|
US3121076A
(en)
|
|
1964-02-11 |
|
Benzodiazepinones and processes |
|
US1873732A
(en)
|
1928-12-28 |
1932-08-23 |
Abbott Lab |
Bactericide applicable to acid-fast bacteria
|
|
US3019843A
(en)
|
1956-07-27 |
1962-02-06 |
Powell Dawson |
Fire inhibitor and extinguisher
|
|
US2942572A
(en)
|
1958-06-17 |
1960-06-28 |
Pall Corp |
Magnetic pressure indicator
|
|
US3136815A
(en)
|
1959-12-10 |
1964-06-09 |
Hoffmann La Roche |
Amino substituted benzophenone oximes and derivatives thereof
|
|
US3371085A
(en)
|
1959-12-10 |
1968-02-27 |
Hoffmann La Roche |
5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
|
|
US3116203A
(en)
|
1962-03-14 |
1963-12-31 |
Hoffmann La Roche |
Oleaginous systems
|
|
NL298071A
(OSRAM)
|
1963-06-04 |
|
|
|
|
CH449645A
(de)
|
1963-07-09 |
1968-01-15 |
Ciba Geigy |
Verfahren zur Herstellung neuer Aminosäuren
|
|
CH427803A
(de)
|
1963-12-06 |
1967-01-15 |
Geigy Ag J R |
Verfahren zur Herstellung eines neuen Isoxazolderivates
|
|
NL129434C
(OSRAM)
|
1966-03-12 |
|
|
|
|
BE759838A
(fr)
|
1969-12-04 |
1971-06-03 |
Wellcome Found |
Cetones a activite biologique
|
|
US3885046A
(en)
|
1969-12-04 |
1975-05-20 |
Burroughs Wellcome Co |
Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
|
|
FR2077918B1
(OSRAM)
|
1970-02-24 |
1973-04-06 |
Berthier Laboratoires |
|
|
US3758528A
(en)
|
1970-03-13 |
1973-09-11 |
Science Union & Cie |
Tricyclic compounds
|
|
US3821249A
(en)
|
1970-03-13 |
1974-06-28 |
En Nom Collectif Science Union |
Dibenzothiazefin derivatives
|
|
US3819631A
(en)
|
1970-12-15 |
1974-06-25 |
May & Baker Ltd |
Azapurinones
|
|
OA04285A
(fr)
|
1972-01-07 |
1979-12-31 |
Rhone Poulenc Sa |
Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
|
|
US3932407A
(en)
|
1973-11-19 |
1976-01-13 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
USRE31617E
(en)
|
1972-02-04 |
1984-06-26 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US4036840A
(en)
|
1972-06-07 |
1977-07-19 |
Icn Pharmaceuticals |
2-Substituted-s-triazolo[1,5a]pyrimidines
|
|
GB1457873A
(en)
|
1973-01-04 |
1976-12-08 |
Allen & Hanburys Ltd |
Imidazotriazines
|
|
GB1422263A
(en)
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
|
US4051236A
(en)
|
1973-02-15 |
1977-09-27 |
E. R. Squibb & Sons, Inc. |
Inhibition of blood platelet aggregation
|
|
US4314081A
(en)
|
1974-01-10 |
1982-02-02 |
Eli Lilly And Company |
Arloxyphenylpropylamines
|
|
US4280957A
(en)
|
1974-09-11 |
1981-07-28 |
Hoffmann-La Roche Inc. |
Imidazodiazepines and processes therefor
|
|
AR208414A1
(es)
|
1974-11-07 |
1976-12-27 |
Rhone Poulenc Ind |
Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
|
|
US4093617A
(en)
|
1974-11-12 |
1978-06-06 |
Icn Pharmaceuticals, Inc. |
3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
|
|
DE2460891C2
(de)
|
1974-12-21 |
1982-09-23 |
Gödecke AG, 1000 Berlin |
1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
|
|
US3960927A
(en)
|
1975-03-18 |
1976-06-01 |
Richardson-Merrell Inc. |
Olefinic derivatives of amino acids
|
|
NL7503310A
(nl)
|
1975-03-20 |
1976-09-22 |
Philips Nv |
Verbindingen met antidepressieve werking.
|
|
NL189199C
(nl)
|
1975-04-05 |
1993-02-01 |
Akzo Nv |
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
|
|
FR2319338A1
(fr)
|
1975-08-01 |
1977-02-25 |
Synthelabo |
Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
|
|
GB1526331A
(en)
|
1976-01-14 |
1978-09-27 |
Kefalas As |
Phthalanes
|
|
YU96177A
(en)
|
1976-04-24 |
1982-08-31 |
Wuelfing Johann A |
Process for obtaining adenine derivatives
|
|
US4107307A
(en)
|
1977-02-03 |
1978-08-15 |
American Cyanamid Company |
Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
USRE30511E
(en)
|
1977-02-03 |
1981-02-10 |
American Cyanamid Company |
Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
US4404380A
(en)
|
1977-02-14 |
1983-09-13 |
Mead Johnson & Company |
Triazolopyrimidines
|
|
CA1095906A
(en)
|
1977-02-14 |
1981-02-17 |
Davis L. Temple, Jr. |
Heterocyclopyrimidines, compositions and therapeutic process
|
|
US4107309A
(en)
|
1977-05-23 |
1978-08-15 |
American Cyanamid Company |
Substituted imidazo[1,2-d]-as-triazines
|
|
US4096257A
(en)
|
1977-05-23 |
1978-06-20 |
American Cyanamid Company |
Substituted imidazo [1,2-d]-as-triazines
|
|
IN148482B
(OSRAM)
|
1977-06-03 |
1981-03-07 |
Pfizer |
|
|
DK270278A
(da)
|
1977-06-20 |
1978-12-21 |
Krogsgaard Larsen P |
Cycliske aminosyrer
|
|
CA1086735A
(en)
|
1977-11-03 |
1980-09-30 |
John C. Danilewicz |
Piperidino-quinazolines
|
|
US4370328A
(en)
|
1977-11-03 |
1983-01-25 |
Pfizer Inc. |
Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
|
|
IL56369A
(en)
|
1978-01-20 |
1984-05-31 |
Erba Farmitalia |
Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
|
|
US4146718A
(en)
|
1978-04-10 |
1979-03-27 |
Bristol-Myers Company |
Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
|
|
US4366156A
(en)
|
1979-03-05 |
1982-12-28 |
Mead Johnson & Company |
Antiallergic methods using diazaheterocyclopurines
|
|
CA1143728A
(en)
|
1979-10-04 |
1983-03-29 |
Max Gerecke |
Imidazodiazepine derivatives
|
|
US4536518A
(en)
|
1979-11-01 |
1985-08-20 |
Pfizer Inc. |
Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
|
|
JPS5668695A
(en)
|
1979-11-10 |
1981-06-09 |
Sankyo Co Ltd |
Enzyme inhibitor griseolic acid and its preparation
|
|
US4642345A
(en)
|
1980-08-14 |
1987-02-10 |
Mead Johnson & Company |
6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones
|
|
US4301176A
(en)
|
1980-08-18 |
1981-11-17 |
Warner-Lambert Company |
Method of administering calcium valproate
|
|
US4361583A
(en)
|
1980-08-19 |
1982-11-30 |
Synthelabo |
Analgesic agent
|
|
FR2492258A1
(fr)
|
1980-10-17 |
1982-04-23 |
Pharmindustrie |
Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
|
|
FR2492382A1
(fr)
|
1980-10-22 |
1982-04-23 |
Synthelabo |
Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
|
|
US4489078A
(en)
|
1980-11-24 |
1984-12-18 |
Mead Johnson & Company |
Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators
|
|
US4338317A
(en)
|
1981-03-16 |
1982-07-06 |
Mead Johnson & Company |
Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
|
|
US4383999A
(en)
|
1981-05-26 |
1983-05-17 |
Smithkline Beckman Corporation |
Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
|
|
FR2508035A1
(fr)
|
1981-06-23 |
1982-12-24 |
Fabre Sa Pierre |
Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
|
|
LU83729A1
(fr)
|
1981-11-04 |
1983-09-01 |
Galephar |
Sels d'acide valproique,leur preparation et leur utilisation
|
|
CH655110A5
(de)
|
1982-09-03 |
1986-03-27 |
Otsuka Pharma Co Ltd |
Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
|
|
US4490371A
(en)
|
1983-02-16 |
1984-12-25 |
Syntex (U.S.A.) Inc. |
N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
|
|
US4663320A
(en)
|
1983-02-16 |
1987-05-05 |
Syntex (U.S.A.) Inc. |
(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
|
|
US4626538A
(en)
|
1983-06-23 |
1986-12-02 |
American Cyanamid Company |
[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
|
|
US4900836A
(en)
|
1983-06-23 |
1990-02-13 |
American Cyanamid Company |
(3-amino-1H-pyrazol-4-yl) (aryl)methanones
|
|
US4521422A
(en)
|
1983-06-23 |
1985-06-04 |
American Cyanamid Company |
Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
|
|
US4513006A
(en)
|
1983-09-26 |
1985-04-23 |
Mcneil Lab., Inc. |
Anticonvulsant sulfamate derivatives
|
|
US4761501A
(en)
|
1983-10-26 |
1988-08-02 |
American Home Products Corporation |
Substituted phenylacetamides
|
|
US4593029A
(en)
|
1984-02-15 |
1986-06-03 |
Syntex (U.S.A.) Inc. |
Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
|
|
GB8425872D0
(en)
|
1984-10-12 |
1984-11-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
US4855290A
(en)
|
1985-05-10 |
1989-08-08 |
State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research |
Derivatives of quinuclidine
|
|
DK288385D0
(da)
|
1985-06-26 |
1985-06-26 |
Novo Industri As |
Aminosyrederivater
|
|
DE3677316D1
(de)
|
1985-10-17 |
1991-03-07 |
Smith Kline French Lab |
4(4-oxo-1,4-dihydropyridin-1-yl)phenyl-derivate.
