MX338151B - Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. - Google Patents

Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.

Info

Publication number
MX338151B
MX338151B MX2011011163A MX2011011163A MX338151B MX 338151 B MX338151 B MX 338151B MX 2011011163 A MX2011011163 A MX 2011011163A MX 2011011163 A MX2011011163 A MX 2011011163A MX 338151 B MX338151 B MX 338151B
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MX
Mexico
Prior art keywords
antibodies
antibody compositions
growth factor
factor receptor
epidermal growth
Prior art date
Application number
MX2011011163A
Other languages
English (en)
Inventor
Lucilla Steinaa
Klaus Koefoed
Per-Johan Meijer
Lars Soegaard Nielsen
Mikkel Wandahl Pedersen
Allan Jensen
Robert Carlsson
Charles Pyke
Original Assignee
Symphogen As
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39495833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX338151(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Symphogen As filed Critical Symphogen As
Publication of MX338151B publication Critical patent/MX338151B/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a una composición de anticuerpos anti-EGFR caracterizada porque comprende al menos dos anticuerpos anti-EGFR distintos, en donde al menos uno de los anticuerpos anti-EGFR se selecciona de: (a) un anticuerpo que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 40 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO: 72 DE 992, y (b) un anticuerpo que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 41 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ LID NO: 73 DE 1024. Una composición farmacéutica que comprende la composición de anticuerpos anti-EGFR y un excipiente farmacéuticamente aceptable para usarse en la terapia del cáncer, en donde la composición está adaptada para ser administrable de forma simultánea, separada o sucesiva en la terapia del cáncer. Un anticuerpo aislado caracterizado porque comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 40 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO: 72 de 992. Un anticuerpo aislado que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 41 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO:73 de 1,024.
MX2011011163A 2007-03-01 2008-02-27 Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. MX338151B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200700317 2007-03-01
US90477307P 2007-03-05 2007-03-05
DKPA200701016 2007-07-10
US92972707P 2007-07-11 2007-07-11
PCT/DK2008/050047 WO2008104183A2 (en) 2007-03-01 2008-02-27 Recombinant anti-epidermal growth factor receptor antibody compositions

Publications (1)

Publication Number Publication Date
MX338151B true MX338151B (es) 2016-04-05

Family

ID=39495833

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011011163A MX338151B (es) 2007-03-01 2008-02-27 Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.
MX2009008909A MX2009008909A (es) 2007-03-01 2008-02-27 Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009008909A MX2009008909A (es) 2007-03-01 2008-02-27 Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.

Country Status (18)

Country Link
US (3) US7887805B2 (es)
EP (2) EP2132229B1 (es)
JP (1) JP5726417B2 (es)
KR (2) KR101676622B1 (es)
CN (2) CN101675075B (es)
AU (1) AU2008221118B2 (es)
BR (1) BRPI0808551B1 (es)
CA (1) CA2676049C (es)
DK (1) DK2132229T3 (es)
ES (1) ES2582386T3 (es)
HK (2) HK1134826A1 (es)
IL (2) IL199725A (es)
MX (2) MX338151B (es)
NZ (2) NZ597466A (es)
PL (1) PL2132229T3 (es)
RU (1) RU2013119724A (es)
TW (1) TWI426083B (es)
WO (1) WO2008104183A2 (es)

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IL199725A (en) 2015-06-30
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