JP2009503114A5 - - Google Patents
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- Publication number
- JP2009503114A5 JP2009503114A5 JP2008525242A JP2008525242A JP2009503114A5 JP 2009503114 A5 JP2009503114 A5 JP 2009503114A5 JP 2008525242 A JP2008525242 A JP 2008525242A JP 2008525242 A JP2008525242 A JP 2008525242A JP 2009503114 A5 JP2009503114 A5 JP 2009503114A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- phenyl
- dimethoxyphenyl
- unsubstituted
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 2,4-dimethoxyphenyl Chemical group 0.000 claims 60
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 17
- 230000003381 solubilizing effect Effects 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 7
- 125000001544 thienyl group Chemical group 0.000 claims 7
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000004188 dichlorophenyl group Chemical group 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70561205P | 2005-08-04 | 2005-08-04 | |
| US60/705,612 | 2005-08-04 | ||
| US74178305P | 2005-12-02 | 2005-12-02 | |
| US60/741,783 | 2005-12-02 | ||
| US77937006P | 2006-03-03 | 2006-03-03 | |
| US60/779,370 | 2006-03-03 | ||
| US79227606P | 2006-04-14 | 2006-04-14 | |
| US60/792,276 | 2006-04-14 | ||
| PCT/US2006/030512 WO2007019346A1 (en) | 2005-08-04 | 2006-08-04 | Benzothiazoles and thiazolopyridines as sirtuin modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012126044A Division JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009503114A JP2009503114A (ja) | 2009-01-29 |
| JP2009503114A5 true JP2009503114A5 (https=) | 2009-09-17 |
| JP5203195B2 JP5203195B2 (ja) | 2013-06-05 |
Family
ID=37074951
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
| JP2008525242A Expired - Fee Related JP5203195B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525272A Pending JP2009503117A (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのベンゾイミダゾール誘導体 |
| JP2008525240A Expired - Fee Related JP5203193B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
| JP2008525273A Expired - Fee Related JP5203196B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュインモジュレーターとしてのオキサゾロピリジン誘導体 |
| JP2008525241A Expired - Fee Related JP5203194B2 (ja) | 2005-08-04 | 2006-08-04 | サーチュイン調節因子としてのイミダゾピリジン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012126044A Withdrawn JP2012211149A (ja) | 2005-08-04 | 2012-06-01 | サーチュインモジュレーターとしてのベンゾチアゾールおよびチアゾロピリジン |
| JP2012125926A Withdrawn JP2012214480A (ja) | 2005-08-04 | 2012-06-01 | サーチュイン調節化合物としてのイミダゾ［２，１−ｂ］チアゾール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20070037865A1 (https=) |
| EP (7) | EP1910385B1 (https=) |
| JP (7) | JP2009503117A (https=) |
| CN (1) | CN103145738A (https=) |
| AU (5) | AU2006278397B2 (https=) |
| CA (5) | CA2618370A1 (https=) |
| DK (1) | DK1910384T3 (https=) |
| ES (3) | ES2396913T3 (https=) |
| PL (1) | PL1910384T3 (https=) |
| PT (1) | PT1910384E (https=) |
| WO (5) | WO2007019416A1 (https=) |
Families Citing this family (235)
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| CN102793972A (zh) * | 2004-12-27 | 2012-11-28 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病 |
| US11207518B2 (en) * | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| EP1833819A1 (en) | 2004-12-30 | 2007-09-19 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases |
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- 2006-08-04 US US11/499,920 patent/US20070037865A1/en not_active Abandoned
- 2006-08-04 EP EP06789500A patent/EP1909910A1/en not_active Withdrawn
- 2006-08-04 WO PCT/US2006/030510 patent/WO2007019344A1/en not_active Ceased
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