PL2132229T3 - Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka - Google Patents
Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórkaInfo
- Publication number
- PL2132229T3 PL2132229T3 PL08706941.5T PL08706941T PL2132229T3 PL 2132229 T3 PL2132229 T3 PL 2132229T3 PL 08706941 T PL08706941 T PL 08706941T PL 2132229 T3 PL2132229 T3 PL 2132229T3
- Authority
- PL
- Poland
- Prior art keywords
- growth factor
- factor receptor
- epidermal growth
- receptor antibody
- antibody compositions
- Prior art date
Links
- 102000009465 Growth Factor Receptors Human genes 0.000 title 1
- 108010009202 Growth Factor Receptors Proteins 0.000 title 1
- 229940116977 epidermal growth factor Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700317 | 2007-03-01 | ||
| US90477307P | 2007-03-05 | 2007-03-05 | |
| DKPA200701016 | 2007-07-10 | ||
| US92972707P | 2007-07-11 | 2007-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2132229T3 true PL2132229T3 (pl) | 2016-12-30 |
Family
ID=39495833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08706941.5T PL2132229T3 (pl) | 2007-03-01 | 2008-02-27 | Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7887805B2 (pl) |
| EP (2) | EP2725036B1 (pl) |
| JP (1) | JP5726417B2 (pl) |
| KR (2) | KR101676622B1 (pl) |
| CN (2) | CN104151430A (pl) |
| AU (1) | AU2008221118B2 (pl) |
| BR (1) | BRPI0808551B1 (pl) |
| CA (1) | CA2676049C (pl) |
| DK (1) | DK2132229T3 (pl) |
| ES (1) | ES2582386T3 (pl) |
| HK (1) | HK1197252A1 (pl) |
| IL (2) | IL199725A (pl) |
| MX (2) | MX338151B (pl) |
| NZ (2) | NZ597466A (pl) |
| PL (1) | PL2132229T3 (pl) |
| RU (1) | RU2013119724A (pl) |
| TW (1) | TWI426083B (pl) |
| WO (1) | WO2008104183A2 (pl) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| CN104151430A (zh) | 2007-03-01 | 2014-11-19 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| RU2459868C2 (ru) * | 2007-03-01 | 2012-08-27 | Симфоген А/С | Способ клонирования когнатных антител |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| EP2190878A1 (en) | 2007-09-06 | 2010-06-02 | Genmab A/S | Novel methods and antibodies for treating cancer |
| WO2009086411A2 (en) * | 2007-12-27 | 2009-07-09 | Abbott Laboratories | Negative mimic antibody for use as a blocking reagent in bnp immunoassays |
| EP2331577B1 (en) * | 2008-08-29 | 2017-06-07 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| EP2331689A4 (en) * | 2008-08-29 | 2012-10-31 | Symphogen As | METHOD OF CLONING AVIAN ORIGIN ANTIBODIES |
| CA2739476A1 (en) * | 2008-10-06 | 2010-04-15 | Symphogen A/S | Method for identifying and selecting drug candidates for combinatorial drug products |
| FR2942928B1 (fr) | 2009-03-03 | 2011-04-01 | Alcatel Lucent | Procede et systeme de gestion multicriteres de notifications de presence |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| US20120264155A1 (en) | 2009-10-09 | 2012-10-18 | Symphogen A/S | Multiplex Quantitation of Individual Recombinant Proteins in a Mixture by Signature Peptides and Mass Spectrometry |
| WO2011106707A2 (en) * | 2010-02-26 | 2011-09-01 | Human Genome Sciences, Inc. | Antibodies that specifically bind to dr3 |
| US8609095B2 (en) | 2010-03-04 | 2013-12-17 | Symphogen A/S | Anti-HER2 antibodies and compositions |
| EP2563393B1 (en) | 2010-04-26 | 2016-06-08 | Abraxis BioScience, LLC | Sparc binding antibodies and uses thereof |