|
|
US4670434A
(en)
|
1985-11-14 |
1987-06-02 |
Syntex (U.S.A.) Inc. |
(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
|
|
US4775674A
(en)
|
1986-05-23 |
1988-10-04 |
Bristol-Myers Company |
Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
|
|
GB8615785D0
(en)
|
1986-06-27 |
1986-08-06 |
Beecham Group Plc |
Compounds
|
|
EP0261763B1
(en)
|
1986-06-27 |
1994-02-09 |
Beecham Group Plc |
Novel bridged bicyclic N-heterocycles
|
|
FR2600650B1
(fr)
|
1986-06-27 |
1988-09-09 |
Synthelabo |
Procede de preparation d'imidazopyridines et composes intermediaires
|
|
US4701459A
(en)
|
1986-07-08 |
1987-10-20 |
Bristol-Myers Company |
7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
|
|
US5093525A
(en)
|
1986-07-10 |
1992-03-03 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
|
|
US5502255A
(en)
|
1986-07-10 |
1996-03-26 |
State Of Oregon Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5312840A
(en)
|
1986-07-10 |
1994-05-17 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US4709094A
(en)
|
1986-07-10 |
1987-11-24 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Sigma brain receptor ligands and their use
|
|
US4761416A
(en)
|
1986-07-25 |
1988-08-02 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
|
|
US4739056A
(en)
|
1986-11-26 |
1988-04-19 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
|
|
US4786648A
(en)
|
1986-12-08 |
1988-11-22 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4710508A
(en)
|
1986-12-08 |
1987-12-01 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4766118A
(en)
|
1986-12-22 |
1988-08-23 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use
|
|
US4721784A
(en)
|
1986-12-22 |
1988-01-26 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
|
|
US5081242A
(en)
|
1986-12-22 |
1992-01-14 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4956388A
(en)
|
1986-12-22 |
1990-09-11 |
Eli Lilly And Company |
3-aryloxy-3-substituted propanamines
|
|
US4992457A
(en)
|
1987-03-18 |
1991-02-12 |
Schulman Jerome M |
Pharmacologically active cholinergic compositions, and methods for making same and use thereof in treating disease
|
|
US4929734A
(en)
|
1987-03-31 |
1990-05-29 |
Warner-Lambert Company |
Tetrahydropyridine oxime compounds
|
|
NZ224237A
(en)
|
1987-04-15 |
1991-04-26 |
Beecham Group Plc |
Bicyclic compounds (n bridged compounds)
|
|
GB8714789D0
(en)
|
1987-06-24 |
1987-07-29 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
US4981858A
(en)
|
1987-08-13 |
1991-01-01 |
State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research |
Optical isomers
|
|
USRE35517E
(en)
|
1987-08-25 |
1997-05-20 |
University Of Southern California |
Method, compositions, and compounds for modulating brain excitability
|
|
US5232917A
(en)
|
1987-08-25 |
1993-08-03 |
University Of Southern California |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
|
|
ES2074441T3
(es)
|
1987-10-05 |
1995-09-16 |
Yamanouchi Pharma Co Ltd |
Compuestos espiro heterociclicos y su preparacion.
|
|
US5412096A
(en)
|
1987-10-05 |
1995-05-02 |
Yamanouchi Pharmaceutical Co., Ltd. |
Hydrochloride salts of heterocyclic spiro compounds
|
|
IL88156A
(en)
|
1987-11-13 |
1997-02-18 |
Novo Nordisk As |
Azacyclic compounds their preparation and pharmaceutical compositions containing them
|
|
EP0322182A3
(en)
|
1987-12-22 |
1992-01-02 |
Beecham Group Plc |
Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
US5091431A
(en)
|
1988-02-08 |
1992-02-25 |
Schering Corporation |
Phosphodiesterase inhibitors
|
|
EP0338723B1
(en)
|
1988-04-15 |
1993-08-04 |
Beecham Group Plc |
Novel compounds
|
|
US4957916A
(en)
|
1988-08-05 |
1990-09-18 |
Janssen Pharmaceutica N.V. |
Antipsychotic 3-piperazinylbenzazole derivatives
|
|
US4861891A
(en)
|
1988-08-31 |
1989-08-29 |
Pfizer Inc. |
Antidepressant N-substituted nicotinamide compounds
|
|
CA2000041A1
(en)
|
1988-10-13 |
1990-04-13 |
Barry S. Orlek |
Compounds
|
|
US5286864A
(en)
|
1988-11-22 |
1994-02-15 |
Boehringer Ingelheim Kg |
Quinuclidines, their use as medicaments and processes for their preparation
|
|
DE8817121U1
(de)
|
1988-11-22 |
1993-02-04 |
Boehringer Ingelheim Kg, 55218 Ingelheim |
Neue Quinuclidine
|
|
US5043345A
(en)
|
1989-02-22 |
1991-08-27 |
Novo Nordisk A/S |
Piperidine compounds and their preparation and use
|
|
US4981870A
(en)
|
1989-03-07 |
1991-01-01 |
Pfizer Inc. |
Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
|
|
US4971972A
(en)
|
1989-03-23 |
1990-11-20 |
Schering Corporation |
Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
|
|
US5278170A
(en)
|
1989-04-13 |
1994-01-11 |
Beecham Group P.L.C. |
Azabicylo oxime compounds
|
|
EP0392803B1
(en)
|
1989-04-13 |
2004-06-16 |
Beecham Group p.l.c. |
Novel compounds
|
|
US4956368A
(en)
|
1989-07-24 |
1990-09-11 |
Bristol-Myers Company |
Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
|
|
US5109002A
(en)
|
1989-09-08 |
1992-04-28 |
Du Pont Merck Pharmaceutical Company |
Antipsychotic 1-cycloalkylpiperidines
|
|
EP0427390B1
(en)
|
1989-10-07 |
1996-03-27 |
Beecham Group Plc |
Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
|
|
US4943573A
(en)
|
1989-11-01 |
1990-07-24 |
Bristol-Myers Squibb Company |
Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
|
|
CA2029497C
(en)
|
1989-11-08 |
2002-06-04 |
Kunihiro Ninomiya (Deceased) |
4-acylaminopyridine derivative
|
|
US5010086A
(en)
|
1990-02-28 |
1991-04-23 |
Sterling Drug Inc. |
Imidazopyridines, compositions and use
|
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
|
US5149817A
(en)
|
1990-03-05 |
1992-09-22 |
Shionogi & Co., Ltd. |
Teirahydropyridine derivatives
|
|
GB9005737D0
(en)
|
1990-03-14 |
1990-05-09 |
Beecham Group Plc |
Novel compounds
|
|
US5169855A
(en)
|
1990-03-28 |
1992-12-08 |
Du Pont Merck Pharmaceutical Company |
Piperidine ether derivatives as psychotropic drugs or plant fungicides
|
|
US5407938A
(en)
|
1990-04-10 |
1995-04-18 |
Israel Institute For Biological Research |
Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
|
|
US5534520A
(en)
|
1990-04-10 |
1996-07-09 |
Fisher; Abraham |
Spiro compounds containing five-membered rings
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
US5116995A
(en)
|
1990-05-25 |
1992-05-26 |
Taisho Pharmaceutical Co., Ltd. |
Carbazole compounds
|
|
AU653729B2
(en)
|
1990-05-25 |
1994-10-13 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5612211A
(en)
|
1990-06-08 |
1997-03-18 |
New York University |
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
|
|
US5250534A
(en)
|
1990-06-20 |
1993-10-05 |
Pfizer Inc. |
Pyrazolopyrimidinone antianginal agents
|
|
US5095015A
(en)
|
1990-07-24 |
1992-03-10 |
Neurogen Corporation |
Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
|
|
JP2935541B2
(ja)
|
1990-06-28 |
1999-08-16 |
サントリー株式会社 |
縮合複素環化合物
|
|
US5086054A
(en)
|
1990-07-31 |
1992-02-04 |
Sri International |
Novel arylcycloalkanepolyalkylamines
|
|
US5376668A
(en)
|
1990-08-21 |
1994-12-27 |
Novo Nordisk A/S |
Heterocyclic compounds
|
|
DK198590D0
(da)
|
1990-08-21 |
1990-08-21 |
Novo Nordisk As |
Heterocykliske forbindelser, deres fremstilling og anvendelse
|
|
US5527813A
(en)
|
1990-08-21 |
1996-06-18 |
Novo Nordisk A/S |
Heterocyclic compounds and their preparation and use
|
|
US5362739A
(en)
|
1990-08-24 |
1994-11-08 |
Beecham Group P.L.C. |
Azabicyclic compounds and pharmaceutical compositions containing them
|
|
CA2050264A1
(en)
|
1990-08-30 |
1992-03-01 |
Raymond Baker |
Substituted pyrazine and its salts, compositions containing them and their use in medicine
|
|
GB9019095D0
(en)
|
1990-09-01 |
1990-10-17 |
Beecham Group Plc |
Novel compounds
|
|
US5185446A
(en)
|
1990-09-04 |
1993-02-09 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
|
|
CA2091986C
(en)
|
1990-10-09 |
1995-11-28 |
Andrew Thurkauf |
Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
|
|
EP0552213A1
(en)
|
1990-10-12 |
1993-07-28 |
Beecham Group Plc |
1,2,5,6-tetrahydropyridine oxime derivatives
|
|
US5139802A
(en)
|
1990-10-15 |
1992-08-18 |
Nestec S.A. |
Oxidation of tea
|
|
EP0481262B1
(en)
|
1990-10-15 |
1995-02-15 |
Societe Des Produits Nestle S.A. |
Treatment of black tea
|
|
US5091242A
(en)
|
1990-10-30 |
1992-02-25 |
The Research Foundation Of State Univ. Of N.Y. |
Carbon fiber composites having improved fatigue resistance
|
|
US5130430A
(en)
|
1990-10-31 |
1992-07-14 |
Neurogen Corporation |
2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
|
|
US6268496B1
(en)
|
1990-10-31 |
2001-07-31 |
Neurogen Corporation |
Certain imidazoquinoxalines: a new class of GABA brain receptor ligands
|
|
US5744602A
(en)
|
1990-10-31 |
1998-04-28 |
Neurogen Corporation |
Certain imidazoquinoxalines; a new class of GABA brain receptor ligands
|
|
US5116837A
(en)
|
1990-12-21 |
1992-05-26 |
Ortho Pharmaceutical Corporation |
2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines
|
|
US5162341A
(en)
|
1991-02-22 |
1992-11-10 |
Du Pont Merck Pharmaceutical Company |
Use of sigma receptor antagonists for treatment of amphetamine abuse
|
|
US5137895A
(en)
|
1991-04-29 |
1992-08-11 |
A. H. Robins Company, Incorporated |
3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols
|
|
US5093333A
(en)
|
1991-04-29 |
1992-03-03 |
American Home Products Corporation |
N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system
|
|
US5124460A
(en)
|
1991-05-06 |
1992-06-23 |
Merck Sharp & Dohme Ltd. |
Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
|
|
ATE168114T1
(de)
|
1991-05-15 |
1998-07-15 |
Yamanouchi Pharma Co Ltd |
(-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8- azaspiro(4,5)decan l-tartrat
|
|
NZ243065A
(en)
|
1991-06-13 |
1995-07-26 |
Lundbeck & Co As H |
Piperidine derivatives and pharmaceutical compositions
|
|
US5641791A
(en)
|
1991-08-13 |
1997-06-24 |
Novo Nordisk A.S |
Heterocyclic compounds and their preparation and use
|
|
US5182386A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
|
|
US5182290A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
|
|
US5369108A
(en)
|
1991-10-04 |
1994-11-29 |
Sloan-Kettering Institute For Cancer Research |
Potent inducers of terminal differentiation and methods of use thereof
|
|
US5585490A
(en)
|
1991-10-08 |
1996-12-17 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands
|
|
US5212310A
(en)
|
1991-12-19 |
1993-05-18 |
Neurogen Corporation |
Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
|
|
US5243049A
(en)
|
1992-01-22 |
1993-09-07 |
Neurogen Corporation |
Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
|
|
MX9300875A
(es)
|
1992-02-20 |
1993-08-31 |
Smithkline Beecham Plc |
Procedimiento para la preparacion de compuestos azabiciclicos.
|
|
US6225115B1
(en)
|
1992-03-04 |
2001-05-01 |
Synaptic Pharmaceutical Corporation |
DNA encoding taurine and GABA transporters and uses thereof
|
|
US5298657A
(en)
|
1992-03-20 |
1994-03-29 |
Cambridge Neuroscience Inc. |
Preparation of substituted guanidines
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
US5367077A
(en)
|
1992-04-08 |
1994-11-22 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
|
|
AU4117493A
(en)
|
1992-04-08 |
1994-11-21 |
Neurogen Corporation |
Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands
|
|
US5266698A
(en)
|
1992-04-30 |
1993-11-30 |
Neurogen Corporation |
Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
|
|
SE9201478D0
(sv)
|
1992-05-11 |
1992-05-11 |
Kabi Pharmacia Ab |
Heteroaromatic quinuclidinenes, their use and preparation
|
|
ES2060547B1
(es)
|
1992-06-04 |
1995-06-16 |
Ferrer Int |
Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
|
|
GB9212693D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
GB9212673D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
JP2683783B2
(ja)
|
1992-07-10 |
1997-12-03 |
雪印乳業株式会社 |
シェーグレン症候群治療剤
|
|
US5928947A
(en)
|
1992-07-27 |
1999-07-27 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
US5306819A
(en)
|
1992-08-27 |
1994-04-26 |
Neurogen Corporation |
Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
|
|
ZA937382B
(en)
|
1992-10-06 |
1994-04-29 |
Warner Lambert Co |
Novel composition for peroral therapy of cognitionimpairment and a process therefor
|
|
GB9222253D0
(en)
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
|
US5668283A
(en)
|
1992-11-12 |
1997-09-16 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5286860A
(en)
|
1992-11-12 |
1994-02-15 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5814651A
(en)
|
1992-12-02 |
1998-09-29 |
Pfizer Inc. |
Catechol diethers as selective PDEIV inhibitors
|
|
US5622977A
(en)
|
1992-12-23 |
1997-04-22 |
Celltech Therapeutics Limited |
Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
|
|
WO1994015937A1
(en)
|
1993-01-06 |
1994-07-21 |
Neurogen Corporation |
Certain aryl substituted imidazopyrazinones a new class of gaba brain receptor ligands
|
|
EP0608713B1
(de)
|
1993-01-23 |
1996-12-27 |
Hoechst Aktiengesellschaft |
2,3-Difluor-6-nitrobenzonitril und 2-Chlor-5,6-difluorbenzonitril, Verfahren zu deren Herstellung und ihre Verwendung zur Herstellung von 2,3,6-Trifluorbenzoesäure
|
|
US5362860A
(en)
|
1993-02-01 |
1994-11-08 |
Warner-Lambert Company |
Neutral stabilization complex for CI-979 HCl, a cognition activator
|
|
US5424301A
(en)
|
1993-02-01 |
1995-06-13 |
Warner-Lambert Company |
Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
|
|
US6013799A
(en)
|
1993-03-03 |
2000-01-11 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands
|
|
GB9304919D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
GB9304920D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
CA2158952C
(en)
|
1993-03-26 |
1999-05-18 |
Shen-Chun Kuo |
2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists
|
|
US5750702A
(en)
|
1993-10-27 |
1998-05-12 |
Neurogen Corporation |
Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
|
|
DE69432984T2
(de)
|
1993-05-27 |
2004-05-27 |
Cenes Ltd. |
Therapeutische substituierte guanidine
|
|
GB9301192D0
(en)
|
1993-06-09 |
1993-06-09 |
Trott Francis W |
Flower shaped mechanised table
|
|
AU7177694A
(en)
|
1993-06-23 |
1995-01-17 |
Cambridge Neuroscience, Inc. |
Sigma receptor ligands and the use thereof
|
|
US5712298A
(en)
|
1993-07-02 |
1998-01-27 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors
|
|
ES2074946B1
(es)
|
1993-07-19 |
1996-06-16 |
Ferrer Int |
Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
|
|
US5665754A
(en)
|
1993-09-20 |
1997-09-09 |
Glaxo Wellcome Inc. |
Substituted pyrrolidines
|
|
US5484944A
(en)
|
1993-10-27 |
1996-01-16 |
Neurogen Corporation |
Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
|
|
PT730587E
(pt)
|
1993-11-26 |
2000-05-31 |
Pfizer |
3-aril-2-isoxazolinas como agentes anti-inflamatorios
|
|
US5502072A
(en)
|
1993-11-26 |
1996-03-26 |
Pfizer Inc. |
Substituted oxindoles
|
|
WO1995014681A1
(en)
|
1993-11-26 |
1995-06-01 |
Pfizer Inc. |
Isoxazoline compounds as antiinflammatory agents
|
|
US5500420A
(en)
|
1993-12-20 |
1996-03-19 |
Cornell Research Foundation, Inc. |
Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia
|
|
GB9326173D0
(en)
|
1993-12-22 |
1994-02-23 |
Celltech Ltd |
Chemical compounds and process
|
|
GB9326600D0
(en)
|
1993-12-22 |
1994-03-02 |
Celltech Ltd |
Chemical compounds
|
|
EP0738268B1
(en)
|
1993-12-22 |
2004-03-03 |
Celltech R&D Limited |
Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors
|
|
WO1995017889A1
(en)
|
1993-12-29 |
1995-07-06 |
Kowa Tekuno Sachi Co., Ltd. |
Therapeutic composition for hyperparathyroidism of patient subjected to artificial dialysis
|
|
US7060450B1
(en)
|
1993-12-30 |
2006-06-13 |
President And Fellows Of Harvard College |
Screening assays for agonists and antagonists of the hedgehog signaling pathway
|
|
GB9401090D0
(en)
|
1994-01-21 |
1994-03-16 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9514465D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
US5939545A
(en)
|
1994-02-14 |
1999-08-17 |
Cocensys, Inc. |
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
|
|
PT752860E
(pt)
|
1994-02-14 |
2000-12-29 |
Euro Celtique Sa |
Androstanos e pregnanos para modulacao alosterica do receptor de gaba
|
|
IL112957A0
(en)
|
1994-03-14 |
1995-06-29 |
Novo Nordisk As |
Thieno [2,3-b] indoles, their preparation and pharmaceutical compositions containing them
|
|
US5783575A
(en)
|
1994-03-14 |
1998-07-21 |
Novo Nordisk A/S |
Antagonists, their preparation and use
|
|
US5696148A
(en)
|
1994-03-14 |
1997-12-09 |
Novo Nordisk A/S |
Indole compounds and their use in treating diseases of the central nervous system
|
|
US5637617A
(en)
|
1994-04-01 |
1997-06-10 |
The Regents Of The University Of California |
Methods for use of GABAa receptor GABAergic compounds
|
|
GB9409705D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9409718D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
|
US5786354A
(en)
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
|
GB9412571D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412672D0
(en)
|
1994-06-23 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
JP2852608B2
(ja)
|
1994-06-27 |
1999-02-03 |
雪印乳業株式会社 |
口腔乾燥症治療剤
|
|
US5750566A
(en)
|
1994-08-12 |
1998-05-12 |
Eli Lilly And Company |
Synthetic excitatory amino acids
|
|
PT777671E
(pt)
|
1994-08-24 |
2000-08-31 |
Astrazeneca Ab |
Compostos espiro-azabiciclicos uteis em terapia
|
|
KR970705562A
(ko)
|
1994-08-29 |
1997-10-09 |
오노다 마사요시 |
신규한 나프티리딘 유도체 및 이의 의약 조성물(Novel naphthyridine derivatives and medicinal composition thereof)
|
|
US5731307A
(en)
|
1994-09-30 |
1998-03-24 |
Pfizer, Inc. |
Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
|
|
US5554645A
(en)
|
1994-10-03 |
1996-09-10 |
