|
US20090169585A1
(en)
*
|
2003-10-23 |
2009-07-02 |
Resveratrol Partners, Llc |
Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
|
|
US20050158376A1
(en)
*
|
2003-10-23 |
2005-07-21 |
Sardi William F. |
Dietary supplement and method of processing same
|
|
US10912712B2
(en)
|
2004-03-25 |
2021-02-09 |
The Feinstein Institutes For Medical Research |
Treatment of bleeding by non-invasive stimulation
|
|
CN1964627B
(zh)
*
|
2004-06-04 |
2011-10-19 |
华盛顿大学 |
治疗神经病变的方法和组合物
|
|
CN101124012B
(zh)
*
|
2004-12-27 |
2012-09-05 |
范因斯坦医学研究院 |
通过电刺激迷走神经治疗炎症性疾病的装置
|
|
US11207518B2
(en)
*
|
2004-12-27 |
2021-12-28 |
The Feinstein Institutes For Medical Research |
Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
|
|
MX2007008008A
(es)
|
2004-12-30 |
2007-11-12 |
Astex Therapeutics Ltd |
Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
|
|
EP1850840A2
(en)
*
|
2005-01-13 |
2007-11-07 |
Sirtris Pharmaceuticals, Inc. |
Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
|
|
EP1853610A1
(en)
*
|
2005-03-03 |
2007-11-14 |
Sirtris Pharmaceuticals, Inc. |
N-phenyl benzamide derivatives as sirtuin modulators
|
|
EP2805719A1
(en)
*
|
2005-03-30 |
2014-11-26 |
Glaxosmithkline LLC |
Nicotinamide riboside and analogues thereof
|
|
US20070014833A1
(en)
*
|
2005-03-30 |
2007-01-18 |
Sirtris Pharmaceuticals, Inc. |
Treatment of eye disorders with sirtuin modulators
|
|
US20060292099A1
(en)
*
|
2005-05-25 |
2006-12-28 |
Michael Milburn |
Treatment of eye disorders with sirtuin modulators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
US8088928B2
(en)
*
|
2005-08-04 |
2012-01-03 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
US8093401B2
(en)
*
|
2005-08-04 |
2012-01-10 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
DK1910384T3
(da)
*
|
2005-08-04 |
2012-12-17 |
Sirtris Pharmaceuticals Inc |
Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser
|
|
US7855289B2
(en)
*
|
2005-08-04 |
2010-12-21 |
Sirtris Pharmaceuticals, Inc. |
Sirtuin modulating compounds
|
|
JP2007063225A
(ja)
*
|
2005-09-01 |
2007-03-15 |
Takeda Chem Ind Ltd |
イミダゾピリジン化合物
|
|
WO2007041643A1
(en)
*
|
2005-10-03 |
2007-04-12 |
University Of Tennessee Research Foundation |
Dietary calcium for reducing the production of reactive oxygen species
|
|
US8399442B2
(en)
|
2005-12-30 |
2013-03-19 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
|
CA2641880C
(en)
|
2006-02-10 |
2014-09-09 |
Summit Corporation Plc |
Treatment of duchenne muscular dystrophy
|
|
JP5523829B2
(ja)
|
2006-06-29 |
2014-06-18 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
|
US20100047177A1
(en)
*
|
2007-01-26 |
2010-02-25 |
Washington University |
Methods and compositions for treating neuropathies
|
|
CA2679659C
(en)
|
2007-03-01 |
2016-01-19 |
Novartis Ag |
Pim kinase inhibitors and methods of their use
|
|
AU2008240103A1
(en)
*
|
2007-04-12 |
2008-10-23 |
Massachusetts Institute Of Technology |
Sirtuin based methods and compositions for treating beta- catenin-related conditions
|
|
US9884031B2
(en)
|
2007-05-09 |
2018-02-06 |
The Trustees Of The University Of Pennsylvania |
Use of HDAC inhibitors for treatment of cardiac rhythm disorders
|
|
CL2008001822A1
(es)
*
|
2007-06-20 |
2009-03-13 |
Sirtris Pharmaceuticals Inc |
Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
|
|
TW200918542A
(en)
*
|
2007-06-20 |
2009-05-01 |
Sirtris Pharmaceuticals Inc |
Sirtuin modulating compounds
|
|
US9370642B2
(en)
|
2007-06-29 |
2016-06-21 |
J.W. Medical Systems Ltd. |
Adjustable-length drug delivery balloon
|
|
AU2008278824A1
(en)
*
|
2007-07-23 |
