HRP20110570T1 - Amidi diazabicikloalkana selektivni na podvrstu nikotinskih acetilkolinskih receptora - Google Patents
Amidi diazabicikloalkana selektivni na podvrstu nikotinskih acetilkolinskih receptora Download PDFInfo
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- HRP20110570T1 HRP20110570T1 HR20110570T HRP20110570T HRP20110570T1 HR P20110570 T1 HRP20110570 T1 HR P20110570T1 HR 20110570 T HR20110570 T HR 20110570T HR P20110570 T HRP20110570 T HR P20110570T HR P20110570 T1 HRP20110570 T1 HR P20110570T1
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 title 1
- 229960004373 acetylcholine Drugs 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 9
- GTUIQNHJSXQMKW-OCAPTIKFSA-N [(3aS,6aR)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-(5-chlorofuran-2-yl)methanone Chemical compound Clc1ccc(o1)C(=O)N1C[C@@H]2CNC[C@@H]2C1 GTUIQNHJSXQMKW-OCAPTIKFSA-N 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 4
- 201000000980 schizophrenia Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 230000007278 cognition impairment Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010065040 AIDS dementia complex Diseases 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 206010036631 Presenile dementia Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010013932 dyslexia Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000022610 schizoaffective disease Diseases 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Spoj N-(5-klorofuran-2-ilkarbonil)-3,7-diazabiciklo[3.3.0]oktan, ili neka njegova farmaceutski prihvatljiva sol. Patent sadrži još 8 patentnih zahtjeva.
Claims (9)
1. Spoj N-(5-klorofuran-2-ilkarbonil)-3,7-diazabiciklo[3.3.0]oktan, ili neka njegova farmaceutski prihvatljiva sol.
2. Spoj prema zahtjevu 1, za upotrebu u tretiranju poremećaja središnjeg živčanog sustava.
3. Farmaceutska kompozicija, koja kao aktivni sastojak sadrži terapeutski efikasnu količinu nekog spoja prema zahtjevu 1 ili 2, i jedan ili više farmaceutski prihvatljivih razblaživača, ekscipijenata i/ili inertnih nosača.
4. Farmaceutska kompozicija prema zahtjevu 3, u kojoj se N-(5-klorofuran-2-ilkarbonil)-3,7-diazabiciklo[3.3.0]oktan, ili neka njegova farmaceutski prihvatljiva sol nalazi u opsegu doze od oko 100 mg/kg do oko 1 mg/kg na dan.
5. Upotreba spoja prema zahtjevu 1 ili 2, ili kompozicije prema zahtjevu 3 ili 4, za proizvodnju lijeka za tretman poremećaja središnjeg živčanog sustava.
6. Spoj prema zahtjevu 2, kompozicija prema zahtjevima 3 ili 4, ili upotreba prema zahtjevu 5, gdje se poremećaji biraju iz skupine koju čine neusaglašenost memorije uslijed starenja, blaga kognitivna neusaglašenost, pre-senilna demencija (rani početak pojave Alzheimerove bolesti), senilna demencija (demencija Alzheimerovog tipa), demencija sa Lewyjevim tijelima, vaskularna demencija, Alzheimerova bolest, moždani udar, kompleks AIDS demencije, poremećaj smanjenja pažnje, kognitivni deficit, poremećaj hiperaktivnosti uslijed smanjenja pažnje, disleksija, shizofrenija, poremećaji shizofrenog oblika i shizoafektivni poremećaji.
7. Spoj, kompozicija ili upotreba prema zahtjevu 6, gdje se poremećaj bira iz skupine koju čine blaga do umjerena demencija Alzheimerovog tipa, blaga kognitivna neusaglašenost i neusaglašenost memorije uslijed starenja.
8. Spoj, kompozicija ili upotreba prema zahtjevu 6, gdje poremećaj predstavlja poremećaj smanjenja pažnje ili poremećaj hiperaktivnosti uslijed smanjenja pažnje.
9. Spoj, kompozicija ili upotreba prema zahtjevu 6, gdje poremećaj predstavlja shizofrenija, poremećaj shizofrenog oblika, kognitivni deficit ili shizoafektivni poremećaj.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85607906P | 2006-11-02 | 2006-11-02 | |
| PCT/US2007/083330 WO2008057938A1 (en) | 2006-11-02 | 2007-11-01 | Nicotinic acetylcholine receptorsub-type selective amides of diazabicycloalkanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110570T1 true HRP20110570T1 (hr) | 2011-09-30 |
Family
ID=39233054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110570T HRP20110570T1 (hr) | 2006-11-02 | 2011-08-02 | Amidi diazabicikloalkana selektivni na podvrstu nikotinskih acetilkolinskih receptora |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US8114889B2 (hr) |
| EP (2) | EP2284171B1 (hr) |
| JP (2) | JP5539723B2 (hr) |
| KR (2) | KR101415705B1 (hr) |
| CN (4) | CN102942569B (hr) |
| AR (2) | AR063451A1 (hr) |
| AT (2) | ATE509022T1 (hr) |
| AU (2) | AU2007317433B2 (hr) |
| BR (2) | BRPI0717930A2 (hr) |
| CA (1) | CA2663925C (hr) |
| CL (1) | CL2007003155A1 (hr) |
| CO (1) | CO6180435A2 (hr) |
| CY (1) | CY1112374T1 (hr) |
| DK (1) | DK2094703T3 (hr) |
| ES (2) | ES2395157T3 (hr) |
| HK (2) | HK1133260A1 (hr) |
| HR (1) | HRP20110570T1 (hr) |
| IL (2) | IL197618A (hr) |
| MX (1) | MX2009004801A (hr) |
| MY (2) | MY156730A (hr) |
| NO (1) | NO20091251L (hr) |
| NZ (2) | NZ587847A (hr) |
| PE (2) | PE20081441A1 (hr) |
| PL (1) | PL2094703T3 (hr) |
| PT (1) | PT2094703E (hr) |
| RS (1) | RS51834B (hr) |
| RU (2) | RU2448969C2 (hr) |
| SA (1) | SA07280584B1 (hr) |
| SI (1) | SI2094703T1 (hr) |
| TW (3) | TWI454262B (hr) |
| UA (2) | UA98944C2 (hr) |
| UY (1) | UY30686A1 (hr) |
| WO (1) | WO2008057938A1 (hr) |
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| TWI454262B (zh) * | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
| EP2257549A1 (en) * | 2008-03-05 | 2010-12-08 | Targacept Inc. | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloal kanes |
| WO2009113950A1 (en) * | 2008-03-10 | 2009-09-17 | Astrazeneca Ab | Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist |
| ES2383246T3 (es) | 2008-06-05 | 2012-06-19 | Glaxo Group Limited | 4-amino-indazoles |
| US8536169B2 (en) | 2008-06-05 | 2013-09-17 | Glaxo Group Limited | Compounds |
| ES2445199T3 (es) | 2008-06-05 | 2014-02-28 | Glaxo Group Limited | Derivados de benzpirazol como inhibidores de PI3-quinasas |
| WO2010028011A1 (en) * | 2008-09-05 | 2010-03-11 | Targacept, Inc. | Amides of diazabicyclononanes and uses thereof |
| US20110263629A1 (en) * | 2008-09-05 | 2011-10-27 | Targacept, Inc. | Amides of diazabicyclooctanes and uses thereof |
| WO2010080757A2 (en) | 2009-01-07 | 2010-07-15 | Astrazeneca Ab | Combinations with an alpha-4beta-2 nicotinic agonist |
| US8524751B2 (en) | 2009-03-09 | 2013-09-03 | GlaxoSmithKline Intellecutual Property Development | 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases |
| US8575162B2 (en) | 2009-04-30 | 2013-11-05 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| RU2417082C2 (ru) * | 2009-07-14 | 2011-04-27 | Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) | Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения |
| HUE033352T2 (en) | 2009-11-18 | 2017-11-28 | Suven Life Sciences Ltd | Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands |
| ES2552932T3 (es) | 2009-12-29 | 2015-12-03 | Suven Life Sciences Limited | Ligandos del receptor nicotínico neuronal de la acetilcolina alfa4beta2 |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| HUE036117T2 (hu) | 2013-11-26 | 2018-06-28 | Hoffmann La Roche | Oktahidro-ciklobuta[1,2-C;3,4-C']dipirrol származékok, mint autotaxin inhibitorok |
| MA39792B1 (fr) | 2014-03-26 | 2019-12-31 | Hoffmann La Roche | Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa) |
| WO2016064759A1 (en) | 2014-10-20 | 2016-04-28 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| UA123362C2 (uk) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильні похідні |
| CN107614505B (zh) * | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | 作为双重atx/ca抑制剂的新型二环化合物 |
| WO2017050791A1 (en) * | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| WO2017177024A1 (en) | 2016-04-07 | 2017-10-12 | Oyster Point Pharma, Inc. | Methods of treating ocular conditions |
| AU2018233079B9 (en) | 2017-03-16 | 2021-07-22 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual ATX/CA inhibitors |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| PL3448859T3 (pl) | 2017-03-20 | 2020-02-28 | Forma Therapeutics, Inc. | Kompozycje pirolopirolu jako aktywatory kinazy pirogronianowej (PKR) |
| JP7450610B2 (ja) | 2018-09-19 | 2024-03-15 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | ピルビン酸キナーゼｒの活性化 |
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| MXPA03008109A (es) | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
| AU2002320958B2 (en) | 2001-07-06 | 2008-02-28 | Neurosearch A/S | Novel compounds, their preparation and use |
| SE0202430D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| AU2004215658B2 (en) * | 2003-02-27 | 2010-06-24 | Neurosearch A/S | Novel diazabicyclic aryl derivatives |
| CN1317280C (zh) * | 2003-02-27 | 2007-05-23 | 神经研究公司 | 新的二氮杂双环芳基衍生物 |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| US7365193B2 (en) * | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
| DE602005004144T2 (de) * | 2004-06-09 | 2009-01-29 | F. Hoffmann-La Roche Ag | Octahydropyrroloä3,4-cüpyrrolderivate und deren verwendung als antivirale mittel |
| DE602005013671D1 (de) | 2004-07-22 | 2009-05-14 | Cumbre Pharmaceuticals Inc | (r/s) rifamycin-derivate, ihre herstellung und pharmazeutische zusammensetzungen |
| EP1893212B1 (en) * | 2005-05-13 | 2013-10-16 | Lexicon Pharmaceuticals, Inc. | Multicyclic compounds and methods of their use |
| TWI454262B (zh) * | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
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2007
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