Mars, Incorporated |
Antineoplastic cocoa extracts and methods for making and using the same
|
|
DE4436509A1
(de)
|
1994-10-13 |
1996-04-18 |
Hoechst Schering Agrevo Gmbh |
Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
|
|
JP3993651B2
(ja)
|
1994-10-21 |
2007-10-17 |
アスビオファーマ株式会社 |
シクロプロパクロメンカルボン酸誘導体
|
|
US5821371A
(en)
|
1994-10-24 |
1998-10-13 |
Eli Lilly And Comany |
Heterocyclic compounds and their preparation and use
|
|
US5605908A
(en)
|
1994-10-24 |
1997-02-25 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
US5473077A
(en)
|
1994-11-14 |
1995-12-05 |
Eli Lilly And Company |
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists
|
|
US5571819A
(en)
|
1994-11-22 |
1996-11-05 |
Sabb; Annmarie L. |
Imidazopyridines as muscarinic agents
|
|
US5510478A
(en)
|
1994-11-30 |
1996-04-23 |
American Home Products Corporation |
2-arylamidothiazole derivatives with CNS activity
|
|
US5512574A
(en)
|
1994-12-21 |
1996-04-30 |
American Home Products Corporation |
Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
|
|
US5468875A
(en)
|
1994-12-22 |
1995-11-21 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
GB9503601D0
(en)
|
1995-02-23 |
1995-04-12 |
Merck Sharp & Dohme |
Method of treatment and method of manufacture of medicament
|
|
US5488055A
(en)
|
1995-03-10 |
1996-01-30 |
Sanofi Winthrop Inc. |
Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
|
|
DE69617665T2
(de)
|
1995-04-21 |
2002-05-08 |
Neurosearch A/S, Ballerup |
Benzmidazolverbindungen und ihre verwendung als modulatoren des gabaa-rezeptor-komplexes
|
|
EP0823905A1
(en)
|
1995-05-05 |
1998-02-18 |
Novo Nordisk A/S |
Novel heterocyclic chemistry
|
|
DE19518082A1
(de)
|
1995-05-17 |
1996-11-21 |
Merck Patent Gmbh |
4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
|
|
AU698028B2
(en)
|
1995-05-18 |
1998-10-22 |
Altana Pharma Ag |
Phenyldihydrobenzofurans
|
|
US6080782A
(en)
|
1995-05-18 |
2000-06-27 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Cyclohexyl dihydrobenzofuranes
|
|
US6514996B2
(en)
|
1995-05-19 |
2003-02-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Derivatives of benzofuran or benzodioxole
|
|
US5637725A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
US5637724A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
CA2223996A1
(en)
|
1995-06-06 |
1996-12-19 |
Cocensys, Inc. |
Neuroactive steroids of the androstane and pregnane series
|
|
US5534522A
(en)
|
1995-06-07 |
1996-07-09 |
Warner-Lambert Company |
(R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
|
|
US5910590A
(en)
|
1995-06-07 |
1999-06-08 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
PT850215E
(pt)
|
1995-07-26 |
2001-03-30 |
Pfizer |
Derivados de acidos n-(aroil)glicina-hidroxamicos e compostos relacionados
|
|
US20010018074A1
(en)
|
1995-07-29 |
2001-08-30 |
Smithkline Beecham P.L.C. |
Process for preparing solid dosage forms of very low-dose drugs
|
|
AU6514196A
(en)
|
1995-07-31 |
1997-02-26 |
Novo Nordisk A/S |
Heterocyclic compounds, their preparation and use
|
|
DE19533975A1
(de)
|
1995-09-14 |
1997-03-20 |
Merck Patent Gmbh |
Arylalkyl-diazinone
|
|
US6166041A
(en)
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
|
US5800539A
(en)
|
1995-11-08 |
1998-09-01 |
Emory University |
Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
|
|
ZA969485B
(en)
|
1995-11-16 |
1998-05-12 |
Lilly Co Eli |
Excitatory amino acid receptor antagonists.
|
|
US5912248A
(en)
|
1995-11-16 |
1999-06-15 |
Eli Lilly And Company |
Excitatory amino acid receptor antagonists
|
|
US5688826A
(en)
|
1995-11-16 |
1997-11-18 |
Eli Lilly And Company |
Excitatory amino acid derivatives
|
|
US5756501A
(en)
|
1995-12-13 |
1998-05-26 |
American Home Products Corporation |
Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
|
|
GB9603723D0
(en)
|
1996-02-22 |
1996-04-24 |
Merck & Co Inc |
Diphenyl pyridyl derivatives as pde iv inhibitors
|
|
US5710170A
(en)
|
1995-12-15 |
1998-01-20 |
Merck Frosst Canada, Inc. |
Tri-aryl ethane derivatives as PDE IV inhibitors
|
|
GB9526246D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526243D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526245D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5804686A
(en)
|
1996-01-19 |
1998-09-08 |
Neurogen Corporation |
fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
US6211365B1
(en)
|
1996-01-19 |
2001-04-03 |
Neurogen Corporation |
Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
HU221380B1
(en)
|
1996-01-31 |
2002-09-28 |
Byk Gulden Lomberg Chem Fab |
Phosphodiesterase inhibitor phenanthridines derivatives and use thereof
|
|
GB9604926D0
(en)
|
1996-03-08 |
1996-05-08 |
Sandoz Ltd |
Organic compounds
|
|
US5792766A
(en)
|
1996-03-13 |
1998-08-11 |
Neurogen Corporation |
Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
|
|
EP0888300A1
(en)
|
1996-03-22 |
1999-01-07 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides as gaba brain receptor ligands
|
|
US5677309A
(en)
|
1996-03-22 |
1997-10-14 |
Neurogen Corporation |
1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
|
|
US6777217B1
(en)
|
1996-03-26 |
2004-08-17 |
President And Fellows Of Harvard College |
Histone deacetylases, and uses related thereto
|
|
US6127378A
(en)
|
1996-03-26 |
2000-10-03 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Phenanthridines substituted in the 6 position
|
|
FR2746800B1
(fr)
|
1996-03-29 |
1998-06-05 |
Jouveinal Inst Rech |
Diazepino-indoles inhibiteurs de phosphodiesterases 4
|
|
US6297273B1
(en)
|
1996-04-02 |
2001-10-02 |
Mars, Inc. |
Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
|
|
FR2754260B1
(fr)
|
1996-10-04 |
1998-10-30 |
Adir |
Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5723462A
(en)
|
1996-04-26 |
1998-03-03 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
|
|
US20020103194A1
(en)
|
1997-04-30 |
2002-08-01 |
Anabella Villalobos |
Novel muscarinic receptor agonists
|
|
KR20000010918A
(ko)
|
1996-05-10 |
2000-02-25 |
게리 엘. 윌콕스 |
카르볼린 유도체
|
|
US6017924A
(en)
|
1996-06-27 |
2000-01-25 |
Ligand Pharmaceuticals Incorporated |
Androgen receptor modulator compounds and methods
|
|
US20020127271A1
(en)
|
1996-07-25 |
2002-09-12 |
Smithkline Beecham P.L.C. |
Formulation for the treatment and/or prophylaxis of dementia
|
|
JP4216905B2
(ja)
|
1996-07-25 |
2009-01-28 |
メルク シヤープ エンド ドーム リミテツド |
Gaba受容体に対するリガンドとしての置換トリアゾローピリダジン誘導体
|
|
SI0956865T2
(sl)
|
1996-08-12 |
2011-04-29 |
Mitsubishi Pharma Corp |
Zdravila, ki obsegajo inhibitor Rho-kinaze
|
|
DE19632549A1
(de)
|
1996-08-13 |
1998-02-19 |
Merck Patent Gmbh |
Arylalkanoylpyridazine
|
|
PT923568E
(pt)
|
1996-08-19 |
2003-04-30 |
Altana Pharma Ag |
Novas benzofuran-4-carboxamidas
|
|
DK0920426T3
(da)
|
1996-08-26 |
2004-02-02 |
Altana Pharma Ag |
Hidtil ukendte thiazolderivater med phosphodiesteraseinhiberende virkning
|
|
US20010003588A1
(en)
|
1996-09-12 |
2001-06-14 |
Smithkline Beecham Corporation |
Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
|
|
US5834458A
(en)
|
1996-10-09 |
1998-11-10 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
AU4920397A
(en)
|
1996-10-11 |
1998-05-11 |
Chiron Corporation |
Purine inhibitors of glycogen synthase kinase 3 (gsk3)
|
|
DE19642451A1
(de)
|
1996-10-15 |
1998-04-16 |
Merck Patent Gmbh |
Aminothiophencarbonsäureamide
|
|
GB9621789D0
(en)
|
1996-10-18 |
1996-12-11 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
|
WO1998017651A1
(en)
|
1996-10-21 |
1998-04-30 |
Neurosearch A/S |
1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
|
|
GB9622386D0
(en)
|
1996-10-28 |
1997-01-08 |
Sandoz Ltd |
Organic compounds
|
|
US5773458A
(en)
|
1996-10-30 |
1998-06-30 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
US6069151A
(en)
|
1996-11-06 |
2000-05-30 |
Darwin Discovery, Ltd. |
Quinolines and their therapeutic use
|
|
WO1998021207A1
(de)
|
1996-11-12 |
1998-05-22 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
(2,3-dihydrobenzofuranyl)-thiazole als phosphodiesterasehemmer
|
|
US6054475A
(en)
|
1996-11-20 |
2000-04-25 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders
|
|
US6492554B2
(en)
|
2000-08-24 |
2002-12-10 |
The University Of Tennessee Research Corporation |
Selective androgen receptor modulators and methods of use thereof
|
|
GB9625184D0
(en)
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
DE69811645T2
(de)
|
1997-01-15 |
2003-12-04 |
Altana Pharma Ag |
Phtalazinonen
|
|
GB9702524D0
(en)
|
1997-02-07 |
1997-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
SI0975347T1
(sl)
|
1997-02-28 |
2008-08-31 |
Nycomed Gmbh |
Sinergistična kombinacija PDE inhibitorjev in agonistov adenilat ciklaze oziroma agonistov gvanil ciklize
|
|
ES2131463B1
(es)
|
1997-04-08 |
2000-03-01 |
Lilly Sa |
Derivados de ciclopropilglicina con propiedades farmaceuticas.
