MA45088A - Méthodes pour traiter des infections par le virus de l'hépatite b au moyen d'inhibiteurs de ns5a, ns5b ou ns3 - Google Patents

Méthodes pour traiter des infections par le virus de l'hépatite b au moyen d'inhibiteurs de ns5a, ns5b ou ns3

Info

Publication number
MA45088A
MA45088A MA045088A MA45088A MA45088A MA 45088 A MA45088 A MA 45088A MA 045088 A MA045088 A MA 045088A MA 45088 A MA45088 A MA 45088A MA 45088 A MA45088 A MA 45088A
Authority
MA
Morocco
Prior art keywords
ns5a
ns5b
inhibitors
methods
virus infections
Prior art date
Application number
MA045088A
Other languages
English (en)
Inventor
Anuj Gaggar
G Mani Subramanian
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA45088A publication Critical patent/MA45088A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA045088A 2016-05-27 2017-05-11 Méthodes pour traiter des infections par le virus de l'hépatite b au moyen d'inhibiteurs de ns5a, ns5b ou ns3 MA45088A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662342787P 2016-05-27 2016-05-27

Publications (1)

Publication Number Publication Date
MA45088A true MA45088A (fr) 2019-04-10

Family

ID=58745467

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045088A MA45088A (fr) 2016-05-27 2017-05-11 Méthodes pour traiter des infections par le virus de l'hépatite b au moyen d'inhibiteurs de ns5a, ns5b ou ns3

Country Status (15)

Country Link
US (1) US11738013B2 (fr)
EP (1) EP3463469B1 (fr)
JP (2) JP6770098B2 (fr)
KR (1) KR102202984B1 (fr)
CN (3) CN118178444A (fr)
AU (1) AU2017271990B2 (fr)
BR (1) BR112018073858A2 (fr)
CA (1) CA3025633C (fr)
EA (1) EA201892375A1 (fr)
ES (1) ES2969239T3 (fr)
MA (1) MA45088A (fr)
MX (1) MX2018014377A (fr)
PL (1) PL3463469T3 (fr)
SG (1) SG11201809893WA (fr)
WO (1) WO2017205078A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3236972T (pt) 2014-12-26 2021-09-24 Univ Emory Derivados antivirais n4-hidroxicitidina
CN111194217B (zh) * 2017-09-21 2024-01-12 里伯赛恩斯有限责任公司 作为hcv rna复制抑制剂的4’-氟-2’-甲基取代的核苷衍生物
EP3706762A4 (fr) 2017-12-07 2021-09-01 Emory University N4-hydroxycytidine et dérivés et leurs utilisations anti-virales
JP7441174B2 (ja) * 2018-11-16 2024-02-29 公益財団法人東京都医学総合研究所 Ｂ型肝炎ウイルスの複製阻害組成物

