EA201892375A1 - Способы лечения инфекций, вызываемых вирусом гепатита b - Google Patents

Способы лечения инфекций, вызываемых вирусом гепатита b

Info

Publication number
EA201892375A1
EA201892375A1 EA201892375A EA201892375A EA201892375A1 EA 201892375 A1 EA201892375 A1 EA 201892375A1 EA 201892375 A EA201892375 A EA 201892375A EA 201892375 A EA201892375 A EA 201892375A EA 201892375 A1 EA201892375 A1 EA 201892375A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
hepatitis
virus
infections caused
treating infections
Prior art date
Application number
EA201892375A
Other languages
English (en)
Inventor
Анудж Джаггар
Дж. Мани Субраманиан
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201892375A1 publication Critical patent/EA201892375A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Предложены способы лечения инфекций, вызванных вирусом гепатита B, путем введения NS5А, ингибитора NS5B, ингибитора NS3 или их комбинаций.
EA201892375A 2016-05-27 2017-05-11 Способы лечения инфекций, вызываемых вирусом гепатита b EA201892375A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662342787P 2016-05-27 2016-05-27
PCT/US2017/032282 WO2017205078A1 (en) 2016-05-27 2017-05-11 Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors

Publications (1)

Publication Number Publication Date
EA201892375A1 true EA201892375A1 (ru) 2019-08-30

Family

ID=58745467

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892375A EA201892375A1 (ru) 2016-05-27 2017-05-11 Способы лечения инфекций, вызываемых вирусом гепатита b

Country Status (13)

Country Link
US (1) US11738013B2 (ru)
EP (1) EP3463469B1 (ru)
JP (2) JP6770098B2 (ru)
KR (1) KR102202984B1 (ru)
CN (1) CN109414508A (ru)
AU (1) AU2017271990B2 (ru)
BR (1) BR112018073858A2 (ru)
CA (1) CA3025633C (ru)
EA (1) EA201892375A1 (ru)
MA (1) MA45088A (ru)
MX (1) MX2018014377A (ru)
SG (1) SG11201809893WA (ru)
WO (1) WO2017205078A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201791460A1 (ru) 2014-12-26 2017-12-29 Эмори Юниверсити N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
AR112702A1 (es) * 2017-09-21 2019-11-27 Riboscience Llc Derivados de nucleósidos sustituidos con 4’-fluoro-2’-metilo como inhibidores de la replicación de hcv arn
BR122022008466B1 (pt) 2017-12-07 2023-12-05 Emory University Uso de um composto
WO2020100994A1 (ja) * 2018-11-16 2020-05-22 公益財団法人東京都医学総合研究所 Ｂ型肝炎ウイルスの複製阻害組成物