| WO2011140151A1 (en) * | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| SG185366A1 (en) * | 2010-05-04 | 2012-12-28 | Merrimack Pharmaceuticals Inc | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| WO2012018260A1 (en) * | 2010-08-05 | 2012-02-09 | Universiteit Utrecht Holding B.V. | Epidermal growth factor receptor targeted immune therapy |
| CA2815277A1 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Novel egfr-binding molecules and immunoconjugates thereof |
| WO2012058592A2 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Non-antagonistic egfr-binding molecules and immunoconjugates thereof |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| EP2635605B1 (en) * | 2010-11-01 | 2018-07-25 | Symphogen A/S | Anti-her3 antibodies and compositions |
| CA3027071A1 (en) | 2011-01-14 | 2013-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| WO2012100346A1 (en) * | 2011-01-24 | 2012-08-02 | Ym Biosciences Inc. | Antibodies selective for cells presenting egfr at high density |
| CN103842379A (zh) | 2011-03-09 | 2014-06-04 | 细胞信号科技公司 | 用于生成单克隆抗体的方法和试剂 |
| SG192844A1 (en) | 2011-03-11 | 2013-09-30 | Merrimack Pharmaceuticals Inc | Use of inhibitors of egfr-family receptors in the treatment of hormone refractory breast cancers |
| BR112013022887A2 (pt) | 2011-03-15 | 2016-12-06 | Merrimack Pharmaceuticals Inc | superação de resistência a inibidores de via de erbb |
| US20120258502A1 (en) * | 2011-04-08 | 2012-10-11 | Vinod Pandiripally | Method of producing recombinant plasmid dna using substantially solid growth medium |
| US8691231B2 (en) * | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| MX2014006087A (es) | 2011-11-21 | 2014-08-01 | Immunogen Inc | Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico. |
| US20150011431A1 (en) * | 2012-01-09 | 2015-01-08 | The Scripps Research Institute | Humanized antibodies |
| US9527913B2 (en) | 2012-05-02 | 2016-12-27 | Symphogen A/S | Humanized pan-HER antibody compositions |
| US20140065655A1 (en) * | 2012-09-05 | 2014-03-06 | Scivax Corporation | Screening method for substance acting on maintenance of epithelial properties of cell |
| US20150293105A1 (en) * | 2012-10-26 | 2015-10-15 | The University Of Queensland | Methods for classifying tumors and uses therefor |
| CN102993305B (zh) * | 2012-11-16 | 2015-05-13 | 上海赛伦生物技术有限公司 | 人源抗人表皮生长因子受体抗体及其编码基因与应用 |
| US9856319B2 (en) * | 2012-12-28 | 2018-01-02 | Abbvie Inc. | Monovalent binding proteins |
| CN104059148B (zh) * | 2013-03-18 | 2016-09-07 | 回而生医药科技(北京)有限公司 | 人源化抗人表皮生长因子受体抗体及其应用 |
| HK1226081A1 (zh) * | 2013-09-12 | 2017-09-22 | Halozyme, Inc. | 修饰的抗表皮生长因子受体抗体及其使用方法 |
| CN106170299A (zh) * | 2014-01-22 | 2016-11-30 | 小利兰斯坦福大学托管委员会 | 用于抗体和抗体负载树突状细胞介导治疗的方法和组合物 |
| GB201402591D0 (en) * | 2014-02-14 | 2014-04-02 | Memo Therapeutics Ag | Method for recovering two or more genes, or gene products, encoding an immunoreceptor |
| AU2015236288A1 (en) * | 2014-03-26 | 2016-09-15 | Siemens Healthcare Diagnostics Inc. | Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| EP3223857A4 (en) * | 2014-10-31 | 2018-06-27 | Formation Biologics Inc. | Egfr antibody-based combination therapy |
| JP6895380B2 (ja) | 2015-02-06 | 2021-06-30 | ナショナル ユニバーシティ オブ シンガポール | 治療免疫細胞の有効性を改良するための方法 |
| AU2016252877A1 (en) | 2015-04-24 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (EGFR) with a combination of three fully human monoclonal anti-EGFR antibodies |
| CN109310754A (zh) | 2016-03-15 | 2019-02-05 | 梅里麦克制药股份有限公司 | 使用包含抗erbb3抗体的联合疗法治疗er+、her2-、hrg+乳腺癌的方法 |
