EA201790154A1 - Соединения и способы для ингибирования гистоновых деметилаз - Google Patents

Соединения и способы для ингибирования гистоновых деметилаз

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Publication number
EA201790154A1
EA201790154A1 EA201790154A EA201790154A EA201790154A1 EA 201790154 A1 EA201790154 A1 EA 201790154A1 EA 201790154 A EA201790154 A EA 201790154A EA 201790154 A EA201790154 A EA 201790154A EA 201790154 A1 EA201790154 A1 EA 201790154A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
histonal
demetylases
inhibiting
methods
Prior art date
Application number
EA201790154A
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English (en)
Inventor
Томас Боэсен
Марк Лабелл
Ин Ян
Нирья Сарасват
Дастагири Дудекула
Сирил Джон Кук
Рамкришна Редди Вакити
Жуй Чжан
Фарман Улла
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201790154A1 publication Critical patent/EA201790154A1/ru

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Настоящая заявка относится к соединениям формулы (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf) и (IIIg). Соединения формулы (I) имеют следующую структуру:где Q, R, R, R, М, А и Y являются такими, как описано в настоящем документе. Соединения согласно настоящей заявке модулируют активность гистоновых деметилаз (HDMEs) и могут быть пригодными для предотвращения и/или лечения заболеваний, в патогенезе которых задействована дисрегуляция генома, например, рака.
EA201790154A 2014-08-27 2015-08-26 Соединения и способы для ингибирования гистоновых деметилаз EA201790154A1 (ru)

Applications Claiming Priority (2)

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US201462042717P 2014-08-27 2014-08-27
PCT/US2015/046921 WO2016033169A1 (en) 2014-08-27 2015-08-26 Compounds and methods for inhibiting histone demethylases

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US (1) US9802941B2 (ru)
EP (1) EP3186238A1 (ru)
JP (1) JP2017526675A (ru)
KR (1) KR20170040805A (ru)
CN (1) CN107074807A (ru)
AR (1) AR101692A1 (ru)
AU (1) AU2015306662A1 (ru)
BR (1) BR112017003442A2 (ru)
CA (1) CA2957947A1 (ru)
EA (1) EA201790154A1 (ru)
IL (1) IL250355A0 (ru)
MA (1) MA40470A (ru)
MX (1) MX2017002451A (ru)
SG (1) SG11201701182VA (ru)
TW (1) TW201625536A (ru)
WO (1) WO2016033169A1 (ru)

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WO2017198785A1 (en) * 2016-05-18 2017-11-23 Ieo - Istituto Europeo Di Oncologia S.R.L. Oxime derivatives useful as inhibitors of histone demethylase kdm4c
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