antigens |
| US20140051585A1 (en) | 2012-08-15 | 2014-02-20 | Natera, Inc. | Methods and compositions for reducing genetic library contamination |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CN108103057B (zh) | 2012-08-28 | 2021-09-03 | 阿科尼生物系统公司 | 用于纯化核酸的方法和试剂盒 |
| DE202013012824U1 (de) | 2012-09-04 | 2020-03-10 | Guardant Health, Inc. | Systeme zum Erfassen von seltenen Mutationen und einer Kopienzahlvariation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20140065621A1 (en) | 2012-09-04 | 2014-03-06 | Natera, Inc. | Methods for increasing fetal fraction in maternal blood |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20220411875A1 (en) | 2012-10-03 | 2022-12-29 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
| EP2728014B1 (en) | 2012-10-31 | 2015-10-07 | Genesupport SA | Non-invasive method for detecting a fetal chromosomal aneuploidy |
| JP2014118334A (ja) | 2012-12-18 | 2014-06-30 | Sumitomo Electric Ind Ltd | 光ファイバ製造方法 |
| EP2943590A4 (en) | 2013-01-13 | 2017-02-15 | Unitaq Bio | Methods and compositions for pcr using blocked and universal primers |
| EP2954054B1 (en) | 2013-02-08 | 2018-12-05 | Qiagen GmbH | Method for separating dna by size |
| US9982255B2 (en) | 2013-03-11 | 2018-05-29 | Kailos Genetics, Inc. | Capture methodologies for circulating cell free DNA |
| EP2971168B1 (en) | 2013-03-15 | 2021-05-05 | Guardant Health, Inc. | Method of detecting cancer |
| GB201304810D0 (en) | 2013-03-15 | 2013-05-01 | Isis Innovation | Assay |
| EP2971152B1 (en) | 2013-03-15 | 2018-08-01 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| US20140272956A1 (en) | 2013-03-15 | 2014-09-18 | Abbott Molecular Inc. | Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits |
| CA3156663A1 (en) | 2013-03-15 | 2014-09-18 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| AU2014233262A1 (en) | 2013-03-15 | 2015-09-10 | Immucor Gti Diagnostics, Inc. | Methods and compositions for assessing renal status using urine cell free DNA |
| WO2014143989A1 (en) | 2013-03-15 | 2014-09-18 | Medical College Of Wisconsin, Inc. | Fetal well being surveillance using fetal specific cell free dna |
| US10385394B2 (en) | 2013-03-15 | 2019-08-20 | The Translational Genomics Research Institute | Processes of identifying and characterizing X-linked disorders |
| US10072298B2 (en) | 2013-04-17 | 2018-09-11 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| HRP20190209T4 (hr) | 2013-05-29 | 2023-09-15 | Chronix Biomedical | Detekcija i kvantifikacija acelularne dnk darivatelja u krvotoku primatelja presađivanja organa |
| WO2015026873A1 (en) | 2013-08-19 | 2015-02-26 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| WO2015035177A1 (en) | 2013-09-06 | 2015-03-12 | Immucor Gti Diagnostics, Inc. | Compositions and methods for diagnosis and prediction of solid organ graft rejection |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| EP3049557B1 (en) | 2013-09-27 | 2021-05-05 | University of Washington | Methods and systems for large scale scaffolding of genome assemblies |
| WO2015069933A1 (en) | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| CA2929557C (en) | 2013-11-07 | 2023-09-26 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
| ES2693217T3 (es) | 2013-12-02 | 2018-12-10 | Personal Genome Diagnostics Inc. | Método para evaluar variantes minoritarias en una muestra |
| SG10201804519RA (en) | 2013-12-28 | 2018-07-30 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| CN114717291A (zh) | 2013-12-30 | 2022-07-08 | 阿特雷卡公司 | 使用核酸条形码分析与单细胞缔合的核酸 |
| EP4219744A3 (en) | 2014-01-27 | 2023-08-30 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
| JP6494045B2 (ja) | 2014-02-11 | 2019-04-03 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 標的シーケンシングおよびuidフィルタリング |
| US20170051343A1 (en) | 2014-02-14 | 2017-02-23 | The Board Of Regents Of The University Of Texas System | Strand exchange hairpin primers that give high allelic discrimination |
| US10208338B2 (en) | 2014-03-03 | 2019-02-19 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| BR112016021038B1 (pt) | 2014-03-14 | 2023-12-12 | CareDx, Inc | Métodos para monitorar terapias imunosupressoras em um receptor de transplante |
| CN106462669A (zh) | 2014-03-25 | 2017-02-22 | 奎斯特诊断投资股份有限公司 | 通过使用平均循环阈值的基因内差异表达(ide)检测基因融合 |
| WO2015164432A1 (en) | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CN106460070B (zh) | 2014-04-21 | 2021-10-08 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
| JP6681841B2 (ja) | 2014-05-09 | 2020-04-15 | ライフコーデックス アーゲー | 特別な細胞タイプに由来するdnaの検出とそれに関連する方法 |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2015197858A1 (en) | 2014-06-27 | 2015-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods employing circulating dna and mirna as biomarkers for female infertility |
| WO2016004368A2 (en) | 2014-07-03 | 2016-01-07 | Rhodx, Inc. | Tagging and assessing a target sequence |
| WO2016001411A1 (en) | 2014-07-03 | 2016-01-07 | Multiplicom N.V. | Methods for non-invasive detection of transplant health or rejection |
| CN106574265B (zh) | 2014-07-17 | 2020-07-28 | 凯杰有限公司 | 高产量分离rna的方法 |
| GB201412834D0 (en) | 2014-07-18 | 2014-09-03 | Cancer Rec Tech Ltd | A method for detecting a genetic variant |
| EP3656875B1 (en) | 2014-07-18 | 2021-09-22 | Illumina, Inc. | Non-invasive prenatal diagnosis |
| CA2957657A1 (en) | 2014-08-22 | 2016-02-25 | Resolution Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| AU2015330844B2 (en) | 2014-10-08 | 2022-02-03 | Cornell University | Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes |
| ES2708030T3 (es) | 2014-10-20 | 2019-04-08 | Inst Nat Sante Rech Med | Métodos para explorar a un individuo en busca de un cáncer |
| EP3209403A4 (en) | 2014-10-24 | 2018-09-12 | Abbott Molecular Inc. | Enrichment of small nucleic acids |
| DK3218519T3 (da) | 2014-11-11 | 2020-12-21 | Bgi Shenzhen | Multipass-sekvensering |
| WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
| US11279974B2 (en) | 2014-12-01 | 2022-03-22 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
| WO2016109604A2 (en) | 2014-12-29 | 2016-07-07 | InnoGenomics Technologies, LLC | Multiplexed assay for quantitating and assessing integrity of cell-free dna in biological fluids for cancer diagnosis, prognosis, and surveillance |
| GB201501907D0 (en) | 2015-02-05 | 2015-03-25 | Technion Res & Dev Foundation | System and method for single cell genetic analysis |
| WO2016123698A1 (en) | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016138080A1 (en) | 2015-02-24 | 2016-09-01 | Trustees Of Boston University | Protection of barcodes during dna amplification using molecular hairpins |
| US20160257993A1 (en) | 2015-02-27 | 2016-09-08 | Cellular Research, Inc. | Methods and compositions for labeling targets |
| EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
| KR101850437B1 (ko) | 2015-04-14 | 2018-04-20 | 이원다이애그노믹스(주) | 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법 |
| CN107580632B (zh) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | 用于全转录组扩增的方法和组合物 |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| MX2017013878A (es) | 2015-04-30 | 2018-06-22 | Medical College Of Wisconsin Inc | Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula. |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| MX388150B (es) | 2015-06-01 | 2025-03-19 | Gea Food Solutions Weert Bv | Metodo para recubrir una paleta. |
| ES2906751T3 (es) | 2015-06-05 | 2022-04-20 | Qiagen Gmbh | Método para separar el DNA por tamaño |
| US20160371428A1 (en) | 2015-06-19 | 2016-12-22 | Natera, Inc. | Systems and methods for determining aneuploidy risk using sample fetal fraction |
| EP3317420B1 (en) | 2015-07-02 | 2021-10-20 | Arima Genomics, Inc. | Accurate molecular deconvolution of mixtures samples |
| CA2992139A1 (en) | 2015-07-10 | 2017-01-19 | West Virginia University | Markers of stroke and stroke severity |