|
|
GB9708945D0
(en)
|
1997-05-01 |
1997-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6387673B1
(en)
|
1997-05-01 |
2002-05-14 |
The Salk Institute For Biological Studies |
Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
|
|
US6043252A
(en)
|
1997-05-05 |
2000-03-28 |
Icos Corporation |
Carboline derivatives
|
|
CA2288789C
(en)
|
1997-05-08 |
2009-07-21 |
Merck Sharp & Dohme Limited |
Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
|
|
ZA983930B
(en)
|
1997-05-14 |
1999-11-08 |
Lilly Co Eli |
Excitatory amino acid receptor modulators.
|
|
EP1014974B1
(en)
|
1997-05-29 |
2004-08-11 |
H. Lundbeck A/S |
Treatment of schizophrenia and psychosis
|
|
US6825211B1
(en)
|
1997-07-18 |
2004-11-30 |
Georgetown University |
Bicyclic metabotropic glutamate receptor ligands
|
|
JP2001515839A
(ja)
|
1997-07-18 |
2001-09-25 |
ジョージタウン・ユニバーシティ |
二環式向代謝性グルタミン酸受容体リガンド
|
|
PL191094B1
(pl)
|
1997-07-25 |
2006-03-31 |
Altana Pharma Ag |
Nowe podstawione 6-fenylofenantrydyny, środek farmaceutyczny zawierający te pochodne oraz ich zastosowanie
|
|
GB9715977D0
(en)
|
1997-07-29 |
1997-10-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ES2137113B1
(es)
|
1997-07-29 |
2000-09-16 |
Almirall Prodesfarma Sa |
Nuevos derivados de triazolo-piridazinas heterociclicos.
|
|
US6107295A
(en)
|
1997-08-01 |
2000-08-22 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Arylalkanoyl pyridazines
|
|
EP0958297A1
(en)
|
1997-08-06 |
1999-11-24 |
Suntory Limited |
1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
|
|
US6143760A
(en)
|
1997-08-25 |
2000-11-07 |
Neurogen Corporation |
Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
|
|
US6207842B1
(en)
|
1997-10-09 |
2001-03-27 |
Mars Incorporated |
Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
|
|
US6127363A
(en)
|
1997-10-28 |
2000-10-03 |
Vivus, Inc. |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6156753A
(en)
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
UA64769C2
(uk)
|
1997-11-07 |
2004-03-15 |
Х. Луннбек А/С |
Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування
|
|
HRP20020585B1
(hr)
|
1997-11-12 |
2013-02-28 |
Bayer Schering Pharma Aktiengesellschaft |
2-fenil supstituirani imidazotriazinoni kao inhibitori fosfodiesteraze
|
|
US6429207B1
(en)
|
1997-11-21 |
2002-08-06 |
Nps Pharmaceuticals, Inc. |
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
|
|
DE19882893T1
(de)
|
1997-12-12 |
2001-02-22 |
Euro Celtique Sa |
Herstellung von 3-substituierten Adeninen
|
|
IT1296985B1
(it)
|
1997-12-19 |
1999-08-03 |
Zambon Spa |
Derivati benzazinici inibitori della fosfodiesterasi 4
|
|
EP1047697A1
(en)
|
1998-01-14 |
2000-11-02 |
MERCK SHARP & DOHME LTD. |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
GB9801202D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
HRP20000492A2
(en)
|
1998-01-21 |
2000-12-31 |
Merck Sharp & Dohme |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
GB9801234D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801210D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801208D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801397D0
(en)
|
1998-01-22 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR20010005830A
(ko)
|
1998-01-29 |
2001-01-15 |
도리이 신이치로 |
타입 ⅳ 포스포디에스테라제 억제활성을 지닌 1-사이클로알킬-1,8-나프틸리딘-4-온 유도체
|
|
AU2879799A
(en)
|
1998-02-26 |
1999-09-15 |
Neurogen Corporation |
4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
|
|
US6194427B1
(en)
|
1998-02-26 |
2001-02-27 |
Neurogen Corporation |
Substituted cycloalkyl-4-Oxonicotinic carboxamides; gaba brain receptor ligands
|
|
US6156898A
(en)
|
1998-02-26 |
2000-12-05 |
Neurogen Corporation |
Substituted 1,4-dihydro-4-oxonicotinic carboxamides; GABA brain receptor ligands
|
|
US6166203A
(en)
|
1998-02-26 |
2000-12-26 |
Neurogen Corporation |
Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
|
|
US6900228B1
(en)
|
1998-03-10 |
2005-05-31 |
Research Triangle Institute |
Opiate compounds, methods of making and methods of use
|
|
US6805883B2
(en)
|
1998-03-12 |
2004-10-19 |
Mars, Incorporated |
Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
|
|
GB9806102D0
(en)
|
1998-03-20 |
1998-05-20 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
FR2776660B1
(fr)
|
1998-03-27 |
2000-05-12 |
Parke Davis |
Diazepino-indoles de phosphodiesterases iv
|
|
US6528529B1
(en)
|
1998-03-31 |
2003-03-04 |
Acadia Pharmaceuticals Inc. |
Compounds with activity on muscarinic receptors
|
|
US6784202B1
(en)
|
1998-04-17 |
2004-08-31 |
Prescient Neuropharma Inc. |
Cubane derivatives as metabotropic glutamate receptor agonists or antagonists and process for their preparation
|
|
HUP0102543A3
(en)
|
1998-04-20 |
2002-01-28 |
Pfizer |
Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction and medicaments containing them
|
|
CN1234705C
(zh)
|
1998-04-28 |
2006-01-04 |
埃尔比昂股份公司 |
新的羟基吲哚、其作为磷酸二酯酶4抑制剂的应用及其制备方法
|
|
US6897305B2
(en)
|
1998-06-08 |
2005-05-24 |
Theravance, Inc. |
Calcium channel drugs and uses
|
|
AU757198B2
(en)
|
1998-06-10 |
2003-02-06 |
Altana Pharma Ag |
Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
|
|
US6479506B1
(en)
|
1998-06-16 |
2002-11-12 |
Merck Sharp & Dohme Ltd. |
Triazolo-pyridine derivatives as ligands for GABA receptors
|
|
GB9813006D0
(en)
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CN1312807A
(zh)
|
1998-06-19 |
2001-09-12 |
希龙公司 |
糖元合成酶激酶3的抑制剂
|
|
AU761647B2
(en)
|
1998-07-06 |
2003-06-05 |
Altana Pharma Ag |
New benzoxazoles with PDE-inhibiting activity
|
|
ITMI981671A1
(it)
|
1998-07-21 |
2000-01-21 |
Zambon Spa |
Derivati ftalazinici inibitori della fosfodisterasi 4
|
|
US6177569B1
(en)
|
1998-08-25 |
2001-01-23 |
Neurogen Corporation |
Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
|
|
PT1110943E
(pt)
|
1998-08-31 |
2004-08-31 |
Taisho Pharmaceutical Co Ltd |
Derivados 6-fluorobiciclo¬3.1.0|hexano
|
|
CH694053A5
(de)
|
1998-09-03 |
2004-06-30 |
Hoffmann La Roche |
Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
|
|
JP3589985B2
(ja)
|
1998-09-03 |
2004-11-17 |
協和醗酵工業株式会社 |
含酸素複素環化合物
|
|
WO2000015639A1
(en)
|
1998-09-16 |
2000-03-23 |
Icos Corporation |
Carboline derivatives as cgmp phosphodiesterase inhibitors
|
|
US6719520B2
(en)
|
1998-10-08 |
2004-04-13 |
Smithkline Beecham Corporation |
Method and compounds
|
|
AU760688B2
(en)
|
1998-10-16 |
2003-05-22 |
Merck Sharp & Dohme Limited |
Pyrazolo-triazine derivatives as ligands for GABA receptors
|
|
CA2349700A1
(en)
|
1998-11-12 |
2000-05-18 |
Merck & Co., Inc. |
Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
|
|
PE20001236A1
(es)
|
1998-11-13 |
2000-11-10 |
Lilly Co Eli |
Moduladores del receptor de aminoacidos excitadores
|
|
SE9804064D0
(sv)
|
1998-11-25 |
1998-11-25 |
A & Science Invest Ab |
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
|
|
US6130333A
(en)
|
1998-11-27 |
2000-10-10 |
Monsanto Company |
Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use
|
|
WO2000037471A1
(en)
|
1998-12-23 |
2000-06-29 |
Neurogen Corporation |
2-amino-9-alkylpurines: gaba brain receptor ligands
|
|
ES2232416T3
(es)
|
1999-01-27 |
2005-06-01 |
MERCK SHARP & DOHME LTD. |
Derivados de triazolo-piridazina como ligandos para receptores gaba.
