JP3854306B2 - ヒト化及びキメラモノクローナル抗体 - Google Patents
ヒト化及びキメラモノクローナル抗体 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| CN1063489C (zh) * | 1993-06-29 | 2001-03-21 | 生化学工业株式会社 | 新多肽及编码该多肽的dna |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| ATE207366T1 (de) * | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
| GB9401182D0 (en) * | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
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| US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US5968753A (en) * | 1994-06-14 | 1999-10-19 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
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| US7803904B2 (en) * | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| IT1277827B1 (it) * | 1995-03-01 | 1997-11-12 | Ministero Uni Ricerca Scient E | Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r) |
| EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
| JP4312259B2 (ja) * | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| US20050241006A1 (en) * | 1995-04-27 | 2005-10-27 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US20050287630A1 (en) * | 1995-04-27 | 2005-12-29 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5641751A (en) * | 1995-05-01 | 1997-06-24 | Centocor, Inc. | Tumor necrosis factor inhibitors |
| ATE208403T1 (de) * | 1995-05-26 | 2001-11-15 | Merck Patent Gmbh | Antiidiotypische antikörper die eine immunantwort gegen den rezeptor für epidermalen wachstumsfaktor induzieren |
| EP0745612B1 (en) * | 1995-05-26 | 2001-11-07 | MERCK PATENT GmbH | Anti-idiotypic antibodies which induce an immune response against epidermal growth factor receptor |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| EP0781847A1 (en) | 1995-11-06 | 1997-07-02 | MERCK PATENT GmbH | Humanized monoclonal antibody |
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| EP0909277B2 (en) | 1996-06-07 | 2008-12-24 | Poniard Pharmaceuticals, Inc. | Humanized antibodies that bind to the same antigen as bound by antibody nr-lu-13, and their use in pretargeting methods |
| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| AU4208897A (en) * | 1996-09-16 | 1998-04-02 | Merck Patent Gmbh | Oligocistronic expression system for the production of heteromeric proteins |
| DE69738539T2 (de) * | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
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| BR9911882A (pt) | 1998-07-13 | 2005-02-15 | Univ Texas | Processo de tratamento de câncer empregando anticorpos a aminofosfolipìdios |
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| RU2292904C2 (ru) * | 2001-01-09 | 2007-02-10 | Мерк Патент Гмбх | Комбинированная терапия, использующая ингибиторы рецептора тирозинкиназы и ингибиторы ангиогенезиса |
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- 1992-03-04 CZ CS923327A patent/CZ282603B6/cs not_active IP Right Cessation
- 1992-03-04 AU AU13403/92A patent/AU658396B2/en not_active Expired
- 1992-03-04 EP EP92905860A patent/EP0531472B1/en not_active Expired - Lifetime
- 1992-03-04 SK SK3327-92A patent/SK281142B6/sk not_active IP Right Cessation
- 1992-03-04 WO PCT/EP1992/000480 patent/WO1992015683A1/en not_active Ceased
- 1992-03-05 IE IE070592A patent/IE920705A1/en not_active IP Right Cessation
- 1992-03-05 PT PT100195A patent/PT100195B/pt not_active IP Right Cessation
- 1992-03-05 ZA ZA921661A patent/ZA921661B/xx unknown
- 1992-03-06 MX MX9201016A patent/MX9201016A/es unknown
- 1992-03-09 TW TW081101780A patent/TW222279B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK332792A3 (en) | 1996-07-03 |
| HU9203484D0 (en) | 1993-01-28 |
| AU1340392A (en) | 1992-10-06 |
| IE920705A1 (en) | 1992-09-09 |
| ES2204890T3 (es) | 2004-05-01 |
| KR100240308B1 (ko) | 2000-01-15 |
| EP0531472A1 (en) | 1993-03-17 |
| CZ282603B6 (cs) | 1997-08-13 |
| DE69233153D1 (de) | 2003-09-18 |
| EP0531472B1 (en) | 2003-08-13 |
| CA2082160C (en) | 2003-05-06 |
| DE69233153T2 (de) | 2004-05-27 |
| HU219537B (hu) | 2001-05-28 |
| PT100195B (pt) | 1999-09-30 |
| TW222279B (enExample) | 1994-04-11 |
| EP1362868A2 (en) | 2003-11-19 |
| DK0531472T3 (da) | 2003-12-01 |
| JPH05506157A (ja) | 1993-09-16 |
| AU658396B2 (en) | 1995-04-13 |
| CZ333796A3 (cs) | 1998-06-17 |
| CZ283717B6 (cs) | 1998-06-17 |
| SK281143B6 (sk) | 2000-12-11 |
| EP1362868A3 (en) | 2004-02-11 |
| US5558864A (en) | 1996-09-24 |
| WO1992015683A1 (en) | 1992-09-17 |
| MX9201016A (es) | 1993-08-01 |
| SK281142B6 (sk) | 2000-12-11 |
| ATE247168T1 (de) | 2003-08-15 |
| CA2082160A1 (en) | 1992-09-07 |
| CZ332792A3 (en) | 1994-02-16 |
| PT100195A (pt) | 1993-05-31 |
| HUT65687A (en) | 1994-07-28 |
| ZA921661B (en) | 1992-11-25 |
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