JP5054975B2 - アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 - Google Patents
アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 Download PDFInfo
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- JP5054975B2 JP5054975B2 JP2006533879A JP2006533879A JP5054975B2 JP 5054975 B2 JP5054975 B2 JP 5054975B2 JP 2006533879 A JP2006533879 A JP 2006533879A JP 2006533879 A JP2006533879 A JP 2006533879A JP 5054975 B2 JP5054975 B2 JP 5054975B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50822603P | 2003-09-30 | 2003-09-30 | |
| US60/508,226 | 2003-09-30 | ||
| US56654604P | 2004-04-29 | 2004-04-29 | |
| US60/566,546 | 2004-04-29 | ||
| PCT/US2004/028817 WO2005033321A2 (en) | 2003-09-30 | 2004-09-30 | Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010272649A Division JP5797397B2 (ja) | 2003-09-30 | 2010-12-07 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2012053003A Division JP5431516B2 (ja) | 2003-09-30 | 2012-03-09 | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007507223A JP2007507223A (ja) | 2007-03-29 |
| JP2007507223A5 JP2007507223A5 (https=) | 2007-11-22 |
| JP5054975B2 true JP5054975B2 (ja) | 2012-10-24 |
Family
ID=34426044
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533879A Expired - Lifetime JP5054975B2 (ja) | 2003-09-30 | 2004-09-30 | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| JP2010272649A Expired - Lifetime JP5797397B2 (ja) | 2003-09-30 | 2010-12-07 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2012053003A Expired - Lifetime JP5431516B2 (ja) | 2003-09-30 | 2012-03-09 | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| JP2013191907A Expired - Lifetime JP5911069B2 (ja) | 2003-09-30 | 2013-09-17 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2015114170A Expired - Lifetime JP6335141B2 (ja) | 2003-09-30 | 2015-06-04 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2016211386A Expired - Lifetime JP6516713B2 (ja) | 2003-09-30 | 2016-10-28 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2018067535A Expired - Lifetime JP6673963B2 (ja) | 2003-09-30 | 2018-03-30 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2019221986A Pending JP2020054373A (ja) | 2003-09-30 | 2019-12-09 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2022161483A Pending JP2022173573A (ja) | 2003-09-30 | 2022-10-06 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010272649A Expired - Lifetime JP5797397B2 (ja) | 2003-09-30 | 2010-12-07 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2012053003A Expired - Lifetime JP5431516B2 (ja) | 2003-09-30 | 2012-03-09 | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| JP2013191907A Expired - Lifetime JP5911069B2 (ja) | 2003-09-30 | 2013-09-17 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2015114170A Expired - Lifetime JP6335141B2 (ja) | 2003-09-30 | 2015-06-04 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2016211386A Expired - Lifetime JP6516713B2 (ja) | 2003-09-30 | 2016-10-28 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2018067535A Expired - Lifetime JP6673963B2 (ja) | 2003-09-30 | 2018-03-30 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2019221986A Pending JP2020054373A (ja) | 2003-09-30 | 2019-12-09 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| JP2022161483A Pending JP2022173573A (ja) | 2003-09-30 | 2022-10-06 | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
Country Status (17)
| Country | Link |
|---|---|
| US (13) | US7906111B2 (https=) |
| EP (7) | EP2345731B1 (https=) |
| JP (9) | JP5054975B2 (https=) |
| CN (4) | CN102212558B (https=) |
| AU (2) | AU2004278684B2 (https=) |
| BE (1) | BE2021C533I2 (https=) |
| CA (3) | CA3072423A1 (https=) |
| CY (3) | CY1119833T1 (https=) |
| DK (4) | DK2345731T3 (https=) |
| ES (5) | ES2555612T3 (https=) |
| FR (1) | FR21C1037I1 (https=) |
| HU (4) | HUE033158T2 (https=) |
| NZ (1) | NZ545628A (https=) |
| PL (2) | PL2292780T3 (https=) |
| PT (2) | PT2292780T (https=) |
| SI (2) | SI2292780T1 (https=) |
| WO (1) | WO2005033321A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012175974A (ja) * | 2003-09-30 | 2012-09-13 | Trustees Of The Univ Of Pennsylvania | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| WO2020101042A1 (en) | 2018-11-16 | 2020-05-22 | Astellas Pharma Inc. | Method for treating muscular dystrophy by targeting utrophin gene |
| WO2020241903A1 (en) | 2019-05-28 | 2020-12-03 | Astellas Pharma Inc. | Method for treating muscular dystrophy by targeting dmpk gene |
Families Citing this family (658)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| ES2361000T3 (es) | 2004-04-28 | 2011-06-13 | The Trustees Of The University Of Pennsylvania | Suministro secuencial de moléculas inmunogénicas mediante administraciones de un adenovirus y de un virus adeno-asociado. |
| CA2563500C (en) | 2004-04-28 | 2016-06-28 | The Trustees Of The University Of Pennsylvania | Immunization regimen with e4-deleted adenovirus prime and e1-deleted adenovirus boost |
| ES2525067T3 (es) * | 2005-04-07 | 2014-12-17 | The Trustees Of The University Of Pennsylvania | Método de incremento de la función de un vector de AAV |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| AU2007234698B2 (en) | 2006-04-07 | 2013-08-01 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to adenoassociated virus-phage particles |
| WO2008027084A2 (en) * | 2006-04-28 | 2008-03-06 | The Trustees Of The University Of Pennsylvania | Modified aav vectors having reduced capsid immunogenicity and use thereof |
| EP2018421B1 (en) | 2006-04-28 | 2012-12-19 | The Trustees of the University of Pennsylvania | Scalable production method for aav |
| US9725485B2 (en) | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| ES2714007T3 (es) | 2007-04-09 | 2019-05-24 | Univ Florida | Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso |
| EP2019143A1 (en) * | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| WO2009108274A2 (en) * | 2008-02-26 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for adeno-associated virus (aav) with hi loop mutations |
| WO2009137006A2 (en) | 2008-04-30 | 2009-11-12 | The University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US11219696B2 (en) | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| EP2425000B1 (en) * | 2009-04-30 | 2019-02-20 | The Trustees Of The University Of Pennsylvania | Compositions for targeting conducting airway cells comprising adeno-associated virus constructs |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012175974A (ja) * | 2003-09-30 | 2012-09-13 | Trustees Of The Univ Of Pennsylvania | アデノ随伴ウイルス(aav)の同源系統群、配列、それらを含有するベクターおよびそれらの用途 |
| JP2018108113A (ja) * | 2003-09-30 | 2018-07-12 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ | アデノ随伴ウイルス(aav)の同源系統群(クレイド)、配列、それらを含有するベクターおよびそれらの用途 |
| WO2020101042A1 (en) | 2018-11-16 | 2020-05-22 | Astellas Pharma Inc. | Method for treating muscular dystrophy by targeting utrophin gene |
| WO2020241903A1 (en) | 2019-05-28 | 2020-12-03 | Astellas Pharma Inc. | Method for treating muscular dystrophy by targeting dmpk gene |
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