JP2012530113A5 - - Google Patents
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- JP2012530113A5 JP2012530113A5 JP2012515500A JP2012515500A JP2012530113A5 JP 2012530113 A5 JP2012530113 A5 JP 2012530113A5 JP 2012515500 A JP2012515500 A JP 2012515500A JP 2012515500 A JP2012515500 A JP 2012515500A JP 2012530113 A5 JP2012530113 A5 JP 2012530113A5
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- JP
- Japan
- Prior art keywords
- group
- formula
- branched
- linear
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 21
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- -1 hexadecyloxypropyl Chemical group 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 4
- 125000003700 epoxy group Chemical group 0.000 claims 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 2
- 150000001336 alkenes Chemical group 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 2
- 238000005865 alkene metathesis reaction Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 150000003457 sulfones Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305562.2 | 2009-06-18 | ||
| EP09305562A EP2270021A1 (en) | 2009-06-18 | 2009-06-18 | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| PCT/EP2010/058567 WO2010146127A1 (en) | 2009-06-18 | 2010-06-17 | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012530113A JP2012530113A (ja) | 2012-11-29 |
| JP2012530113A5 true JP2012530113A5 (OSRAM) | 2013-08-01 |
Family
ID=41171101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515500A Pending JP2012530113A (ja) | 2009-06-18 | 2010-06-17 | より良好な生物学的利用能を示すホスホネート誘導体の合成のためのホスホネートシントン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8785629B2 (OSRAM) |
| EP (2) | EP2270021A1 (OSRAM) |
| JP (1) | JP2012530113A (OSRAM) |
| CA (1) | CA2764827C (OSRAM) |
| ES (1) | ES2601849T3 (OSRAM) |
| WO (1) | WO2010146127A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130231307A1 (en) * | 2010-09-14 | 2013-09-05 | Centre National De La Recherche Scientifique | Novel antiviral acyclic nucleoside phosphonates |
| US20230130333A1 (en) * | 2020-03-04 | 2023-04-27 | Fujifilm Wako Pure Chemical Corporation | Method for manufacturing phosphonate esters and method for manufacturing phosphate esters |
| US20250025564A1 (en) * | 2021-07-15 | 2025-01-23 | Alnylam Pharmaceuticals, Inc. | Simple chemical approaches to introduce 2,6-diaminopurine and 2-aminoadenine conjugates into oligonucleotides |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6814978A (OSRAM) | 1967-10-30 | 1969-05-02 | ||
| BR6914868D0 (pt) * | 1969-01-23 | 1973-03-20 | & Co Inc Merck | Processos quimicos |
| JPS6069089A (ja) | 1983-09-26 | 1985-04-19 | Nissan Chem Ind Ltd | ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法 |
| JP3347723B2 (ja) * | 1990-06-13 | 2002-11-20 | グラツィエル，アーノルド | 含リンプロドラッグ |
| EP0521622B1 (en) | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| ZA941088B (en) * | 1993-02-19 | 1995-09-27 | Symphar Sa | Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them |
| DE4343599A1 (de) | 1993-12-21 | 1995-06-22 | Bayer Ag | Verwendung von Phosphonsäureestern zur Behandlung von Hirnleistungsstörungen und Depressionen |
| US5635449A (en) * | 1995-04-07 | 1997-06-03 | American Cyanamid Company | Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents |
| IT1281498B1 (it) * | 1995-06-07 | 1998-02-18 | Sardinian Antiviral Research C | Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e |
| ES2218660T3 (es) * | 1996-01-16 | 2004-11-16 | Bristol-Myers Squibb Company | Inhibidores aromaticos conformacionalmente restringidos de la proteina de transferencia de trigliceridos microsomales y procedimiento. |
| IT1290444B1 (it) | 1997-03-27 | 1998-12-03 | Boehringer Mannheim Italia | Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale |
| EP1233770B1 (en) * | 1999-12-03 | 2008-02-13 | The Regents of The University of California at San Diego | Phosphonate compounds |
| EA008775B1 (ru) | 2002-04-26 | 2007-08-31 | Джилид Сайэнс, Инк. | Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция |
| WO2004026315A1 (en) | 2002-09-19 | 2004-04-01 | Ilex Oncology Research, Sarl | Substituted ketophosphonate compounds having bone anabolic activity |
| AU2003301439A1 (en) * | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| JP2010535701A (ja) * | 2003-04-25 | 2010-11-25 | ギリアード サイエンシーズ， インコーポレイテッド | 抗癌ホスホネートアナログ |
| JP2007512359A (ja) | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| US20080261923A1 (en) * | 2004-08-04 | 2008-10-23 | Etzkorn Felicia A | Alkene Mimics |
| WO2008096002A1 (en) | 2007-02-08 | 2008-08-14 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting macrocyclic phosphonates and amidophosphates |
-
2009
- 2009-06-18 EP EP09305562A patent/EP2270021A1/en not_active Withdrawn
-
2010
- 2010-06-17 EP EP10725716.4A patent/EP2443130B1/en not_active Not-in-force
- 2010-06-17 US US13/377,652 patent/US8785629B2/en not_active Expired - Fee Related
- 2010-06-17 JP JP2012515500A patent/JP2012530113A/ja active Pending
- 2010-06-17 ES ES10725716.4T patent/ES2601849T3/es active Active
- 2010-06-17 WO PCT/EP2010/058567 patent/WO2010146127A1/en not_active Ceased
- 2010-06-17 CA CA2764827A patent/CA2764827C/en not_active Expired - Fee Related
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