|
US3798209A
(en)
|
1971-06-01 |
1974-03-19 |
Icn Pharmaceuticals |
1,2,4-triazole nucleosides
|
|
USRE29835E
(en)
|
1971-06-01 |
1978-11-14 |
Icn Pharmaceuticals |
1,2,4-Triazole nucleosides
|
|
US3994974A
(en)
|
1972-02-05 |
1976-11-30 |
Yamanouchi Pharmaceutical Co., Ltd. |
α-Aminomethylbenzyl alcohol derivatives
|
|
US3852267A
(en)
|
1972-08-04 |
1974-12-03 |
Icn Pharmaceuticals |
Phosphoramidates of 3{40 ,5{40 -cyclic purine nucleotides
|
|
US4138547A
(en)
|
1977-12-22 |
1979-02-06 |
Icn Pharmaceuticals, Inc. |
Process for preparing 1,2,4-triazole nucleosides
|
|
JPS57146593A
(en)
|
1981-03-09 |
1982-09-10 |
Ajinomoto Co Inc |
Preparation of ribofuranosyltriazole derivative
|
|
US4816570A
(en)
|
1982-11-30 |
1989-03-28 |
The Board Of Regents Of The University Of Texas System |
Biologically reversible phosphate and phosphonate protective groups
|
|
US4526988A
(en)
|
1983-03-10 |
1985-07-02 |
Eli Lilly And Company |
Difluoro antivirals and intermediate therefor
|
|
US5077056A
(en)
|
1984-08-08 |
1991-12-31 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
US5736155A
(en)
|
1984-08-08 |
1998-04-07 |
The Liposome Company, Inc. |
Encapsulation of antineoplastic agents in liposomes
|
|
NL8403224A
(nl)
|
1984-10-24 |
1986-05-16 |
Oce Andeno Bv |
Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
|
|
US5223263A
(en)
|
1988-07-07 |
1993-06-29 |
Vical, Inc. |
Liponucleotide-containing liposomes
|
|
US5246937A
(en)
|
1985-09-18 |
1993-09-21 |
Beecham Group P.L.C. |
Purine derivatives
|
|
US4797285A
(en)
|
1985-12-06 |
1989-01-10 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
Lipsome/anthraquinone drug composition and method
|
|
US5154930A
(en)
|
1987-03-05 |
1992-10-13 |
The Liposome Company, Inc. |
Pharmacological agent-lipid solution preparation
|
|
GB8719367D0
(en)
|
1987-08-15 |
1987-09-23 |
Wellcome Found |
Therapeutic compounds
|
|
EP0380558A4
(en)
|
1987-09-22 |
1991-07-31 |
The Regents Of The University Of California |
Liposomal nucleoside analogues for treating aids
|
|
IL91664A
(en)
|
1988-09-28 |
1993-05-13 |
Yissum Res Dev Co |
Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
|
|
US6132763A
(en)
|
1988-10-20 |
2000-10-17 |
Polymasc Pharmaceuticals Plc |
Liposomes
|
|
US5705363A
(en)
|
1989-03-02 |
1998-01-06 |
The Women's Research Institute |
Recombinant production of human interferon τ polypeptides and nucleic acids
|
|
US5277914A
(en)
|
1989-03-31 |
1994-01-11 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5077057A
(en)
|
1989-04-05 |
1991-12-31 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5549910A
(en)
|
1989-03-31 |
1996-08-27 |
The Regents Of The University Of California |
Preparation of liposome and lipid complex compositions
|
|
US5411947A
(en)
|
1989-06-28 |
1995-05-02 |
Vestar, Inc. |
Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
|
|
US5194654A
(en)
|
1989-11-22 |
1993-03-16 |
Vical, Inc. |
Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5463092A
(en)
|
1989-11-22 |
1995-10-31 |
Vestar, Inc. |
Lipid derivatives of phosphonacids for liposomal incorporation and method of use
|
|
US5026687A
(en)
|
1990-01-03 |
1991-06-25 |
The United States Of America As Represented By The Department Of Health And Human Services |
Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
|
|
KR100217483B1
(ko)
|
1990-04-06 |
1999-09-01 |
프랭크 쿵 |
C형 간염 바이러스 에피토프
|
|
US5091188A
(en)
|
1990-04-26 |
1992-02-25 |
Haynes Duncan H |
Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
|
|
WO1991016920A1
(en)
|
1990-05-07 |
1991-11-14 |
Vical, Inc. |
Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs
|
|
WO1991018914A1
(en)
|
1990-05-29 |
1991-12-12 |
Vical, Inc. |
Synthesis of glycerol di- and triphosphate derivatives
|
|
ATE131825T1
(de)
|
1990-06-13 |
1996-01-15 |
Arnold Glazier |
Phosphorylierte prodrugs
|
|
US6060080A
(en)
|
1990-07-16 |
2000-05-09 |
Daiichi Pharmaceutical Co., Ltd. |
Liposomal products
|
|
JP2599492B2
(ja)
|
1990-08-21 |
1997-04-09 |
第一製薬株式会社 |
リポソーム製剤の製造法
|
|
EP0481214B1
(en)
|
1990-09-14 |
1998-06-24 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Prodrugs of phosphonates
|
|
US5372808A
(en)
|
1990-10-17 |
1994-12-13 |
Amgen Inc. |
Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
|
|
US5543389A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization |
Covalent polar lipid-peptide conjugates for use in salves
|
|
US5256641A
(en)
|
1990-11-01 |
1993-10-26 |
State Of Oregon |
Covalent polar lipid-peptide conjugates for immunological targeting
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5149794A
(en)
|
1990-11-01 |
1992-09-22 |
State Of Oregon |
Covalent lipid-drug conjugates for drug targeting
|
|
US5145684A
(en)
|
1991-01-25 |
1992-09-08 |
Sterling Drug Inc. |
Surface modified drug nanoparticles
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5157027A
(en)
|
1991-05-13 |
1992-10-20 |
E. R. Squibb & Sons, Inc. |
Bisphosphonate squalene synthetase inhibitors and method
|
|
EP0594677A4
(en)
|
1991-07-12 |
1997-09-17 |
Vical Inc |
Antiviral liponucleosides: treatment of hepatitis b
|
|
NZ243567A
(en)
|
1991-07-22 |
1995-04-27 |
Bristol Myers Squibb Co |
Pharmaceutical oral formulation of a dideoxy purine nucleoside comprising the nucleoside together with a water-insoluble antacid buffering composition
|
|
US5554728A
(en)
|
1991-07-23 |
1996-09-10 |
Nexstar Pharmaceuticals, Inc. |
Lipid conjugates of therapeutic peptides and protease inhibitors
|
|
TW224053B
(OSRAM)
|
1991-09-13 |
1994-05-21 |
Paul B Chretien |
|
|
DE4200821A1
(de)
|
1992-01-15 |
1993-07-22 |
Bayer Ag |
Geschmacksmaskierte pharmazeutische mittel
|
|
US5676942A
(en)
|
1992-02-10 |
1997-10-14 |
Interferon Sciences, Inc. |
Composition containing human alpha interferon species proteins and method for use thereof
|
|
US5405598A
(en)
|
1992-02-24 |
1995-04-11 |
Schinazi; Raymond F. |
Sensitizing agents for use in boron neutron capture therapy
|
|
US5610054A
(en)
|
1992-05-14 |
1997-03-11 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecule targeted against Hepatitis C virus
|
|
US5849905A
(en)
|
1994-11-23 |
1998-12-15 |
Centre National De La Recherche Scientifique |
Biologically active phosphotriester-type nucleosides and methods for preparing same
|
|
US6020482A
(en)
|
1992-05-25 |
2000-02-01 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
US5770725A
(en)
|
1992-05-25 |
1998-06-23 |
Gosselin; Gilles |
Phosphotriester type biologically active compounds
|
|
US5426183A
(en)
|
1992-06-22 |
1995-06-20 |
Eli Lilly And Company |
Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
|
|
US5256798A
(en)
|
1992-06-22 |
1993-10-26 |
Eli Lilly And Company |
Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
|
|
ES2103433T3
(es)
|
1992-06-22 |
1997-09-16 |
Lilly Co Eli |
Procedimiento para preparar derivados de 1-halo-2-desoxi-2,2-difluoro-d-ribofuranosilo enriquecidos en anomero alfa.