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3521297B1 (fr) 2003-05-30 2021-12-22 Gilead Pharmasset LLC Analogues de nucléoside fluorés modifiés
BRPI0513426A (pt) 2004-07-16 2007-11-27 Gilead Sciences Inc processo de preparação de amino ácidos úteis na preparação de moduladores de receptores de peptìdeos
TWI389908B (zh) 2005-07-14 2013-03-21 Gilead Sciences Inc 抗病毒化合物類
TW201402124A (zh) 2005-08-19 2014-01-16 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
TWI382019B (zh) 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
RU2422454C2 (ru) 2005-12-09 2011-06-27 Ф. Хоффманн-Ля Рош Аг Антивирусные нуклеозиды
CN102532198A (zh) 2006-07-07 2012-07-04 吉里德科学公司 抗病毒的次膦酸酯化合物
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AP2874A (en) 2007-06-29 2014-03-31 Gilead Sciences Inc Antiviral compounds
EP2170888B1 (fr) 2007-06-29 2015-04-22 Gilead Sciences, Inc. Dérivés de purine et leur utilisation comme modulateurs du récepteur de type toll-7
KR20100038417A (ko) 2007-06-29 2010-04-14 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PL2315756T3 (pl) 2008-07-08 2015-02-27 Incyte Holdings Corp 1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy
US8242106B2 (en) 2008-08-01 2012-08-14 Ventirx Pharmaceuticals, Inc. Toll-like receptor agonist formulations and their use
TWI480268B (zh) 2008-12-09 2015-04-11 Gilead Sciences Inc 類鐸受體的調節劑
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
CL2009002208A1 (es) 2008-12-23 2010-10-29 Gilead Pharmasset Llc Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
EP3002281B1 (fr) 2009-05-13 2017-09-13 Gilead Pharmasset LLC Composés antiviraux
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
WO2011022509A2 (fr) 2009-08-18 2011-02-24 Ventirx Pharmaceuticals, Inc. Benzoazépines substituées comme modulateurs des récepteurs de type toll
DK2467377T3 (en) 2009-08-18 2017-04-03 Ventirx Pharmaceuticals Inc SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS
SI2491035T1 (sl) 2009-10-22 2017-10-30 Gilead Sciences, Inc. Derivati purina ali deazapurina uporabni za zdravljenje (med drugimi) virusnih okužb
WO2011106573A2 (fr) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibiteurs de la lysine déméthylase utilisés dans le traitement et la prévention de maladies et de troubles associés à hepadnaviridae
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
ES2948312T3 (es) 2010-05-31 2023-09-08 Ono Pharmaceutical Co Derivado de purinona como inhibidor de Btk quinasa
RU2016118628A (ru) 2010-10-01 2018-11-02 Вентиркс Фармасьютикалз, Инк. Способы лечения аллергических заболеваний
NZ608673A (en) 2010-10-01 2015-04-24 Univ Pennsylvania Therapeutic use of a tlr agonist and combination therapy
SI2640719T1 (sl) 2010-11-17 2017-07-31 Gilead Pharmasset Llc Antivirusne spojine
AR084044A1 (es) 2010-11-30 2013-04-17 Pharmasset Inc Compuestos 2’-espiro-nucleosidos
UY33775A (es) 2010-12-10 2012-07-31 Gilead Sciences Inc Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos
CN106749023A (zh) 2011-01-12 2017-05-31 帆德制药股份有限公司 作为toll样受体调节剂的取代的苯并氮杂卓
HUE032638T2 (en) 2011-01-12 2017-10-30 Ventirx Pharmaceuticals Inc Toll receptor modulator substituted benzoazepines
KR101946499B1 (ko) 2011-04-08 2019-02-11 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 치료를 위한 피리미딘 유도체
KR102119700B1 (ko) 2011-05-18 2020-06-08 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염 및 기타 질환 치료용 퀴나졸린 유도체
PL2907816T3 (pl) 2011-11-16 2019-03-29 Gilead Pharmasset Llc Skondensowane imidazolyloimidazole jako związki przeciwwirusowe
JP5704252B2 (ja) 2011-11-29 2015-04-22 小野薬品工業株式会社 プリノン誘導体塩酸塩
CN104144913B (zh) 2011-12-21 2017-05-17 诺维拉治疗公司 B型肝炎抗病毒剂
WO2013117615A1 (fr) 2012-02-08 2013-08-15 Janssen R&D Ireland Dérivés de pipéridino-pyrimidine pour le traitement d'infections virales
KR20140143160A (ko) 2012-03-31 2014-12-15 에프. 호프만-라 로슈 아게 B형 간염 바이러스 감염의 치료 및 예방을 위한 신규한 4-메틸-다이하이드로피리미딘
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
US20130309196A1 (en) 2012-05-16 2013-11-21 Gilead Sciences, Inc. Antiviral compounds
SI2859009T1 (sl) 2012-06-08 2017-12-29 Gilead Sciences, Inc. Makrociklični inhibitorji flaviviridae virusov
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
EP2861604B1 (fr) 2012-06-08 2017-03-01 Gilead Sciences, Inc. Inhibiteurs macrocycliques des virus flaviviridae