| WO2017009851A2 (en) | 2015-07-16 | 2017-01-19 | Pomvom Ltd. | Coordinating communication and/or storage based on image analysis |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| CN106544407B (zh) | 2015-09-18 | 2019-11-08 | 广州华大基因医学检验所有限公司 | 确定受体cfDNA样本中供体来源cfDNA比例的方法 |
| EP3356559A4 (en) | 2015-09-29 | 2019-03-06 | Ludwig Institute for Cancer Research Ltd | TYPING AND COMPOSITION OF DISCONTINUOUS GENOMIC ELEMENTS |
| WO2017070123A1 (en) | 2015-10-19 | 2017-04-27 | Dovetail Genomics, Llc | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| AU2016342263B2 (en) | 2015-10-22 | 2021-07-22 | Cytosorbents Corporation | Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins an potassium from biological fluids |
| WO2017079593A1 (en) | 2015-11-04 | 2017-05-11 | Atreca, Inc. | Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells |
| CN108779487A (zh) | 2015-11-16 | 2018-11-09 | 普罗格尼迪公司 | 用于检测甲基化状态的核酸和方法 |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| CN108603232A (zh) | 2015-12-03 | 2018-09-28 | 阿尔佛雷德医疗集团 | 监测骨髓瘤的治疗或进展 |
| CN105986030A (zh) | 2016-02-03 | 2016-10-05 | 广州市基准医疗有限责任公司 | 甲基化dna检测方法 |
| EP4574992A3 (en) | 2016-03-22 | 2025-07-16 | Myriad Women's Health, Inc. | Combinatorial dna screening |
| US10781439B2 (en) | 2016-03-30 | 2020-09-22 | Covaris, Inc. | Extraction of cfDNA from biological samples |
| EP3436606B8 (en) | 2016-04-01 | 2023-03-15 | M.A.G.I.C. Clinic Ltd. | Plasma derived cell-free mitochondrial deoxyribonucleic acid |
| SG11201808740TA (en) | 2016-04-07 | 2018-11-29 | Rutgers The State University Of New Jersey | Multiplex nucleic acid assay methods capable of detecting closely related alleles, and reagents therefor |
| ES3002715T3 (en) | 2016-04-14 | 2025-03-07 | Guardant Health Inc | Methods for early detection of cancer |
| ES2913468T3 (es) | 2016-04-15 | 2022-06-02 | Natera Inc | Métodos para la detección del cáncer de pulmón. |
| CN109661476A (zh) | 2016-04-29 | 2019-04-19 | 威斯康星州立大学医学院 | 用于评估胎儿健康的多重优化错配扩增(moma)实时pcr |
| EA201892489A1 (ru) | 2016-04-29 | 2019-05-31 | Дзе Медикал Колледж Оф Висконсин, Инк. | Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma) |
| CA3022545A1 (en) | 2016-04-29 | 2017-11-02 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| WO2017205540A1 (en) | 2016-05-24 | 2017-11-30 | The Translational Genomics Research Institute | Molecular tagging methods and sequencing libraries |
| EP4043581A1 (en) | 2016-05-27 | 2022-08-17 | Sequenom, Inc. | Method for generating a paralog assay system |
| EP3510171A4 (en) | 2016-07-01 | 2020-04-29 | Natera, Inc. | COMPOSITIONS AND METHODS FOR DETECTION OF NUCLEIC ACID MUTATIONS |
| EP4322168A3 (en) | 2016-07-06 | 2024-05-15 | Guardant Health, Inc. | Methods for fragmentome profiling of cell-free nucleic acids |
| CN109890977A (zh) | 2016-08-17 | 2019-06-14 | 加利福尼亚大学董事会 | 通过基于生物流体的无细胞dna(cfdna)测定评价器官损伤状态的基于免疫探针的新方法 |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| CN109890984B (zh) | 2016-10-19 | 2024-03-29 | 香港中文大学 | 通过母体血浆dna的甲基化和大小谱分析进行胎龄评估 |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| AU2017355464A1 (en) | 2016-11-02 | 2019-05-30 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total and specific cell-free DNA |
| WO2018085597A1 (en) | 2016-11-02 | 2018-05-11 | Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| EP4628595A3 (en) | 2016-11-08 | 2025-11-05 | Becton, Dickinson and Company | Methods for cell label classification |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| WO2018119422A1 (en) | 2016-12-22 | 2018-06-28 | Duke University | Polycationic microfibers and methods of using the same |
| CN110249060A (zh) | 2017-01-17 | 2019-09-17 | 生命技术公司 | 用于免疫组库测序的组合物和方法 |
| US10894976B2 (en) | 2017-02-21 | 2021-01-19 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| EP3642367A1 (en) | 2017-06-20 | 2020-04-29 | The Medical College of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