|
|
CA2105112C
(en)
|
1992-09-01 |
2005-08-02 |
Thomas C. Britton |
A process for anomerizing nucleosides
|
|
GB9226729D0
(en)
|
1992-12-22 |
1993-02-17 |
Wellcome Found |
Therapeutic combination
|
|
US6096331A
(en)
|
1993-02-22 |
2000-08-01 |
Vivorx Pharmaceuticals, Inc. |
Methods and compositions useful for administration of chemotherapeutic agents
|
|
US6753006B1
(en)
|
1993-02-22 |
2004-06-22 |
American Bioscience, Inc. |
Paclitaxel-containing formulations
|
|
US6749868B1
(en)
|
1993-02-22 |
2004-06-15 |
American Bioscience, Inc. |
Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
|
|
US5439686A
(en)
|
1993-02-22 |
1995-08-08 |
Vivorx Pharmaceuticals, Inc. |
Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
|
|
AU673057B2
(en)
|
1993-02-22 |
1996-10-24 |
Abraxis Bioscience, Llc |
Methods for (in vivo) delivery of biologics and compositionsuseful therefor
|
|
US6537579B1
(en)
|
1993-02-22 |
2003-03-25 |
American Bioscience, Inc. |
Compositions and methods for administration of pharmacologically active compounds
|
|
US5496546A
(en)
|
1993-02-24 |
1996-03-05 |
Jui H. Wang |
Compositions and methods of application of reactive antiviral polyadenylic acid derivatives
|
|
US6180134B1
(en)
|
1993-03-23 |
2001-01-30 |
Sequus Pharmaceuticals, Inc. |
Enhanced ciruclation effector composition and method
|
|
CA2162574A1
(en)
|
1993-05-12 |
1994-11-24 |
Karl Y. Hostetler |
Acyclovir derivatives for topical use
|
|
CA2167537A1
(en)
|
1993-07-19 |
1995-02-02 |
Tsuneo Ozeki |
Hepatitis c virus proliferation inhibitor
|
|
US7375198B2
(en)
|
1993-10-26 |
2008-05-20 |
Affymetrix, Inc. |
Modified nucleic acid probes
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
KR960705579A
(ko)
|
1993-11-10 |
1996-11-08 |
에릭에스. 딕커 |
개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates)
|
|
AU6550394A
(en)
|
1994-03-11 |
1995-09-25 |
Isis Pharmaceuticals, Inc. |
Novel pyrimidine nucleosides
|
|
DE4447588C2
(de)
|
1994-05-03 |
1997-11-20 |
Omer Osama Dr Dr Med |
Pflanzliches Arzneimittel zur Behandlung von chronischen und allergischen Rhino-Sino-Bronchitiden
|
|
AU710074B2
(en)
|
1994-06-22 |
1999-09-16 |
Proligo Llc |
Novel method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
|
|
US5840891A
(en)
|
1994-07-28 |
1998-11-24 |
Syntex (U.S.A.) Inc. |
2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
|
|
DE4432623A1
(de)
|
1994-09-14 |
1996-03-21 |
Huels Chemische Werke Ag |
Verfahren zur Bleichung von wäßrigen Tensidlösungen
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5696277A
(en)
|
1994-11-15 |
1997-12-09 |
Karl Y. Hostetler |
Antiviral prodrugs
|
|
US6391859B1
(en)
|
1995-01-27 |
2002-05-21 |
Emory University |
[5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
|
|
US5703058A
(en)
|
1995-01-27 |
1997-12-30 |
Emory University |
Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
|
|
GB9505025D0
(en)
|
1995-03-13 |
1995-05-03 |
Medical Res Council |
Chemical compounds
|
|
DE19514523A1
(de)
|
1995-04-12 |
1996-10-17 |
Schering Ag |
Neue Cytosin- und Cytidinderivate
|
|
US5981247A
(en)
|
1995-09-27 |
1999-11-09 |
Emory University |
Recombinant hepatitis C virus RNA replicase
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5767097A
(en)
|
1996-01-23 |
1998-06-16 |
Icn Pharmaceuticals, Inc. |
Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
|
|
GB9602028D0
(en)
|
1996-02-01 |
1996-04-03 |
Amersham Int Plc |
Nucleoside analogues
|
|
US5980884A
(en)
|
1996-02-05 |
1999-11-09 |
Amgen, Inc. |
Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon
|
|
JP2000506010A
(ja)
|
1996-02-29 |
2000-05-23 |
イミューソル インコーポレイテッド |
Ｃ型肝炎ウイルスリボザイム
|
|
US5830905A
(en)
|
1996-03-29 |
1998-11-03 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5633388A
(en)
|
1996-03-29 |
1997-05-27 |
Viropharma Incorporated |
Compounds, compositions and methods for treatment of hepatitis C
|
|
US5990276A
(en)
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
|
GB9609932D0
(en)
|
1996-05-13 |
1996-07-17 |
Hoffmann La Roche |
Use of IL-12 and IFN alpha for the treatment of infectious diseases
|
|
US5891874A
(en)
|
1996-06-05 |
1999-04-06 |
Eli Lilly And Company |
Anti-viral compound
|
|
US7875733B2
(en)
|
2003-09-18 |
2011-01-25 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
|
|
US5837257A
(en)
|
1996-07-09 |
1998-11-17 |
Sage R&D |
Use of plant extracts for treatment of HIV, HCV and HBV infections
|
|
US6214375B1
(en)
|
1996-07-16 |
2001-04-10 |
Generex Pharmaceuticals, Inc. |
Phospholipid formulations
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
US5922757A
(en)
|
1996-09-30 |
1999-07-13 |
The Regents Of The University Of California |
Treatment and prevention of hepatic disorders
|
|
US6224903B1
(en)
|
1996-10-11 |
2001-05-01 |
Sequus Pharmaceuticals, Inc. |
Polymer-lipid conjugate for fusion of target membranes
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
DE69729887T2
(de)
|
1996-10-16 |
2005-07-28 |
ICN Pharmaceuticals, Inc., Costa Mesa |
Purin-L-Nukleoside, Analoga und deren Verwendung
|
|
US6455690B1
(en)
|
1996-10-16 |
2002-09-24 |
Robert Tam |
L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine
|
|
ES2195970T3
(es)
|
1996-10-16 |
2003-12-16 |
Ribapharm Inc |
L-ribavirina y usos de la misma.