|
|
US6342496B1
(en)
|
1999-03-01 |
2002-01-29 |
Sepracor Inc. |
Bupropion metabolites and methods of use
|
|
US6498176B1
(en)
|
1999-03-04 |
2002-12-24 |
Smithklinebeecham Corporation |
3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
|
|
TW575561B
(en)
|
1999-03-25 |
2004-02-11 |
Hoffmann La Roche |
1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
|
|
FR2792938B1
(fr)
|
1999-04-28 |
2001-07-06 |
Warner Lambert Co |
NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
|
|
US6528499B1
(en)
|
2000-04-27 |
2003-03-04 |
Georgetown University |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
|
|
CA2367787C
(en)
|
1999-04-28 |
2011-07-26 |
Alan P. Kozikowski |
Ligands for metabotropic glutamate receptors
|
|
US6943166B1
(en)
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
|
US6316472B1
(en)
|
1999-05-13 |
2001-11-13 |
Merck Frosst Canada & Co. |
Heterosubstituted pyridine derivatives as PDE 4 inhibitors
|
|
WO2000071528A1
(en)
|
1999-05-25 |
2000-11-30 |
Neurogen Corporation |
4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
|
|
AU5073600A
(en)
|
1999-06-03 |
2000-12-28 |
Lilly, S.A. |
Excitatory amino acid receptor modulators
|
|
CA2376432A1
(en)
|
1999-06-10 |
2000-12-21 |
Takeda Chemical Industries, Ltd. |
Novel protein and dna thereof
|
|
US6146876A
(en)
|
1999-06-11 |
2000-11-14 |
Millennium Pharmaceuticals, Inc. |
22025, a novel human cyclic nucleotide phosphodiesterase
|
|
US6297256B1
(en)
|
1999-06-15 |
2001-10-02 |
Neurogen Corporation |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
|
|
DE19928146A1
(de)
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
HUP0202186A3
(en)
|
1999-07-21 |
2003-02-28 |
Fujisawa Pharmaceutical Co |
Benzimidazolone derivatives, process for their preparation, pharmaceutical compositions containing them and their use as phosphodiesterase inhibitors for producing pharmaceutical compositions
|
|
US6821975B1
(en)
|
1999-08-03 |
2004-11-23 |
Lilly Icos Llc |
Beta-carboline drug products
|
|
DE60006618T2
(de)
|
1999-08-06 |
2004-09-23 |
F. Hoffmann-La Roche Ag |
Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten
|
|
AU6525300A
(en)
|
1999-08-13 |
2001-03-13 |
Sepracor, Inc. |
Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof
|
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US6313159B1
(en)
|
1999-08-20 |
2001-11-06 |
Guilford Pharmaceuticals Inc. |
Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
|
|
GB9919957D0
(en)
|
1999-08-23 |
1999-10-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6956049B1
(en)
|
1999-08-31 |
2005-10-18 |
Merck & Co., Inc. |
Methods of modulating processes mediated by excitatory amino acid receptors
|
|
US20050014939A1
(en)
|
1999-08-31 |
2005-01-20 |
Neurogen Corporation |
Fused pyrrolecarboxamides: GABA brain receptor ligands
|
|
GB9921150D0
(en)
|
1999-09-07 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9921351D0
(en)
|
1999-09-09 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
DE60009116T2
(de)
|
1999-10-15 |
2005-02-17 |
F. Hoffmann-La Roche Ag |
Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
|
|
US7491742B2
(en)
|
1999-10-21 |
2009-02-17 |
Merck Patent Gmbh |
Imidazole derivatives as phosphodiesterase VII inhibitors
|
|
US6534287B1
(en)
|
1999-10-25 |
2003-03-18 |
Nps Pharmaceuticals, Inc. |
Human metabotropic glutamate receptor
|
|
AR029185A1
(es)
|
1999-10-25 |
2003-06-18 |
Yamanouchi Pharma Co Ltd |
Derivado de naftiridina
|
|
DE19953025A1
(de)
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Pyrrolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953414A1
(de)
|
1999-11-06 |
2001-05-10 |
Merck Patent Gmbh |
Imidazopyridinderivate als Phospodiesterase VII-Hemmer
|
|
DE19954707A1
(de)
|
1999-11-13 |
2001-05-17 |
Merck Patent Gmbh |
Imidazolverbindungen als Phosphodiesterase VII-Hemmer
|
|
WO2001038322A1
(en)
|
1999-11-23 |
2001-05-31 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
GB9927687D0
(en)
|
1999-11-23 |
2000-01-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
DE60008917T2
(de)
|
1999-12-08 |
2005-03-10 |
Grelan Pharmaceutical Co., Ltd., Hamura |
Neue 1,8-naphtyridin-2(1h)-on-derivate
|
|
ATE253918T1
(de)
|
1999-12-08 |
2003-11-15 |
Centre Nat Rech Scient |
Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel
|
|
GB9929687D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6680336B2
(en)
|
1999-12-15 |
2004-01-20 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB9929685D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6376489B1
(en)
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
WO2001044246A1
(en)
|
1999-12-17 |
2001-06-21 |
Chiron Corporation |
Bicyclic inhibitors of glycogen synthase kinase 3
|
|
US6258833B1
(en)
|
1999-12-23 |
2001-07-10 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6362213B1
(en)
|
1999-12-23 |
2002-03-26 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6569885B1
(en)
|
1999-12-23 |
2003-05-27 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6348602B1
(en)
|
1999-12-23 |
2002-02-19 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6313156B1
(en)
|
1999-12-23 |
2001-11-06 |
Icos Corporation |
Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors
|
|
US6294561B1
(en)
|
1999-12-23 |
2001-09-25 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB0000564D0
(en)
|
2000-01-11 |
2000-03-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
SK10342002A3
(sk)
|
2000-01-31 |
2003-12-02 |
Pfizer Products Inc. |
Pyrimidínkarboxamidy užitočné ako selektívne inhibítory izozymov PDE4
|
|
AU2001233156A1
(en)
|
2000-02-01 |
2001-08-14 |
Human Genome Sciences, Inc. |
Bcl-2-like polynucleotides, polypeptides, and antibodies
|
|
WO2001056990A2
(en)
|
2000-02-03 |
2001-08-09 |
Eli Lilly And Company |
Pyridine derivates as potentiators of glutamate receptors
|
|
US20010039275A1
(en)
|
2000-02-04 |
2001-11-08 |
Bowler Andrew Neil |
Use of 2,4-diaminothiazole derivatives
|
|
US20010034373A1
(en)
*
|
2000-02-09 |
2001-10-25 |
Matthew Miller |
Low dose modafinil for enhancement of cognitive function
|
|
GB0003254D0
(en)
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
FR2804959B1
(fr)
|
2000-02-15 |
2006-04-28 |
Centre Nat Rech Scient |
Utilisation de derives de paullones pour la fabrication de medicaments
|
|
EP1260512B1
(en)
|
2000-02-29 |
2007-07-04 |
Mitsubishi Pharma Corporation |
Novel cyclic amide derivatives
|
|
GB0005700D0
(en)
|
2000-03-09 |
2000-05-03 |
Glaxo Group Ltd |
Therapy
|
|
AU2001250892A1
(en)
|
2000-03-20 |
2001-10-03 |
Teva Pharmaceutical Industries Ltd. |
Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
|
|
US6924292B2
(en)
|
2000-03-23 |
2005-08-02 |
Takeda Chemical Industries, Ltd. |
Furoisoquinoline derivatives, process for producing the same and use thereof
|
|
US7288567B2
(en)
|
2000-03-24 |
2007-10-30 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
GB0007193D0
(en)
|
2000-03-25 |
2000-05-17 |
Univ Manchester |
Treatment of movrmrnt disorders
|
|
GB0008696D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU2001253294A1
(en)
|
2000-04-14 |
2001-10-30 |
Mars, Incorporated |
Compositions and methods for improving vascular health
|
|
CA2306170A1
(en)
|
2000-04-18 |
2001-10-18 |
Kenneth Curry |
Novel amino, carboxy derivatives of barbituric acid
|
|
AR028385A1
(es)
|
2000-04-28 |
2003-05-07 |
Acadia Pharm Inc |
Agonistas muscarinicos
|
|
AU2001256039A1
(en)
|
2000-05-11 |
2001-11-20 |
Kenneth Curry |
Novel spiro(2.4)heptane amino carboxy compounds and derivatives thereof
|
|
WO2001085685A1
(en)
|
2000-05-11 |
2001-11-15 |
Consejo Superior Investigaciones Cientificas |
Heterocyclic inhibitors of glycogen synthase kinase gsk-3
|
|
UA74826C2
(en)
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
AU783521B2
(en)
|
2000-05-24 |