| CN109475627B (zh) | 2016-05-26 | 2023-01-06 | 齐鲁普吉湾生物治疗公司 | 抗体混合物 |
| EP3484518B1 (en) | 2016-07-07 | 2024-08-14 | The Board of Trustees of the Leland Stanford Junior University | Antibody adjuvant conjugates |
| US11440958B2 (en) | 2016-11-22 | 2022-09-13 | National University Of Singapore | Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies |
| KR20240133790A (ko) * | 2016-12-23 | 2024-09-04 | 비스테라, 인크. | 결합 폴리펩타이드 및 이의 제조 방법 |
| WO2018152634A1 (en) * | 2017-02-22 | 2018-08-30 | University Of Saskatchewan | Egfr-binding agents and uses thereof |
| WO2018166119A1 (zh) * | 2017-03-14 | 2018-09-20 | 北京伟峰益民科技有限公司 | 一种多肽或其衍生物及其在制备治疗肿瘤的药物中的应用 |
| JP2020530291A (ja) | 2017-08-10 | 2020-10-22 | ナショナル ユニバーシティ オブ シンガポール | T細胞受容体欠損キメラ抗原受容体t細胞およびその使用方法 |
| WO2019043059A1 (en) | 2017-08-30 | 2019-03-07 | Symphogen A/S | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER BY ANTI-EGFR ANTIBODIES |
| CN109912716B (zh) * | 2017-12-13 | 2022-08-23 | 凯惠科技发展(上海)有限公司 | 一种egfr抗体及其制备方法和应用 |
| AU2019211411B2 (en) * | 2018-01-25 | 2025-11-27 | Cullinan Mica Corp. | MICA/B antibodies and methods of use |
| KR20210008408A (ko) | 2018-05-23 | 2021-01-21 | 싱가포르국립대학교 | T-세포 악성 종양의 면역요법을 위한 cd2 표면 발현 및 키메라 항원 수용체의 발현에 대한 차단 |
| US11274035B2 (en) | 2019-04-24 | 2022-03-15 | X-Celeprint Limited | Overhanging device structures and related methods of manufacture |
| US12162747B2 (en) | 2018-12-03 | 2024-12-10 | X-Celeprint Limited | Enclosed cavity structures |
| US10456776B1 (en) | 2019-02-21 | 2019-10-29 | King Saud University | Method of fabricating a photocatalyst for water splitting |
| JP2022525594A (ja) | 2019-03-15 | 2022-05-18 | ボルト バイオセラピューティクス、インコーポレーテッド | Her2を標的とする免疫結合体 |
| CN111018990A (zh) * | 2020-02-10 | 2020-04-17 | 张喜田 | 一种新型的重组抗表皮生长因子受体单克隆抗体及其应用 |
| CA3233771A1 (en) | 2021-10-04 | 2023-04-13 | Les Laboratoires Servier | Cancer therapy targeting nkg2a |
| AR127893A1 (es) | 2021-12-10 | 2024-03-06 | Servier Lab | Terapia del cáncer dirigida a egfr |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) * | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) * | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| AU4128089A (en) * | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| US5459061A (en) * | 1990-01-26 | 1995-10-17 | W. Alton Jones Cell Science Center, Inc. | Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor |
| WO1992015683A1 (en) * | 1991-03-06 | 1992-09-17 | MERCK Patent Gesellschaft mit beschränkter Haftung | Humanized and chimeric monoclonal antibodies |
| JPH08504172A (ja) | 1992-06-30 | 1996-05-07 | オンコロジクス,インコーポレイティド | 抗−erbB−2モノクロナール抗体の組み合わせ物及び使用方法 |
| GB9401182D0 (en) | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
| EP0831880A4 (en) | 1995-06-07 | 2004-12-01 | Imclone Systems Inc | ANTIBODIES AND FRAGMENTS OF ANTIBODIES INHIBITING TUMOR GROWTH |
| US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| CN1432064A (zh) | 2000-03-23 | 2003-07-23 | 格林维尔医院系统公司 | 双功能癌症治疗剂 |
| WO2001088138A1 (en) * | 2000-05-19 | 2001-11-22 | Scancell Limited | Humanised antibodies to the epidermal growth factor receptor |
| US6849259B2 (en) * | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
| EP1361893B1 (en) | 2001-02-19 | 2012-10-24 | Merck Patent GmbH | Modified anti-egfr antibodies with reduced immunogenicity |