|
|
US6509320B1
(en)
|
1996-10-16 |
2003-01-21 |
Icn Pharmaceuticals, Inc. |
Purine L-nucleosides, analogs and uses thereof
|
|
DE69709671T2
(de)
|
1996-10-18 |
2002-08-22 |
Vertex Pharmaceuticals Inc., Cambridge |
Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus
|
|
GB9623908D0
(en)
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
IL119833A
(en)
|
1996-12-15 |
2001-01-11 |
Lavie David |
Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis
|
|
US5827533A
(en)
|
1997-02-06 |
1998-10-27 |
Duke University |
Liposomes containing active agents aggregated with lipid surfactants
|
|
US6004933A
(en)
|
1997-04-25 |
1999-12-21 |
Cortech Inc. |
Cysteine protease inhibitors
|
|
ES2200358T3
(es)
|
1997-06-30 |
2004-03-01 |
MERZ PHARMA GMBH & CO. KGAA |
1-amino-alquilciclohexanos antagonistas del receptor de nmda.
|
|
DE69827956T2
(de)
|
1997-08-11 |
2005-04-14 |
Boehringer Ingelheim (Canada) Ltd., Laval |
Peptidanaloga mit inhibitorischer wirkung auf hepatitis c
|
|
EP1317929A3
(en)
|
1997-09-21 |
2003-07-02 |
Schering Corporation |
Combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis c infection
|
|
US6703374B1
(en)
|
1997-10-30 |
2004-03-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Nucleosides for imaging and treatment applications
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
WO1999037753A1
(en)
|
1998-01-23 |
1999-07-29 |
Newbiotics, Inc. |
Enzyme catalyzed therapeutic agents
|
|
PT1058686E
(pt)
|
1998-02-25 |
2007-01-31 |
Raymond F Schinazi |
2'-fluoronucleósidos
|
|
US6312662B1
(en)
|
1998-03-06 |
2001-11-06 |
Metabasis Therapeutics, Inc. |
Prodrugs phosphorus-containing compounds
|
|
US6787305B1
(en)
|
1998-03-13 |
2004-09-07 |
Invitrogen Corporation |
Compositions and methods for enhanced synthesis of nucleic acid molecules
|
|
WO1999049873A1
(en)
|
1998-03-27 |
1999-10-07 |
Regents Of The University Of Minnesota |
Nucleosides with antiviral and anticancer activity
|
|
GB9806815D0
(en)
|
1998-03-30 |
1998-05-27 |
Hoffmann La Roche |
Amino acid derivatives
|
|
AU766597B2
(en)
|
1998-05-15 |
2003-10-16 |
Schering Corporation |
Combination therapy comprising ribavirin and interferon alpha in antiviral treatment naive patients having chronic hepatitis C infection
|
|
US20010014352A1
(en)
|
1998-05-27 |
2001-08-16 |
Udit Batra |
Compressed tablet formulation
|
|
NZ508249A
(en)
|
1998-06-08 |
2003-02-28 |
F |
Use of PEG-IFN-alpha conjugates in association with ribavirin for the treatment of chronic hepatitis C
|
|
US6726925B1
(en)
|
1998-06-18 |
2004-04-27 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
US6200598B1
(en)
|
1998-06-18 |
2001-03-13 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
ES2244204T3
(es)
|
1998-07-27 |
2005-12-01 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Derivados de dicetoacidos como inhibidores de polimerasas.
|
|
GB9816358D0
(en)
|
1998-07-27 |
1998-09-23 |
Angeletti P Ist Richerche Bio |
Enzyme inhibitors
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
MXPA01001507A
(es)
|
1998-08-10 |
2003-09-10 |
Novirio Pharmaceuticals Ltd |
°l-2'desoxi-nucleosidos para el tratamiento de hepatitis b.