2009-01-29 |
Biomarin Iga Limited |
Compounds for treating Duchenne muscular dystrophy
|
|
CA2685540C
(en)
|
2007-08-03 |
2018-10-16 |
Graham Michael Wynne |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
CN101970012A
(zh)
|
2007-09-14 |
2011-02-09 |
日东电工株式会社 |
药物载体
|
|
JP2010540444A
(ja)
*
|
2007-09-20 |
2010-12-24 |
レスベラトロル パートナーズ， エルエルシー |
遺伝子産物の濃縮または活性を調節するためのレスベラトロールを含む組成物
|
|
US8039668B2
(en)
*
|
2008-10-17 |
2011-10-18 |
Burnham Institute For Medical Research |
Naphthalene-based inhibitors of anti-apoptotic proteins
|
|
EP2205088B1
(en)
*
|
2007-10-19 |
2018-02-21 |
Burnham Institute for Medical Research |
Naphthalene-based inhibitors of anti-apoptotic proteins
|
|
WO2009054994A2
(en)
*
|
2007-10-23 |
2009-04-30 |
President And Fellows Of Harvard College |
Sirt-3 related methods and compositions for mimicking exercise
|
|
EP2216052A4
(en)
*
|
2007-10-30 |
2012-11-21 |
Nihon Mediphysics Co Ltd |
USE OF A NEW COMPOUND WITH AFFINITY FOR AMYLOID AND METHOD FOR THE PRODUCTION THEREOF
|
|
WO2009058348A1
(en)
*
|
2007-11-01 |
2009-05-07 |
Sirtris Pharmaceuticals, Inc. |
Amide derivatives as sirtuin modulators
|
|
US7868001B2
(en)
*
|
2007-11-02 |
2011-01-11 |
Hutchison Medipharma Enterprises Limited |
Cytokine inhibitors
|
|
MX2010005186A
(es)
*
|
2007-11-08 |
2010-05-27 |
Sirtris Pharmaceuticals Inc |
Tiazolopiridinas solubilizadas.
|
|
RU2364597C1
(ru)
*
|
2007-12-14 |
2009-08-20 |
Андрей Александрович Иващенко |
ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ Hh-СИГНАЛЬНОГО КАСКАДА, ЛЕКАРСТВЕННЫЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АББЕРАНТНОЙ АКТИВНОСТЬЮ Hh СИГНАЛЬНОЙ СИСТЕМЫ
|
|
US8188131B2
(en)
*
|
2008-02-07 |
2012-05-29 |
Massachusetts Eye & Ear Infirmary |
Compounds that enhance Atoh1 expression
|
|
WO2009099643A1
(en)
*
|
2008-02-07 |
2009-08-13 |
The J. David Gladstone Institutes |
Use of sirt1 activators or inhibitors to modulate an immune response
|
|
WO2009146030A1
(en)
*
|
2008-03-31 |
2009-12-03 |
The Feinstein Institute For Medical Research |
Methods and systems for reducing inflammation by neuromodulation of t-cell activity
|
|
US9662490B2
(en)
|
2008-03-31 |
2017-05-30 |
The Feinstein Institute For Medical Research |
Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
|
|
EP2257340A2
(en)
*
|
2008-04-04 |
2010-12-08 |
BioMarin IGA Limited |
Compounds for treating muscular dystrophy
|
|
ES2586459T3
(es)
|
2008-05-01 |
2016-10-14 |
Glaxosmithkline Llc |
Quinolinas y análogos relacionados como moduladores de sirtuina
|
|
CA2724023C
(en)
*
|
2008-05-13 |
2014-02-18 |
Genmedica Therapeutics Sl |
Salicylate conjugates useful for treating metabolic disorders
|
|
CA2724842A1
(en)
*
|
2008-05-19 |
2009-11-26 |
Sunovion Pharmaceuticals Inc. |
Imidazo[1,2-a]pyridine compounds
|
|
WO2009146358A1
(en)
*
|
2008-05-29 |
2009-12-03 |
Sirtris Pharmaceuticals, Inc. |
Imidazopyridine and related analogs as sirtuin modulators
|
|
CA2729128C
(en)
*
|
2008-07-03 |
2016-05-31 |
Sirtris Pharmaceuticals, Inc. |
Benzimidazoles and related analogs as sirtuin modulators
|
|
JP5693452B2
(ja)
|
2008-08-04 |
2015-04-01 |
シーエイチディーアイ ファウンデーション，インコーポレーテッド |
特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法
|
|
PL2344474T3
(pl)
|
2008-09-02 |
2016-03-31 |
Novartis Ag |
Pochodne pikolinamidu jako inhibitory kinaz
|
|
CA2737028C
(en)
|
2008-09-23 |
2017-06-27 |
Wista Laboratories Ltd. |
Ligands for aggregated tau molecules
|
|
MX2011003373A
(es)
|
2008-09-29 |
2011-06-09 |
Sirtris Pharmaceuticals Inc |
Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina.
|
|
RU2011121655A
(ru)
*
|
2008-10-29 |
2012-12-10 |
Сертрис Фармасьютикалз, Инк. |
Производные пиридина, бициклические производные пиридина и родственные аналоги в качестве модуляторов сиртуина
|
|
GB0821307D0
(en)
*
|
2008-11-21 |
2008-12-31 |
Summit Corp Plc |
Compounds for treatment of duchenne muscular dystrophy
|
|
CN102300578A
(zh)
*
|
2008-12-01 |
2011-12-28 |
延寿有限责任公司 |
用于改变健康、安康和寿命的方法和组合物
|
|
EP2376490B1
(en)
*
|
2008-12-04 |
2013-01-23 |
Proximagen Limited |
Imidazopyridine compounds
|
|
WO2010077642A1
(en)
|
2008-12-08 |
2010-07-08 |
Northwestern University |
Method of modulating hsf-1
|
|
BRPI0922435A2
(pt)
|
2008-12-19 |
2018-09-11 |
Sirtris Pharmaceuticals Inc |
"composto de tiazolopiridina moduladores de sirtuina, composição farmacêutica compreendendo o mesmo e seu uso."
|
|
WO2010090830A1
(en)
*
|
2009-01-20 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Modulation of sirt1 expression
|
|
WO2010088574A1
(en)
*
|
2009-01-30 |
2010-08-05 |
Sirtris Pharmaceuticals, Inc. |
Azabenzimidazoles and related analogs as sirtuin modulators
|
|
US20100239552A1
(en)
*
|
2009-03-16 |
2010-09-23 |
Genmedica Therapeutics Sl |
Combination Therapies for Treating Metabolic Disorders
|
|
JP2012520342A
(ja)
*
|
2009-03-16 |
2012-09-06 |
ジェンメディカ・セラピューティックス・ソシエダッド・リミターダ |
代謝障害を処置するのに有用な抗炎症剤および抗酸化剤のコンジュゲート
|
|
US8487131B2
(en)
|
2009-04-15 |
2013-07-16 |
Sanford-Burnham Medical Research Institute |
Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2)
|
|
US9211410B2
(en)
|
2009-05-01 |
2015-12-15 |
Setpoint Medical Corporation |
Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
|
|
US8996116B2
(en)
|
2009-10-30 |
2015-03-31 |
Setpoint Medical Corporation |
Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
|
|
US8788034B2
(en)
|
2011-05-09 |
2014-07-22 |
Setpoint Medical Corporation |
Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
|
|
TWI482771B
(zh)
*
|
2009-05-04 |
2015-05-01 |
Du Pont |
磺醯胺殺線蟲劑
|
|
NZ596302A
(en)
|
2009-05-15 |
2014-01-31 |
Novartis Ag |
Aryl pyridine as aldosterone synthase inhibitors
|
|
EP2440053A4
(en)
|
2009-06-09 |
2012-10-31 |
California Capital Equity Llc |
BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THERAPEUTIC APPLICATIONS THEREOF
|
|
CA2765053C
(en)
|
2009-06-09 |
2015-08-18 |
California Capital Equity, Llc |
Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
|
|
JP5785940B2
(ja)
|
2009-06-09 |
2015-09-30 |
アブラクシス バイオサイエンス， エルエルシー |
トリアジン誘導体類及びそれらの治療応用
|
|
CN102573986B
(zh)
|
2009-06-09 |
2016-01-20 |
赛博恩特医疗器械公司 |
用于无导线刺激器的具有袋部的神经封套
|
|
US8299295B2
(en)
*
|
2009-10-15 |
2012-10-30 |
Johnson Matthey Public Limited Company |
Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
|
|
GB0919757D0
(en)
*
|
2009-11-12 |
2009-12-30 |
Johnson Matthey Plc |
Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs
|
|
MX2012004995A
(es)
|
2009-10-29 |
2012-10-03 |
Sirtris Pharmaceuticals Inc |
Piridinas biciclicas y analogos como moduladores de sirtuina.