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
US20140019288A1 (en) 2012-07-13 2014-01-16 Overall Parts Solutions, Inc. Supply Chain Management System and Method
CA2879617C (fr) 2012-08-10 2021-05-04 Janssen Sciences Ireland Uc Derives d'alkylpyrimidine pour le traitement des infections virales et d'autres maladies
TWI636036B (zh) 2012-08-28 2018-09-21 健生科學愛爾蘭無限公司 胺磺醯基－芳基醯胺類及其作為用於治療ｂ型肝炎的藥物之用途
US9156839B2 (en) 2012-08-28 2015-10-13 Janssen Sciences Ireland Uc Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis B
EP2892893B2 (fr) 2012-09-10 2019-10-16 F.Hoffmann-La Roche Ag Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b
HUE033380T2 (en) 2012-10-02 2017-11-28 Gilead Sciences Inc Inhibitors of histone demethylases
HUE037064T2 (hu) 2012-10-10 2018-08-28 Janssen Sciences Ireland Uc Pirrolo[3,2-d]-pirimidin származékok vírusos fertõzések és egyéb betegségek kezelésére
ES2655843T3 (es) 2012-11-16 2018-02-21 Janssen Sciences Ireland Uc Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas
JP6256771B2 (ja) 2012-12-06 2018-01-10 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤
PL2934145T3 (pl) 2012-12-19 2018-04-30 Celgene Quanticel Research, Inc. Inhibitory demetylazy histonowej
CN105026372B (zh) 2012-12-21 2018-06-05 赛尔基因昆蒂赛尔研究公司 组蛋白脱甲基酶抑制剂
US9233974B2 (en) 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds
MY172166A (en) 2013-01-31 2019-11-15 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
EA035174B1 (ru) 2013-02-21 2020-05-12 Янссен Сайенсиз Айрлэнд Юси Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8
CN105263906B (zh) 2013-02-27 2018-11-23 吉利德科学公司 组蛋白脱甲基酶的抑制剂
US10125094B2 (en) 2013-02-28 2018-11-13 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B
WO2014137929A1 (fr) * 2013-03-04 2014-09-12 Gilead Pharmasset Llc Méthodes de traitement du virus de l'hépatite c
WO2014165128A2 (fr) 2013-03-12 2014-10-09 Novira Therapeutics, Inc. Agents antiviraux contre l'hépatite b
US9738637B2 (en) 2013-03-12 2017-08-22 Celgene Quantical Research, Inc. Histone demethylase inhibitors
KR20150130491A (ko) 2013-03-13 2015-11-23 제넨테크, 인크. 피라졸로 화합물 및 그것의 용도
US9133166B2 (en) 2013-03-14 2015-09-15 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
DK2970211T3 (en) 2013-03-15 2017-10-16 Quanticel Pharmaceuticals Inc HISTONDEMETHYLASE INHIBITORS
PL2981536T3 (pl) 2013-04-03 2017-11-30 Janssen Sciences Ireland Uc Pochodne N-fenylo-karboksyamidu i ich zastosowanie jako leku do leczenia wirusowego zapalenia wątroby typu B
PT2997019T (pt) 2013-05-17 2018-11-21 Janssen Sciences Ireland Uc Derivados de sulfamoíltiofenamida e o seu uso como medicamentos para o tratamento da hepatite b
JP6533217B2 (ja) 2013-05-17 2019-06-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療および予防のための６−架橋ヘテロアリールジヒドロピリミジン類
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
NO3024819T3 (fr) 2013-07-25 2018-07-21
JP6452119B2 (ja) 2013-10-23 2019-01-16 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー カルボキサミド誘導体およびｂ型肝炎の処置のための医薬品としてのその使用
AU2014348518B2 (en) 2013-11-14 2019-01-03 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2015113990A1 (fr) 2014-01-30 2015-08-06 F. Hoffmann-La Roche Ag Nouvelles dihydroquinolizinones pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b
UY35980A (es) 2014-02-06 2015-08-31 Janssen Sciences Ireland Uc Derivados de sulfamoilpirrolamida como inhibidores del hbv y composiciones farmacéuticas que los contienen
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
CA2948080A1 (fr) 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Nouvelles dihydroquinolizinones pour le traitement et la prophylaxie d'une infection par le virus de l'hepatite b
MX2017001862A (es) 2014-08-14 2017-05-15 Hoffmann La Roche Nuevas piridazonas y triazinonas para el tratamiento y la profilaxis de infeccion por virus de hepatitis b.
US9802941B2 (en) 2014-08-27 2017-10-31 Gilead Sciences, Inc. Compounds and methods for inhibiting histone demethylases
EP3204379B1 (fr) 2014-10-10 2019-03-06 Genentech, Inc. Composés de pyrrolidine à utiliser en tant qu'inhibiteurs de l'histone déméthylase
US9637485B2 (en) 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
CN104546886A (zh) * 2014-12-12 2015-04-29 安徽一灵药业有限公司 一种雷迪帕韦与索非布韦复方包衣片制剂及其制备方法