|
|
JP4533537B2
(ja)
|
1998-10-16 |
2010-09-01 |
メルシャン株式会社 |
塩酸ドキソルビシンの結晶化
|
|
US6635278B1
(en)
|
1998-12-15 |
2003-10-21 |
Gilead Sciences, Inc. |
Pharmaceutical formulations
|
|
WO2000037110A2
(en)
|
1998-12-18 |
2000-06-29 |
Schering Corporation |
Ribavirin-pegylated interferon alfa induction hcv combination therapy
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6294192B1
(en)
|
1999-02-26 |
2001-09-25 |
Lipocine, Inc. |
Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
|
|
US6267985B1
(en)
|
1999-06-30 |
2001-07-31 |
Lipocine Inc. |
Clear oil-containing pharmaceutical compositions
|
|
US6383471B1
(en)
|
1999-04-06 |
2002-05-07 |
Lipocine, Inc. |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
|
|
US6395300B1
(en)
|
1999-05-27 |
2002-05-28 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
US7919119B2
(en)
|
1999-05-27 |
2011-04-05 |
Acusphere, Inc. |
Porous drug matrices and methods of manufacture thereof
|
|
CN1079473C
(zh)
|
1999-05-31 |
2002-02-20 |
李岭群 |
预制梁连接筋
|
|
WO2001005433A2
(en)
|
1999-07-14 |
2001-01-25 |
Board Of Regents, The University Of Texas System |
Delivery and retention of activity agents to lymph nodes
|
|
AU6388900A
(en)
|
1999-07-30 |
2001-02-19 |
Abbott Gmbh & Co. Kg |
2-pyrazolin-5-ones
|
|
US7388370B2
(en)
|
2005-07-29 |
2008-06-17 |
Automotive Systems Laboratory Systems, Inc. |
Magnetic crash sensor
|
|
US6752981B1
(en)
|
1999-09-08 |
2004-06-22 |
Metabasis Therapeutics, Inc. |
Prodrugs for liver specific drug delivery
|
|
US6566365B1
(en)
|
1999-11-04 |
2003-05-20 |
Biochem Pharma Inc. |
Method for the treatment of Flaviviridea viral infection using nucleoside analogues
|
|
CN1919859A
(zh)
|
1999-11-12 |
2007-02-28 |
法玛赛特有限公司 |
2＇－脱氧－l－核苷的合成
|
|
US20060034937A1
(en)
|
1999-11-23 |
2006-02-16 |
Mahesh Patel |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
KR20030005197A
(ko)
|
2000-02-18 |
2003-01-17 |
샤이어 바이오켐 인코포레이티드 |
뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법
|
|
US7094770B2
(en)
|
2000-04-13 |
2006-08-22 |
Pharmasset, Ltd. |
3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
|
|
WO2001081359A1
(en)
|
2000-04-20 |
2001-11-01 |
Schering Corporation |
Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
|
|
MY164523A
(en)
|
2000-05-23 |
2017-12-29 |
Univ Degli Studi Cagliari |
Methods and compositions for treating hepatitis c virus
|
|
US6787526B1
(en)
|
2000-05-26 |
2004-09-07 |
Idenix Pharmaceuticals, Inc. |
Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
|
|
CA2410579C
(en)
|
2000-05-26 |
2010-04-20 |
Jean-Pierre Sommadossi |
Methods and compositions for treating flaviviruses and pestiviruses
|
|
CN100490818C
(zh)
|
2000-05-26 |
2009-05-27 |
诺瓦蒂斯有限公司 |
β-L-2′-脱氧核苷在制备用于治疗丁型肝炎病毒感染的药物中的用途
|
|
FR2810322B1
(fr)
|
2000-06-14 |
2006-11-10 |
Pasteur Institut |
PRODUCTION COMBINATOIRE D'ANALOGUES DE NUCLEOTIDES ET NUCLEOTIDES (XiTP)
|
|
MY141594A
(en)
|
2000-06-15 |
2010-05-14 |
Novirio Pharmaceuticals Ltd |
3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
UA72612C2
(en)
|
2000-07-06 |
2005-03-15 |
|
Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
|
|
US6680068B2
(en)
|
2000-07-06 |
2004-01-20 |
The General Hospital Corporation |
Drug delivery formulations and targeting
|
|
AR029851A1
(es)
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
|
AR034127A1
(es)
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
|
MXPA03000587A
(es)
|
2000-07-21 |
2004-04-05 |
Gilead Sciences Inc |
Profarmacos de analogos de nucleotido de fosfonato y metodos para seleccionar y elaborar los mismos.
|
|
CA2418199A1
(en)
|
2000-07-21 |
2002-01-31 |
Corvas International, Inc. |
Peptides as ns3-serine protease inhibitors of hepatitis c virus
|
|
AU8063701A
(en)
|
2000-07-21 |
2002-02-05 |
Schering Corp |
Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
US6897201B2
(en)
|
2000-08-21 |
2005-05-24 |
Inspire Pharmaceuticals, Inc. |
Compositions and methods for the treatment of glaucoma or ocular hypertension
|
|
US7018985B1
(en)
|
2000-08-21 |
2006-03-28 |
Inspire Pharmaceuticals, Inc. |
Composition and method for inhibiting platelet aggregation
|
|
AR039558A1
(es)
|
2000-08-21 |
2005-02-23 |
Inspire Pharmaceuticals Inc |
Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
AU2002213343A1
(en)
|
2000-10-18 |
2002-04-29 |
Schering Corporation |
Ribavirin-pegylated interferon alfa HCV combination therapy
|
|
KR20090089922A
(ko)
|
2000-10-18 |
2009-08-24 |
파마셋 인코포레이티드 |
바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
|
|
US6555677B2
(en)
|
2000-10-31 |
2003-04-29 |
Merck & Co., Inc. |
Phase transfer catalyzed glycosidation of an indolocarbazole
|
|
PE20020707A1
(es)
|
2000-11-20 |
2002-08-11 |
Bristol Myers Squibb Co |
Compuestos tripeptidicos como inhibidores de la proteasa ns3 del virus de hepatitis c
|
|
DE60138567D1
(de)
|
2000-12-12 |
2009-06-10 |
Schering Corp |
Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus
|
|
AU2002230764A1
(en)
|
2000-12-13 |
2002-06-24 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
|
|
WO2002048116A2
(en)
|
2000-12-13 |
2002-06-20 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
US20040266723A1
(en)
|
2000-12-15 |
2004-12-30 |
Otto Michael J. |
Antiviral agents for treatment of Flaviviridae infections
|
|
US7105499B2
(en)
|
2001-01-22 |
2006-09-12 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
SI1355916T1
(sl)
|
2001-01-22 |
2007-04-30 |
Merck & Co Inc |
Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
|
|
MY129350A
(en)
|
2001-04-25 |
2007-03-30 |
Bristol Myers Squibb Co |
Aripiprazole oral solution
|
|
GB0112617D0
(en)
|
2001-05-23 |
2001-07-18 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
GB0114286D0
(en)
|
2001-06-12 |
2001-08-01 |
Hoffmann La Roche |
Nucleoside Derivatives
|
|
WO2003000713A1
(en)
|
2001-06-21 |
2003-01-03 |
Glaxo Group Limited |
Nucleoside compounds in hcv
|
|
JP4455056B2
(ja)
|
2001-07-11 |
2010-04-21 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
架橋二環式セリンプロテアーゼ阻害剤
|
|
EP2335700A1
(en)
|
2001-07-25 |
2011-06-22 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C virus polymerase inhibitors with a heterobicylic structure
|
|
ATE252594T1
(de)
|
2001-07-30 |
2003-11-15 |
Clariant Lsm Italia Spa |
Verfahren zur herstellung von ribavirin
|
|
JP4593917B2
(ja)
|
2001-08-02 |
2010-12-08 |
アイレックス オンコロジー， インコーポレイテッド |
プリンヌクレオシドを調製する方法
|
|
US6962991B2
(en)
|
2001-09-12 |
2005-11-08 |
Epoch Biosciences, Inc. |
Process for the synthesis of pyrazolopyrimidines
|
|
US7227019B2
(en)
|
2001-09-13 |
2007-06-05 |
Bristol-Myers Squibb Company |
Process for the preparation of rebeccamycin and analogs thereof
|
|
WO2003024461A1
(en)
|
2001-09-20 |
2003-03-27 |
Schering Corporation |
Hcv combination therapy
|
|
AU2002330154A1
(en)
|
2001-09-28 |
2003-04-07 |
Centre National De La Recherche Scientifique |
Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
|
|
ES2289161T3
(es)
|
2001-11-02 |
2008-02-01 |
Glaxo Group Limited |
Derivados de 4-(heteroaril de 6 miembros)-acil pirrolidina como inhibidores de hcv.
