EP0380558A4 - Liposomal nucleoside analogues for treating aids - Google Patents

Liposomal nucleoside analogues for treating aids

Info

Publication number
EP0380558A4
EP0380558A4 EP19880908811 EP88908811A EP0380558A4 EP 0380558 A4 EP0380558 A4 EP 0380558A4 EP 19880908811 EP19880908811 EP 19880908811 EP 88908811 A EP88908811 A EP 88908811A EP 0380558 A4 EP0380558 A4 EP 0380558A4
Authority
EP
European Patent Office
Prior art keywords
liposomal
nucleoside analogues
treating aids
aids
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19880908811
Other versions
EP0380558A1 (en
Inventor
Karl Y. Hostetler
Douglas D. Richman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP0380558A1 publication Critical patent/EP0380558A1/en
Publication of EP0380558A4 publication Critical patent/EP0380558A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
EP19880908811 1987-09-22 1988-09-19 Liposomal nucleoside analogues for treating aids Ceased EP0380558A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9975587A 1987-09-22 1987-09-22
US99755 1993-07-30

Publications (2)

Publication Number Publication Date
EP0380558A1 EP0380558A1 (en) 1990-08-08
EP0380558A4 true EP0380558A4 (en) 1991-07-31

Family

ID=22276457

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880908811 Ceased EP0380558A4 (en) 1987-09-22 1988-09-19 Liposomal nucleoside analogues for treating aids

Country Status (4)

Country Link
EP (1) EP0380558A4 (en)
JP (1) JPH03501253A (en)
AU (1) AU2526188A (en)
WO (1) WO1989002733A1 (en)

