PL3463469T3 - Kombinacja ledipaswiru i sofosbuwiru do zastosowania w leczeniu zakażeń wirusem zapalenia wątroby typu b u ludzi - Google Patents
Kombinacja ledipaswiru i sofosbuwiru do zastosowania w leczeniu zakażeń wirusem zapalenia wątroby typu b u ludziInfo
- Publication number
- PL3463469T3 PL3463469T3 PL17725086.7T PL17725086T PL3463469T3 PL 3463469 T3 PL3463469 T3 PL 3463469T3 PL 17725086 T PL17725086 T PL 17725086T PL 3463469 T3 PL3463469 T3 PL 3463469T3
- Authority
- PL
- Poland
- Prior art keywords
- ledipasvir
- sofosbuvir
- hepatitis
- humans
- treatment
- Prior art date
Links
- 208000002672 hepatitis B Diseases 0.000 title 1
- VRTWBAAJJOHBQU-KMWAZVGDSA-N ledipasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N([C@@H](C1)C=2NC(=CN=2)C=2C=C3C(F)(F)C4=CC(=CC=C4C3=CC=2)C=2C=C3NC(=NC3=CC=2)[C@H]2N([C@@H]3CC[C@H]2C3)C(=O)[C@@H](NC(=O)OC)C(C)C)CC21CC2 VRTWBAAJJOHBQU-KMWAZVGDSA-N 0.000 title 1
- 229960002461 ledipasvir Drugs 0.000 title 1
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 title 1
- 229960002063 sofosbuvir Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342787P | 2016-05-27 | 2016-05-27 | |
| PCT/US2017/032282 WO2017205078A1 (en) | 2016-05-27 | 2017-05-11 | Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3463469T3 true PL3463469T3 (pl) | 2024-04-22 |
Family
ID=58745467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17725086.7T PL3463469T3 (pl) | 2016-05-27 | 2017-05-11 | Kombinacja ledipaswiru i sofosbuwiru do zastosowania w leczeniu zakażeń wirusem zapalenia wątroby typu b u ludzi |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11738013B2 (pl) |
| EP (1) | EP3463469B1 (pl) |
| JP (2) | JP6770098B2 (pl) |
| KR (1) | KR102202984B1 (pl) |
| CN (1) | CN109414508A (pl) |
| AU (1) | AU2017271990B2 (pl) |
| BR (1) | BR112018073858A2 (pl) |
| CA (1) | CA3025633C (pl) |
| EA (1) | EA201892375A1 (pl) |
| ES (1) | ES2969239T3 (pl) |
| MA (1) | MA45088A (pl) |
| MX (1) | MX2018014377A (pl) |
| PL (1) | PL3463469T3 (pl) |
| SG (1) | SG11201809893WA (pl) |
| WO (1) | WO2017205078A1 (pl) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170123308A (ko) | 2014-12-26 | 2017-11-07 | 에모리 유니버시티 | Ｎ4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도 |
| CA3075645A1 (en) * | 2017-09-21 | 2019-03-28 | Riboscience Llc | 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
| US11331331B2 (en) | 2017-12-07 | 2022-05-17 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| EP3881850A4 (en) * | 2018-11-16 | 2022-08-24 | Tokyo Metropolitan Institute of Medical Science | COMPOSITION FOR INHIBITING HEPATITIS B VIRUS REPLICATION |
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| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| WO2015173164A1 (en) | 2014-05-13 | 2015-11-19 | F. Hoffmann-La Roche Ag | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection |
| MX2017001862A (es) | 2014-08-14 | 2017-05-15 | Hoffmann La Roche | Nuevas piridazonas y triazinonas para el tratamiento y la profilaxis de infeccion por virus de hepatitis b. |
| EP3186238A1 (en) | 2014-08-27 | 2017-07-05 | Gilead Sciences, Inc. | Compounds and methods for inhibiting histone demethylases |
| EP3204379B1 (en) | 2014-10-10 | 2019-03-06 | Genentech, Inc. | Pyrrolidine amide compounds as histone demethylase inhibitors |
| US9637485B2 (en) | 2014-11-03 | 2017-05-02 | Hoffmann-La Roche Inc. | 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection |
| CN104546886A (zh) | 2014-12-12 | 2015-04-29 | 安徽一灵药业有限公司 | 一种雷迪帕韦与索非布韦复方包衣片制剂及其制备方法 |
-
2017
- 2017-05-11 CN CN201780039972.3A patent/CN109414508A/zh active Pending
- 2017-05-11 MX MX2018014377A patent/MX2018014377A/es unknown
- 2017-05-11 PL PL17725086.7T patent/PL3463469T3/pl unknown
- 2017-05-11 EP EP17725086.7A patent/EP3463469B1/en active Active
- 2017-05-11 SG SG11201809893WA patent/SG11201809893WA/en unknown
- 2017-05-11 MA MA045088A patent/MA45088A/fr unknown
- 2017-05-11 CA CA3025633A patent/CA3025633C/en active Active
- 2017-05-11 JP JP2018561567A patent/JP6770098B2/ja active Active
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- 2017-05-11 KR KR1020187037210A patent/KR102202984B1/ko active IP Right Grant
- 2017-05-11 BR BR112018073858-1A patent/BR112018073858A2/pt not_active Application Discontinuation
- 2017-05-11 EA EA201892375A patent/EA201892375A1/ru unknown
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- 2017-05-11 WO PCT/US2017/032282 patent/WO2017205078A1/en unknown
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3463469B1 (en) | 2023-12-13 |
| EA201892375A1 (ru) | 2019-08-30 |
| AU2017271990A1 (en) | 2018-11-29 |
| US20220117952A1 (en) | 2022-04-21 |
| KR20190010631A (ko) | 2019-01-30 |
| CA3025633A1 (en) | 2017-11-30 |
| JP6770098B2 (ja) | 2020-10-14 |
| SG11201809893WA (en) | 2018-12-28 |
| CA3025633C (en) | 2021-02-23 |
| MX2018014377A (es) | 2019-03-14 |
| US11738013B2 (en) | 2023-08-29 |
| JP2019519526A (ja) | 2019-07-11 |
| ES2969239T3 (es) | 2024-05-17 |
| WO2017205078A1 (en) | 2017-11-30 |
| BR112018073858A2 (pt) | 2019-02-26 |
| EP3463469A1 (en) | 2019-04-10 |
| AU2017271990B2 (en) | 2019-12-19 |
| EP3463469C0 (en) | 2023-12-13 |
| JP2020203947A (ja) | 2020-12-24 |
| KR102202984B1 (ko) | 2021-01-13 |
| MA45088A (fr) | 2019-04-10 |
| CN109414508A (zh) | 2019-03-01 |
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