|
|
DK2496594T3
(en)
*
|
2009-11-06 |
2018-03-05 |
The J David Gladstone Inst |
METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS
|
|
US11051744B2
(en)
|
2009-11-17 |
2021-07-06 |
Setpoint Medical Corporation |
Closed-loop vagus nerve stimulation
|
|
US9833621B2
(en)
*
|
2011-09-23 |
2017-12-05 |
Setpoint Medical Corporation |
Modulation of sirtuins by vagus nerve stimulation
|
|
ES2758554T3
(es)
|
2009-12-08 |
2020-05-05 |
Univ Case Western Reserve |
Aminoácidos gama para tratamiento de trastornos oculares
|
|
CN102821814B
(zh)
|
2009-12-23 |
2015-07-15 |
赛博恩特医疗器械公司 |
用于治疗慢性炎症的神经刺激设备和系统
|
|
CA2787365A1
(en)
|
2010-01-25 |
2011-07-28 |
Chdi Foundation, Inc. |
Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
|
|
EP2554163A4
(en)
*
|
2010-03-26 |
2013-07-17 |
Univ Hokkaido Nat Univ Corp |
THERAPEUTIC ACTIVE FOR NEURODEGENERATIVE DISEASES
|
|
CN102985553B
(zh)
|
2010-04-15 |
2015-11-25 |
西特里斯药业公司 |
沉默调节蛋白活化剂和活化测定
|
|
US9133123B2
(en)
|
2010-04-23 |
2015-09-15 |
Cytokinetics, Inc. |
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
|
|
AR081331A1
(es)
|
2010-04-23 |
2012-08-08 |
Cytokinetics Inc |
Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
|
|
AR081626A1
(es)
|
2010-04-23 |
2012-10-10 |
Cytokinetics Inc |
Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
|
|
EP2563759B1
(en)
*
|
2010-04-27 |
2022-04-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
US20130109672A1
(en)
*
|
2010-04-29 |
2013-05-02 |
The United States Of America,As Represented By The Secretary, Department Of Health And Human Service |
Activators of human pyruvate kinase
|
|
WO2011139387A1
(en)
|
2010-05-03 |
2011-11-10 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
|
EP2388255A1
(en)
*
|
2010-05-11 |
2011-11-23 |
Ikerchem, S.L. |
Polysubstituted benzofurans and medicinal applications thereof
|
|
US20120058088A1
(en)
*
|
2010-06-28 |
2012-03-08 |
Resveratrol Partners, Llc |
Resveratrol-Containing Compositions And Methods Of Use
|
|
US20130158035A1
(en)
*
|
2010-08-24 |
2013-06-20 |
Brigham Young University |
Antimetastatic compounds
|
|
WO2012033149A1
(ja)
|
2010-09-10 |
2012-03-15 |
塩野義製薬株式会社 |
Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体
|
|
TW201217387A
(en)
*
|
2010-09-15 |
2012-05-01 |
Hoffmann La Roche |
Azabenzothiazole compounds, compositions and methods of use
|
|
BR112013011520A2
(pt)
|
2010-11-19 |
2019-09-24 |
Hoffmann La Roche |
pirazolo piridinas e pirazolo piridinas e seu uso como inibidores de tyk2
|
|
US8466197B2
(en)
|
2010-12-14 |
2013-06-18 |
Genmedica Therapeutics Sl |
Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
|
|
DK2670404T3
(en)
|
2011-02-02 |
2018-11-19 |
Univ Princeton |
CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
|
|
EP2766349B1
(de)
|
2011-03-08 |
2016-06-01 |
Sanofi |
Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
|
|
EP2683699B1
(de)
|
2011-03-08 |
2015-06-24 |
Sanofi |
Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
WO2012120056A1
(de)
|
2011-03-08 |
2012-09-13 |
Sanofi |
Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
EP2683704B1
(de)
|
2011-03-08 |
2014-12-17 |
Sanofi |
Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
|
|
US8828994B2
(en)
|
2011-03-08 |
2014-09-09 |
Sanofi |
Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
|
|
US8759380B2
(en)
|
2011-04-22 |