2005-11-03 |
Merck Sharp & Dohme Limited |
3-phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors
|
|
AU781526B2
(en)
|
2000-05-30 |
2005-05-26 |
Societe Des Produits Nestle S.A. |
Primary composition containing a lipophilic bioactive compound
|
|
US7081481B2
(en)
|
2000-05-31 |
2006-07-25 |
Eli Lilly And Company |
Excitatory amino acid receptor modulators
|
|
WO2001094350A1
(en)
|
2000-06-07 |
2001-12-13 |
Almirall Prodesfarma S.A. |
6-phenylpyrrolopyrimidinedione derivatives
|
|
US6825197B2
(en)
|
2000-06-23 |
2004-11-30 |
Lilly Icos Llc |
Cyclic GMP-specific phosphodiesterase inhibitors
|
|
US6589978B2
(en)
|
2000-06-30 |
2003-07-08 |
Hoffman-La Roche Inc. |
1-sulfonyl pyrrolidine derivatives
|
|
US6399641B1
(en)
|
2000-07-13 |
2002-06-04 |
Hoffmann-La Roche Inc. |
2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists
|
|
GB0018473D0
(en)
|
2000-07-27 |
2000-09-13 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1307201B1
(de)
|
2000-08-01 |
2004-11-24 |
Bayer HealthCare AG |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
US6645990B2
(en)
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
US6576644B2
(en)
|
2000-09-06 |
2003-06-10 |
Bristol-Myers Squibb Co. |
Quinoline inhibitors of cGMP phosphodiesterase
|
|
AU2001288972A1
(en)
|
2000-09-11 |
2002-03-26 |
Sepracor, Inc. |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
|
|
ATE346064T1
(de)
|
2000-09-15 |
2006-12-15 |
Vertex Pharma |
Pyrazolverbindungen als protein-kinasehemmer
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US7569724B2
(en)
|
2000-09-29 |
2009-08-04 |
Topotarget Uk Limited |
Carbamic acid compounds comprising an amide linkage as HDAC inhibitors
|
|
GB0023983D0
(en)
|
2000-09-29 |
2000-11-15 |
Prolifix Ltd |
Therapeutic compounds
|
|
US6888027B2
(en)
|
2000-09-29 |
2005-05-03 |
Topotarget Uk Limited |
Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
|
|
CA2421782A1
(en)
|
2000-10-02 |
2002-04-11 |
Janssen Pharmaceutica N.V. |
Quinoline and quinolinone derivatives as metabotropic glutamate receptor antagonists
|
|
EP1193261A1
(en)
|
2000-10-02 |
2002-04-03 |
Warner-Lambert Company |
New thiadiazoles and their use as phosphodiesterase-7 inhibitors
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
GB0027561D0
(en)
|
2000-11-10 |
2000-12-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2427779A1
(en)
|
2000-11-10 |
2002-05-16 |
Merck Sharp & Dohme Limited |
Imidazo-triazine derivatives as ligands for gaba receptors
|
|
GB0117277D0
(en)
|
2001-07-16 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
SK5782003A3
(en)
|
2000-11-14 |
2003-10-07 |
Altana Pharma Ag |
3,4-Dihydroisoquinoline and isoquinoline compounds, pharmaceutical composition comprising the same and their use
|
|
AR035659A1
(es)
|
2000-12-07 |
2004-06-23 |
Hoffmann La Roche |
Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos
|
|
US6930114B2
(en)
|
2000-12-13 |
2005-08-16 |
Bayer Pharmaceuticals Corporation |
Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
|
|
US6900215B2
(en)
|
2000-12-15 |
2005-05-31 |
Merck Sharp & Dohme Ltd. |
Imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
US6720445B2
(en)
|
2000-12-21 |
2004-04-13 |
Beacon Laboratories, Inc. |
Acetyloxymethyl esters and methods for using the same
|
|
WO2002068415A1
(en)
|
2000-12-21 |
2002-09-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6562995B1
(en)
|
2000-12-21 |
2003-05-13 |
Beacon Laboratories, Inc. |
Delta dicarbonyl compounds and methods for using the same
|
|
MXPA03005515A
(es)
|
2000-12-22 |
2003-09-25 |
Hoffmann La Roche |
Derivados de tetrahidro-(benzo o tieno)-azepina-pirazina y triazina como antagonistas de mglur 1.
|
|
AR035513A1
(es)
|
2000-12-23 |
2004-06-02 |
Hoffmann La Roche |
Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos
|
|
GR1003861B
(el)
|
2000-12-29 |
2002-04-11 |
|
Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
|
|
US6974824B2
(en)
|
2001-01-08 |
2005-12-13 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
AR035417A1
(es)
|
2001-01-27 |
2004-05-26 |
Hoffmann La Roche |
Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
|
|
EA200300652A1
(ru)
|
2001-01-31 |
2003-12-25 |
Пфайзер Продактс Инк. |
Эфирные производные, полезные в качестве ингибиторов изозимов pde4
|
|
EP1355884A1
(en)
|
2001-01-31 |
2003-10-29 |
Pfizer Products Inc. |
Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
|
|
PL365443A1
(en)
|
2001-01-31 |
2005-01-10 |
Pfizer Products Inc. |
Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
|
|
US6559159B2
(en)
|
2001-02-01 |
2003-05-06 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
|
US20020177594A1
(en)
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
US6900329B2
(en)
|
2001-03-21 |
2005-05-31 |
Schering Corporation |
MCH antagonists and their use in the treatment of obesity
|
|
AP1699A
(en)
|
2001-03-21 |
2006-12-26 |
Warner Lambert Co |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
|
CA2439117C
(en)
|
2001-04-19 |
2011-02-08 |
Mitsubishi Pharma Corporation |
Polymorph forms of n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
GB0111191D0
(en)
|
2001-05-08 |
2001-06-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US20030187027A1
(en)
|
2001-05-09 |
2003-10-02 |
Schreiber Stuart L. |
Dioxanes and uses thereof
|
|
MXPA03010961A
(es)
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
EP1401821A4
(en)
|
2001-06-12 |
2006-05-31 |
Sk Corp |
NOVEL ANALOGUES OF PHENYLALKYL DIAMINE AND AMIDE
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
EP1397142A4
(en)
|
2001-06-19 |
2004-11-03 |
Bristol Myers Squibb Co |
PYRIMIDINE PHOSPHODIESTERASE (PDE) INHIBITORS 7
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
GB0117060D0
(en)
|
2001-07-12 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JPWO2003013522A1
(ja)
|
2001-08-06 |
2004-12-02 |
三菱ウェルファーマ株式会社 |
コリン作動性神経障害予防・治療薬
|
|
EP1285922A1
(en)
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
|
|
JO2311B1
(en)
|
2001-08-29 |
2005-09-12 |
ميرك فروست كندا ليمتد |
Alkyl inhibitors Ariel phosphodiesterase-4
|
|
KR20100107509A
(ko)
|
2001-09-14 |
2010-10-05 |
9222-9129 퀘벡 인코포레이티드 |
히스톤 데아세틸라아제의 억제제
|
|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1295885A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
|
|
EP1295884A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
|
|
JP2005504808A
(ja)
|
2001-09-26 |
2005-02-17 |
バイエル・フアーマシユーチカルズ・コーポレーシヨン |
抗糖尿病薬としての1,6−ナフチリジン誘導体
|
|
KR20040047877A
(ko)
|
2001-10-02 |
2004-06-05 |
아카디아 파마슈티칼스 인코포레이티드 |
무스카린 제제로서 벤즈이미다졸리디논 유도체
|
|
US6951849B2
(en)
|
2001-10-02 |
2005-10-04 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
US6924311B2
(en)
|
2001-10-17 |
2005-08-02 |
X-Ceptor Therapeutics, Inc. |
Methods for affecting various diseases utilizing LXR compounds
|
|
KR20040047935A
(ko)
|
2001-10-25 |
2004-06-05 |
쉐링 코포레이션 |
비만 치료용 mch 길항제
|
|
HUP0402330A3
(en)
|
2001-11-01 |
2010-03-29 |
Janssen Pharmaceutica Nv |
Amide derivatives as glycogen synthase kinase 3-beta inhibitors, process for producing them, pharmaceutical compositions containing them and use thereof
|
|
IL161662A0
(en)
|
2001-11-01 |
2004-09-27 |
Janssen Pharmaceutica Nv |
Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors (gsk3 inhibitors)
|
|
WO2003042213A1
(en)
|
2001-11-14 |
2003-05-22 |
Ortho-Mcneil Pharmaceutical Corporation |
Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
|
|
FR2832711B1
(fr)
|
2001-11-26 |
2004-01-30 |
Warner Lambert Co |
Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
|
|
US7087601B2
(en)
|
2001-11-30 |
2006-08-08 |
Merck & Co., Inc. |
Metabotropic glutamate receptor-5 modulators
|
|
ES2294189T3
(es)
|
2001-12-13 |
2008-04-01 |
Asubio Pharma Co., Ltd. |
Derivados de pirazolopirimidinona que tienen accion inhibidora de pde7.
