JP2004505965A5 - - Google Patents
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- Publication number
- JP2004505965A5 JP2004505965A5 JP2002518202A JP2002518202A JP2004505965A5 JP 2004505965 A5 JP2004505965 A5 JP 2004505965A5 JP 2002518202 A JP2002518202 A JP 2002518202A JP 2002518202 A JP2002518202 A JP 2002518202A JP 2004505965 A5 JP2004505965 A5 JP 2004505965A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00402257 | 2000-08-09 | ||
| PCT/GB2001/003561 WO2002012227A2 (en) | 2000-08-09 | 2001-08-08 | Indole, azaindole and indazole derivatives having vegf inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004505965A JP2004505965A (ja) | 2004-02-26 |
| JP2004505965A5 true JP2004505965A5 (OSRAM) | 2005-03-17 |
Family
ID=8173808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002518202A Pending JP2004505965A (ja) | 2000-08-09 | 2001-08-08 | 化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20030207878A1 (OSRAM) |
| EP (1) | EP1311500A2 (OSRAM) |
| JP (1) | JP2004505965A (OSRAM) |
| KR (1) | KR20030029812A (OSRAM) |
| CN (1) | CN1245402C (OSRAM) |
| AU (2) | AU7993801A (OSRAM) |
| BR (1) | BR0113078A (OSRAM) |
| CA (1) | CA2416525A1 (OSRAM) |
| IL (1) | IL154034A0 (OSRAM) |
| MX (1) | MXPA03000874A (OSRAM) |
| NO (1) | NO20030628L (OSRAM) |
| NZ (1) | NZ523987A (OSRAM) |
| WO (1) | WO2002012227A2 (OSRAM) |
| ZA (1) | ZA200300489B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK288365B6 (sk) | 1999-02-10 | 2016-07-01 | Astrazeneca Ab | Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy |
| IL149034A0 (en) | 1999-11-05 | 2002-11-10 | Astrazeneca Ab | Quinazoline derivatives as vegf inhibitors |
| ATE300303T1 (de) | 2000-03-06 | 2005-08-15 | Astrazeneca Ab | Verwendung von quinazolinderivate als inhibitoren der angiogenese |
| SI1274692T1 (sl) | 2000-04-07 | 2006-12-31 | Astrazeneca Ab | Kinazolinske spojine |
| CN1625555A (zh) * | 2002-02-01 | 2005-06-08 | 阿斯特拉曾尼卡有限公司 | 喹唑啉化合物 |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| US6933386B2 (en) * | 2002-07-19 | 2005-08-23 | Bristol Myers Squibb Company | Process for preparing certain pyrrolotriazine compounds |
| TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| CA2500727A1 (en) * | 2002-10-03 | 2004-04-15 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| NZ539408A (en) | 2002-11-04 | 2007-09-28 | Astrazeneca Ab | Quinazoline derivatives as SRC tyrosine kinase inhibitors for treating solid tumours |
| EP1625121B1 (en) | 2002-12-20 | 2010-02-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| WO2004078126A2 (en) | 2003-02-28 | 2004-09-16 | Oxigene, Inc. | Compositions and methods with enhanced therapeutic activity |
| WO2004103159A2 (en) * | 2003-05-14 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating endometrium |
| WO2005111022A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidines derivatives for the treatment of abnormal cell growth |
| BRPI0510963A (pt) | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
| JP2007537235A (ja) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療用ピリミジン誘導体 |
| CL2007003158A1 (es) * | 2006-11-02 | 2008-05-16 | Astrazeneca Ab | Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion. |
| US20080190689A1 (en) * | 2007-02-12 | 2008-08-14 | Ballard Ebbin C | Inserts for engine exhaust systems |
| CN104945311A (zh) | 2009-01-19 | 2015-09-30 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
| AU2010216263A1 (en) | 2009-02-23 | 2011-07-14 | Merck Sharp & Dohme Corp. | Pyrazolo [4,3-c] cinnolin-3-one M1 receptor positive allosteric modulators |
| US8653079B2 (en) | 2011-08-15 | 2014-02-18 | Merck Sharp & Dohme Corp. | Pyrazolo [4,3-C] cinnolin-3-one M1 receptor positive allosteric modulators |
| BR122020023385B1 (pt) | 2014-06-19 | 2021-05-25 | Merial, Inc | composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos |
| BR112021022734A2 (pt) * | 2019-05-14 | 2022-03-08 | Scripps Research Inst | Compostos para tratamento de distúrbios neurodegenerativos e metabólicos |
| CN116406271B (zh) * | 2020-07-14 | 2024-09-24 | 南京再明医药有限公司 | 双环类化合物 |
| BR112023021111A2 (pt) | 2021-04-13 | 2023-12-19 | Nuvalent Inc | Composto, composição farmacêutica, método de tratamento de câncer, método para inibir seletivamente her2, método de regulação de um nível de her2, método para aumentar um nível de her2, método de diminuição da fosforilação de her2 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987332A (en) * | 1975-10-09 | 1976-10-19 | Varian Associates | Gang tuner for multi-cavity klystron |
| US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5237629A (en) * | 1992-03-19 | 1993-08-17 | The United States Of America As Represented By The United States Department Of Energy | Digitally controlled distributed phase shifter |
| US5440270A (en) * | 1992-07-14 | 1995-08-08 | Linear Technology Corporation | Linear-phase filter having high gain selectivity |
| SE9302453L (sv) * | 1993-07-20 | 1994-10-17 | Telia Ab | Förfarande och anordning för synkronisering i digitalt transmissionssystem av typen OFDM |
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| US5639757A (en) * | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
| US6395733B1 (en) * | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
| GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| JP3727406B2 (ja) * | 1996-03-07 | 2005-12-14 | 株式会社日立国際電気 | 関数変換演算器 |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| CA2263479A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Quinoline derivatives inhibiting the effect of growth factors such as vegf |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| BR9814018A (pt) * | 1997-11-11 | 2000-09-26 | Pfizer Prod Inc | Derivados de tienopirimidina e tienopiridina úteis como agentes anticâncer |
| JPH11259454A (ja) * | 1998-03-09 | 1999-09-24 | Sharp Corp | フーリエ変換装置 |
| JP4516690B2 (ja) * | 1998-08-11 | 2010-08-04 | ノバルティス アーゲー | 血管形成阻害活性を有するイソキノリン誘導体 |
| US20030162795A1 (en) * | 1998-10-22 | 2003-08-28 | Pfizer Inc. | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| KR200212866Y1 (ko) * | 1998-12-26 | 2001-02-15 | 서평원 | 선왜곡 방식 전력증폭기용 능동 왜곡신호 발생회로 |
| US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| CA2373990C (en) * | 1999-05-21 | 2007-05-08 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| DOP2000000070A (es) * | 1999-09-28 | 2002-02-28 | Bayer Healthcare Llc | Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis |
| WO2001094353A1 (en) * | 2000-06-06 | 2001-12-13 | Pfizer Products Inc. | Thiophene derivatives useful as anticancer agents |
-
2001
- 2001-08-08 US US10/343,236 patent/US20030207878A1/en not_active Abandoned
- 2001-08-08 AU AU7993801A patent/AU7993801A/xx active Pending
- 2001-08-08 AU AU2001279938A patent/AU2001279938B2/en not_active Ceased
- 2001-08-08 CN CNB018166962A patent/CN1245402C/zh not_active Expired - Fee Related
- 2001-08-08 JP JP2002518202A patent/JP2004505965A/ja active Pending
- 2001-08-08 NZ NZ523987A patent/NZ523987A/en unknown
- 2001-08-08 KR KR10-2003-7001852A patent/KR20030029812A/ko not_active Ceased
- 2001-08-08 WO PCT/GB2001/003561 patent/WO2002012227A2/en not_active Ceased
- 2001-08-08 BR BR0113078-1A patent/BR0113078A/pt not_active IP Right Cessation
- 2001-08-08 IL IL15403401A patent/IL154034A0/xx unknown
- 2001-08-08 CA CA002416525A patent/CA2416525A1/en not_active Abandoned
- 2001-08-08 EP EP01958210A patent/EP1311500A2/en not_active Withdrawn
- 2001-08-08 MX MXPA03000874A patent/MXPA03000874A/es not_active Application Discontinuation
-
2003
- 2003-01-17 ZA ZA200300489A patent/ZA200300489B/en unknown
- 2003-02-07 NO NO20030628A patent/NO20030628L/no not_active Application Discontinuation
-
2006
- 2006-02-16 US US11/355,006 patent/US20060148819A1/en not_active Abandoned
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