| CN110945136A (zh) | 2017-06-20 | 2020-03-31 | 威斯康星州立大学医学院 | 使用总无细胞dna评估移植并发症风险 |
| EP3642356A4 (en) | 2017-06-20 | 2021-03-17 | The Medical College of Wisconsin, Inc. | FOLLOW-UP OF A TRANSPLANTED PATIENT WITH ACELLULAR DNA |
| US20200141925A1 (en) | 2017-07-07 | 2020-05-07 | Mcmaster University | Risk Assessment Tool for Patients with Sepsis |
| WO2019008408A1 (en) | 2017-07-07 | 2019-01-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM MYELOPROLIFERATIVE NEOPLASM IS AT RISK OF THROMBOSIS |
| CN107365769B (zh) | 2017-07-25 | 2021-05-04 | 深圳华大智造科技股份有限公司 | 一种鼓泡状引物及其组成的试剂盒和应用 |
| KR102775704B1 (ko) | 2017-08-07 | 2025-02-28 | 더 존스 홉킨스 유니버시티 | 암을 평가하고 치료하기 위한 방법 및 재료 |
| EA202090517A1 (ru) | 2017-08-17 | 2020-06-03 | Тэй Дайагностикс, Инк. | Способы определения донорской внеклеточной днк без генотипа донора |
| EP3676399B1 (en) | 2017-09-01 | 2022-05-11 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| AU2018332326B2 (en) | 2017-09-18 | 2025-04-03 | Santersus Ag | Method and device for purification of blood from circulating cell free DNA |
| US11091800B2 (en) | 2017-09-20 | 2021-08-17 | University Of Utah Research Foundation | Size-selection of cell-free DNA for increasing family size during next-generation sequencing |
| KR20200116081A (ko) | 2017-12-01 | 2020-10-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | 유전자 조작된 세포의 투약 및 조절 방법 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| CA3085565A1 (en) | 2017-12-15 | 2019-06-20 | Acrannolife Genomics Pvt. Ltd. | A non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
| US20210071246A1 (en) | 2018-01-12 | 2021-03-11 | Natera, Inc. | Novel primers and uses thereof |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| GB201819134D0 (en) | 2018-11-23 | 2019-01-09 | Cancer Research Tech Ltd | Improvements in variant detection |
| JP7573443B2 (ja) | 2018-04-14 | 2024-10-25 | ナテラ, インコーポレイテッド | 循環腫瘍dnaの個別化された検出を用いる癌検出およびモニタリングの方法 |
| WO2019217918A1 (en) | 2018-05-10 | 2019-11-14 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets |
| US20210257048A1 (en) | 2018-06-12 | 2021-08-19 | Natera, Inc. | Methods and systems for calling mutations |
| EP3818177A1 (en) | 2018-07-03 | 2021-05-12 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020018522A1 (en) | 2018-07-17 | 2020-01-23 | Natera, Inc. | Methods and systems for calling ploidy states using a neural network |
| KR20210038577A (ko) | 2018-07-23 | 2021-04-07 | 가던트 헬쓰, 인크. | 종양 분율 및 커버리지에 의해 종양 돌연변이 부담을 조정하기 위한 방법 및 시스템 |
| WO2020041449A1 (en) | 2018-08-21 | 2020-02-27 | Zymo Research Corporation | Methods and compositions for tracking sample quality |
| WO2020076957A1 (en) | 2018-10-09 | 2020-04-16 | Tai Diagnostics, Inc. | Cell lysis assay for cell-free dna analysis |
| BR112021009706A2 (pt) | 2018-11-21 | 2021-08-17 | Karius, Inc. | detecção e predição de doença infecciosa |
| EP3899033A4 (en) | 2018-12-17 | 2022-10-19 | The Medical College of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| CA3123847A1 (en) | 2018-12-17 | 2020-06-25 | Natera, Inc. | Methods for analysis of circulating cells |
| WO2020206269A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| WO2020206292A2 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
| WO2020206290A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| WO2020214547A1 (en) | 2019-04-15 | 2020-10-22 | Natera, Inc. | Improved liquid biopsy using size selection |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| US20220340963A1 (en) | 2019-09-20 | 2022-10-27 | Natera, Inc. | Methods for assessing graft suitability for transplantation |
| CA3180334A1 (en) | 2020-05-29 | 2021-12-02 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| WO2022015676A1 (en) | 2020-07-13 | 2022-01-20 | The Medical College Of Wisconsin, Inc. | Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values |
| CN116964223A (zh) | 2021-02-25 | 2023-10-27 | 纳特拉公司 | 用于检测多个器官的移植受体中的供体源性游离dna的方法 |
