PT100195B - Anticorpos monoclonais quimericos e humanos que se ligam a epitopos de receptores de factor de crescimento da epiderme, seus vectores de expressao, processo de preparacao e composicoes farmaceuticas que os contem - Google Patents
Anticorpos monoclonais quimericos e humanos que se ligam a epitopos de receptores de factor de crescimento da epiderme, seus vectores de expressao, processo de preparacao e composicoes farmaceuticas que os contem Download PDFInfo
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Classifications
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91103389 | 1991-03-06 |
Publications (2)
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| PT100195A PT100195A (pt) | 1993-05-31 |
| PT100195B true PT100195B (pt) | 1999-09-30 |
Family
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Family Applications (1)
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| PT100195A PT100195B (pt) | 1991-03-06 | 1992-03-05 | Anticorpos monoclonais quimericos e humanos que se ligam a epitopos de receptores de factor de crescimento da epiderme, seus vectores de expressao, processo de preparacao e composicoes farmaceuticas que os contem |
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| EP (2) | EP1362868A3 (enExample) |
| JP (1) | JP3854306B2 (enExample) |
| KR (1) | KR100240308B1 (enExample) |
| AT (1) | ATE247168T1 (enExample) |
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| CA (1) | CA2082160C (enExample) |
| CZ (2) | CZ283717B6 (enExample) |
| DE (1) | DE69233153T2 (enExample) |
| DK (1) | DK0531472T3 (enExample) |
| ES (1) | ES2204890T3 (enExample) |
| HU (1) | HU219537B (enExample) |
| IE (1) | IE920705A1 (enExample) |
| MX (1) | MX9201016A (enExample) |
| PT (1) | PT100195B (enExample) |
| SK (2) | SK281143B6 (enExample) |
| TW (1) | TW222279B (enExample) |
| WO (1) | WO1992015683A1 (enExample) |
| ZA (1) | ZA921661B (enExample) |
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| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
| US5994510A (en) * | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
| AU662311B2 (en) * | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6800738B1 (en) * | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| CN1063489C (zh) * | 1993-06-29 | 2001-03-21 | 生化学工业株式会社 | 新多肽及编码该多肽的dna |
| UA40577C2 (uk) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
| ATE207366T1 (de) * | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
| GB9401182D0 (en) * | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
| US6448077B1 (en) * | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
| US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US5968753A (en) * | 1994-06-14 | 1999-10-19 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
| EP0706799B1 (en) * | 1994-09-16 | 2001-11-14 | MERCK PATENT GmbH | Immunoconjugates II |
| US7803904B2 (en) * | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| IT1277827B1 (it) * | 1995-03-01 | 1997-11-12 | Ministero Uni Ricerca Scient E | Anticorpo monoclonale chimerico murino/umano o un suo frammento specifico per il recettore egf (egf-r) |
| EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
| JP4312259B2 (ja) * | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク． | 免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体 |
| US20050241006A1 (en) * | 1995-04-27 | 2005-10-27 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US20050287630A1 (en) * | 1995-04-27 | 2005-12-29 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5641751A (en) * | 1995-05-01 | 1997-06-24 | Centocor, Inc. | Tumor necrosis factor inhibitors |
| ATE208403T1 (de) * | 1995-05-26 | 2001-11-15 | Merck Patent Gmbh | Antiidiotypische antikörper die eine immunantwort gegen den rezeptor für epidermalen wachstumsfaktor induzieren |
| EP0745612B1 (en) * | 1995-05-26 | 2001-11-07 | MERCK PATENT GmbH | Anti-idiotypic antibodies which induce an immune response against epidermal growth factor receptor |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| EP0781847A1 (en) | 1995-11-06 | 1997-07-02 | MERCK PATENT GmbH | Humanized monoclonal antibody |
| AR005035A1 (es) * | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
| EP0909277B2 (en) | 1996-06-07 | 2008-12-24 | Poniard Pharmaceuticals, Inc. | Humanized antibodies that bind to the same antigen as bound by antibody nr-lu-13, and their use in pretargeting methods |
| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| AU4208897A (en) * | 1996-09-16 | 1998-04-02 | Merck Patent Gmbh | Oligocistronic expression system for the production of heteromeric proteins |
| DE69738539T2 (de) * | 1996-12-03 | 2009-03-26 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
| ES2236634T3 (es) * | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
| US20020173629A1 (en) * | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
| DE19722888A1 (de) * | 1997-05-28 | 1998-12-03 | Thomas Prof Dr Huenig | Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten |
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| US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
| WO1999055369A1 (en) * | 1998-04-28 | 1999-11-04 | Smithkline Beecham Corporation | Monoclonal antibodies with reduced immunogenicity |
| ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| BR9911882A (pt) | 1998-07-13 | 2005-02-15 | Univ Texas | Processo de tratamento de câncer empregando anticorpos a aminofosfolipìdios |
| AU760766B2 (en) * | 1998-08-18 | 2003-05-22 | Regents Of The University Of California, The | Preventing airway mucus production by administration of EGF-R antagonists |
| KR20020000223A (ko) * | 1999-05-14 | 2002-01-05 | 존 비. 랜디스 | 표피성장인자 수용체 길항제를 사용한 인간 난치성 종양의치료 방법 |
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| US20010051147A1 (en) * | 2000-03-27 | 2001-12-13 | Van De Winkel Jan G.J. | Methods for immunostimulation using binding agents for the Fc receptor of immunoglobulin A |
| WO2002011677A2 (en) * | 2000-08-09 | 2002-02-14 | Imclone Systems Incorporated | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
| RU2292904C2 (ru) * | 2001-01-09 | 2007-02-10 | Мерк Патент Гмбх | Комбинированная терапия, использующая ингибиторы рецептора тирозинкиназы и ингибиторы ангиогенезиса |
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- 1992-03-04 CZ CZ963337A patent/CZ283717B6/cs not_active IP Right Cessation
- 1992-03-04 US US07/946,421 patent/US5558864A/en not_active Expired - Lifetime
- 1992-03-04 SK SK360-99A patent/SK281143B6/sk not_active IP Right Cessation
- 1992-03-04 ES ES92905860T patent/ES2204890T3/es not_active Expired - Lifetime
- 1992-03-04 KR KR1019920702755A patent/KR100240308B1/ko not_active Expired - Lifetime
- 1992-03-04 EP EP03018303A patent/EP1362868A3/en not_active Ceased
- 1992-03-04 JP JP50595192A patent/JP3854306B2/ja not_active Expired - Lifetime
- 1992-03-04 HU HU9203484A patent/HU219537B/hu unknown
- 1992-03-04 DE DE69233153T patent/DE69233153T2/de not_active Expired - Lifetime
- 1992-03-04 AT AT92905860T patent/ATE247168T1/de active
- 1992-03-04 CA CA002082160A patent/CA2082160C/en not_active Expired - Lifetime
- 1992-03-04 CZ CS923327A patent/CZ282603B6/cs not_active IP Right Cessation
- 1992-03-04 AU AU13403/92A patent/AU658396B2/en not_active Expired
- 1992-03-04 EP EP92905860A patent/EP0531472B1/en not_active Expired - Lifetime
- 1992-03-04 SK SK3327-92A patent/SK281142B6/sk not_active IP Right Cessation
- 1992-03-04 WO PCT/EP1992/000480 patent/WO1992015683A1/en not_active Ceased
- 1992-03-05 IE IE070592A patent/IE920705A1/en not_active IP Right Cessation
- 1992-03-05 PT PT100195A patent/PT100195B/pt not_active IP Right Cessation
- 1992-03-05 ZA ZA921661A patent/ZA921661B/xx unknown
- 1992-03-06 MX MX9201016A patent/MX9201016A/es unknown
- 1992-03-09 TW TW081101780A patent/TW222279B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK332792A3 (en) | 1996-07-03 |
| HU9203484D0 (en) | 1993-01-28 |
| AU1340392A (en) | 1992-10-06 |
| IE920705A1 (en) | 1992-09-09 |
| ES2204890T3 (es) | 2004-05-01 |
| KR100240308B1 (ko) | 2000-01-15 |
| EP0531472A1 (en) | 1993-03-17 |
| CZ282603B6 (cs) | 1997-08-13 |
| DE69233153D1 (de) | 2003-09-18 |
| EP0531472B1 (en) | 2003-08-13 |
| CA2082160C (en) | 2003-05-06 |
| DE69233153T2 (de) | 2004-05-27 |
| HU219537B (hu) | 2001-05-28 |
| TW222279B (enExample) | 1994-04-11 |
| EP1362868A2 (en) | 2003-11-19 |
| DK0531472T3 (da) | 2003-12-01 |
| JPH05506157A (ja) | 1993-09-16 |
| AU658396B2 (en) | 1995-04-13 |
| CZ333796A3 (cs) | 1998-06-17 |
| JP3854306B2 (ja) | 2006-12-06 |
| CZ283717B6 (cs) | 1998-06-17 |
| SK281143B6 (sk) | 2000-12-11 |
| EP1362868A3 (en) | 2004-02-11 |
| US5558864A (en) | 1996-09-24 |
| WO1992015683A1 (en) | 1992-09-17 |
| MX9201016A (es) | 1993-08-01 |
| SK281142B6 (sk) | 2000-12-11 |
| ATE247168T1 (de) | 2003-08-15 |
| CA2082160A1 (en) | 1992-09-07 |
| CZ332792A3 (en) | 1994-02-16 |
| PT100195A (pt) | 1993-05-31 |
| HUT65687A (en) | 1994-07-28 |
| ZA921661B (en) | 1992-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19930121 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990601 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20121203 |