ES2601849T3 - Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad - Google Patents
Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad Download PDFInfo
- Publication number
- ES2601849T3 ES2601849T3 ES10725716.4T ES10725716T ES2601849T3 ES 2601849 T3 ES2601849 T3 ES 2601849T3 ES 10725716 T ES10725716 T ES 10725716T ES 2601849 T3 ES2601849 T3 ES 2601849T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- branched
- linear
- nmr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305562A EP2270021A1 (en) | 2009-06-18 | 2009-06-18 | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
| EP09305562 | 2009-06-18 | ||
| PCT/EP2010/058567 WO2010146127A1 (en) | 2009-06-18 | 2010-06-17 | Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2601849T3 true ES2601849T3 (es) | 2017-02-16 |
Family
ID=41171101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10725716.4T Active ES2601849T3 (es) | 2009-06-18 | 2010-06-17 | Sintones de fosfonatos para la síntesis de derivados de fosfonatos que muestran mejor biodisponibilidad |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8785629B2 (OSRAM) |
| EP (2) | EP2270021A1 (OSRAM) |
| JP (1) | JP2012530113A (OSRAM) |
| CA (1) | CA2764827C (OSRAM) |
| ES (1) | ES2601849T3 (OSRAM) |
| WO (1) | WO2010146127A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2616474A1 (en) * | 2010-09-14 | 2013-07-24 | Centre National De La Recherche Scientifique | Novel antiviral acyclic nucleoside phosphonates |
| US20230130333A1 (en) * | 2020-03-04 | 2023-04-27 | Fujifilm Wako Pure Chemical Corporation | Method for manufacturing phosphonate esters and method for manufacturing phosphate esters |
| EP4370136A4 (en) * | 2021-07-15 | 2025-10-29 | Alnylam Pharmaceuticals Inc | SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6814978A (OSRAM) | 1967-10-30 | 1969-05-02 | ||
| BR6914868D0 (pt) * | 1969-01-23 | 1973-03-20 | & Co Inc Merck | Processos quimicos |
| JPS6069089A (ja) | 1983-09-26 | 1985-04-19 | Nissan Chem Ind Ltd | ジヒドロピリジン−５−ホスホネ−ト誘導体およびその製造法 |
| WO1991019721A1 (en) * | 1990-06-13 | 1991-12-26 | Arnold Glazier | Phosphorous produgs |
| EP0521622B1 (en) | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| ZA941088B (en) * | 1993-02-19 | 1995-09-27 | Symphar Sa | Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them |
| DE4343599A1 (de) | 1993-12-21 | 1995-06-22 | Bayer Ag | Verwendung von Phosphonsäureestern zur Behandlung von Hirnleistungsstörungen und Depressionen |
| US5635449A (en) * | 1995-04-07 | 1997-06-03 | American Cyanamid Company | Arylthioalkyl- and arylthioalkenylphosphonic acids and derivatives thereof useful as herbicidal agents |
| IT1281498B1 (it) * | 1995-06-07 | 1998-02-18 | Sardinian Antiviral Research C | Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e |
| AU716729B2 (en) * | 1996-01-16 | 2000-03-02 | Bristol-Myers Squibb Company | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| IT1290444B1 (it) | 1997-03-27 | 1998-12-03 | Boehringer Mannheim Italia | Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale |
| BR0016058A (pt) * | 1999-12-03 | 2003-07-15 | Univ California San Diego | Compostos de fosfonato |
| JP4942915B2 (ja) | 2002-04-26 | 2012-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖプロテアーゼ阻害剤化合物のホスホネートアナログの細胞蓄積 |
| WO2004026245A2 (en) | 2002-09-19 | 2004-04-01 | Ilex Oncology Research, Sarl | Substituted phosphonate compounds having bone anabolic activity |
| AU2003301439A1 (en) * | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| JP2010535701A (ja) * | 2003-04-25 | 2010-11-25 | ギリアード サイエンシーズ， インコーポレイテッド | 抗癌ホスホネートアナログ |
| WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| WO2006020417A2 (en) * | 2004-08-04 | 2006-02-23 | Virginia Tech Intellectual Properties, Inc. | Alkene mimics |
| WO2008096002A1 (en) | 2007-02-08 | 2008-08-14 | Tibotec Pharmaceuticals Ltd. | Hcv inhibiting macrocyclic phosphonates and amidophosphates |
-
2009
- 2009-06-18 EP EP09305562A patent/EP2270021A1/en not_active Withdrawn
-
2010
- 2010-06-17 WO PCT/EP2010/058567 patent/WO2010146127A1/en not_active Ceased
- 2010-06-17 US US13/377,652 patent/US8785629B2/en not_active Expired - Fee Related
- 2010-06-17 EP EP10725716.4A patent/EP2443130B1/en not_active Not-in-force
- 2010-06-17 ES ES10725716.4T patent/ES2601849T3/es active Active
- 2010-06-17 CA CA2764827A patent/CA2764827C/en not_active Expired - Fee Related
- 2010-06-17 JP JP2012515500A patent/JP2012530113A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US8785629B2 (en) | 2014-07-22 |
| US20120142897A1 (en) | 2012-06-07 |
| EP2443130A1 (en) | 2012-04-25 |
| CA2764827A1 (en) | 2010-12-23 |
| JP2012530113A (ja) | 2012-11-29 |
| WO2010146127A1 (en) | 2010-12-23 |
| EP2443130B1 (en) | 2016-08-03 |
| CA2764827C (en) | 2018-08-21 |
| EP2270021A1 (en) | 2011-01-05 |
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