| EP2163256B1 (en) | 2001-05-11 | 2015-09-02 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| BRPI0210405B8 (pt) * | 2001-06-13 | 2021-05-25 | Genmab As | anticorpo monoclonal humano, molécula biespecífica, método in vitro para inibir o crescimento de uma célula expressando egfr, para induzir a citólise de uma célula expressando egfr, e para detectar a presença de antígeno egfr ou uma célula expressando egfr em uma amostra, e, vetor de expressão |
| WO2003012072A2 (en) * | 2001-08-03 | 2003-02-13 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbb family members and methods of use thereof |
| AU2003211342A1 (en) | 2002-03-01 | 2003-09-16 | Japan Envirochemicals, Ltd. | Proteins capable of binding to environmental hormones and process for producing the same |
| AU2003236649A1 (en) | 2002-05-15 | 2003-12-02 | Falko Fend | Egf receptor antagonists in the treatment of gastric cancer |
| WO2003099205A2 (en) | 2002-05-20 | 2003-12-04 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
| WO2004008099A2 (en) | 2002-07-15 | 2004-01-22 | Genentech, Inc. | METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| AU2003250074B2 (en) | 2002-07-18 | 2010-09-09 | Merus N.V. | Recombinant production of mixtures of antibodies |
| MXPA05003796A (es) * | 2002-10-10 | 2006-02-22 | Merck Patent Gmbh | Anticuerpos anti-erb-b biespecificos y su uso en terapia de tumor. |
| PT1583830E (pt) | 2003-01-07 | 2006-11-30 | Symphogen As | Método para produzir proteínas policlonais recombinantes |
| US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| CA2450289A1 (en) | 2003-03-20 | 2005-05-19 | Imclone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| AT500651B9 (de) | 2003-05-27 | 2010-04-15 | Altropus Gmbh | Aktiv immunisierender antikörper |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| US7655751B2 (en) * | 2004-01-23 | 2010-02-02 | Green Peptide Co., Ltd. | Epidermal growth factor receptor-derived peptides |
| US20110142822A1 (en) | 2004-06-14 | 2011-06-16 | Kussie Paul H | Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof |
| ES2332524T3 (es) * | 2004-07-20 | 2010-02-08 | Symphogen A/S | Un procedimiento para la caracterizacion de una linea celular policlonal. |
| BRPI0513706A (pt) * | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| TWI441646B (zh) | 2005-01-21 | 2014-06-21 | Genentech Inc | 帕妥珠單抗(pertuzumab)用於製備治療人類病患癌症之藥物的用途 |
| US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
| CA2596133C (en) | 2005-02-23 | 2016-11-15 | Genentech, Inc. | Extending time to disease progression or survival in cancer patients |
| US7981605B2 (en) | 2005-02-24 | 2011-07-19 | Amgen Inc. | Epidermal growth factor receptor mutations |
| US20060216288A1 (en) | 2005-03-22 | 2006-09-28 | Amgen Inc | Combinations for the treatment of cancer |
| WO2006110478A2 (en) | 2005-04-11 | 2006-10-19 | Novartis Ag | Mutations and polymorphisms of epidermal growth factor receptor |
| JP2008535508A (ja) | 2005-04-14 | 2008-09-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 腫瘍組織における増大したコピー数のegfr遺伝子に基づく抗egfr抗体療法 |
| CN101277716A (zh) | 2005-04-27 | 2008-10-01 | 回而生医药科技有限公司 | 治疗癌症的抗体 |
| KR101607288B1 (ko) * | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| BRPI0612814A2 (pt) * | 2005-07-11 | 2017-06-20 | Macrogenics Inc | anticorpo, métodos para redução e para tratamento de uma resposta imune prejudicial em um mamífero, proteína de ligação ao cd16a, e, método para redução dos efeitos colaterais de primeira dose em um paciente |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| US7498142B2 (en) * | 2006-01-31 | 2009-03-03 | Yeda Research And Development Co., Ltd. | Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies |
| AU2007222798A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| CN104151430A (zh) * | 2007-03-01 | 2014-11-19 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| RU2459868C2 (ru) | 2007-03-01 | 2012-08-27 | Симфоген А/С | Способ клонирования когнатных антител |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| EP2331577B1 (en) | 2008-08-29 | 2017-06-07 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| US9155802B2 (en) * | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
-
2008
- 2008-02-27 CN CN201410211600.2A patent/CN104151430A/zh active Pending
- 2008-02-27 ES ES08706941.5T patent/ES2582386T3/es active Active
- 2008-02-27 MX MX2011011163A patent/MX338151B/es unknown
- 2008-02-27 NZ NZ597466A patent/NZ597466A/xx not_active IP Right Cessation
- 2008-02-27 BR BRPI0808551-0A patent/BRPI0808551B1/pt active IP Right Grant
- 2008-02-27 CA CA2676049A patent/CA2676049C/en active Active
- 2008-02-27 KR KR1020097020519A patent/KR101676622B1/ko active Active
- 2008-02-27 JP JP2009551102A patent/JP5726417B2/ja active Active
- 2008-02-27 CN CN200880006835.0A patent/CN101675075B/zh active Active
- 2008-02-27 MX MX2009008909A patent/MX2009008909A/es active IP Right Grant
- 2008-02-27 AU AU2008221118A patent/AU2008221118B2/en active Active
- 2008-02-27 EP EP13187455.4A patent/EP2725036B1/en not_active Not-in-force
- 2008-02-27 KR KR1020167031076A patent/KR101805140B1/ko not_active Expired - Fee Related
- 2008-02-27 EP EP08706941.5A patent/EP2132229B1/en active Active
- 2008-02-27 NZ NZ578943A patent/NZ578943A/xx unknown
- 2008-02-27 DK DK08706941.5T patent/DK2132229T3/en active
- 2008-02-27 PL PL08706941.5T patent/PL2132229T3/pl unknown
- 2008-02-27 WO PCT/DK2008/050047 patent/WO2008104183A2/en not_active Ceased
- 2008-02-29 US US12/074,056 patent/US7887805B2/en active Active
- 2008-02-29 TW TW097107005A patent/TWI426083B/zh active
-
2009
- 2009-07-07 IL IL199725A patent/IL199725A/en active IP Right Grant
-
2010
- 2010-11-12 US US12/945,527 patent/US8414896B2/en active Active
- 2010-11-12 US US12/945,495 patent/US20110129855A1/en not_active Abandoned
-
2011
- 2011-12-08 IL IL216850A patent/IL216850A/en active IP Right Grant
-
2013
- 2013-04-26 RU RU2013119724/10A patent/RU2013119724A/ru not_active Application Discontinuation
-
2014
- 2014-10-29 HK HK14110853.9A patent/HK1197252A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL216850A0 (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
| ZA201100301B (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
| HRP20171640T1 (hr) | Monoklonska protutijela za receptor faktora rasta fibroblasta 2 | |
| ZA200906345B (en) | Anti-sclerostin antibodies | |
| PL2195026T3 (pl) | Przeciwciała przeciw sklerostynie | |
| IL229512A0 (en) | Anti-vegf antibodies | |
| IL204536A0 (en) | Anti - il -6 receptor antibody | |
| PL2170390T3 (pl) | Preparaty przeciwciała natalizumab | |
| ZA201002422B (en) | Modified antibody constant region | |
| IL202950A0 (en) | Antibody formulations | |
| IL200321A0 (en) | Stable antibody formulations | |
| EP2173163A4 (en) | ANTIBODY FORMULATIONS | |
| IL236236A (en) | Antibodies to the fam26f polypeptide | |
| ZA200905341B (en) | Recombinant anti-epidermal growth factor receptor antibody compositions | |
| EP2167635A4 (en) | ANTIBODY FORMULATIONS | |
| AU2007900058A0 (en) | Recombinant Antibodies |