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122018015050B1 (pt) 2003-05-30 2021-07-13 Gilead Pharmasset Llc Derivados fosfatados de nucleosídeo e composição farmacêutica dos mesmos
EA200700336A1 (ru) 2004-07-16 2009-12-30 Джилид Сайэнс, Инк. Противовирусные соединения
TWI389908B (zh) 2005-07-14 2013-03-21 Gilead Sciences Inc 抗病毒化合物類
TWI382019B (zh) 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
TWI404537B (zh) 2005-08-19 2013-08-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
NZ568909A (en) 2005-12-09 2011-10-28 Hoffmann La Roche Antiviral 4-fluoro-4-methyl nucleoside prodrugs
US20090227491A1 (en) 2006-07-07 2009-09-10 Gilead Sciences, Inc. Antiviral phosphinate compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
KR101596524B1 (ko) 2007-06-29 2016-02-22 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
EP2162432A2 (en) 2007-06-29 2010-03-17 Gilead Sciences, Inc. Antiviral compounds
BRPI0813952A2 (pt) 2007-06-29 2017-05-09 Gilead Sciences Inc derivados de purina e seu emprego como moduladores e receptor 7 semelhante ao dobre de sino
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8088803B2 (en) 2008-07-08 2012-01-03 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
PL2313111T3 (pl) 2008-08-01 2014-08-29 Ventirx Pharmaceuticals Inc Preparaty agonistów receptora Toll-podobnego i ich zastosowanie
WO2010077613A1 (en) 2008-12-09 2010-07-08 Gilead Sciences, Inc. Modulators of toll-like receptors
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
KR20190029771A (ko) 2009-05-13 2019-03-20 길리애드 파마셋 엘엘씨 항바이러스 화합물
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
PT2467380T (pt) 2009-08-18 2017-03-07 Array Biopharma Inc Benzoazepinas substituídas como moduladores de recetor de tipo toll 3
PL2467377T3 (pl) 2009-08-18 2017-10-31 Ventirx Pharmaceuticals Inc Podstawione benzoazepiny jako modulatory receptora toll-podobnego
AP3103A (en) 2009-10-22 2015-01-31 Gilead Sciences Inc Derivatives of purine or deazapurine useful for the treatment of (inter alia)viral infections
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
SG185617A1 (en) 2010-05-31 2012-12-28 Ono Pharmaceutical Co Purinone derivative
JP5951615B2 (ja) 2010-10-01 2016-07-13 ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｔｌｒアゴニストの治療用途および組み合わせ治療
CA2812787A1 (en) 2010-10-01 2012-04-05 Robert Hershberg Methods for the treatment of allergic diseases
TWI548629B (zh) 2010-11-17 2016-09-11 吉李德製藥公司 抗病毒化合物
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
AR084217A1 (es) 2010-12-10 2013-05-02 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
BR112013017947A2 (pt) 2011-01-12 2018-12-18 Array Biopharma Inc benzoazepinas substituídas como moduladores de receptor toll-like
CN103562186B (zh) 2011-01-12 2017-02-15 帆德制药股份有限公司 作为toll样受体调节剂的取代的苯并氮杂卓
SG194131A1 (en) 2011-04-08 2013-11-29 Janssen R & D Ireland Pyrimidine derivatives for the treatment of viral infections
SI2709989T1 (en) 2011-05-18 2018-04-30 Janssen Sciences Ireland Uc Quinazoline derivatives for the treatment of viral infections and other diseases
DK2907816T3 (en) 2011-11-16 2018-09-24 Gilead Pharmasset Llc CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS
DK2786996T3 (en) 2011-11-29 2016-12-19 Ono Pharmaceutical Co Hydrochloride PURINONDERIVAT
KR20190007106A (ko) 2011-12-21 2019-01-21 노비라 테라퓨틱스, 인코포레이티드 B형 간염의 항바이러스성 제제
EP2812331B1 (en) 2012-02-08 2019-01-02 Janssen Sciences Ireland Unlimited Company Piperidino-pyrimidine derivatives for the treatment of viral infections
RU2014142598A (ru) 2012-03-31 2016-05-27 Ф. Хоффманн-Ля Рош Аг Новые 4-метилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
MX2014014766A (es) 2012-06-08 2015-05-11 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae.
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
US9090653B2 (en) 2012-06-08 2015-07-28 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
US20140019288A1 (en) 2012-07-13 2014-01-16 Overall Parts Solutions, Inc. Supply Chain Management System and Method
DK2882721T3 (en) 2012-08-10 2019-03-18 Janssen Sciences Ireland Unlimited Co ALKYLPYRIMIDINE DERIVATIVES FOR TREATING VIRAL INFECTIONS AND ADDITIONAL DISEASES
CA2881057C (en) 2012-08-28 2020-10-27 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
AU2013307328B2 (en) 2012-08-28 2017-10-19 Janssen Sciences Ireland Uc Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis B
JP6113285B2 (ja) 2012-09-10 2017-04-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療及び予防用の６−アミノ酸ヘテロアリールジヒドロピリミジン
LT2903968T (lt) 2012-10-02 2017-02-27 Gilead Sciences, Inc. Histondemetilazių inhibitoriai
PT2906563T (pt) 2012-10-10 2018-05-23 Janssen Sciences Ireland Uc Derivados de pirrolo[3,2-d]pirimidina para o tratamento de infeções virais e outras doenças
JP6297055B2 (ja) 2012-11-16 2018-03-20 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染症の治療のための複素環置換２−アミノ−キナゾリン誘導体
CA2894399A1 (en) 2012-12-06 2014-06-12 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
CA2895355A1 (en) 2012-12-19 2014-06-26 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
MX2015007997A (es) 2012-12-21 2016-02-18 Quanticel Pharmaceuticals Inc Inhibidores de histona desmetilasa.
US9233974B2 (en) 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds
WO2014120981A1 (en) * 2013-01-31 2014-08-07 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US9598378B2 (en) 2013-02-21 2017-03-21 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
PL2961736T3 (pl) 2013-02-27 2018-08-31 Gilead Sciences, Inc. Inhibitory demetylaz histonowych
AU2014222641B2 (en) 2013-02-28 2018-03-15 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B
US20140249101A1 (en) 2013-03-04 2014-09-04 Gilead Pharmasset Llc Methods for treating hepatitis c virus infection
EP2968282B1 (en) 2013-03-12 2018-05-09 Celgene Quanticel Research, Inc. Histone dementhylase inhibitors
WO2014165128A2 (en) 2013-03-12 2014-10-09 Novira Therapeutics, Inc. Hepatitis b antiviral agents
US10035801B2 (en) 2013-03-13 2018-07-31 Genentech, Inc. Pyrazolo compounds and uses thereof
CA2903081A1 (en) 2013-03-14 2014-09-25 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
ES2644828T3 (es) 2013-03-15 2017-11-30 Quanticel Pharmaceuticals Inc Inhibidores de histona desmetilasa
PL2981536T3 (pl) 2013-04-03 2017-11-30 Janssen Sciences Ireland Uc Pochodne N-fenylo-karboksyamidu i ich zastosowanie jako leku do leczenia wirusowego zapalenia wątroby typu B
PL2997019T3 (pl) 2013-05-17 2019-03-29 Janssen Sciences Ireland Uc Pochodne sulfamoilotiofenamidu i ich zastosowanie jako leków do leczenia wirusowego zapalenia wątroby typu B
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
TW201512193A (zh) 2013-05-17 2015-04-01 Hoffmann La Roche 用於治療及防治ｂ型肝炎病毒感染之新穎６－橋聯雜芳基二氫嘧啶
AU2014294997B2 (en) 2013-07-25 2018-03-22 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US9567299B2 (en) 2013-10-23 2017-02-14 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
CN106255684B (zh) 2013-11-14 2019-08-23 诺维拉治疗公司 氮杂环庚烷衍生物和治疗乙型肝炎感染的方法
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2015113990A1 (en) 2014-01-30 2015-08-06 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
KR20160110419A (ko) 2014-02-06 2016-09-21 얀센 사이언시즈 아일랜드 유씨 술파모일피롤아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
CA2948080A1 (en) 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
BR112017002970B1 (pt) 2014-08-14 2023-04-11 F. Hoffmann-La Roche Ag Novas piridazonas e triazinonas para o tratamento e profilaxia da infecção pelo vírus da hepatite b
AR101692A1 (es) 2014-08-27 2017-01-04 Epitherapeutics Aps Compuestos y métodos para inhibir histonas demetilasas
CN107912040B (zh) 2014-10-10 2021-04-06 基因泰克公司 作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
CN104546886A (zh) 2014-12-12 2015-04-29 安徽一灵药业有限公司 一种雷迪帕韦与索非布韦复方包衣片制剂及其制备方法

