MX338151B - Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. - Google Patents
Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.Info
- Publication number
- MX338151B MX338151B MX2011011163A MX2011011163A MX338151B MX 338151 B MX338151 B MX 338151B MX 2011011163 A MX2011011163 A MX 2011011163A MX 2011011163 A MX2011011163 A MX 2011011163A MX 338151 B MX338151 B MX 338151B
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- antibody compositions
- growth factor
- factor receptor
- epidermal growth
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a una composición de anticuerpos anti-EGFR caracterizada porque comprende al menos dos anticuerpos anti-EGFR distintos, en donde al menos uno de los anticuerpos anti-EGFR se selecciona de: (a) un anticuerpo que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 40 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO: 72 DE 992, y (b) un anticuerpo que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 41 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ LID NO: 73 DE 1024. Una composición farmacéutica que comprende la composición de anticuerpos anti-EGFR y un excipiente farmacéuticamente aceptable para usarse en la terapia del cáncer, en donde la composición está adaptada para ser administrable de forma simultánea, separada o sucesiva en la terapia del cáncer. Un anticuerpo aislado caracterizado porque comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 40 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO: 72 de 992. Un anticuerpo aislado que comprende CDR1, CDR2, y CDR3 de la cadena pesada de SEQ ID NO: 41 y CDR1, CDR2, y CDR3 de la cadena ligera de SEQ ID NO:73 de 1,024.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200700317 | 2007-03-01 | ||
US90477307P | 2007-03-05 | 2007-03-05 | |
DKPA200701016 | 2007-07-10 | ||
US92972707P | 2007-07-11 | 2007-07-11 | |
PCT/DK2008/050047 WO2008104183A2 (en) | 2007-03-01 | 2008-02-27 | Recombinant anti-epidermal growth factor receptor antibody compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX338151B true MX338151B (es) | 2016-04-05 |
Family
ID=39495833
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011011163A MX338151B (es) | 2007-03-01 | 2008-02-27 | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
MX2009008909A MX2009008909A (es) | 2007-03-01 | 2008-02-27 | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008909A MX2009008909A (es) | 2007-03-01 | 2008-02-27 | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
Country Status (18)
Country | Link |
---|---|
US (3) | US7887805B2 (es) |
EP (2) | EP2132229B1 (es) |
JP (1) | JP5726417B2 (es) |
KR (2) | KR101676622B1 (es) |
CN (2) | CN101675075B (es) |
AU (1) | AU2008221118B2 (es) |
BR (1) | BRPI0808551B1 (es) |
CA (1) | CA2676049C (es) |
DK (1) | DK2132229T3 (es) |
ES (1) | ES2582386T3 (es) |
HK (2) | HK1134826A1 (es) |
IL (2) | IL199725A (es) |
MX (2) | MX338151B (es) |
NZ (2) | NZ597466A (es) |
PL (1) | PL2132229T3 (es) |
RU (1) | RU2013119724A (es) |
TW (1) | TWI426083B (es) |
WO (1) | WO2008104183A2 (es) |
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