|
|
DE60223720T2
(de)
|
2001-12-18 |
2008-10-30 |
Merck & Co., Inc. |
Heteroaryl-substituierte pyrazol-modulatoren des metabotropen glutamatrezeptors-5
|
|
CA2469821C
(en)
|
2001-12-18 |
2009-10-20 |
Merck & Co., Inc. |
Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
EP1458385A4
(en)
|
2001-12-19 |
2005-12-21 |
Merck & Co Inc |
METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS
|
|
US7371767B2
(en)
|
2001-12-21 |
2008-05-13 |
Merck & Co., Inc. |
Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
|
|
DE10163991A1
(de)
|
2001-12-24 |
2003-07-03 |
Merck Patent Gmbh |
Pyrrolo-pyrimidine
|
|
MXPA04006322A
(es)
|
2001-12-27 |
2004-10-04 |
Taisho Pharmaceutical Co Ltd |
Derivados de 6-fluorobiciclo[3.1.0]hexano.
|
|
CA2366325A1
(en)
|
2001-12-27 |
2003-06-27 |
Todd Howley |
Method of forming turbine blade root
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
AU2002359875B2
(en)
|
2001-12-28 |
2009-01-08 |
Acadia Pharmaceuticals Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
RU2315051C2
(ru)
|
2001-12-28 |
2008-01-20 |
Акадиа Фармасьютикалз, Инк. |
Спироазациклические соединения, способ ингибирования активности или активации серотонинового 5-нт2а рецептора, способ лечения болезненного состояния, связанного с серотониновым 5-нт2а рецептором, и их применение
|
|
US6495700B1
(en)
|
2002-01-09 |
2002-12-17 |
Axonyx, Inc. |
Process for producing phenserine and its analog
|
|
WO2003061658A1
(en)
|
2002-01-22 |
2003-07-31 |
Eisai Co., Ltd. |
Sigma receptor binder containing indanone derivative
|
|
WO2003064389A1
(en)
|
2002-01-31 |
2003-08-07 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
|
|
AP2004003100A0
(en)
|
2002-02-11 |
2004-09-30 |
Pfizer |
Nicotinamide derivatives useful as PDE4 inhibitors
|
|
JPWO2003070730A1
(ja)
|
2002-02-22 |
2005-06-09 |
帝人株式会社 |
ピロロピリミジン誘導体
|
|
US7592337B2
(en)
|
2002-03-12 |
2009-09-22 |
Merck & Co., Inc. |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
|
|
ATE395343T1
(de)
|
2002-03-13 |
2008-05-15 |
Janssen Pharmaceutica Nv |
Sulfonylderivate als histone-deacetylase- inhibitoren
|
|
US7501417B2
(en)
|
2002-03-13 |
2009-03-10 |
Janssen Pharmaceutica, N.V. |
Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase
|
|
DE60321667D1
(en)
|
2002-03-13 |
2008-07-31 |
Janssen Pharmaceutica Nv |
Piperazinyl-, piperidinyl- und morpholinylderivate als neue inhibitoren von histon-deacetylase
|
|
OA12793A
(en)
|
2002-03-13 |
2006-07-10 |
Janssen Pharmaceutica Nv |
Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
|
|
EP1346640B1
(en)
|
2002-03-20 |
2007-05-09 |
Société des Produits Nestlé S.A. |
A low fat cocoa extract
|
|
US7514107B2
(en)
|
2002-03-21 |
2009-04-07 |
Mars, Incorporated |
Treatment of diseases involving defective gap junctional communication
|
|
NZ536116A
(en)
|
2002-04-03 |
2007-01-26 |
Topotarget Uk Ltd |
Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
|
|
GB0210124D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0212048D0
(en)
|
2002-05-24 |
2002-07-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
EP1534707B9
(en)
|
2002-06-19 |
2008-11-26 |
Janssen Pharmaceutica N.V. |
Substituted 2,4-dihydro-pyrrolo (3, 4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors
|
|
US7405230B2
(en)
|
2002-07-19 |
2008-07-29 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
|
|
EP1400244A1
(en)
|
2002-09-17 |
2004-03-24 |
Warner-Lambert Company LLC |
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
|
|
US7323334B2
(en)
|
2002-10-04 |
2008-01-29 |
The Regents Of The University Of California |
Screening and therapeutic methods relating to neurogenesis
|
|
CA2502819A1
(en)
|
2002-10-21 |
2004-05-06 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
US6969702B2
(en)
|
2002-11-20 |
2005-11-29 |
Neuronova Ab |
Compounds and methods for increasing neurogenesis
|
|
US20050009847A1
(en)
|
2002-11-20 |
2005-01-13 |
Goran Bertilsson |
Compounds and methods for increasing neurogenesis
|
|
US20040185429A1
(en)
|
2002-12-09 |
2004-09-23 |
Judith Kelleher-Andersson |
Method for discovering neurogenic agents
|
|
ES2209650B2
(es)
|
2002-12-09 |
2006-11-01 |
Laboratorios Del Dr. Esteve, S.A. |
Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
|
|
WO2004063201A1
(ja)
*
|
2003-01-08 |
2004-07-29 |
Mitsubishi Pharma Corporation |
統合失調症治療剤
|
|
US7135493B2
(en)
|
2003-01-13 |
2006-11-14 |
Astellas Pharma Inc. |
HDAC inhibitor
|
|
BRPI0406810A
(pt)
|
2003-01-31 |
2005-12-27 |
Astrazeneca Ab |
Compostos, processos de preparação e uso respectivos, composição farmacêutica e métodos de inibição da ativação dos receptores de mglur do grupo i e de tratamento de desordens mediadas pelos mesmos
|
|
US6969716B2
(en)
|
2003-02-07 |
2005-11-29 |
Merck Sharp & Dohme Ltd. |
5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression
|
|
CA2515132C
(en)
|
2003-02-07 |
2012-01-03 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl substituted pyrroles useful as inhibitors of protein kinases
|
|
TWI292318B
(en)
|
2003-03-10 |
2008-01-11 |
Hoffmann La Roche |
Imidazol-4-yl-ethynyl-pyridine derivatives
|
|
EP1608628A2
(en)
|
2003-03-17 |
2005-12-28 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
BRPI0409523A
(pt)
|
2003-03-28 |
2006-04-18 |
Acadia Pharm Inc |
método para o tratamento da dor neuropática, método de identificação de um composto e composição farmacêutica
|
|
ES2290741T3
(es)
|
2003-04-04 |
2008-02-16 |
Dynogen Pharmaceuticals Inc. |
Metodo de tratamiento de trastornos del tracto urinario inferior.
|
|
SG169900A1
(en)
|
2003-04-16 |
2011-04-29 |
Memory Pharm Corp |
4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
|
|
EP1622577A4
(en)
|
2003-04-17 |
2007-09-26 |
Univ Leland Stanford Junior |
PREVENTION OF NEUROGENESE DEFICITES WITH ANTI-INFLAMMATORY AGENTS
|
|
GB0311859D0
(en)
|
2003-05-22 |
2003-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7763588B2
(en)
|
2003-06-13 |
2010-07-27 |
The Salk Institute For Biological Studies |
Method for increasing cognitive function and neurogenesis
|
|
US7842835B2
(en)
|
2003-07-07 |
2010-11-30 |
Georgetown University |
Histone deacetylase inhibitors and methods of use thereof
|
|
SI1651234T1
(sl)
|
2003-07-25 |
2008-02-29 |
Hoffmann La Roche |
Kombinacija antagonista mglur2 in inhibitorja ache za zdravljenje akutnih in/ali kronicnih nevroloskih motenj
|
|
JP2007519393A
(ja)
|
2003-08-05 |
2007-07-19 |
ユニバーシティー オブ フロリダ リサーチ ファンデーション, インク. |
神経系細胞アッセイ
|
|
TWI339206B
(en)
|
2003-09-04 |
2011-03-21 |
Vertex Pharma |
Compositions useful as inhibitors of protein kinases
|
|
CA2541548A1
(en)
|
2003-10-10 |
2005-04-21 |
Mars, Incorporated |
Treatment of diseases involving erbb2 kinase overexpression
|
|
DE602004020042D1
(de)
*
|
2003-12-02 |
2009-04-30 |
Pharmaneuroboost N V |
er SSRI zur Behandlung von Stimmungs- oder Angststörungen
|
|
US20050159470A1
(en)
|
2003-12-19 |
2005-07-21 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
WO2005066151A2
(en)
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
NZ547911A
(en)
|
2003-12-22 |
2010-06-25 |
Acadia Pharm Inc |
Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
|
|
WO2005074632A2
(en)
|
2004-01-30 |
2005-08-18 |
Mars, Incorporated |
Methods and compositions for treating cancer
|
|
TWI301760B
(en)
|
2004-02-27 |
2008-10-11 |
Merz Pharma Gmbh & Co Kgaa |
Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
|
|
US20070015138A1
(en)
|
2005-07-08 |
2007-01-18 |
Braincells, Inc. |
Methods for identifying agents and conditions that modulate neurogenesis
|
|
JP2009525979A
(ja)
*
|
2006-02-07 |
2009-07-16 |
田辺三菱製薬株式会社 |
4−アシルアミノピリジン誘導体を介した神経新生
|