MX2011007194A - Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc). - Google Patents

Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc).

Info

Publication number
MX2011007194A
MX2011007194A MX2011007194A MX2011007194A MX2011007194A MX 2011007194 A MX2011007194 A MX 2011007194A MX 2011007194 A MX2011007194 A MX 2011007194A MX 2011007194 A MX2011007194 A MX 2011007194A MX 2011007194 A MX2011007194 A MX 2011007194A
Authority
MX
Mexico
Prior art keywords
nucleosides
combination
treating hcv
cyclosporine derivative
cyclosporine
Prior art date
Application number
MX2011007194A
Other languages
English (en)
Inventor
Samuel Earl Hopkins
Original Assignee
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scynexis Inc filed Critical Scynexis Inc
Publication of MX2011007194A publication Critical patent/MX2011007194A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Esta invención se refiere a combinaciones que comprenden 3-[(3)-2-(N,N-Dimetilamino o una sal, solvato o hidrato farmacéuticamente aceptable de la misma; y ciertos análogos de nucleosido, y su uso en el tratamiento de virus de hepatitis C.
MX2011007194A 2009-01-07 2010-01-07 Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc). MX2011007194A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14306209P 2009-01-07 2009-01-07
US15602609P 2009-02-27 2009-02-27
US25723109P 2009-11-02 2009-11-02
PCT/US2010/020323 WO2010080878A1 (en) 2009-01-07 2010-01-07 Combination of a cyclosporine derivative and nucleosides for treating hcv

Publications (1)

Publication Number Publication Date
MX2011007194A true MX2011007194A (es) 2013-07-12

Family

ID=42084646

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011007194A MX2011007194A (es) 2009-01-07 2010-01-07 Combinacion de un derivado ciclosporina y nucleosidos para tratar virus de hepatitis c (vhc).

Country Status (11)

Country Link
US (1) US20100227801A1 (es)
EP (1) EP2385833A1 (es)
JP (1) JP2012514606A (es)
CN (1) CN102271688A (es)
AU (1) AU2010203660A1 (es)
BR (1) BRPI1007027A2 (es)
CA (1) CA2748792A1 (es)
IL (1) IL213862A0 (es)
MX (1) MX2011007194A (es)
RU (1) RU2011127079A (es)
WO (1) WO2010080878A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2399628C2 (ru) * 2004-10-01 2010-09-20 Скайнексис, Инк. Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с
WO2007041631A1 (en) * 2005-09-30 2007-04-12 Scynexis, Inc. ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
CN101511357B (zh) 2006-05-19 2011-11-02 西尼克斯公司 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用
EP2027761A1 (fr) * 2006-06-02 2009-02-25 Claude Annie Perrichon Gestion des electrons actifs
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
WO2010002428A2 (en) 2008-06-06 2010-01-07 Scynexis, Inc. Novel macrocyclic peptides
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
JP5793084B2 (ja) 2008-12-23 2015-10-14 ギリアド ファーマセット エルエルシー プリンヌクレオシドの合成
CN102307892A (zh) * 2008-12-31 2012-01-04 西尼克斯公司 环孢菌素a的衍生物
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
CN102858790A (zh) 2010-03-31 2013-01-02 吉利德制药有限责任公司 核苷氨基磷酸酯
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
SG10201602044WA (en) 2011-09-16 2016-04-28 Gilead Pharmassett Llc Methods For Treating HCV
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CA2852867C (en) 2013-01-31 2016-12-06 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US20140357595A1 (en) * 2013-06-04 2014-12-04 Gilead Pharmasset Llc Methods of preventing and treating recurrence of a hepatitis c virus infection in a subject after the subject has received a liver transplant
MX2016002185A (es) 2013-08-27 2016-06-06 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales.
CN106536538A (zh) * 2014-04-24 2017-03-22 共晶制药股份有限公司 用于治疗黄病毒家族病毒和癌症的2’‑双取代核苷类似物
WO2020118714A1 (en) 2018-12-14 2020-06-18 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Maleate of scy-635 and uses thereof in medicine
EP4041274B1 (en) * 2019-10-11 2024-05-08 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Ws-635 for use in the treatment of postoperative cognitive dysfunction
WO2023085242A1 (ja) * 2021-11-12 2023-05-19 国立大学法人北海道大学 抗ウイルス剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2726998T3 (es) * 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
EP1933859A2 (en) * 2005-09-30 2008-06-25 Scynexis, Inc. Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
KR101238461B1 (ko) * 2005-12-09 2013-03-05 길리어드 파마셋 엘엘씨 항바이러스성 뉴클레오시드

Also Published As

Publication number Publication date
RU2011127079A (ru) 2013-02-20
AU2010203660A1 (en) 2011-07-28
AU2010203660A2 (en) 2011-09-29
CA2748792A1 (en) 2010-07-15
WO2010080878A1 (en) 2010-07-15
US20100227801A1 (en) 2010-09-09
CN102271688A (zh) 2011-12-07
JP2012514606A (ja) 2012-06-28
EP2385833A1 (en) 2011-11-16
IL213862A0 (en) 2011-07-31
BRPI1007027A2 (pt) 2019-09-24

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