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US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
ZA902710B (en) * 1989-05-22 1991-12-24 Univ Georgia Res Found Enzyme luminescence assay
DE3916595A1 (en) * 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh METHOD FOR NON-RADIOACTIVE MEASURING OF NUCLEIC ACID SYNTHESIS IN EUKARYONTIC CELLS
US5194654A (en) * 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
CA2045601A1 (en) * 1989-12-08 1991-06-09 Kevin J. Scanlon Circumvention of human tumor drug resistance
US5817646A (en) * 1991-11-15 1998-10-06 Laboratoires Inocosm Polar lipid composition of plant origin
FR2683721B1 (en) * 1991-11-15 1995-06-09 Inocosm Laboratoires POLAR LIPID COMPOSITION FOR VEHICULATING AN ACTIVE AGENT AND / OR PENETRATING IT INTO A TARGET CELL.
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
AU722214B2 (en) 1995-06-07 2000-07-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis B virus activity
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
BR9908270A (en) 1998-02-25 2004-06-29 Univ Emory 2-Fluoro-nucleosides, pharmaceutical compositions and their uses
ES2579903T3 (en) 1998-08-10 2016-08-17 Centre National De La Recherche Scientifique (Cnrs) Beta-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
EP1382343B1 (en) 1998-11-02 2010-02-17 Gilead Sciences, Inc. Combination therapy to treat hepatitis B virus
EP1207907B1 (en) * 1999-08-13 2004-11-03 University Of Maryland Biotechnology Institute Compositions for treating viral infections, and methods therefor
EP1284720B1 (en) 2000-03-29 2006-09-13 Georgetown University L-fmau for the treatment of hepatitis delta viral infection
US6761901B1 (en) 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
NZ547204A (en) 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US6689760B1 (en) 2000-07-10 2004-02-10 Enzrel Inc. Anti-mycobacterial compositions
US6455073B1 (en) 2000-07-10 2002-09-24 Enzrel, Inc. Covalent microparticle-drug conjugates for biological targeting
CN1646141B (en) 2000-10-18 2014-06-25 吉利德制药有限责任公司 Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
AU2002335489B2 (en) 2001-03-01 2008-06-05 Abbott Laboratories Polymorphic and other crystalline forms of cis-FTC
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
JP2005523249A (en) 2002-01-09 2005-08-04 エンズレル インコーポレイテッド Liposomal drug delivery of polycyclic aromatic antioxidants or anti-inflammatory compounds
WO2004002999A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited Modified 2' and 3' -nucleoside produgs for treating flaviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
PT1572095E (en) 2002-09-13 2015-10-13 Novartis Ag Beta-l-2'-deoxynucleosides for use in the treatment of resistant hbv strains
KR20050088079A (en) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-branched nucleosides and flaviviridae mutation
CA2734052A1 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
PL1658302T3 (en) 2003-07-25 2011-03-31 Idenix Pharmaceuticals Inc Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
ES2629682T3 (en) 2004-03-29 2017-08-14 University Of South Florida Effective treatment of tumors and cancer with triciribin phosphate
RU2433124C2 (en) 2004-09-14 2011-11-10 Фармассет, Инк. Methods of producing 2'-fluoro-2'-alkyl-substituted or other substituted ribofuranosyl pyrimidines and purines and derivatives thereof
CA2623522C (en) 2005-09-26 2015-12-08 Pharmasset, Inc. Modified 4'-nucleosides as antiviral agents
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP3042660A3 (en) 2008-04-15 2016-10-26 RFS Pharma, LLC. Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
CL2009002206A1 (en) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compounds derived from pyrrolo - (2-3-d] -pyrimidin-7 (6h) -tetrahydrofuran-2-yl phosphonamidate, pharmaceutical composition; and its use in the treatment of viral diseases.
EA201100851A1 (en) 2008-12-23 2012-04-30 Фармассет, Инк. NUCLEOSIDE ANALOGUES
TWI576352B (en) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
BR112012024884A2 (en) 2010-03-31 2016-10-18 Gilead Pharmasset Llc stereo-selective synthesis of phosphorus-containing assets
AR084044A1 (en) 2010-11-30 2013-04-17 Pharmasset Inc 2’-ESPIRO-NUCLEOSID COMPOUNDS
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
ES2792503T3 (en) 2013-08-27 2020-11-11 Gilead Pharmasset Llc Combined formulation of two antiviral compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114577A1 (en) * 1983-01-21 1984-08-01 MAGIS FARMACEUTICI S.p.A. New pharmaceutical composition
EP0152379A2 (en) * 1984-02-15 1985-08-21 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
EP0216511A2 (en) * 1985-08-26 1987-04-01 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Inhibition of in vitro infectivity and cytopathic effect of HTLV-III/LAV by 2'3'-dideoxycytidine
EP0267050A2 (en) * 1986-11-06 1988-05-11 Research Development Foundation Aerosols containg liposomes and method for their preparation.
NL8700089A (en) * 1987-01-15 1988-08-01 Stichting Rega V Z W Medicaments for treating AIDS - contg. 2',3'-di:deoxy-thymidine or 2',3'-di:deoxy-thymidinene
WO1988005657A1 (en) * 1987-01-28 1988-08-11 Chu Chung K 3'-azido-2',3'-dideoxyuridine anti-retroviral composition
EP0286418A1 (en) * 1987-04-10 1988-10-12 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Anti-retroviral agents and delivery systems for the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
ZA833446B (en) * 1982-05-28 1984-02-29 Solco Basel Ag Process for the preparation of cell-and tissue-regenerating substances
US4704357A (en) * 1985-09-30 1987-11-03 United States Of America As Represented By The Department Of Health And Human Services Immortalized T-lymphocyte cell line for testing HTLV-III inactivation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114577A1 (en) * 1983-01-21 1984-08-01 MAGIS FARMACEUTICI S.p.A. New pharmaceutical composition
EP0152379A2 (en) * 1984-02-15 1985-08-21 Ciba-Geigy Ag Process for preparing pharmaceutical compositions containing unilamellar liposomes
EP0216511A2 (en) * 1985-08-26 1987-04-01 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Inhibition of in vitro infectivity and cytopathic effect of HTLV-III/LAV by 2'3'-dideoxycytidine
EP0267050A2 (en) * 1986-11-06 1988-05-11 Research Development Foundation Aerosols containg liposomes and method for their preparation.
NL8700089A (en) * 1987-01-15 1988-08-01 Stichting Rega V Z W Medicaments for treating AIDS - contg. 2',3'-di:deoxy-thymidine or 2',3'-di:deoxy-thymidinene
WO1988005657A1 (en) * 1987-01-28 1988-08-11 Chu Chung K 3'-azido-2',3'-dideoxyuridine anti-retroviral composition
EP0286418A1 (en) * 1987-04-10 1988-10-12 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Anti-retroviral agents and delivery systems for the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8902733A1 *

Also Published As

Publication number Publication date
EP0380558A1 (en) 1990-08-08
WO1989002733A1 (en) 1989-04-06
AU2526188A (en) 1989-04-18
JPH03501253A (en) 1991-03-22

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Legal Events

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