2014-06-24 |
Cytokinetics, Inc. |
Certain heterocycles, compositions thereof, and methods for their use
|
|
US9181231B2
(en)
|
2011-05-03 |
2015-11-10 |
Agios Pharmaceuticals, Inc |
Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia
|
|
US12172017B2
(en)
|
2011-05-09 |
2024-12-24 |
Setpoint Medical Corporation |
Vagus nerve stimulation to treat neurodegenerative disorders
|
|
RU2631597C2
(ru)
|
2011-07-15 |
2017-09-25 |
Нусерт Сайенсиз, Инк. |
Композиции и способы модулирования метаболических путей
|
|
KR20140072037A
(ko)
|
2011-08-30 |
2014-06-12 |
씨에이치디아이 파운데이션, 인코포레이티드 |
키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
|
|
SI2750677T1
(sl)
|
2011-08-30 |
2017-10-30 |
Chdi Foundation, Inc. |
Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
|
|
EP2567959B1
(en)
|
2011-09-12 |
2014-04-16 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
WO2013049585A1
(en)
*
|
2011-09-30 |
2013-04-04 |
Hengrui (Usa), Ltd. |
Arylsubstituted thiazolotriazoles and thiazoloimidazoles
|
|
JP6073343B2
(ja)
|
2011-10-20 |
2017-02-01 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ |
サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
|
|
US8916528B2
(en)
|
2011-11-16 |
2014-12-23 |
Resveratrol Partners, Llc |
Compositions containing resveratrol and nucleotides
|
|
EP2790701A1
(en)
*
|
2011-12-12 |
2014-10-22 |
SMB Innovation |
Novel heterocyclic compounds useful in sirtuin binding and modulation
|
|
EP2793871A4
(en)
*
|
2011-12-23 |
2015-07-22 |
Auckland Uniservices Ltd |
COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION
|
|
US9198454B2
(en)
|
2012-03-08 |
2015-12-01 |
Nusirt Sciences, Inc. |
Compositions, methods, and kits for regulating energy metabolism
|
|
US9572983B2
(en)
|
2012-03-26 |
2017-02-21 |
Setpoint Medical Corporation |
Devices and methods for modulation of bone erosion
|
|
WO2013166502A1
(en)
*
|
2012-05-04 |
2013-11-07 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Regulation of cardiac sodium channels by sirt1 and sirt1 activators
|
|
US9173883B2
(en)
|
2012-05-21 |
2015-11-03 |
Novartis Ag |
Ring-substituted N-pyridinyl amides as kinase inhibitors
|
|
EP2671885A1
(en)
*
|
2012-06-05 |
2013-12-11 |
Ares Trading S.A. |
Imidazo-oxadiazole and Imidazo-thiadiazole derivatives
|
|
JP6273272B2
(ja)
*
|
2012-07-04 |
2018-01-31 |
ジージー バイオテック エルエルシー |
炎症性皮膚障害の治療
|
|
EP2682395A1
(en)
|
2012-07-04 |
2014-01-08 |
Laboratorios Del. Dr. Esteve, S.A. |
Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
|
|
US9212209B2
(en)
|
2012-07-13 |
2015-12-15 |
Indiana University Research And Technology Corporation |
Screening methods for spinal muscular atrophy
|
|
US10092574B2
(en)
|
2012-09-26 |
2018-10-09 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
|
|
SG10201709195TA
(en)
|
2012-11-13 |
2017-12-28 |
Nusirt Sciences Inc |
Compositions and methods for increasing energy metabolism
|
|
CN103027912A
(zh)
*
|
2012-12-11 |
2013-04-10 |
南京医科大学附属南京儿童医院 |
N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-b]噻唑-6-基]苯基]-2-喹喔啉甲酰胺在制备防治高血压药物中的应用
|
|
WO2014139144A1
(en)
|
2013-03-15 |
2014-09-18 |
Agios Pharmaceuticals, Inc. |
Therapeutic compounds and compositions
|
|
CN105228627B
(zh)
|
2013-03-15 |
2018-07-13 |
纽斯尔特科学公司 |
亮氨酸和烟酸降低脂质水平
|
|
WO2014151729A1
(en)
|
2013-03-15 |
2014-09-25 |
Irm Llc |
Compounds and compositions for the treatment of parasitic diseases
|
|
WO2014151630A2
(en)
|
2013-03-15 |
2014-09-25 |
Irm Llc |
Compounds and compositions for the treatment of parasitic diseases
|
|
US9296754B2
(en)
|
2013-03-15 |
2016-03-29 |
Novartis Ag |
Compounds and compositions for the treatment of parasitic diseases
|
|
SG11201509650YA
(en)
*
|
2013-05-24 |
2015-12-30 |
Iomet Pharma Ltd |
Slc2a transporter inhibitors
|
|
EP3049393A4
(en)
*
|
2013-09-25 |
2017-06-21 |
Valorisation-Recherche, Limited Partnership |
Inhibitors of polynucleotide repeat-associated rna foci and uses thereof
|
|
US10172915B2
(en)
|
2013-10-20 |
2019-01-08 |
Duke University |
Methods and compositions for activation of sirtuins with Annexin A1 peptides
|
|
US20160271090A1
(en)
*
|
2013-10-29 |
2016-09-22 |
Tokyo University Of Agriculture |
Frataxin enhancer
|
|
EP3384908B1
(en)
|
2013-12-02 |
2020-09-30 |
The Trustees of Columbia University in the City of New York |
Modulating ferroptosis and treating excitotoxic disorders
|
|
BR112016014004B1
(pt)
|
2013-12-19 |
2022-11-01 |
Novartis Ag |
Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
|
|
KR20160119863A
(ko)
|
2014-02-27 |
2016-10-14 |
뉴서트 사이언시스, 인크. |
간 지방증의 감소 또는 예방을 위한 조성물 및 방법
|
|
WO2015143654A1
(en)
*
|
2014-03-26 |
2015-10-01 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
|
|
KR20170012449A
(ko)
|
2014-06-02 |
2017-02-02 |
글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 |
결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도
|
|
US10294243B2
(en)
*
|
2014-06-05 |
2019-05-21 |
Bayer Cropscience Aktiengesellschaft |
Bicyclic compounds as pesticides
|
|
CA2951287A1
(en)
|
2014-06-06 |
2015-12-10 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
|
|
AU2015289492B2
(en)
|
2014-07-17 |
2020-02-20 |
Chdi Foundation, Inc. |
Methods and compositions for treating HIV-related disorders
|
|
CA3000985C
(en)
|
2014-10-14 |
2023-01-31 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for treating neurodegenerative diseases
|
|
US11311725B2
(en)
|
2014-10-24 |
2022-04-26 |
Setpoint Medical Corporation |
Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
|
|
DK3209655T3
(da)
|
2014-10-24 |
2020-09-28 |
Landos Biopharma Inc |
Lanthioninsyntease C-lignende 2-baserede Therapeutica
|
|
WO2016126807A1
(en)
|
2015-02-03 |
2016-08-11 |
Setpoint Medical Corporation |
Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
|
|
WO2016130501A1
(en)
|
2015-02-09 |
2016-08-18 |
Incyte Corporation |
Aza-heteroaryl compounds as pi3k-gamma inhibitors
|
|
PL3328843T3
(pl)
|
2015-07-27 |
2023-02-27 |
Chong Kun Dang Pharmaceutical Corp. |
Związki będące pochodnymi 1,3,4 oksadiazolosulfonamidów jako inhibitor deacetylazy histonowej 6, oraz kompozycja farmaceutyczna je zawierająca
|
|
CN108026056B
(zh)
|
2015-07-27 |
2021-08-03 |
株式会社钟根堂 |
作为组蛋白脱乙酰酶6抑制剂的1,3,4-噁二唑酰胺衍生物化合物及其药物组合物
|
|
RU2695227C9
(ru)
|
2015-07-27 |
2020-03-04 |
Чонг Кун Данг Фармасьютикал Корп. |
Производные 1,3,4-оксадиазолсульфамида в качестве ингибитора гистондеацетилазы 6 и содержащая их фармацевтическая композиция
|
|
JP6491393B2
(ja)
|
2015-08-04 |
2019-03-27 |
チョン クン ダン ファーマシューティカル コーポレーション |
ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾール誘導体化合物及びこれを含有する薬剤学的組成物
|
|
MX2018004185A
(es)
|
2015-10-08 |
2018-11-09 |
Fmc Corp |
Pesticidas de azoles biciclicos sustituidos con heterociclos.
|
|
JP6697074B2
(ja)
|
2015-10-12 |
2020-05-20 |
チョン クン ダン ファーマシューティカル コーポレーション |
ヒストン脱アセチル化酵素６阻害剤としてのオキサジアゾールアミン誘導体化合物及びこれを含有する薬剤学的組成物
|
|
PT3371190T
(pt)
|
2015-11-06 |
2022-07-08 |
Incyte Corp |
Compostos heterocíclicos como inibidores de pi3k-gamma
|
|
WO2017096270A1
(en)
|
2015-12-03 |
2017-06-08 |
The Regents Of The University Of California |
Methods for treating mitochondrial diseases
|
|
AU2016371598B2
(en)
|
2015-12-15 |
2021-05-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation
|
|
US20170190689A1
(en)
|
2016-01-05 |
2017-07-06 |
Incyte Corporation |
Pyridine and pyridimine compounds as pi3k-gamma inhibitors
|
|
US10596367B2
(en)
|
2016-01-13 |
2020-03-24 |
Setpoint Medical Corporation |
Systems and methods for establishing a nerve block
|
|
EP3405255B1
(en)
|
2016-01-20 |
2025-12-31 |
Setpoint Medical Corporation |
IMPLANTABLE MICROSTIMULATORS AND INDUCTION CHARGING SYSTEMS
|
|
US11471681B2
(en)
|
2016-01-20 |
2022-10-18 |
Setpoint Medical Corporation |
Batteryless implantable microstimulators
|
|
EP3405107B1
(en)
|
2016-01-20 |
2023-04-12 |
Setpoint Medical Corporation |
Control of vagal stimulation
|
|
US10583304B2
(en)
|
2016-01-25 |
2020-03-10 |
Setpoint Medical Corporation |
Implantable neurostimulator having power control and thermal regulation and methods of use
|
|
WO2017152073A1
(en)
|
2016-03-04 |
2017-09-08 |
University Of Louisville Research Foundation, Inc. |
Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (vsels)
|
|
EP4234552A3
(en)
|
2016-03-09 |
2023-10-18 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
DK3426243T3
(da)
|
2016-03-09 |
2021-07-19 |
Raze Therapeutics Inc |
3-phosphoglyceratdehydrogenase-inhibitorer og anvendelser deraf
|
|
US10138248B2
(en)
|
2016-06-24 |
2018-11-27 |
Incyte Corporation |
Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors
|
|
CN115819417A
(zh)
|
2016-09-09 |
2023-03-21 |
因赛特公司 |
作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
|
|
US20180072741A1
(en)
|
2016-09-09 |
2018-03-15 |
Incyte Corporation |
Pyrazolopyrimidine compounds and uses thereof
|
|
US10280164B2
(en)
|
2016-09-09 |
2019-05-07 |
Incyte Corporation |
Pyrazolopyridone compounds and uses thereof
|
|
WO2018049214A1
(en)
|
2016-09-09 |
2018-03-15 |
Incyte Corporation |
Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
|
|
WO2018152220A1
(en)
|
2017-02-15 |
2018-08-23 |
Incyte Corporation |
Pyrazolopyridine compounds and uses thereof
|
|
LT3483164T
(lt)
|
2017-03-20 |
2020-05-11 |
Forma Therapeutics, Inc. |
Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
|
|
KR102101234B1
(ko)
*
|
2017-04-18 |
2020-04-16 |
부산대학교 산학협력단 |
신규 sirt 1 활성화제 및 이의 의학적 용도
|
|
CN110621316B
(zh)
|
2017-04-21 |
2024-01-26 |
Epizyme股份有限公司 |
用ehmt2抑制剂进行的组合疗法
|
|
CN107173817A
(zh)
*
|
2017-05-19 |
2017-09-19 |
广州弘宝元生物科技有限公司 |
sir2蛋白在制备抗氧化的食品或药品中的应用
|
|
KR102101235B1
(ko)
*
|
2017-07-13 |
2020-04-16 |
부산대학교 산학협력단 |
신규 sirt 1 활성화제 및 이의 의학적 용도
|
|
WO2019036470A1
(en)
|
2017-08-14 |
2019-02-21 |
Setpoint Medical Corporation |
TESTING TEST FOR STIMULATION OF NERVE WAVE
|
|
US11612681B2
(en)
*
|
2017-09-06 |
2023-03-28 |
The Research Foundation For The State University Of New York |
Compositions and devices for removal of endotoxins and cytokines from fluids
|
|
US10722495B2
(en)
|
2017-09-08 |
2020-07-28 |
Incyte Corporation |
Cyanoindazole compounds and uses thereof
|
|
KR102717072B1
(ko)
|
2017-10-18 |
2024-10-15 |
인사이트 코포레이션 |
Pi3k-감마 저해제로서의 3차 하이드록시기로 치환된 축합된 이미다졸 유도체
|
|
EP3710007A4
(en)
*
|
2017-11-14 |
2021-12-15 |
Children's Medical Center Corporation |
USE OF IMIDAZOPYRIMIDINE TO MODULATE HUMAN IMMUNE RESPONSE
|
|
KR102740831B1
(ko)
*
|
2017-11-14 |
2024-12-11 |
칠드런'즈 메디컬 센터 코포레이션 |
신규 이미다조피리미딘 화합물 및 그의 용도
|
|
KR20200090873A
(ko)
|
2017-11-30 |
2020-07-29 |
란도스 바이오파마, 인크. |
란티오닌 c-유사 단백질 2 리간드 및 이와 함께 제조된 세포를 이용한 치료법
|
|
US10752635B2
(en)
|
2018-02-20 |
2020-08-25 |
Incyte Corporation |
Indazole compounds and uses thereof
|
|
EP3755703B1
(en)
|
2018-02-20 |
2022-05-04 |
Incyte Corporation |
N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer
|
|
US10745388B2
