JP5379692B2 - 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 - Google Patents

潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 Download PDF

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JP5379692B2
JP5379692B2 JP2009535728A JP2009535728A JP5379692B2 JP 5379692 B2 JP5379692 B2 JP 5379692B2 JP 2009535728 A JP2009535728 A JP 2009535728A JP 2009535728 A JP2009535728 A JP 2009535728A JP 5379692 B2 JP5379692 B2 JP 5379692B2
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heteroaryl
aryl
compound
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JP2010509284A (ja
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トホルマンン ミチャエル
アルムステトテル ミチャエル
トレムル アンドレアス
ヘイセル ウルリクフ
ブクフホルズ ミルコ
ジョハンネス ニエストロジェ アンドレ
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プロビオドルグ エージー
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JP2009535728A 2006-11-09 2007-11-08 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 Expired - Fee Related JP5379692B2 (ja)

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US86498606P 2006-11-09 2006-11-09
US60/864,986 2006-11-09
PCT/EP2007/062030 WO2008055945A1 (en) 2006-11-09 2007-11-08 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases

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JP2013154932A Division JP5798157B2 (ja) 2006-11-09 2013-07-25 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体

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JP2010509284A JP2010509284A (ja) 2010-03-25
JP2010509284A5 JP2010509284A5 (enExample) 2011-02-17
JP5379692B2 true JP5379692B2 (ja) 2013-12-25

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JP2009535728A Expired - Fee Related JP5379692B2 (ja) 2006-11-09 2007-11-08 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
JP2013154932A Expired - Fee Related JP5798157B2 (ja) 2006-11-09 2013-07-25 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体

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US (1) US8278345B2 (enExample)
EP (1) EP2089383B1 (enExample)
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KR101706789B1 (ko) 2008-07-21 2017-02-14 프로비오드룩 아게 진단용 항체 검사법
TW201016702A (en) * 2008-09-25 2010-05-01 Shionogi & Co Novel pyrrolinone derivative and pharmaceutical composition comprising the same
CN102695546B (zh) 2009-09-11 2014-09-10 前体生物药物股份公司 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物
US20110152341A1 (en) 2009-12-22 2011-06-23 Probiodrug Ag Cleavage of b-amyloid precursor protein
CN102947705A (zh) 2010-02-18 2013-02-27 前体生物药物股份公司 通过确定焦谷氨酸修饰的mcp-1诊断炎性疾病的方法和谷氨酰胺酰基环化酶抑制剂的筛选方法
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
SG183229A1 (en) 2010-03-10 2012-09-27 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
EP2606129B1 (en) 2010-08-19 2015-03-25 Probiodrug AG Crystal structure of glutaminyl cyclase
EP2686346B1 (en) 2011-03-16 2016-12-14 Probiodrug AG Diagnostic antibody assay
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
JP2014515364A (ja) * 2011-05-27 2014-06-30 プロビオドルグ エージー 放射能標識グルタミニルシクラーゼ阻害剤
US9737522B2 (en) 2012-08-09 2017-08-22 Emory University NMDA receptor modulators and uses related thereto
GB201308217D0 (en) 2013-05-08 2013-06-12 Ucl Business Plc Compounds and their use in therapy
WO2015004610A1 (en) 2013-07-11 2015-01-15 Adamed Sp. Z O.O. 1,5-dihydropyrrol-2-one derivatives as inhibitors of p53-mdm2/mdm4 protein-protein interaction
US20170363645A1 (en) 2014-12-19 2017-12-21 Probiodrug Ag Novel Method for the Detection of pGlu-Abeta Peptides
EP3287453A1 (en) * 2015-04-24 2018-02-28 Medshine Discovery Inc. Imidazole compound
WO2018072702A1 (zh) * 2016-10-20 2018-04-26 南京明德新药研发股份有限公司 一种咪唑类化合物的晶型、盐型及其制备方法
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase
EP3521308B1 (en) 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Humanized and de-immunized antibodies
EP3543231A1 (en) * 2018-03-19 2019-09-25 ETH Zurich Compounds for treating cns- and neurodegenerative diseases
CN109535140A (zh) * 2018-12-29 2019-03-29 常州大学 一种基于肟酯与吲哚构建双吲哚取代二氢吡咯酮类衍生物的方法

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