Also Published As

Publication number Publication date
PL3463469T3 (pl) 2024-04-22
EP3463469C0 (fr) 2023-12-13
EA201892375A1 (ru) 2019-08-30
KR20190010631A (ko) 2019-01-30
US20220117952A1 (en) 2022-04-21
MX2018014377A (es) 2019-03-14
KR102202984B1 (ko) 2021-01-13
SG11201809893WA (en) 2018-12-28
CN109414508A (zh) 2019-03-01
CN118178652A (zh) 2024-06-14
US11738013B2 (en) 2023-08-29
CA3025633A1 (fr) 2017-11-30
WO2017205078A1 (fr) 2017-11-30
AU2017271990B2 (en) 2019-12-19
BR112018073858A2 (pt) 2019-02-26
AU2017271990A1 (en) 2018-11-29
EP3463469A1 (fr) 2019-04-10
CA3025633C (fr) 2021-02-23
ES2969239T3 (es) 2024-05-17
JP2019519526A (ja) 2019-07-11
JP6770098B2 (ja) 2020-10-14
CN118178444A (zh) 2024-06-14
EP3463469B1 (fr) 2023-12-13
JP2020203947A (ja) 2020-12-24

Similar Documents

Publication Publication Date Title
MA50278A (fr) Méthodes pour le traitement de sujets atteints d'une infection par le virus de l'hépatite b (vhb)
MA45088A (fr) Méthodes pour traiter des infections par le virus de l'hépatite b au moyen d'inhibiteurs de ns5a, ns5b ou ns3
CL2019000278A1 (es) Agentes rnai para infección con virus de hepatitis b.
PH12019502003A1 (en) Cyclic sulfamide compounds and methods of using same
EA201691726A1 (ru) Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201890731A1 (ru) Модуляторы корового белка гепатита b
MX2023013140A (es) Vacunas contra el virus de la hepatitis b.
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
EA201690979A1 (ru) Производные азепана и способы лечения инфекций гепатита в
EA201992546A1 (ru) Средства на основе антител к cd33
EA201792182A1 (ru) Композиции и способы для лечения анемии
EA201792069A1 (ru) Производные азокана и азонана и способы лечения инфекций гепатита в
EA201691440A1 (ru) Производные азепана и способы лечения инфекций гепатита в
UY34570A (es) Combinaciones de compuestos inhibidores de la proteína ns5a en el virus de hepatitis c
CL2009000305A1 (es) Compuestos derivados de 2-aril-sustituido-1-benzofurano-3-carboxamida, inhibidores de la polimerasa ns5b; composicion farmaceutica; y su uso en el tratamiento de una enfermedad causada por el virus de la hepatitis c (hcv).
EA201390190A1 (ru) Ингибиторы вируса гепатита с
EA201391152A1 (ru) Ингибиторы вируса гепатита с
EA201270423A1 (ru) Ингибиторы протеазы hcv
MA46535A (fr) Méganucléases modifiées spécifiques de séquences de reconnaissance dans le génome du virus de l'hépatite b
IL285257A (en) RNAi materials for hepatitis b virus infection
MA43298A (fr) Derives heterocycliques d'indole pour des infections par le virus de la influenza
EA200970916A1 (ru) Соединения 5,6-дигидро-1н-пиридин-2-она
EA201000948A1 (ru) Ингибиторы вирусной полимеразы
EA202091849A1 (ru) Тиазолидные соединения для лечения вирусных инфекций
MX2018002707A (es) Derivados de tetrahidrofurano antivirales.