(en)
|
2018-02-20 |
2020-08-18 |
Incyte Corporation |
Indazole compounds and uses thereof
|
|
US11299473B2
(en)
|
2018-04-13 |
2022-04-12 |
Incyte Corporation |
Benzimidazole and indole compounds and uses thereof
|
|
KR102101236B1
(ko)
*
|
2018-04-19 |
2020-04-16 |
부산대학교 산학협력단 |
신규 sirt 1 활성화제 및 이의 의학적 용도
|
|
KR102316234B1
(ko)
|
2018-07-26 |
2021-10-22 |
주식회사 종근당 |
히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
|
|
KR20210068399A
(ko)
|
2018-08-06 |
2021-06-09 |
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 |
신경퇴행성 질병의 치료를 위한 피피에이알지씨1알파 활성제로서 2-아릴벤즈이미다졸
|
|
US10899755B2
(en)
|
2018-08-08 |
2021-01-26 |
Incyte Corporation |
Benzothiazole compounds and uses thereof
|
|
CN108774187A
(zh)
*
|
2018-08-14 |
2018-11-09 |
天津安浩生物科技有限公司 |
一种苯并噁唑衍生物其制备方法和应用
|
|
CR20250050A
(es)
|
2018-09-05 |
2025-03-19 |
Incyte Corp |
Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
|
|
EP3853206B1
(en)
|
2018-09-19 |
2024-04-10 |
Novo Nordisk Health Care AG |
Treating sickle cell disease with a pyruvate kinase r activating compound
|
|
EP3852791B1
(en)
|
2018-09-19 |
2024-07-03 |
Novo Nordisk Health Care AG |
Activating pyruvate kinase r
|
|
US11260229B2
(en)
|
2018-09-25 |
2022-03-01 |
The Feinstein Institutes For Medical Research |
Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
|
|
WO2020068729A1
(en)
|
2018-09-25 |
2020-04-02 |
Incyte Corporation |
Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
|
|
US20210393621A1
(en)
|
2018-10-26 |
2021-12-23 |
The Research Foundation For The State University Of New York |
Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
|
|
KR102797127B1
(ko)
*
|
2018-12-29 |
2025-04-21 |
우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드 |
헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도
|
|
US11174263B2
(en)
|
2018-12-31 |
2021-11-16 |
Biomea Fusion, Inc. |
Inhibitors of menin-MLL interaction
|
|
SG11202106304RA
(en)
|
2018-12-31 |
2021-07-29 |
Biomea Fusion Llc |
Irreversible inhibitors of menin-mll interaction
|
|
AU2020272128B9
(en)
|
2019-04-12 |
2025-11-20 |
Setpoint Medical Corporation |
Vagus nerve stimulation to treat neurodegenerative disorders
|
|
MY207444A
(en)
|
2019-05-31 |
2025-02-27 |
Chong Kun Dang Pharmaceutical Corp |
1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
|
|
BR112022002059A2
(pt)
|
2019-08-06 |
2022-06-07 |
Incyte Corp |
Formas sólidas de um inibidor de hpk1
|
|
HRP20251148T1
(hr)
|
2019-09-19 |
2025-11-21 |
Novo Nordisk Health Care Ag |
Pripravci koji aktiviraju piruvat-kinazu r (pkr)
|
|
JPWO2021070957A1
(https=)
*
|
2019-10-09 |
2021-04-15 |
|
|
|
KR102267662B1
(ko)
*
|
2019-11-19 |
2021-06-22 |
한국화학연구원 |
벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
KR20230026522A
(ko)
|
2019-12-20 |
2023-02-24 |
란도스 바이오파마, 인크. |
란티오닌 c-유사 단백질 2 리간드, 이로 제조된 세포, 및 이를 사용하는 치료법
|
|
JP2023512447A
(ja)
|
2020-01-13 |
2023-03-27 |
ザ ファインスタイン インスティチューツ フォー メディカル リサーチ |
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|
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|
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|
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|
|
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|
|
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|
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|
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|
|
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|
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|
|
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|
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|
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|
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|
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|
|
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|
|
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*
|
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|
|
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|
|
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|
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