Also Published As

Publication number Publication date
SG11201809893WA (en) 2018-12-28
JP2019519526A (ja) 2019-07-11
US11738013B2 (en) 2023-08-29
AU2017271990A1 (en) 2018-11-29
JP6770098B2 (ja) 2020-10-14
EP3463469C0 (en) 2023-12-13
AU2017271990B2 (en) 2019-12-19
EP3463469A1 (en) 2019-04-10
US20220117952A1 (en) 2022-04-21
CN109414508A (zh) 2019-03-01
JP2020203947A (ja) 2020-12-24
CA3025633C (en) 2021-02-23
CA3025633A1 (en) 2017-11-30
KR20190010631A (ko) 2019-01-30
WO2017205078A1 (en) 2017-11-30
KR102202984B1 (ko) 2021-01-13
MA45088A (fr) 2019-04-10
BR112018073858A2 (pt) 2019-02-26
EP3463469B1 (en) 2023-12-13
MX2018014377A (es) 2019-03-14

Similar Documents

Publication Publication Date Title
CL2019000278A1 (es) Agentes rnai para infección con virus de hepatitis b.
EA201691726A1 (ru) Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
CO2020004202A2 (es) Compuestos químicos
EA201890736A1 (ru) Модуляторы корового белка вируса гепатита b
EA201690452A1 (ru) Ингибиторы полимеразы hcv
EA201790630A1 (ru) Способы получения рибозидов
UY34570A (es) Combinaciones de compuestos inhibidores de la proteína ns5a en el virus de hepatitis c
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
EA201691261A1 (ru) Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
MX2018005569A (es) Vacunas contra el virus de la hepatitis b.
CL2015003298A1 (es) Novedosas heteroarildihidropirimidinas unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de la hepatitis b
EA201792182A1 (ru) Композиции и способы для лечения анемии
BR112014030630A2 (pt) inibidores macrocíclicos de vírus flaviviridae
CL2014000778A1 (es) Metodo de tratamiento para hcv que comprende al menos dos agentes antivirales de accion directa (daas), que no incluye interferon o ribavirina.
BR112017012859A2 (pt) fosforamidatos para o tratamento do vírus da hepatite b
CL2014003634A1 (es) Inhibidores del virus de la hepatitis c
UY34851A (es) Inhibidores macrocíclicos de virus flaviviridae
BR112014030649A2 (pt) inibidores macrocíclicos da flaviviridae vírus
EA201270423A1 (ru) Ингибиторы протеазы hcv
EA201391152A1 (ru) Ингибиторы вируса гепатита с
EA201892375A1 (ru) Способы лечения инфекций, вызываемых вирусом гепатита b
CY1123221T1 (el) Ενωσεις θειαζολιδιου για αντιμετωπιση ιογενων λοιμοξεων
EA201692358A1 (ru) Производные изоиндолина для применения в лечении вирусной инфекции
UY34274A (es) Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv).
EA201790517A1 (ru) Способы и композиции для индуцирования защитного иммунитета против филовирусной инфекции