UY34274A - Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv). - Google Patents

Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv).

Info

Publication number
UY34274A
UY34274A UY0001034274A UY34274A UY34274A UY 34274 A UY34274 A UY 34274A UY 0001034274 A UY0001034274 A UY 0001034274A UY 34274 A UY34274 A UY 34274A UY 34274 A UY34274 A UY 34274A
Authority
UY
Uruguay
Prior art keywords
hcv
hepatitis
infections
virus
treatment
Prior art date
Application number
UY0001034274A
Other languages
English (en)
Inventor
John Brad Shotwell
Andrew James Peat
Pek Yoke Chong
John F Miller
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47746761&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34274(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of UY34274A publication Critical patent/UY34274A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona los compuestos de la fórmula (I) y las sales de los mismos, composiciones farmacéuticas que comprenden estos compuestos, y el uso de estos compuestos en el tratamiento o en la prevención de infecciones virales, tales como las infecciones por el virus de hepatitis C (HCV), y las enfermedades asociadas con esas infecciones.
UY0001034274A 2011-08-19 2012-08-17 Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv). UY34274A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161525440P 2011-08-19 2011-08-19
US201261650681P 2012-05-23 2012-05-23

Publications (1)

Publication Number Publication Date
UY34274A true UY34274A (es) 2013-04-05

Family

ID=47746761

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034274A UY34274A (es) 2011-08-19 2012-08-17 Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv).

Country Status (37)

Country Link
US (2) US8927593B2 (es)
EP (2) EP3199531A1 (es)
JP (2) JP6367712B2 (es)
KR (1) KR101913800B1 (es)
CN (1) CN103732065B (es)
AR (1) AR087563A1 (es)
AU (1) AU2012299295B2 (es)
BR (1) BR112014002845A2 (es)
CA (1) CA2844086A1 (es)
CL (2) CL2014000393A1 (es)
CO (1) CO6862153A2 (es)
CR (1) CR20140078A (es)
CY (1) CY1118399T1 (es)
DK (1) DK2744332T3 (es)
DO (1) DOP2014000034A (es)
EA (1) EA032841B1 (es)
ES (1) ES2611731T3 (es)
HR (1) HRP20161743T1 (es)
HU (1) HUE030300T2 (es)
IL (1) IL230487B (es)
IN (1) IN2014CN00572A (es)
JO (1) JO3281B1 (es)
LT (1) LT2744332T (es)
MA (1) MA35443B1 (es)
ME (1) ME02588B (es)
MX (1) MX354676B (es)
PE (1) PE20141201A1 (es)
PL (1) PL2744332T3 (es)
PT (1) PT2744332T (es)
RS (1) RS55462B1 (es)
SG (1) SG10201606883QA (es)
SI (1) SI2744332T1 (es)
SM (1) SMT201700028B (es)
TW (1) TWI538915B (es)
UY (1) UY34274A (es)
WO (1) WO2013028371A1 (es)
ZA (1) ZA201401020B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103929965B (zh) 2011-08-17 2016-08-17 葛兰素史克有限责任公司 治疗方法
JP6367712B2 (ja) 2011-08-19 2018-08-01 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｃ型肝炎ウイルス感染の治療のためのベンゾフラン化合物
AU2015344741A1 (en) * 2014-11-10 2017-05-25 Glaxosmithkline Intellectual Property (No.2) Limited Combination long acting compositions and methods for hepatitis C
WO2016075583A1 (en) 2014-11-10 2016-05-19 Glaxosmithkline Intelle Ctual Property (No.2) Limited Long acting pharmaceutical compositions for hepatitis c
KR20180006522A (ko) 2016-07-07 2018-01-18 삼성디스플레이 주식회사 액정 조성물 및 이를 포함하는 액정 표시 장치
US11738088B2 (en) 2016-08-01 2023-08-29 University of Pittsburgh—of the Commonwealth System of Higher Education Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles
KR20190126102A (ko) * 2017-03-02 2019-11-08 어셈블리 바이오사이언시스, 인크. 시클릭 술파미드 화합물 및 그의 사용 방법
MX2020007521A (es) * 2018-01-17 2022-12-05 Glaxosmithkline Ip Dev Ltd Inhibidores de pi4kiii.
KR20220088736A (ko) * 2019-10-25 2022-06-28 스미토모 파마 가부시키가이샤 신규 치환 축환형 화합물
CN111026203B (zh) * 2019-12-02 2021-01-26 宁波德晶元科技有限公司 一种适用于真空热水壶的加热控制方法与系统

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AU5920400A (en) * 1999-07-07 2001-01-22 Du Pont Pharmaceuticals Company Cell-based assay systems for examining hcv ns3 protease activity
CA2435146C (en) 2001-01-25 2011-03-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Formulation of boronic acid compounds
EA009943B1 (ru) * 2002-11-01 2008-04-28 Вирофарма Инкорпорейтед Соединения бензофурана, композиции и способы лечения и профилактики инфекций, вызванных вирусом гепатита с, и связанных с ним заболеваний
WO2008051244A2 (en) 2005-12-01 2008-05-02 Wyeth Anthranilic acid derivatives useful in treating infection with hepatitis c virus
CN101420854B (zh) 2006-02-16 2013-08-07 安纳考尔医药公司 作为抗炎药的含硼的小分子
EP2015757A4 (en) * 2006-05-02 2011-01-26 Anacor Pharmaceuticals Inc HYDROLYSERESISTENT, BOROYED THERAPEUTIC USES
US20070286822A1 (en) 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
US7858666B2 (en) * 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors
GB0719366D0 (en) * 2007-10-03 2007-11-14 Smithkline Beecham Corp Compounds
WO2009111676A2 (en) 2008-03-06 2009-09-11 Anacor Pharmaceuticals, Inc Boron-containing small molecules as anti-inflammatory agents
AU2009214194B2 (en) 2008-02-14 2012-05-17 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
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TW201008933A (en) 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
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WO2011050284A1 (en) * 2009-10-23 2011-04-28 Glaxosmithkline Llc Pyrazolylpyridine antiviral agents
AR080185A1 (es) 2010-02-19 2012-03-21 Glaxo Group Ltd Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv).
AR080433A1 (es) 2010-03-02 2012-04-11 Merck Sharp & Dohme Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen.
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AU2011329485A1 (en) 2010-11-18 2013-04-18 Glaxo Group Limited Compounds
TW201221518A (en) 2010-11-18 2012-06-01 Glaxo Group Ltd Compounds
WO2013025975A1 (en) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
CN103929965B (zh) * 2011-08-17 2016-08-17 葛兰素史克有限责任公司 治疗方法
JP6367712B2 (ja) 2011-08-19 2018-08-01 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｃ型肝炎ウイルス感染の治療のためのベンゾフラン化合物

Also Published As

Publication number Publication date
SG10201606883QA (en) 2016-10-28
KR101913800B1 (ko) 2018-11-01
EA032841B1 (ru) 2019-07-31
EP2744332A1 (en) 2014-06-25
IN2014CN00572A (es) 2015-04-03
ZA201401020B (en) 2020-11-25
US8927593B2 (en) 2015-01-06
JP2014527529A (ja) 2014-10-16
RS55462B1 (sr) 2017-04-28
CO6862153A2 (es) 2014-02-10
CR20140078A (es) 2014-03-20
HUE030300T2 (en) 2017-04-28
WO2013028371A1 (en) 2013-02-28
AU2012299295B2 (en) 2016-03-31
JP2017125010A (ja) 2017-07-20
PT2744332T (pt) 2017-01-24
TW201321390A (zh) 2013-06-01
EP3199531A1 (en) 2017-08-02
HRP20161743T1 (hr) 2017-02-24
SI2744332T1 (sl) 2017-01-31
EP2744332B1 (en) 2016-10-26
AU2012299295A1 (en) 2014-02-20
EA201490213A1 (ru) 2014-07-30
KR20140054287A (ko) 2014-05-08
ME02588B (me) 2017-06-20
CA2844086A1 (en) 2013-02-28
IL230487A0 (en) 2014-03-31
DOP2014000034A (es) 2014-06-01
LT2744332T (lt) 2017-01-10
US9682999B2 (en) 2017-06-20
TWI538915B (zh) 2016-06-21
JO3281B1 (ar) 2018-09-16
SMT201700028B (it) 2017-03-08
CN103732065B (zh) 2016-10-26
MX2014001989A (es) 2014-02-27
DK2744332T3 (en) 2017-01-16
BR112014002845A2 (pt) 2017-02-21
IL230487B (en) 2019-06-30
CY1118399T1 (el) 2017-06-28
EP2744332A4 (en) 2015-01-14
MX354676B (es) 2018-03-15
US20150080343A1 (en) 2015-03-19
PE20141201A1 (es) 2014-10-03
AR087563A1 (es) 2014-04-03
JP6367712B2 (ja) 2018-08-01
ES2611731T3 (es) 2017-05-10
PL2744332T3 (pl) 2017-03-31
CL2014000393A1 (es) 2014-08-01
CL2017000293A1 (es) 2017-10-06
CN103732065A (zh) 2014-04-16
MA35443B1 (fr) 2014-09-01
US20130237501A1 (en) 2013-09-12

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