| JP2024511980A (ja) | 2021-03-18 | 2024-03-18 | ナテラ, インコーポレイテッド | 移植拒絶反応の判定方法 |
| WO2022225933A1 (en) | 2021-04-22 | 2022-10-27 | Natera, Inc. | Methods for determining velocity of tumor growth |
| CA3225014A1 (en) | 2021-08-02 | 2023-02-09 | Georgina GOLDRING | Methods for detecting neoplasm in pregnant women |
| EP4396378A1 (en) | 2021-09-01 | 2024-07-10 | Natera, Inc. | Methods for non-invasive prenatal testing |
-
2011
- 2011-11-18 RU RU2013141237A patent/RU2671980C2/ru active
- 2011-11-18 JP JP2013553423A patent/JP6153874B2/ja active Active
- 2011-11-18 AU AU2011358564A patent/AU2011358564B9/en active Active
- 2011-11-18 WO PCT/US2011/061506 patent/WO2012108920A1/en not_active Ceased
- 2011-11-18 CA CA2824387A patent/CA2824387C/en active Active
- 2011-11-18 BR BR112013020220-3A patent/BR112013020220B1/pt active IP Right Grant
- 2011-11-18 EP EP11858061.2A patent/EP2673729B1/en active Active
- 2011-11-18 CN CN201180069972.0A patent/CN103608818B/zh active Active
- 2011-11-18 US US13/300,235 patent/US10017812B2/en active Active
-
2013
- 2013-03-08 US US13/791,397 patent/US9163282B2/en active Active
- 2013-08-07 IL IL227842A patent/IL227842A0/en unknown
-
2017
- 2017-05-03 US US15/586,013 patent/US20170242960A1/en not_active Abandoned
- 2017-10-06 US US15/727,428 patent/US20180025109A1/en not_active Abandoned
-
2018
- 2018-03-09 US US15/917,383 patent/US10174369B2/en active Active
-
2019
- 2019-02-28 US US16/289,049 patent/US20190211391A1/en not_active Abandoned
- 2019-02-28 US US16/289,528 patent/US20190249241A1/en not_active Abandoned
- 2019-03-21 US US16/360,843 patent/US20190203290A1/en not_active Abandoned
- 2019-03-22 US US16/361,611 patent/US20190211393A1/en not_active Abandoned
- 2019-03-22 US US16/361,511 patent/US12020778B2/en active Active
- 2019-04-30 US US16/399,991 patent/US20190256908A1/en active Granted
- 2019-04-30 US US16/399,794 patent/US20190256906A1/en not_active Abandoned
- 2019-05-02 US US16/401,535 patent/US20190256909A1/en not_active Abandoned
- 2019-05-28 US US16/424,290 patent/US20190360036A1/en not_active Abandoned
-
2020
- 2020-02-27 US US16/803,782 patent/US20200190573A1/en active Granted
-
2021
- 2021-07-16 US US17/377,802 patent/US20210355536A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12494267B2 (en) | Methods for non-invasive prenatal ploidy calling | |
| JP7503043B2 (ja) | 高度多重pcr法および組成物 | |
| US12152275B2 (en) | Methods for non-invasive prenatal ploidy calling | |
| US12020778B2 (en) | Methods for non-invasive prenatal ploidy calling | |
| US11339429B2 (en) | Methods for non-invasive prenatal ploidy calling | |
| US11332785B2 (en) | Methods for non-invasive prenatal ploidy calling | |
| US20190309358A1 (en) | Methods for non-invasive prenatal ploidy calling | |
| US20190284623A1 (en) | Methods for non-invasive prenatal ploidy calling | |
| US20170051355A1 (en) | Highly multiplex pcr methods and compositions | |
| EP2847347B1 (en) | Highly multiplex pcr methods and compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141118 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20141118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160105 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160404 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160705 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20160705 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20160705 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20160705 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20160722 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161220 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170113 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170509 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170531 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6153874 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |