MX2010000997A - Combinaciones farmaceuticas que comprenden un inhibidor de tirosina cinasa y un anticuerpo contra integrina alfa 1 beta 5 (cd49b). - Google Patents
Combinaciones farmaceuticas que comprenden un inhibidor de tirosina cinasa y un anticuerpo contra integrina alfa 1 beta 5 (cd49b).Info
- Publication number
- MX2010000997A MX2010000997A MX2010000997A MX2010000997A MX2010000997A MX 2010000997 A MX2010000997 A MX 2010000997A MX 2010000997 A MX2010000997 A MX 2010000997A MX 2010000997 A MX2010000997 A MX 2010000997A MX 2010000997 A MX2010000997 A MX 2010000997A
- Authority
- MX
- Mexico
- Prior art keywords
- tyrosine kinase
- kinase inhibitor
- pharmaceutical combinations
- cd49e
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Las combinaciones farmacéuticas que comprenden un antagonista de a5ß1 en combinación con un inhibidor de tirosina cinasa. En algunas modalidades, el antagonista de a5ß1 es volociximab. En algunas modalidades, el inhibidor de tirosina cinasa es sunitinib o una sal farmacéuticamente aceptable del mismo. La invención también se refiere a métodos para tratar cáncer administrando las combinaciones farmacéuticas a un sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95232807P | 2007-07-27 | 2007-07-27 | |
PCT/US2008/071379 WO2009018226A2 (en) | 2007-07-27 | 2008-07-28 | Pharmaceutical combinations comprising a tyrosine kinase inhibitor and an antibody against integrin alpha 1 beta 5 (cd49e) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010000997A true MX2010000997A (es) | 2010-03-31 |
Family
ID=40291258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010000997A MX2010000997A (es) | 2007-07-27 | 2008-07-28 | Combinaciones farmaceuticas que comprenden un inhibidor de tirosina cinasa y un anticuerpo contra integrina alfa 1 beta 5 (cd49b). |
Country Status (9)
Country | Link |
---|---|
US (1) | US20090041767A1 (es) |
EP (1) | EP2193148A2 (es) |
JP (1) | JP2010534685A (es) |
KR (1) | KR20100040877A (es) |
AU (1) | AU2008282331A1 (es) |
BR (1) | BRPI0813630A2 (es) |
CA (1) | CA2694644A1 (es) |
MX (1) | MX2010000997A (es) |
WO (1) | WO2009018226A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2255792A1 (en) * | 2009-05-20 | 2010-12-01 | Ratiopharm GmbH | Pharmaceutical compositions for N-[2-(Diethylamino)ethyl]5-[(fluoro-1,2-dihydro-2-oxo-3H-indole-3-ylidene) methyl]-2,4-dimenthyl-1H-pyrrole-3-carboxamide |
EP2484678B1 (en) * | 2009-09-28 | 2015-01-21 | Qilu Pharmaceutical Co., Ltd | 4-(substituted anilino)quinazoline derivatives as tyrosine kinase inhibitors |
US20140079637A1 (en) * | 2011-03-23 | 2014-03-20 | The Regents Of The University Of California | Methods and compositions for improving antiangiogenic therapy with anti-integrins |
MX2014009898A (es) * | 2012-02-16 | 2015-07-06 | Capnia Inc | Dispensador de gas con boquilla de difusion. |
CN103656656A (zh) * | 2013-12-18 | 2014-03-26 | 北京科源创欣科技有限公司 | 甲苯磺酸索拉非尼药物组合物及制备方法 |
AU2016311298A1 (en) | 2015-08-25 | 2018-02-08 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
WO2017046229A1 (en) * | 2015-09-17 | 2017-03-23 | Histide Ag | Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof |
US20190330290A1 (en) * | 2015-09-17 | 2019-10-31 | Histide Ag | Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof |
AU2016323407A1 (en) * | 2015-09-17 | 2018-04-19 | Histide Ag | Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US4704366A (en) * | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4801687A (en) * | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
SK281142B6 (sk) * | 1991-03-06 | 2000-12-11 | Merck Patent Gesellschaft Mit Beschr�Nkter Haftung | Humanizovaná monoklonálna protilátka, expresné vektory a farmaceutický prostriedok |
AU669124B2 (en) * | 1991-09-18 | 1996-05-30 | Kyowa Hakko Kirin Co., Ltd. | Process for producing humanized chimera antibody |
GB9125979D0 (en) * | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
SG52215A1 (en) * | 1992-02-19 | 1998-09-28 | Schering Corp | Cloning and expresssion of humanized monoclonal antibodies against human interleukin-4 |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
JP3490443B2 (ja) * | 1992-10-29 | 2004-01-26 | ジ・オーストラリアン・ナショナル・ユニバーシティ | 血管形成阻害性抗体 |
US5536814A (en) * | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
US5922676A (en) * | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
US5846536A (en) * | 1996-10-04 | 1998-12-08 | The Regents Of The University Of California | Restoration of normal phenotype in cancer cells |
US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
US20040259152A1 (en) * | 2000-02-22 | 2004-12-23 | Richard Murray | Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases |
ES2387985T3 (es) * | 2002-11-26 | 2012-10-05 | Abbott Biotherapeutics Corp. | Anticuerpos quiméricos y humanizados de integrina alfa 5 beta 1 que modulan la angiogénesis |
US7276589B2 (en) * | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
WO2004089988A2 (en) * | 2003-04-03 | 2004-10-21 | Protein Design Labs, Inc | Inhibitors of integrin alpha5beta1 and their use for the control of tissue granulation |
NZ549893A (en) * | 2004-03-24 | 2010-05-28 | Facet Biotech Corp | Use of anti-alpha5beta1 antibodiesin a stabilising solution to inhibit cancer cell proliferation |
US7908091B2 (en) * | 2006-03-17 | 2011-03-15 | Prometheus Laboratories Inc. | Methods of predicting and monitoring tyrosine kinase inhibitor therapy |
NZ615012A (en) * | 2006-03-21 | 2015-11-27 | Genentech Inc | Combinatorial therapy involving alpha5beta1 antagonists |
US7612178B2 (en) * | 2006-03-28 | 2009-11-03 | Biogen Idec Ma Inc | Anti-IGF-1R antibodies and uses thereof |
-
2008
- 2008-07-28 MX MX2010000997A patent/MX2010000997A/es not_active Application Discontinuation
- 2008-07-28 EP EP08782456A patent/EP2193148A2/en not_active Withdrawn
- 2008-07-28 KR KR1020107001803A patent/KR20100040877A/ko not_active Application Discontinuation
- 2008-07-28 CA CA2694644A patent/CA2694644A1/en not_active Abandoned
- 2008-07-28 AU AU2008282331A patent/AU2008282331A1/en not_active Abandoned
- 2008-07-28 BR BRPI0813630A patent/BRPI0813630A2/pt not_active IP Right Cessation
- 2008-07-28 JP JP2010518437A patent/JP2010534685A/ja not_active Withdrawn
- 2008-07-28 US US12/181,201 patent/US20090041767A1/en not_active Abandoned
- 2008-07-28 WO PCT/US2008/071379 patent/WO2009018226A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2010534685A (ja) | 2010-11-11 |
KR20100040877A (ko) | 2010-04-21 |
WO2009018226A2 (en) | 2009-02-05 |
CA2694644A1 (en) | 2009-02-05 |
AU2008282331A1 (en) | 2009-02-05 |
WO2009018226A3 (en) | 2009-04-02 |
BRPI0813630A2 (pt) | 2019-09-24 |
US20090041767A1 (en) | 2009-02-12 |
EP2193148A2 (en) | 2010-06-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |