|
JP2005289809A
(ja)
*
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US9453251B2
(en)
|
2002-10-08 |
2016-09-27 |
Pfenex Inc. |
Expression of mammalian proteins in Pseudomonas fluorescens
|
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
CA2505316C
(en)
|
2002-11-08 |
2014-08-05 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
US8603824B2
(en)
|
2004-07-26 |
2013-12-10 |
Pfenex, Inc. |
Process for improved protein expression by strain engineering
|
|
WO2006122787A1
(en)
*
|
2005-05-18 |
2006-11-23 |
Ablynx Nv |
Serum albumin binding proteins
|
|
DE102005023617A1
(de)
*
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
|
US20070269422A1
(en)
*
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
CN101646689A
(zh)
*
|
2006-09-08 |
2010-02-10 |
埃博灵克斯股份有限公司 |
具有长半衰期的血清清蛋白结合蛋白
|
|
WO2008043821A1
(en)
|
2006-10-11 |
2008-04-17 |
Ablynx N. V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and use thereof
|
|
WO2008071685A1
(en)
*
|
2006-12-13 |
2008-06-19 |
Ablynx N.V. |
Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex
|
|
EP2102241A2
(en)
*
|
2006-12-15 |
2009-09-23 |
Ablynx N.V. |
Amino acid sequences that modulate the interaction between cells of the immune system
|
|
US9512236B2
(en)
|
2006-12-19 |
2016-12-06 |
Ablynx N.V. |
Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
WO2008074839A2
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
|
EP2102244A2
(en)
|
2006-12-19 |
2009-09-23 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
|
|
WO2008074868A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Ablynx N.V. |
Oral delivery of polypeptides
|
|
JP2010518839A
(ja)
*
|
2007-02-21 |
2010-06-03 |
アブリンクス エン．ヴェー． |
血管内皮増殖因子に指向性を有するアミノ酸配列、及び過度の及び／もしくは病的な血管形成又は血管新生を特徴とする症状及び疾患を治療するためにこれを含むポリペプチド
|
|
JP5444553B2
(ja)
|
2007-04-27 |
2014-03-19 |
フェネックス インコーポレイテッド |
微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法
|
|
US9580719B2
(en)
|
2007-04-27 |
2017-02-28 |
Pfenex, Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
CN101796072B
(zh)
|
2007-05-24 |
2014-09-24 |
埃博灵克斯股份有限公司 |
用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽
|
|
EP2173772A2
(en)
|
2007-07-03 |
2010-04-14 |
Ablynx N.V. |
Providing improved immunoglobulin sequences by mutating cdr and/or fr positions
|
|
WO2009040562A1
(en)
*
|
2007-09-26 |
2009-04-02 |
Ucb Pharma S.A. |
Dual specificity antibody fusions
|
|
EP2220120A2
(en)
|
2007-11-27 |
2010-08-25 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
CN101965362A
(zh)
*
|
2008-03-05 |
2011-02-02 |
埃博灵克斯股份有限公司 |
新型抗原结合二聚体-复合物及其制备方法和应用
|
|
GB0809069D0
(en)
|
2008-05-19 |
2008-06-25 |
Univ Leuven Kath |
Gene signatures
|
|
AU2009235467A1
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Single variable domains against the Notch pathways
|
|
EP2268668A1
(en)
*
|
2008-04-17 |
2011-01-05 |
Ablynx N.V. |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
|
US8444976B2
(en)
|
2008-07-02 |
2013-05-21 |
Argen-X B.V. |
Antigen binding polypeptides
|
|
HRP20170374T1
(hr)
|
2008-09-26 |
2017-05-05 |
Ucb Biopharma Sprl |
Biološki proizvodi
|
|
EP2362767B1
(en)
|
2008-10-29 |
2017-12-06 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
BRPI0919879A2
(pt)
*
|
2008-10-29 |
2016-02-16 |
Wyeth Llc |
métodos para purificação de moléculas de ligação a antígeno de domínio único
|
|
AU2013202856B2
(en)
*
|
2008-10-29 |
2016-02-11 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
US9265834B2
(en)
*
|
2009-03-05 |
2016-02-23 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
WO2011026948A1
(en)
|
2009-09-03 |
2011-03-10 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
WO2010100135A1
(en)
|
2009-03-05 |
2010-09-10 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof
|
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
ES2551854T3
(es)
|
2009-04-30 |
2015-11-24 |
Ablynx N.V. |
Procedimiento para la producción de anticuerpos de dominio
|
|
ES2643034T3
(es)
|
2009-06-05 |
2017-11-21 |
Ablynx N.V. |
Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias
|
|
HUE051430T2
(hu)
|
2009-07-10 |
2021-03-01 |
Ablynx Nv |
Eljárás variábilis domének elõállítására
|
|
GB201005063D0
(en)
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
|
US20110172398A1
(en)
|
2009-10-02 |
2011-07-14 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules for anti-angiogenesis therapy
|
|
US20110195494A1
(en)
|
2009-10-02 |
2011-08-11 |
Boehringer Ingelheim International Gmbh |
Dll4-binging molecules
|
|
WO2011064382A1
(en)
|
2009-11-30 |
2011-06-03 |
Ablynx N.V. |
Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
|
|
EP2513145B1
(en)
|
2009-12-14 |
2018-01-24 |
Ablynx N.V. |
Single variable domain antibodies against ox40l, constructs and therapeutic use
|
|
WO2011083141A2
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Method for generation of immunoglobulin sequences by using lipoprotein particles
|
|
CN102781959A
(zh)
|
2010-02-05 |
2012-11-14 |
埃博灵克斯股份有限公司 |
能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽
|
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
|
US20130012916A1
(en)
|
2010-02-11 |
2013-01-10 |
Glide Pharmaceutical Technologies Limited |
Delivery of immunoglobulin variable domains and constructs thereof
|
|
PT3501499T
(pt)
|
2010-02-11 |
2022-11-22 |
Ablynx Nv |
Métodos e composições para a preparação de aerossóis
|
|
UY33253A
(es)
|
2010-03-03 |
2011-09-30 |
Boehringer Ingelheim Int |
Polipéptidos de unión a a-beta
|
|
US8937164B2
(en)
|
2010-03-26 |
2015-01-20 |
Ablynx N.V. |
Biological materials related to CXCR7
|
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
CN102906118B
(zh)
|
2010-05-20 |
2017-07-28 |
埃博灵克斯股份有限公司 |
与her3相关的生物材料
|
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
|
CN108314733A
(zh)
*
|
2010-07-16 |
2018-07-24 |
埃博灵克斯股份有限公司 |
修饰的单结构域抗原结合分子及其应用
|
|
US20120225081A1
(en)
|
2010-09-03 |
2012-09-06 |
Boehringer Ingelheim International Gmbh |
Vegf-binding molecules
|
|
EP2621953B1
(en)
|
2010-09-30 |
2017-04-05 |
Ablynx N.V. |
Biological materials related to c-met
|
|
US11644471B2
(en)
|
2010-09-30 |
2023-05-09 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
DK2632946T3
(en)
|
2010-10-29 |
2018-03-12 |
Ablynx Nv |
PROCEDURE FOR MANUFACTURING VARIABLE IMMUNGLOBULIN SINGLE DOMAINS
|
|
EA202092589A3
(ru)
|
2010-11-08 |
2021-06-30 |
Аблинкс Н.В. |
Cxcr2-связывающие полипептиды
|
|
DK2643349T3
(da)
|
2010-11-26 |
2019-11-25 |
Molecular Partners Ag |
Designede repeat-proteiner, der binder til serumalbumin
|
|
CN103917560B
(zh)
*
|
2011-03-28 |
2017-05-24 |
埃博灵克斯股份有限公司 |
双特异性抗‑cxcr7免疫球蛋白单可变结构域
|
|
ES2688591T3
(es)
|
2011-03-28 |
2018-11-05 |
Ablynx N.V. |
Método para producir formulaciones sólidas que comprenden dominios variables individuales de inmunoglobulina
|
|
CN103547592A
(zh)
*
|
2011-03-30 |
2014-01-29 |
埃博灵克斯股份有限公司 |
使用针对TNFα的单结构域抗体治疗免疫病症的方法
|
|
US9527925B2
(en)
*
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
US20130078247A1
(en)
*
|
2011-04-01 |
2013-03-28 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to dii4 and ang2
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
EP3590950A1
(en)
|
2011-05-09 |
2020-01-08 |
Ablynx NV |
Method for the production of immunoglobulin single varible domains
|
|
WO2012163887A1
(en)
|
2011-05-27 |
2012-12-06 |
Ablynx Nv |
Inhibition of bone resorption with rankl binding peptides
|
|
IN2014CN00437A
(https=)
|
2011-06-23 |
2015-04-03 |
Ablynx Nv |
|
|
DK2723769T4
(da)
|
2011-06-23 |
2022-09-05 |
Ablynx Nv |
Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
|
|
DK2974737T3
(da)
|
2011-06-23 |
2026-01-19 |
Ablynx Nv |
Fremgangsmåder til forudsigelse, påvisning og reduktion af en specifik proteininterferens i assays, der involverer variable immunglobulin-enkeltdomæner
|
|
CN106046168A
(zh)
*
|
2011-06-23 |
2016-10-26 |
埃博灵克斯股份有限公司 |
结合血清白蛋白的蛋白
|
|
EP2944653A1
(en)
|
2011-06-23 |
2015-11-18 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
|
|
US10138302B2
(en)
|
2011-09-23 |
2018-11-27 |
Ablynx N.V. |
Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
|
|
BR112014006929A2
(pt)
|
2011-09-23 |
2017-04-04 |
Technophage Investigação E Desenvolvimento Em Biotecnologia Sa |
agentes anti-fator de necrose tumoral-alfa e seus usos
|
|
CN103889451B
(zh)
|
2011-09-30 |
2016-06-29 |
埃博灵克斯股份有限公司 |
与C-Met相关的生物物质
|
|
US9346884B2
(en)
|
2011-09-30 |
2016-05-24 |
Ablynx N.V. |
Biological materials related to c-Met
|
|
AU2013226340B2
(en)
|
2012-02-27 |
2017-06-22 |
Ablynx N.V. |
CX3CR1-binding polypeptides
|
|
TR201908638T4
(tr)
|
2012-03-30 |
2019-07-22 |
Boehringer Ingelheim Int |
Ang2 bağlayıcı moleküller.
|
|
US20130302250A1
(en)
|
2012-05-07 |
2013-11-14 |
The University Court Of The University Of Aberdeen |
Single domain binding molecule
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
CN108524919A
(zh)
|
2012-05-17 |
2018-09-14 |
延伸生物科学股份有限公司 |
用于改进的药物递送的载体
|
|
ES2715279T3
(es)
|
2012-05-24 |
2019-06-03 |
Vib Vzw |
Dominios variables individuales inmunoglobulínicos anti-receptor de manosa de macrófagos para elegir como diana y obtener imágenes in vivo de macrófagos asociados a tumores
|
|
RU2530553C2
(ru)
*
|
2012-11-07 |
2014-10-10 |
Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) |
Рекомбинантное однодоменное антитело, способное специфически связывать фактор некроза опухолей человека, и его производные
|
|
US9315280B2
(en)
*
|
2012-11-20 |
2016-04-19 |
Lockheed Martin Corporation |
Heat pipe with axial wick
|
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
|
EP3514175A1
(fr)
|
2012-12-17 |
2019-07-24 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes
|
|
WO2014111550A1
(en)
|
2013-01-17 |
2014-07-24 |
Glaxosmithkline Intellectual Property Development Limited |
Modified anti-serum albumin binding proteins
|
|
WO2014118297A1
(en)
|
2013-01-30 |
2014-08-07 |
Vib Vzw |
Novel chimeric polypeptides for screening and drug discovery purposes
|
|
PL2953973T3
(pl)
|
2013-02-05 |
2020-01-31 |
Vib Vzw |
Środki wiążące muskarynowy receptor acetylocholiny i ich zastosowania
|
|
TW201444871A
(zh)
|
2013-02-13 |
2014-12-01 |
Lab Francais Du Fractionnement |
具有修飾的糖化作用之西妥昔單抗及其用途
|
|
EP3594231A1
(en)
|
2013-02-13 |
2020-01-15 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Highly galactosylated anti-tnf-alpha antibodies and uses thereof
|
|
EP2956485A2
(en)
|
2013-02-13 |
2015-12-23 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Highly galactosylated anti-her2 antibodies and uses thereof
|
|
USRE48805E1
(en)
|
2013-03-06 |
2021-11-02 |
Vision Global Holdings Ltd. |
Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
|
|
US9255262B2
(en)
|
2013-03-06 |
2016-02-09 |
Vision Global Holdings Ltd. |
Albumin-binding arginine deminase and the use thereof
|
|
CN105358708B
(zh)
|
2013-03-14 |
2024-07-16 |
儿童医学中心公司 |
Cd36鉴定癌症对象以用于治疗的用途
|
|
JP6499090B2
(ja)
|
2013-03-15 |
2019-04-10 |
ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ |
心血管疾患において使用するための抗マクロファージマンノース受容体単一可変ドメイン
|
|
CA2909923A1
(en)
|
2013-04-23 |
2014-10-30 |
The University Court Of The University Of Aberdeen |
Isolation of therapeutic target specific vnar domains to icosl
|
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
|
CA2927695C
(en)
|
2013-10-21 |
2022-03-01 |
Dyax Corp. |
Diagnosis and treatment of autoimmune diseases
|
|
JP6687525B2
(ja)
|
2014-01-30 |
2020-04-22 |
ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ |
オピオイド受容体結合剤およびその使用
|
|
MX373485B
(es)
*
|
2014-03-26 |
2020-04-27 |
Cell Medica Switzerland Ag |
Miembros de unión al factor de necrosis tumoral (tnf) alfa.
|
|
WO2015164714A1
(en)
|
2014-04-24 |
2015-10-29 |
Immusant, Inc. |
Use of interleukin-2 for diagnosis of celiac disease
|
|
ES2900852T3
(es)
*
|
2014-05-16 |
2022-03-18 |
Ablynx Nv |
Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento
|
|
PL3248986T3
(pl)
|
2014-05-16 |
2022-05-16 |
Ablynx Nv |
Domeny zmienne immunoglobuliny
|
|
KR20250099289A
(ko)
|
2014-05-16 |
2025-07-01 |
아블린쓰 엔.브이. |
개선된 면역글로불린 가변 도메인
|
|
CA2949816A1
(en)
|
2014-05-16 |
2015-11-19 |
Children's Hospital Medical Center |
Methods for assessing responsiveness to asthma treatment based on vnn-1 expression and promoter methylation
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
|
EP3194976B1
(en)
|
2014-07-22 |
2020-04-01 |
Vib Vzw |
Methods to select agents that stabilize protein complexes
|
|
CN117138060A
(zh)
|
2014-10-07 |
2023-12-01 |
免疫医疗公司 |
抗体-药物缀合物的新辅助剂用途
|
|
US20170224758A1
(en)
|
2014-10-17 |
2017-08-10 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
|
US20170267784A1
(en)
|
2014-10-23 |
2017-09-21 |
Singh Molecular Medicine, Llc |
Single domain antibodies directed against intracellular antigens
|
|
KR102207381B1
(ko)
|
2014-10-23 |
2021-01-27 |
싱 몰레큘러 메디신, 엘엘씨 |
세포내 항원에 대해 지향된 단일 도메인 항체
|
|
EP3230457B1
(en)
|
2014-12-09 |
2021-06-30 |
New York University |
Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
|
|
AU2015366284B2
(en)
|
2014-12-19 |
2021-07-22 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
EP3623386B1
(en)
|
2015-01-08 |
2022-04-13 |
BioNTech SE |
Agonistic tnf receptor binding agents
|
|
WO2016156468A1
(en)
|
2015-03-31 |
2016-10-06 |
Vhsquared Limited |
Polypeptides
|
|
DK3277719T3
(da)
*
|
2015-03-31 |
2022-05-02 |
Sorriso Pharmaceuticals Inc |
Polypeptider
|
|
HK1250011A1
(zh)
|
2015-03-31 |
2018-11-23 |
Sorriso Pharmaceuticals, Inc. |
具有蛋白酶可切割接头的肽构建体
|
|
AU2016240220B2
(en)
|
2015-04-02 |
2019-11-21 |
Molecular Partners Ag |
Designed ankyrin repeat domains with binding specificity for serum albumin
|
|
WO2016172427A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
CA3155409A1
(en)
|
2015-05-13 |
2016-11-17 |
Ablynx N.V. |
T cell recruiting polypeptides based on cd3 reactivity
|
|
PT3294768T
(pt)
|
2015-05-13 |
2019-11-05 |
Ablynx Nv |
Polipétidos de recrutamento de células t com base na reatividade do tcr alfa/beta
|
|
EA201792573A1
(ru)
|
2015-05-21 |
2018-04-30 |
Харпун Терапьютикс, Инк. |
Триспецифические связанные белки и способы их применения
|
|
GB201510758D0
(en)
|
2015-06-18 |
2015-08-05 |
Ucb Biopharma Sprl |
Novel TNFa structure for use in therapy
|
|
EP3313519B1
(en)
|
2015-06-29 |
2023-05-31 |
Children's Medical Center Corporation |
Jak-stat inhibitors for the treatment of congenital myopathies
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
WO2017048872A1
(en)
|
2015-09-14 |
2017-03-23 |
Leukemia Therapeutics, LLC |
Identification of novel diagnostics and therapeutics by modulating rhoh
|
|
TWI746473B
(zh)
|
2015-11-02 |
2021-11-21 |
美商辛分子醫藥有限公司 |
針對細胞內抗原之單域抗體
|
|
NO2768984T3
(https=)
*
|
2015-11-12 |
2018-06-09 |
|
|
|
CN115925919A
(zh)
|
2015-11-13 |
2023-04-07 |
埃博灵克斯股份有限公司 |
改进的血清白蛋白结合免疫球蛋白可变结构域
|
|
CA3005042A1
(en)
*
|
2015-11-13 |
2017-05-18 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-bcma polypeptides and proteins
|
|
MA43260A
(fr)
|
2015-11-18 |
2018-09-26 |
Merck Sharp & Dohme |
Liants pd1 et/ou lag3
|
|
US10544222B2
(en)
|
2015-11-18 |
2020-01-28 |
Merck Sharp & Dohme Corp. |
PD1/CTLA4 binders
|
|
CN120535622A
(zh)
|
2015-11-18 |
2025-08-26 |
埃博灵克斯股份有限公司 |
改进的血清白蛋白结合剂
|
|
CR20180279A
(es)
|
2015-11-18 |
2018-08-24 |
Merck Sharp & Dohme |
Enlazadores de ctla4
|
|
WO2017089618A1
(en)
|
2015-11-27 |
2017-06-01 |
Ablynx Nv |
Polypeptides inhibiting cd40l
|
|
KR102802241B1
(ko)
|
2015-12-04 |
2025-05-07 |
베링거 인겔하임 인터내셔날 게엠베하 |
종양 세포에서 wnt 신호 전달을 길항하는 바이파라토픽 폴리펩타이드
|
|
GB201522394D0
(en)
*
|
2015-12-18 |
2016-02-03 |
Ucb Biopharma Sprl |
Antibodies
|
|
US10465003B2
(en)
*
|
2016-02-05 |
2019-11-05 |
Janssen Biotech, Inc. |
Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
|
|
US11001631B2
(en)
|
2016-02-05 |
2021-05-11 |
Orionis Biosciences BV |
Clec9A binding agents
|
|
US11248057B2
(en)
|
2016-03-07 |
2022-02-15 |
Vib Vzw |
CD20 binding single domain antibodies
|
|
CA3022697A1
(en)
|
2016-05-02 |
2017-11-09 |
Ablynx Nv |
Treatment of rsv infection
|
|
CN109563141A
(zh)
|
2016-05-13 |
2019-04-02 |
奥里尼斯生物科学公司 |
对非细胞结构的治疗性靶向
|
|
CN116987189A
(zh)
|
2016-05-20 |
2023-11-03 |
哈普恩治疗公司 |
单链可变片段cd3结合蛋白质
|
|
JP7101621B2
(ja)
|
2016-05-20 |
2022-07-15 |
ハープーン セラピューティクス，インク． |
単一ドメイン血清アルブミン結合タンパク質
|
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
|
MX2018016413A
(es)
|
2016-06-23 |
2019-05-09 |
Ablynx Nv |
Ensayos farmacocineticos mejorados para dominios variables unicos de inmunoglobulina.
|
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
|
EP3519438A1
(en)
|
2016-09-30 |
2019-08-07 |
VHsquared Limited |
Compositions
|
|
CA3043515A1
(en)
*
|
2016-11-16 |
2018-05-24 |
Ablynx Nv |
T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
|
|
CN110198955A
(zh)
|
2016-11-23 |
2019-09-03 |
哈普恩治疗公司 |
前列腺特异性膜抗原结合蛋白质
|
|
EP3544629A4
(en)
|
2016-11-23 |
2020-06-17 |
Harpoon Therapeutics, Inc. |
PSMA TO BE TRISPECIFIC PROTEINS AND METHOD FOR USE THEREOF
|
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
|
RU2022101604A
(ru)
|
2016-12-07 |
2022-03-29 |
Аблинкс Нв |
Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
|
|
GB201621907D0
(en)
|
2016-12-21 |
2017-02-01 |
Ucb Biopharma Sprl And Sanofi |
Antibody epitope
|
|
CN107674122A
(zh)
*
|
2016-12-28 |
2018-02-09 |
天津天锐生物科技有限公司 |
一种识别人血清白蛋白的单域抗体
|
|
SG10202108972RA
(en)
|
2017-01-17 |
2021-09-29 |
Ablynx Nv |
Improved serum albumin binders
|
|
HRP20241501T1
(hr)
|
2017-01-17 |
2025-01-03 |
Ablynx Nv |
Poboljšana veziva albumina u serumu
|
|
EP3577133A1
(en)
|
2017-02-06 |
2019-12-11 |
Orionis Biosciences NV |
Targeted chimeric proteins and uses thereof
|
|
HRP20250319T1
(hr)
|
2017-02-16 |
2025-05-09 |
Sonnet BioTherapeutics, Inc. |
Fuzijski proteini s domenom za vezanje na albumin
|
|
CA3054623A1
(en)
|
2017-02-28 |
2018-09-07 |
Vib Vzw |
Means and methods for oral protein delivery
|
|
EP3589662A4
(en)
|
2017-02-28 |
2020-12-30 |
Harpoon Therapeutics, Inc. |
INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN
|
|
EP3602056A1
(en)
|
2017-03-31 |
2020-02-05 |
Ablynx N.V. |
Improved immunogenicity assays
|
|
WO2018206734A1
(en)
|
2017-05-11 |
2018-11-15 |
Vib Vzw |
Glycosylation of variable immunoglobulin domains
|
|
AU2018265856B2
(en)
|
2017-05-12 |
2023-04-27 |
Harpoon Therapeutics, Inc. |
Mesothelin binding proteins
|
|
WO2018209304A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Msln targeting trispecific proteins and methods of use
|
|
PL3630816T3
(pl)
|
2017-05-31 |
2024-08-05 |
Boehringer Ingelheim International Gmbh |
Polipeptydy antagonizujące sygnalizację wnt w komórkach nowotworowych
|
|
MX2019014199A
(es)
|
2017-06-02 |
2020-01-23 |
Boehringer Ingelheim Int |
Tratamiento de combinacion antineoplasico.
|
|
TW202428621A
(zh)
|
2017-06-02 |
2024-07-16 |
德商麥克專利有限公司 |
與ａｄａｍｔｓ５、ｍｍｐ１３及聚集蛋白聚醣結合的多肽
|
|
EP3630818A1
(en)
|
2017-06-02 |
2020-04-08 |
Ablynx NV |
Aggrecan binding immunoglobulins
|
|
IL270908B1
(en)
|
2017-06-02 |
2026-04-01 |
Merck Patent Gmbh |
ADAMTS-binding immunoglobulins
|
|
BR112019025097A2
(pt)
|
2017-06-02 |
2020-07-28 |
Merck Patent Gmbh |
imunoglobulinas de ligação a mmp13
|
|
GB201710973D0
(en)
|
2017-07-07 |
2017-08-23 |
Avacta Life Sciences Ltd |
Scaffold proteins
|
|
KR102625929B1
(ko)
|
2017-07-19 |
2024-01-16 |
브이아이비 브이지더블유 |
혈청 알부민 결합제
|
|
SG11202000198QA
(en)
|
2017-08-04 |
2020-02-27 |
Genmab As |
Binding agents binding to pd-l1 and cd137 and use thereof
|
|
HRP20241268T1
(hr)
|
2017-10-13 |
2024-12-06 |
Harpoon Therapeutics, Inc. |
Trispecifični proteini i postupci primjene
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
CA3076791A1
(en)
|
2017-10-31 |
2019-05-09 |
Vib Vzw |
Novel antigen-binding chimeric proteins and methods and uses thereof
|
|
US20210070854A1
(en)
*
|
2017-12-29 |
2021-03-11 |
Board Of Regents, The University Of Texas System |
Antimicrobial nanobodies
|
|
US20200354424A1
(en)
|
2018-01-26 |
2020-11-12 |
Orionis Biosciences, Inc. |
Xcr1 binding agents and uses thereof
|
|
JP2021513361A
(ja)
|
2018-02-05 |
2021-05-27 |
オリオニス バイオサイエンシーズ，インコーポレイテッド |
線維芽細胞結合物質およびその使用
|
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
|
WO2019165105A1
(en)
*
|
2018-02-26 |
2019-08-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Ligands of the urokinase receptor and their use in treating, detecting, and imaging cancer
|
|
EP3758742A1
(en)
|
2018-03-01 |
2021-01-06 |
Vrije Universiteit Brussel |
Human pd-l1-binding immunoglobulins
|
|
WO2019204634A1
(en)
*
|
2018-04-20 |
2019-10-24 |
Stc. Unm |
Rap1-gtp, rac1-gtp and fms-like tyrosine kinase 3 ligand (flt3-l) as biomarkers for early detection of sepsis
|
|
KR20210020903A
(ko)
|
2018-05-14 |
2021-02-24 |
하푼 테라퓨틱스, 인크. |
면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티
|
|
CN110613838A
(zh)
*
|
2018-06-19 |
2019-12-27 |
姜石松 |
增强细胞通透性的多肽及其应用
|
|
DE102018122275A1
(de)
|
2018-09-12 |
2020-03-12 |
Osram Opto Semiconductors Gmbh |
Lichtemittierendes bauteil und verfahren zum betreiben eines lichtemittierenden bauteils
|
|
WO2020061482A1
(en)
|
2018-09-21 |
2020-03-26 |
Harpoon Therapeutics, Inc. |
Egfr binding proteins and methods of use
|
|
SG11202103022WA
(en)
|
2018-09-25 |
2021-04-29 |
Harpoon Therapeutics Inc |
Dll3 binding proteins and methods of use
|
|
EP3636657A1
(en)
|
2018-10-08 |
2020-04-15 |
Ablynx N.V. |
Chromatography-free antibody purification method
|
|
CN111138536B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
抗人血清白蛋白单域抗体的制备及其应用
|
|
CN111138537B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
一种抗人血清白蛋白抗体片段、制备方法和应用
|
|
US12410225B2
(en)
|
2018-11-08 |
2025-09-09 |
Orionis Biosciences, Inc |
Modulation of dendritic cell lineages
|
|
GB201818460D0
(en)
*
|
2018-11-13 |
2018-12-26 |
Crescendo Biologics Ltd |
Single domain antibodies that bind human serum albumin
|
|
CN111423509B
(zh)
*
|
2019-01-10 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
抗hsa单域抗体及其融合蛋白的亲和层析纯化方法
|
|
CN109627334B
(zh)
*
|
2019-01-29 |
2020-07-17 |
康元医疗科技(大连)有限公司 |
一种纳米抗体、以该纳米抗体为配基的吸附剂及其用途
|
|
GB201901306D0
(en)
|
2019-01-30 |
2019-03-20 |
Immunocore Ltd |
Multi-domain binding molecules
|
|
CA3133648A1
(en)
|
2019-03-28 |
2020-10-01 |
Orionis Biosciences, Inc. |
Fibroblast activation protein binding agents and use thereof
|
|
TW202104258A
(zh)
|
2019-03-29 |
2021-02-01 |
德商百靈佳殷格翰國際股份有限公司 |
抗癌組合療法
|
|
BR112021016520A2
(pt)
|
2019-03-29 |
2021-10-26 |
Boehringer Ingelheim International Gmbh |
Terapia de combinação anticâncer
|
|
CA3138642A1
(en)
|
2019-04-29 |
2020-11-05 |
Confo Therapeutics N.V. |
Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
|
|
US20220289837A1
(en)
|
2019-04-30 |
2022-09-15 |
Vib Vzw |
Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents
|
|
US12516128B2
(en)
|
2019-05-14 |
2026-01-06 |
Harpoon Therapeutics, Inc. |
EpCAM binding proteins and methods of use
|
|
EP3976067A1
(en)
|
2019-05-28 |
2022-04-06 |
Vib Vzw |
Cd8+ t-cells lacking plexins and their application in cancer treatment
|
|
US20220220197A1
(en)
|
2019-05-28 |
2022-07-14 |
Vib Vzw |
Cancer Treatment by Targeting Plexins in the Immune Compartment
|
|
US12441772B2
(en)
|
2019-06-04 |
2025-10-14 |
Molecular Partners Ag |
Designed ankyrin repeat domain with improved stability
|
|
JP7680377B2
(ja)
|
2019-06-21 |
2025-05-20 |
ソリッソ ファーマシューティカルズ，インク． |
ポリペプチド
|
|
KR20220063148A
(ko)
|
2019-06-21 |
2022-05-17 |
소리소 파마슈티컬스 인크. |
조성물
|
|
WO2020254827A1
(en)
|
2019-06-21 |
2020-12-24 |
Vhsquared Limited |
Polypeptides
|
|
TWI844709B
(zh)
|
2019-07-31 |
2024-06-11 |
美商美國禮來大藥廠 |
鬆弛素(relaxin)類似物及其使用方法
|
|
CN112409480B
(zh)
*
|
2019-08-20 |
2024-08-27 |
四川科伦博泰生物医药股份有限公司 |
结合血清白蛋白的蛋白及其用途
|
|
WO2021039574A1
(ja)
*
|
2019-08-23 |
2021-03-04 |
株式会社カネカ |
Ｏ結合型糖鎖修飾が抑制された重鎖抗体
|
|
CN112480253B
(zh)
|
2019-09-12 |
2022-09-20 |
普米斯生物技术(珠海)有限公司 |
一种抗pd-l1纳米抗体及其衍生物和用途
|
|
CN110642946A
(zh)
*
|
2019-09-30 |
2020-01-03 |
中国药科大学 |
一种人源化纳米抗体及其制备方法
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021078786A1
(en)
|
2019-10-21 |
2021-04-29 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
|
CN112746331A
(zh)
*
|
2019-10-29 |
2021-05-04 |
安升（上海）医药科技有限公司 |
半衰期延长的药物及其文库、以及制备方法和应用
|
|
BR112022009087A2
(pt)
|
2019-11-11 |
2022-07-26 |
Ibi Ag Innovative Bio Insecticides Ltd |
Nanocorpos para controle de insetos e usos dos mesmos
|
|
EP4065603A1
(en)
|
2019-11-27 |
2022-10-05 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
|
PH12022551231A1
(en)
*
|
2019-12-06 |
2023-07-31 |
Ablynx Nv |
Polypeptides comprising immunoglobulin single variable domains targeting tnfa and ox40l
|
|
JP7657797B2
(ja)
|
2019-12-06 |
2025-04-07 |
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ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド
|
|
WO2021116182A1
(en)
|
2019-12-09 |
2021-06-17 |
Ablynx Nv |
Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp
|
|
GB201918279D0
(en)
|
2019-12-12 |
2020-01-29 |
Vib Vzw |
Glycosylated single chain immunoglobulin domains
|
|
CN110988361B
(zh)
*
|
2019-12-13 |
2020-09-18 |
山东民康生物科技有限公司 |
人血清白蛋白去除试剂盒
|
|
US20240027467A1
(en)
|
2019-12-20 |
2024-01-25 |
Vib Vzw |
Nanobody Exchange Chromatography
|
|
CN112300289B
(zh)
*
|
2019-12-30 |
2022-06-10 |
中国药科大学 |
RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
|
|
BR112022013554A2
(pt)
|
2020-01-08 |
2022-09-06 |
argenx BV |
Métodos para tratar distúrbios do pênfigo
|
|
WO2021140205A1
(en)
|
2020-01-10 |
2021-07-15 |
Confo Therapeutics N.V. |
Methods for generating antibodies and antibody fragments and libraries comprising same
|
|
WO2021156490A2
(en)
|
2020-02-06 |
2021-08-12 |
Vib Vzw |
Corona virus binders
|
|
CA3170833A1
(en)
|
2020-02-21 |
2021-08-26 |
Harpoon Therapeutics, Inc. |
Flt3 binding proteins and methods of use
|
|
KR20230012464A
(ko)
|
2020-02-25 |
2023-01-26 |
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류신-풍부 반복 키나제 2 알로스테릭 조절제
|
|
JP7754510B2
(ja)
*
|
2020-03-06 |
2025-10-15 |
ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション |
血清アルブミン結合ナノボディ組成物、及びその使用方法
|
|
JP2023523600A
(ja)
|
2020-04-22 |
2023-06-06 |
マブウェル （シャンハイ） バイオサイエンス カンパニー リミテッド |
ヒトプログラム細胞死リガンド１（ｐｄ－ｌ１）を標的とする単一可変ドメイン抗体およびその誘導体
|
|
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(en)
|
2020-05-15 |
2021-11-18 |
Université de Liège |
Anti-cd38 single-domain antibodies in disease monitoring and treatment
|
|
GB202101299D0
(en)
|
2020-06-09 |
2021-03-17 |
Avacta Life Sciences Ltd |
Diagnostic polypetides and methods
|
|
WO2022003156A1
(en)
|
2020-07-02 |
2022-01-06 |
Oncurious Nv |
Ccr8 non-blocking binders
|
|
CN116284373B
(zh)
*
|
2020-08-14 |
2026-04-14 |
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非pH依赖性长效型抗血清白蛋白纳米抗体及其应用
|
|
CN114106190B
(zh)
*
|
2020-08-31 |
2025-04-08 |
普米斯生物技术(珠海)有限公司 |
一种抗vegf/pd-l1双特异性抗体及其用途
|
|
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(en)
|
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2022-03-31 |
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Biomarker for anti-tumor therapy
|
|
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(en)
|
2020-09-24 |
2023-08-02 |
Vib Vzw |
Combination of p2y6 inhibitors and immune checkpoint inhibitors
|
|
MX2023003522A
(es)
|
2020-09-25 |
2023-04-19 |
Ablynx Nv |
Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l.
|
|
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(en)
|
2020-10-27 |
2022-05-05 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion proteins of gdf15 and use thereof
|
|
WO2022098743A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
|
|
WO2022098745A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, delivery systems, and methods useful in tumor therapy
|
|
WO2022117569A1
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
|
|
WO2022117572A2
(en)
|
2020-12-02 |
2022-06-09 |
Oncurious Nv |
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|
|
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(ko)
|
2020-12-18 |
2023-08-23 |
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글리피칸-3 및 t세포 수용체를 표적으로 하는 면역글로불린단일 가변 도메인을 포함하는 폴리펩티드
|
|
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(ko)
|
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|
|
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(ko)
|
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IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
|
|
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(en)
|
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2021-02-03 |
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Antibody composistion for treatment of corona virus infection
|
|
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(en)
|
2020-12-24 |
2022-06-30 |
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|
|
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(en)
|
2020-12-24 |
2023-11-01 |
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Non-blocking human ccr8 binders
|
|
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(en)
|
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Murine cross-reactive human ccr8 binders
|
|
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(zh)
|
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|
|
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(en)
|
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Vib Vzw [Be/Be |
Sarbevirus binders
|
|
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(zh)
|
2021-02-17 |
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在癌症治疗中slc4a4的抑制
|
|
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(en)
|
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2025-08-21 |
Vib Vzw |
Cation-Independent Mannose-6-Phosphate Receptor Binders
|
|
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(en)
|
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2022-09-29 |
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|
|
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(en)
|
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2022-11-10 |
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|
|
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(en)
|
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Université de Liège |
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|
|
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(en)
|
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2024-05-01 |
Vib Vzw |
Means and methods for selection of specific binders
|
|
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(zh)
|
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2023-01-05 |
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|
|
CA3224743A1
(en)
*
|
2021-07-14 |
2023-01-19 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion polypeptides for metabolic disorders
|
|
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(zh)
*
|
2021-07-20 |
2023-01-17 |
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|
|
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(en)
|
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2023-02-16 |
Vib Vzm |
Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
|
|
AU2022320667A1
(en)
|
2021-07-30 |
2024-03-14 |
Shandong Simcere Biopharmaceutical Co., Ltd. |
Anti-pvrig/anti-tigit bispecific antibody and application
|
|
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(zh)
|
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2023-09-01 |
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(zh)
*
|
2021-12-14 |
2022-03-04 |
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|
|
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(en)
|
2021-12-17 |
2024-08-01 |
Ablynx Nv |
POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123
|
|
US20250145705A1
(en)
|
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2025-05-08 |
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Gprc5d antibody and application thereof
|
|
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(en)
|
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2023-07-20 |
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Human ntcp binders for therapeutic use and liver-specific targeted delivery
|
|
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(en)
|
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|
|
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(ko)
|
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|
|
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(zh)
*
|
2022-03-31 |
2023-10-24 |
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抗血清白蛋白纳米抗体及其衍生物
|
|
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(en)
|
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2023-10-19 |
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|
|
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(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
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(en)
|
2022-05-18 |
2025-10-09 |
Vib Vzw |
Sarbecovirus spike s2 subunit binders
|
|
CN115028719B
(zh)
*
|
2022-05-27 |
2023-01-13 |
深圳市人民医院 |
血清白蛋白结合纳米抗体及其制备方法与应用
|
|
TW202411253A
(zh)
|
2022-06-06 |
2024-03-16 |
大陸商山東先聲生物製藥有限公司 |
靶向bcma、gprc5d和t細胞的多特異性抗體及其應用
|
|
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(ko)
|
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2025-02-18 |
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T 세포 수용체를 표적화하는 면역글로불린 단일 가변 도메인
|
|
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(en)
|
2022-06-15 |
2023-12-21 |
argenx BV |
FCRN/ANTIGEN BINDING MOLECULES AND METHODS OF USE
|
|
WO2024003873A1
(en)
*
|
2022-06-30 |
2024-01-04 |
Intrexon Actobiotics Nv D/B/A Precigen Actobio |
Single variable domain antibodies against tumor necrosis factor-alpha
|
|
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(ja)
|
2022-07-04 |
2025-07-23 |
ブイアイビー ブイゼットダブリュ |
血液－脳脊髄液関門通過抗体
|
|
MA71603A
(fr)
|
2022-07-27 |
2025-05-30 |
Ablynx Nv |
Polypeptides se liant à un épitope spécifique du récepteur fc néonatal
|
|
EP4573119A1
(en)
|
2022-08-17 |
2025-06-25 |
Institut National de la Santé et de la Recherche Médicale |
Improved anti-albumin nanobodies and their uses
|
|
WO2024068744A1
(en)
|
2022-09-27 |
2024-04-04 |
Vib Vzw |
Antivirals against human parainfluenza virus
|
|
EP4593867A2
(en)
|
2022-09-30 |
2025-08-06 |
Extend Biosciences, Inc. |
Long-acting parathyroid hormone
|
|
EP4605077A1
(en)
|
2022-10-18 |
2025-08-27 |
Confo Therapeutics N.V. |
Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
|
|
CN120322456A
(zh)
|
2022-10-28 |
2025-07-15 |
嘉和生物药业有限公司 |
新型抗ctla4抗体
|
|
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(en)
|
2022-11-15 |
2025-09-24 |
Imec VZW |
Method and system for droplet manipulation
|
|
EP4634214A1
(en)
|
2022-12-15 |
2025-10-22 |
Aarhus Universitet |
Synthetic activation of multimeric transmembrane receptors
|
|
AR131494A1
(es)
|
2022-12-23 |
2025-03-26 |
Ablynx Nv |
Vehículos de conjugación a base de proteína
|
|
CN120529914A
(zh)
|
2023-01-09 |
2025-08-22 |
奥德赛治疗股份有限公司 |
抗tnfr2抗原结合蛋白及其用途
|
|
EP4652190A1
(en)
*
|
2023-01-18 |
2025-11-26 |
Beijing QL Biopharmaceutical Co., Ltd. |
Liquid pharmaceutical compositions of fusion polypeptides and methods of uses thereof
|
|
CR20250279A
(es)
|
2023-01-20 |
2025-08-25 |
Boehringer Ingelheim Int |
Proteínas de fusión fc de il-12
|
|
WO2024156888A1
(en)
|
2023-01-27 |
2024-08-02 |
Vib Vzw |
Cd163-binding conjugates
|
|
WO2024156881A1
(en)
|
2023-01-27 |
2024-08-02 |
Vib Vzw |
CD8b-BINDING POLYPEPTIDES
|
|
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(ja)
|
2023-02-17 |
2026-02-20 |
アブリンクス エン．ヴェー． |
新生児型ｆｃ受容体に結合するポリペプチド
|
|
WO2024175787A1
(en)
|
2023-02-24 |
2024-08-29 |
Vrije Universiteit Brussel |
Anti-inflammatory pannexin 1 channel inhibitors
|
|
US20240344078A1
(en)
|
2023-03-14 |
2024-10-17 |
Aarhus Universitet |
Genetically altered nfr5 receptor kinases
|
|
WO2024192065A1
(en)
|
2023-03-14 |
2024-09-19 |
Odyssey Therapeutics, Inc. |
Anti-cd25 antigen-binding proteins and uses thereof
|
|
EP4688825A1
(en)
|
2023-03-31 |
2026-02-11 |
AffyXell Therapeutics Co., Ltd. |
Tnfr2 binding polypeptides and methods of use
|
|
FR3147278A1
(fr)
|
2023-03-31 |
2024-10-04 |
Avacta Life Sciences Limited |
Polypeptides de liaison au tnfr2 et procedes d'utilisation
|
|
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(en)
|
2023-04-03 |
2024-10-10 |
Vib Vzw |
Blood-brain barrier crossing antibodies
|
|
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(ko)
|
2023-04-24 |
2026-01-28 |
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Trop2 결합제 및 그의 접합체
|
|
EP4709753A1
(en)
|
2023-05-11 |
2026-03-18 |
Vib Vzw |
Slc4a4/nbce1 inhibitors
|
|
CN121511255A
(zh)
|
2023-05-17 |
2026-02-10 |
奥德赛治疗股份有限公司 |
经修饰的单结构域抗体
|
|
WO2024240162A1
(en)
|
2023-05-23 |
2024-11-28 |
Shanghai Allygen Biologics Co., Ltd. |
Pd-l1 and trop-2 targeting conjugates comprising effector molecules and uses thereof
|
|
KR20260028051A
(ko)
|
2023-06-22 |
2026-03-03 |
아블린쓰 엔.브이. |
사이토카인의 수용체-활성을 조절하기 위한 키메라 단백질
|
|
WO2024261344A1
(en)
|
2023-06-23 |
2024-12-26 |
Vib Vzw |
Novel binders targeting the multi-drug resistant pathogen acinetobacter baumannii
|
|
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(en)
|
2023-06-29 |
2026-02-01 |
Odyssey Therapeutics Inc |
Anti-TRAILR2 antigen-binding proteins and their uses
|
|
EP4483951A1
(en)
|
2023-06-30 |
2025-01-01 |
Université de Liège |
Single-domain antibody for inhibition of neutrophil elastase activity
|
|
AR133188A1
(es)
|
2023-07-05 |
2025-09-03 |
Ablynx Nv |
ANTAGONISTAS DE FcRn MEJORADOS PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON IgG
|
|
WO2025038362A1
(en)
|
2023-08-11 |
2025-02-20 |
Merck Sharp & Dohme Llc |
Monovalent interleukin 12 (il-12) heterodimeric fc proteins
|
|
WO2025051767A1
(en)
|
2023-09-04 |
2025-03-13 |
Sanofi |
Polypeptides for use in the treatment of glypican-3-expressing tumours
|
|
US20250129145A1
(en)
|
2023-09-22 |
2025-04-24 |
Ablynx N.V. |
Bi- and multivalent albumin binders
|
|
WO2025080751A2
(en)
|
2023-10-13 |
2025-04-17 |
Odyssey Therapeutics, Inc. |
Anti-cdh17 antigen-binding proteins and uses thereof
|
|
WO2025090840A1
(en)
*
|
2023-10-27 |
2025-05-01 |
Rutgers, The State University Of New Jersey |
Antigen binding molecules targeting tnf-alpha
|
|
WO2025093683A1
(en)
|
2023-11-03 |
2025-05-08 |
Neuvasq Biotechnologies Sa |
Wnt7 signaling agonists
|
|
AR134267A1
(es)
|
2023-11-08 |
2025-12-17 |
Sanofi Sa |
Degradador lisosómico basado en cd25 y usos del mismo
|
|
WO2025109176A1
(en)
|
2023-11-22 |
2025-05-30 |
Exevir Bio Bv |
Optimized sarbecovirus spike s2 subunit binders and compositions comprising the same
|
|
TW202540188A
(zh)
|
2023-12-01 |
2025-10-16 |
比利時商艾伯霖克斯公司 |
精準活化的多肽
|
|
WO2025125577A1
(en)
|
2023-12-14 |
2025-06-19 |
Vib Vzw |
Antibodies against influenza b virus
|
|
TW202543670A
(zh)
|
2023-12-22 |
2025-11-16 |
比利時商艾伯霖克斯公司 |
用於核內投予之基於蛋白質的接合載劑
|
|
US20250236673A1
(en)
|
2023-12-22 |
2025-07-24 |
Ablynx N.V. |
Protein-based carriers for site-specific amine conjugation
|
|
US12134635B1
(en)
|
2023-12-29 |
2024-11-05 |
Sonnet BioTherapeutics, Inc. |
Interleukin 18 (IL-18) variants and fusion proteins comprising same
|
|
WO2025147862A1
(zh)
*
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WO2025255558A2
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Odyssey Therapeutics, Inc. |
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Odyssey Therapeutics, Inc. |
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Vib Vzw |
Allosteric modulators of inhibitory immune receptor complexes
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Genzyme Corporation |
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Ablynx Nv |
Immune cell engagers and methods comprising the same
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