|
|
EP1448170A4
(en)
|
2001-11-27 |
2010-05-12 |
Bristol Myers Squibb Co |
EFAVIRENZ STAMP PREPARATIONS HAVING UNIQUE BIOPHARMACEUTICAL CHARACTERISTICS
|
|
GB0129945D0
(en)
|
2001-12-13 |
2002-02-06 |
Mrc Technology Ltd |
Chemical compounds
|
|
US7105527B2
(en)
|
2001-12-14 |
2006-09-12 |
Otto Michael J |
N4-acylcytosine nucleosides for treatment of viral infections
|
|
WO2003051899A1
(en)
|
2001-12-17 |
2003-06-26 |
Ribapharm Inc. |
Deazapurine nucleoside libraries and compounds
|
|
JP2005514401A
(ja)
|
2001-12-21 |
2005-05-19 |
マイクロロジックス バイオテック，インコーポレイテッド |
抗ウイルス性７−デアザｌ−ヌクレオシド
|
|
WO2003062256A1
(en)
|
2002-01-17 |
2003-07-31 |
Ribapharm Inc. |
2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
|
|
US7070801B2
(en)
|
2002-01-30 |
2006-07-04 |
National Institute Of Advanced Industrial Science And Technology |
Sugar-modified liposome and products comprising the liposome
|
|
CA2370396A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
AU2003209045B2
(en)
|
2002-02-13 |
2006-12-14 |
Isis Pharmaceuticals, Inc. |
Methods of inhibiting orthopoxvirus replication with nucleoside compounds
|
|
JP2005525358A
(ja)
|
2002-02-28 |
2005-08-25 |
ビオタ インコーポレーティッド |
ヌクレオチド模倣体およびそのプロドラッグ
|
|
JP2005524662A
(ja)
|
2002-02-28 |
2005-08-18 |
ビオタ インコーポレーティッド |
ヌクレオシド５’−一リン酸模倣物およびこれらのプロドラッグ
|
|
NZ535828A
(en)
|
2002-04-26 |
2007-10-26 |
Gilead Sciences Inc |
Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
|
|
US20040014108A1
(en)
|
2002-05-24 |
2004-01-22 |
Eldrup Anne B. |
Oligonucleotides having modified nucleoside units
|
|
CA2487211C
(en)
|
2002-06-04 |
2010-09-14 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo(1,5a) pyrimidine compounds as antiviral agents
|
|
US7449488B2
(en)
|
2002-06-04 |
2008-11-11 |
Schering Corporation |
Pyrazolopyrimidines as protein kinase inhibitors
|
|
JP4902958B2
(ja)
|
2002-06-07 |
2012-03-21 |
ユニバーシテール・メディッシュ・セントラム・ユトレヒト |
ｃＡＭＰによって直接活性化される交換タンパク質（Ｅｐａｃ）の活性をモジュレートするための新規な化合物
|
|
AU2003251524A1
(en)
|
2002-06-17 |
2003-12-31 |
Isis Pharmaceuticals, Inc. |
Carbocyclic nucleoside analogs as RNA-antivirals
|
|
AU2003248708A1
(en)
|
2002-06-17 |
2003-12-31 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
JP2005530843A
(ja)
|
2002-06-21 |
2005-10-13 |
メルク エンド カムパニー インコーポレーテッド |
Ｒｎａ依存性ｒｎａウィルスポリメラーゼ阻害剤としてのヌクレオシド誘導体
|
|
EP1572945A2
(en)
|
2002-06-27 |
2005-09-14 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
RS114004A
(sr)
|
2002-06-28 |
2007-02-05 |
Idenix (Cayman) Limited, |
Modifikovani 2'i 3'-nukleozid prolekovi za lečenje flaviridae infekcija
|
|
US7608600B2
(en)
|
2002-06-28 |
2009-10-27 |
Idenix Pharmaceuticals, Inc. |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
|
|
CN1678326A
(zh)
|
2002-06-28 |
2005-10-05 |
埃迪尼克斯(开曼)有限公司 |
用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
|
|
AU2003263412A1
(en)
|
2002-06-28 |
2004-01-19 |
Centre National De La Recherche Scientifique (Cnrs) |
1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
|
|
US6973905B2
(en)
|
2002-07-01 |
2005-12-13 |
Cinetic Automation Corporation |
Valve lash adjustment apparatus and method
|
|
MXPA05000020A
(es)
|
2002-07-01 |
2005-12-05 |
Pharmacia & Upjohn Co Llc |
Inhibidores de polimerasa ns5b de la infeccion del virus de la hepatitis c (hcv).
|
|
US6930106B2
(en)
|
2002-07-01 |
2005-08-16 |
Pharmacia & Upjohn Company |
Inhibitors of HCV NS5B polymerase
|
|
US20060264389A1
(en)
|
2002-07-16 |
2006-11-23 |
Balkrishen Bhat |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
CA2493816A1
(en)
|
2002-07-24 |
2004-01-29 |
Ptc Therapeutics, Inc. |
Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
|
|
WO2004009020A2
(en)
|
2002-07-24 |
2004-01-29 |
Merck & Co., Inc. |
Pyrrolopyrimidine thionucleoside analogs as antivirals
|
|
AU2003254657A1
(en)
|
2002-07-25 |
2004-02-16 |
Micrologix Biotech Inc. |
Anti-viral 7-deaza d-nucleosides and uses thereof
|
|
WO2004014313A2
(en)
|
2002-08-12 |
2004-02-19 |
Bristol-Myers Squibb Company |
Combination pharmaceutical agents as inhibitors of hcv replication
|
|
WO2004024095A2
(en)
|
2002-09-13 |
2004-03-25 |
Idenix (Cayman) Limited |
ß-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
|
|
JP2006505571A
(ja)
|
2002-10-15 |
2006-02-16 |
リゲル ファーマシューテイカルズ、インコーポレイテッド |
置換されたインドール及びｈｃｖ阻害剤としてのその使用
|
|
US20040229840A1
(en)
|
2002-10-29 |
2004-11-18 |
Balkrishen Bhat |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
|
|
BR0315937A
(pt)
|
2002-11-01 |
2005-09-13 |
Viropharma Inc |
Composto, composição para a profilaxia ou tratamento de infecções virais, e, método para a profilaxia ou tratamento de infecções da hepatite c e doenças associadas com tais infecções em um hospedeiro vivo
|
|
WO2004044139A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
JP2006519753A
(ja)
|
2002-11-15 |
2006-08-31 |
イデニクス（ケイマン）リミテツド |
２’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異
|
|
TWI332507B
(en)
|
2002-11-19 |
2010-11-01 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
LT1585548T
(lt)
|
2002-12-09 |
2018-09-25 |
Abraxis Bioscience, Llc |
Farmakologinių agentų kompozicijos ir įvedimo būdai
|
|
MXPA05006230A
(es)
|
2002-12-12 |
2005-09-20 |
Idenix Cayman Ltd |
Proceso para la produccion de nucleosidos ramificados-2'.
|
|
AU2004206821C1
(en)
|
2003-01-14 |
2009-10-01 |
Gilead Sciences, Inc. |
Compositions and methods for combination antiviral therapy
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
KR20060008297A
(ko)
|
2003-03-20 |
2006-01-26 |
마이크로 바이올로지카 퀴미카 이 파마슈티카 리미티드 |
2'-데옥시-β-Ｌ-뉴클레오시드의 제조방법
|
|
JP4733023B2
(ja)
|
2003-04-16 |
2011-07-27 |
ブリストル−マイヤーズ スクイブ カンパニー |
Ｃ型肝炎ウイルスの大環状イソキノリンペプチド阻害剤
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
EA200501676A1
(ru)
|
2003-04-25 |
2006-04-28 |
Джилид Сайэнс, Инк. |
Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты)
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
KR20060061930A
(ko)
|
2003-04-25 |
2006-06-08 |
길리애드 사이언시즈, 인코포레이티드 |
항암성 포스포네이트 유사체
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
DK1628685T3
(da)
|
2003-04-25 |
2011-03-21 |
Gilead Sciences Inc |
Antivirale phosphonatanaloge
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
WO2004096210A1
(en)
|
2003-05-01 |
2004-11-11 |
Glaxo Group Limited |
Acylated indoline and tetrahydroquinoline derivatives as hcv inhibitors
|
|
US20040259934A1
(en)
|
2003-05-01 |
2004-12-23 |
Olsen David B. |
Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
|
|
EP1656093A2
(en)
|
2003-05-14 |
2006-05-17 |
Idenix (Cayman) Limited |
Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
|
|
US20040229839A1
(en)
|
2003-05-14 |
2004-11-18 |
Biocryst Pharmaceuticals, Inc. |
Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
PL3521297T3
(pl)
|
2003-05-30 |
2022-04-04 |
Gilead Pharmasset Llc |
Zmodyfikowane fluorowane analogi nukleozydów
|
|
EP1644479A4
(en)
|
2003-06-16 |
2008-04-23 |
Mark W Grinstaff |
MACROMOLECULES AND FUNCTIONAL SYNTHETIC MOLECULES FOR GENES ADMINISTRATION
|
|
GB0317009D0
(en)
|
2003-07-21 |
2003-08-27 |
Univ Cardiff |
Chemical compounds
|
|
WO2005009418A2
(en)
|
2003-07-25 |
2005-02-03 |
Idenix (Cayman) Limited |
Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
|
|
ES2355565T3
(es)
|
2003-08-27 |
2011-03-29 |
Biota Scientific Management Pty. Ltd. |
Nuevos nucleósidos o nucleótidos tricíclos como agentes terapéuticos.
|
|
US20050119189A1
(en)
|
2003-09-18 |
2005-06-02 |
Cottrell Kevin M. |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
US20050148534A1
(en)
|
2003-09-22 |
2005-07-07 |
Castellino Angelo J. |
Small molecule compositions and methods for increasing drug efficiency using compositions thereof
|
|
TW201245229A
(en)
|
2003-10-14 |
2012-11-16 |
Hoffmann La Roche |
Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication
|
|
US7491794B2
(en)
|
2003-10-14 |
2009-02-17 |
Intermune, Inc. |
Macrocyclic compounds as inhibitors of viral replication
|
|
US20060003942A1
(en)
|
2003-10-27 |
2006-01-05 |
Roger Tung |
Combinations for HCV treatment
|
|
US7026339B2
(en)
|
2003-11-07 |
2006-04-11 |
Fan Yang |
Inhibitors of HCV NS5B polymerase
|
|
TW200528459A
(en)
|
2004-01-06 |
2005-09-01 |
Achillion Pharmaceuticals Inc |
Azabenzofuran substituted thioureas; inhibitors of viral replication
|
|
CN1913778A
(zh)
|
2004-01-28 |
2007-02-14 |
默克公司 |
趋化因子受体活性的氨基环戊基吡啶并吡嗪酮调节剂
|
|
AU2005216971A1
(en)
|
2004-02-25 |
2005-09-09 |
Government Of The United States Of America, As Represented By The Secretary Department Of Health And Human Services Office Of Technology Transfer |
Methylation inhibitor compounds
|
|
WO2005087788A2
(en)
|
2004-03-04 |
2005-09-22 |
The Regents Of The University Of California |
Methods for preparation of nucleoside phosphonate esters
|
|
GEP20104926B
(en)
|
2004-03-30 |
2010-03-25 |
Intermune Inc |
Macrocyclic compounds as inhibitors of viral replication
|
|
GB0408995D0
(en)
|
2004-04-22 |
2004-05-26 |
Glaxo Group Ltd |
Compounds
|
|
WO2005121372A2
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
US7534767B2
(en)
|
2004-06-15 |
2009-05-19 |
Merck & Co., Inc. |
C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
|
|
JP2008503562A
(ja)
|
2004-06-23 |
2008-02-07 |
イデニクス（ケイマン）リミテツド |
フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体
|
|
US20070265222A1
(en)
|
2004-06-24 |
2007-11-15 |
Maccoss Malcolm |
Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
|
|
US7217523B2
(en)
|
2004-07-02 |
2007-05-15 |
Regents Of The University Of Minnesota |
Nucleoside phosphoramidates and nucleoside phosphoramidases
|
|
NZ552927A
(en)
|
2004-07-21 |
2010-05-28 |
Pharmasset Inc |
Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives
|
|
CN101023094B
(zh)
|
2004-07-21 |
2011-05-18 |
法莫赛特股份有限公司 |
烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
|
|
AU2005330489B2
(en)
|
2004-07-27 |
2011-08-25 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates as anti HIV agents
|
|
US7348425B2
(en)
|
2004-08-09 |
2008-03-25 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
US7153848B2
(en)
|
2004-08-09 |
2006-12-26 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
EP1794172B1
(en)
|
2004-08-23 |
2009-07-15 |
F.Hoffmann-La Roche Ag |
Antiviral 4'-azido-nucleosides
|
|
DE602005015732D1
(de)
|
2004-08-23 |
2009-09-10 |
Hoffmann La Roche |
Heterozyklische antivirale verbindungen
|
|
WO2006029081A2
(en)
|
2004-09-02 |
2006-03-16 |
Neopharm, Inc. |
Nucleoside-lipid conjugates, their method of preparation and uses thereof
|
|
JP5001842B2
(ja)
|
2004-09-14 |
2012-08-15 |
ギリアド ファーマセット エルエルシー |
２’−フルオロ−２’−アルキル−置換又は他の置換されていてもよいリボフラノシルピリミジン類及びプリン類並びにそれらの誘導体の製造
|
|
RU2007115419A
(ru)
|
2004-09-24 |
2008-10-27 |
Айденикс (Кайман) Лимитед (Ky) |
Способы и композиции для лечения флавивирусов, пестивирусов и гепацивируса
|
|
KR20070058602A
(ko)
|
2004-09-30 |
2007-06-08 |
티보텍 파마슈티칼즈 리미티드 |
Ｈｃｖ 저해 바이-사이클릭 피리미딘
|
|
AU2005317081A1
(en)
|
2004-10-21 |
2006-06-22 |
Merck & Co., Inc. |
Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection
|
|
EP1827460A4
(en)
|
2004-12-09 |
2012-03-14 |
Univ Minnesota |
NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT
|
|
WO2006065590A2
(en)
|
2004-12-16 |
2006-06-22 |
Xtl Biopharmaceuticals Inc. |
Pyridine and pyrimidine antiviral compositions
|
|
WO2006063717A2
(en)
|
2004-12-16 |
2006-06-22 |
Febit Biotech Gmbh |
Polymerase-independent analysis of the sequence of polynucleotides
|
|
WO2006093801A1
(en)
|
2005-02-25 |
2006-09-08 |
Abbott Laboratories |
Thiadiazine derivatives useful as anti-infective agents
|
|
US7524825B2
(en)
|
2005-02-28 |
2009-04-28 |
Smithkline Beecham Corporation |
Tricyclic-nucleoside compounds for treating viral infections
|
|
JP2008532950A
(ja)
|
2005-03-08 |
2008-08-21 |
バイオタ サイエンティフィック マネージメント ピーティーワイ リミテッド |
治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド
|
|
JP2008534479A
(ja)
|
2005-03-25 |
2008-08-28 |
テイボテク・フアーマシユーチカルズ・リミテツド |
Ｈｃｖの複素二環式阻害剤
|
|
US7405204B2
(en)
|
2005-04-25 |
2008-07-29 |
Genelabs Technologies, Inc. |
Nucleoside compounds for treating viral infections
|
|
WO2006119347A1
(en)
|
2005-05-02 |
2006-11-09 |
Pharmaessentia Corp. |
STEREOSELECTIVE SYNTHESIS OF β-NUCLEOSIDES
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
AR056347A1
(es)
|
2005-05-12 |
2007-10-03 |
Tibotec Pharm Ltd |
Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
|
|
AR054122A1
(es)
|
2005-05-12 |
2007-06-06 |
Tibotec Pharm Ltd |
Pirido[2,3-d]pirimidas utiles como inhibidores de hcv, y metodos para la preparacion de las mismas
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
US20060276405A1
(en)
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Methods for treating hepatitis C
|
|
US8143288B2
(en)
|
2005-06-06 |
2012-03-27 |
Bristol-Myers Squibb Company |
Inhibitors of HCV replication
|
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
|
US20060293752A1
(en)
|
2005-06-27 |
2006-12-28 |
Missoum Moumene |
Intervertebral disc prosthesis and associated methods
|
|
NZ565059A
(en)
|
2005-07-25 |
2011-08-26 |
Intermune Inc |
Novel macrocyclic inhibitors of hepatitus C virus replication
|
|
JP2009502969A
(ja)
|
2005-07-28 |
2009-01-29 |
アイエスピー インヴェストメンツ インコーポレイテッド |
非晶質エファビレンツ及びその製造
|
|
DK1919904T3
(da)
|
2005-07-29 |
2014-04-07 |
Janssen R & D Ireland |
Makrocykliske inhibitorer af hepatitis-c-virus
|
|
US20070059360A1
(en)
|
2005-07-29 |
2007-03-15 |
Ashish Jaiswal |
Water-dispersible anti-retroviral pharmaceutical compositions
|
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
|
AR055361A1
(es)
|
2005-07-29 |
2007-08-22 |
Medivir Ab |
Inhibidores macrociclicos del virus de la hepatitis c
|
|
AR055105A1
(es)
|
2005-07-29 |
2007-08-08 |
Tibotec Pharm Ltd |
Inhibidores macrociclicos del virus de la hepatitis c
|
|
DK1919898T3
(da)
|
2005-07-29 |
2011-05-02 |
Tibotec Pharm Ltd |
Makrocykliske inhibitorer af hepatitis-C-virus
|
|
CN101287472B
(zh)
|
2005-08-15 |
2011-10-12 |
弗·哈夫曼-拉罗切有限公司 |
抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物
|
|
GB0519488D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
GB0519478D0
(en)
|
2005-09-23 |
2005-11-02 |
Glaxo Group Ltd |
Compounds
|
|
MY150667A
(en)
|
2005-12-09 |
2014-02-28 |
Gilead Pharmasset Llc |
Antiviral nucleosides
|
|
AU2006326494A1
(en)
|
2005-12-12 |
2007-06-21 |
Genelabs Technologies, Inc. |
N-(6-membered aromatic ring)-amido anti-viral compounds
|
|
NZ569817A
(en)
|
2005-12-21 |
2011-10-28 |
Abbott Lab |
Anti-viral compounds
|
|
EP1979349B1
(en)
|
2005-12-21 |
2010-07-28 |
Abbott Laboratories |
Anti-viral compounds
|
|
GB0602046D0
(en)
|
2006-02-01 |
2006-03-15 |
Smithkline Beecham Corp |
Compounds
|
|
WO2007092000A1
(en)
|
2006-02-06 |
2007-08-16 |
Bristol-Myers Squibb Company |
Inhibitors of hcv replication
|
|
US7879815B2
(en)
|
2006-02-14 |
2011-02-01 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
JP2009528989A
(ja)
|
2006-02-17 |
2009-08-13 |
ファイザー・リミテッド |
Ｔｌｒ７変調剤としての３−デアザプリン誘導体
|
|
US8895531B2
(en)
|
2006-03-23 |
2014-11-25 |
Rfs Pharma Llc |
2′-fluoronucleoside phosphonates as antiviral agents
|
|
US7521442B2
(en)
|
2006-05-25 |
2009-04-21 |
Bristol-Myers Squibb Company |
Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
|
|
EP2029606B1
(en)
|
2006-05-25 |
2010-05-26 |
Brystol-Myers Squibb Company |
Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
|
|
SI2049506T2
(sl)
|
2006-07-07 |
2024-07-31 |
Gilead Sciences, Inc. |
Modulatorji farmakokinetičnih lastnosti terapevtikov
|
|
US20080014228A1
(en)
|
2006-07-14 |
2008-01-17 |
Olivia Darmuzey |
Solid form
|
|
EP1881001A1
(en)
|
2006-07-20 |
2008-01-23 |
Tibotec Pharmaceuticals Ltd. |
HCV NS-3 serine protease inhibitors
|
|
US8329159B2
(en)
|
2006-08-11 |
2012-12-11 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
JP5252459B2
(ja)
|
2006-10-10 |
2013-07-31 |
ギリアド ファーマセット エルエルシー |
リボフラノシルピリミジンヌクレオシドの調製
|
|
PL216525B1
(pl)
|
2006-10-17 |
2014-04-30 |
Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk |
5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
|
|
GB0623493D0
(en)
|
2006-11-24 |
2007-01-03 |
Univ Cardiff |
Chemical compounds
|
|
EP2120565B1
(en)
|
2006-12-20 |
2012-11-28 |
Merck Sharp & Dohme Corp. |
Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection
|
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
US8071568B2
(en)
|
2007-01-05 |
2011-12-06 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
GB0709791D0
(en)
|
2007-05-22 |
2007-06-27 |
Angeletti P Ist Richerche Bio |
Antiviral agents
|
|
CN101108870A
(zh)
|
2007-08-03 |
2008-01-23 |
冷一欣 |
核苷磷酸酯类化合物及制备方法和应用
|
|
US8629171B2
(en)
|
2007-08-08 |
2014-01-14 |
Bristol-Myers Squibb Company |
Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt
|
|
SI2061513T1
(sl)
|
2007-09-14 |
2011-11-30 |
Schering Corp |
Postopek zdravljenja pacientov s hepatitisom c
|
|
JO2778B1
(en)
|
2007-10-16 |
2014-03-15 |
ايساي انك |
Certain Compounds, Compositions and Methods
|
|
JP5238939B2
(ja)
|
2007-11-07 |
2013-07-17 |
三菱化学株式会社 |
長繊維強化複合樹脂組成物および成形品
|
|
US20090318380A1
(en)
|
2007-11-20 |
2009-12-24 |
Pharmasset, Inc. |
2',4'-substituted nucleosides as antiviral agents
|
|
TW200936146A
(en)
|
2007-11-29 |
2009-09-01 |
Metabasis Therapeutics Inc |
Antiviral nucleoside compounds
|
|
US20090176732A1
(en)
|
2007-12-21 |
2009-07-09 |
Alios Biopharma Inc. |
Protected nucleotide analogs
|
|
US8227431B2
(en)
|
2008-03-17 |
2012-07-24 |
Hetero Drugs Limited |
Nucleoside derivatives
|
|
WO2009120878A2
(en)
|
2008-03-26 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Non-natural ribonucleotides, and methods of use thereof
|
|
CA2720729A1
(en)
|
2008-04-15 |
2009-11-26 |
Intermune, Inc. |
Novel macrocyclic inhibitors of hepatitis c virus replication
|
|
WO2009129120A2
(en)
|
2008-04-15 |
2009-10-22 |
Rfs Pharma, Llc |
Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
|
|
CN102015714B
(zh)
|
2008-04-23 |
2014-09-24 |
吉里德科学公司 |
用于抗病毒治疗的1’-取代的carba-核苷类似物
|
|
WO2010036407A2
(en)
|
2008-05-15 |
2010-04-01 |
Biocryst Pharmaceuticals, Inc. |
Antiviral nucleoside analogs
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
WO2010002877A2
(en)
|
2008-07-03 |
2010-01-07 |
Biota Scientific Management |
Bycyclic nucleosides and nucleotides as therapeutic agents
|
|
TWI480272B
(zh)
|
2008-10-09 |
2015-04-11 |
Anadys Pharmaceuticals Inc |
藉由５，６－二氫－１ｈ－吡啶－２－酮與一或多種其他抗病毒化合物的組合物抑制ｃ型肝炎病毒的方法
|
|
CL2009002208A1
(es)
|
2008-12-23 |
2010-10-29 |
Gilead Pharmasset Llc |
Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
|
|
CL2009002207A1
(es)
|
2008-12-23 |
2011-02-18 |
Gilead Pharmasset Llc |
Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
|
|
KR20110104074A
(ko)
|
2008-12-23 |
2011-09-21 |
파마셋 인코포레이티드 |
퓨린 뉴클레오시드의 합성
|
|
MX2011007194A
(es)
|
2009-01-07 |
2013-07-12 |
Scynexis Inc |
Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc).
|
|
PT2719701T
(pt)
|
2009-02-10 |
2017-06-29 |
Gilead Sciences Inc |
Método para a preparação de ribósidos de tieno[3,4-d]pirimidin-7-ilo
|
|
JO3027B1
(ar)
|
2009-05-14 |
2016-09-05 |
Janssen Products Lp |
نيوكليوسيدات يوراسيل سبيرواوكسيتان
|
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
|
TWI583692B
(zh)
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
MX2012011171A
(es)
|
2010-03-31 |
2013-02-01 |
Gilead Pharmasset Llc |
Fosforamidatos de nucleosido.
|
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
|
AU2011336632B2
(en)
|
2010-11-30 |
2015-09-03 |
Gilead Pharmasset Llc |
Compounds
|