|
JP2005289809A
(ja)
*
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US9453251B2
(en)
|
2002-10-08 |
2016-09-27 |
Pfenex Inc. |
Expression of mammalian proteins in Pseudomonas fluorescens
|
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
|
EP1900753B1
(en)
|
2002-11-08 |
2017-08-09 |
Ablynx N.V. |
Method of administering therapeutic polypeptides, and polypeptides therefor
|
|
BRPI0513826A2
(pt)
|
2004-07-26 |
2010-06-22 |
Dow Global Technologies Inc |
processo para expressão de proteìna melhorada através de engenharia de cepa
|
|
US8188223B2
(en)
|
2005-05-18 |
2012-05-29 |
Ablynx N.V. |
Serum albumin binding proteins
|
|
DE102005023617A1
(de)
*
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
|
US20070269422A1
(en)
*
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
AU2007293614A1
(en)
*
|
2006-09-08 |
2008-03-13 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
ATE536369T1
(de)
|
2006-10-11 |
2011-12-15 |
Ablynx Nv |
Im wesentlichen ph-wert-unabhängigerweise an serumproteine bindende aminosäuresequenzen, verbindungen, die diese enthalten, und deren verwendung
|
|
WO2008071685A1
(en)
*
|
2006-12-13 |
2008-06-19 |
Ablynx N.V. |
Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex
|
|
AU2007331672A1
(en)
*
|
2006-12-15 |
2008-06-19 |
Ablynx N.V. |
Amino acid sequences that modulate the interaction between cells of the immune system
|
|
US9512236B2
(en)
|
2006-12-19 |
2016-12-06 |
Ablynx N.V. |
Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
|
CA2673331A1
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
|
EP2102244A2
(en)
*
|
2006-12-19 |
2009-09-23 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
|
|
WO2008074868A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Ablynx N.V. |
Oral delivery of polypeptides
|
|
EP2121757A2
(en)
*
|
2007-02-21 |
2009-11-25 |
Ablynx N.V. |
Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization
|
|
US9394571B2
(en)
|
2007-04-27 |
2016-07-19 |
Pfenex Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
US9580719B2
(en)
|
2007-04-27 |
2017-02-28 |
Pfenex, Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
|
CA2687903C
(en)
|
2007-05-24 |
2016-09-13 |
Ablynx N.V. |
Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders
|
|
AU2008270274B2
(en)
|
2007-07-03 |
2012-06-28 |
Ablynx N.V. |
Providing improved immunoglobulin sequences by mutating CDR and/or FR positions
|
|
EP2535349A1
(en)
|
2007-09-26 |
2012-12-19 |
UCB Pharma S.A. |
Dual specificity antibody fusions
|
|
EP2650311A3
(en)
|
2007-11-27 |
2014-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
GB2470328A
(en)
*
|
2008-03-05 |
2010-11-17 |
Ablynx Nv |
Novel antigen binding dimer complexes, methods of making and uses thereof
|
|
GB0809069D0
(en)
|
2008-05-19 |
2008-06-25 |
Univ Leuven Kath |
Gene signatures
|
|
JP2011516520A
(ja)
|
2008-04-07 |
2011-05-26 |
アブリンクス エン．ヴェー． |
Ｎｏｔｃｈ経路に指向性を有するアミノ酸配列及びその使用
|
|
WO2009127691A1
(en)
*
|
2008-04-17 |
2009-10-22 |
Ablynx N.V. |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
|
US8444976B2
(en)
|
2008-07-02 |
2013-05-21 |
Argen-X B.V. |
Antigen binding polypeptides
|
|
CA2737241C
(en)
|
2008-09-26 |
2017-08-29 |
Ucb Pharma S.A. |
Multivalent antibody fusion proteins
|
|
AU2013202856B2
(en)
*
|
2008-10-29 |
2016-02-11 |
Ablynx N.V. |
Formulations of single domain antigen binding molecules
|
|
BRPI0919879A2
(pt)
*
|
2008-10-29 |
2016-02-16 |
Wyeth Llc |
métodos para purificação de moléculas de ligação a antígeno de domínio único
|
|
CA2738243C
(en)
|
2008-10-29 |
2020-09-29 |
Wyeth Llc |
Formulations of single domain antigen binding molecules
|
|
US20160095939A1
(en)
|
2014-10-07 |
2016-04-07 |
Immunomedics, Inc. |
Neoadjuvant use of antibody-drug conjugates
|
|
US10005830B2
(en)
|
2009-03-05 |
2018-06-26 |
Ablynx N.V. |
Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
|
|
US9265834B2
(en)
*
|
2009-03-05 |
2016-02-23 |
Ablynx N.V. |
Stable formulations of polypeptides and uses thereof
|
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
|
AU2010243551B2
(en)
|
2009-04-30 |
2015-03-26 |
Ablynx Nv |
Method for the production of domain antibodies
|
|
PT2438087T
(pt)
|
2009-06-05 |
2017-08-04 |
Ablynx Nv |
Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório
|
|
WO2011003622A1
(en)
|
2009-07-10 |
2011-01-13 |
Ablynx N.V. |
Method for the production of variable domains
|
|
LT2805731T
(lt)
|
2009-09-03 |
2019-02-11 |
Ablynx N.V. |
Stabilios polipeptidų kompozicijos ir jų panaudojimas
|
|
GB201005063D0
(en)
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
|
UY32917A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moléculas de unión a dll-4
|
|
US20110172398A1
(en)
|
2009-10-02 |
2011-07-14 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules for anti-angiogenesis therapy
|
|
WO2011064382A1
(en)
|
2009-11-30 |
2011-06-03 |
Ablynx N.V. |
Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
|
|
EP3309176B1
(en)
|
2009-12-14 |
2025-10-01 |
Ablynx N.V. |
Immunoglobulin single variable domain antibodies against ox40l, constructs and their therapeutic use
|
|
WO2011083140A1
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
EP2531523A1
(en)
|
2010-02-05 |
2012-12-12 |
Ablynx N.V. |
Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
|
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
|
EP2533814A2
(en)
|
2010-02-11 |
2012-12-19 |
Ablynx N.V. |
Delivery of immunoglobulin variable domains and constructs thereof
|
|
DK2533761T3
(da)
|
2010-02-11 |
2019-06-24 |
Ablynx Nv |
Fremgangsmåder og sammensætninger til fremstilling af aerosoler
|
|
NZ601117A
(en)
|
2010-03-03 |
2014-06-27 |
Boehringer Ingelheim Int |
Biparatopic abeta binding polypeptides
|
|
WO2011117423A1
(en)
|
2010-03-26 |
2011-09-29 |
Ablynx N.V. |
Immunoglobulin single variable domains directed against cxcr7
|
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
|
EP2571901B1
(en)
|
2010-05-20 |
2019-01-02 |
Ablynx N.V. |
Biological materials related to her3
|
|
WO2011161263A1
(en)
|
2010-06-25 |
2011-12-29 |
Ablynx Nv |
Pharmaceutical compositions for cutaneous administration
|
|
CN103119062A
(zh)
*
|
2010-07-16 |
2013-05-22 |
埃博灵克斯股份有限公司 |
修饰的单结构域抗原结合分子及其应用
|
|
US20120225081A1
(en)
|
2010-09-03 |
2012-09-06 |
Boehringer Ingelheim International Gmbh |
Vegf-binding molecules
|
|
EP2621953B1
(en)
|
2010-09-30 |
2017-04-05 |
Ablynx N.V. |
Biological materials related to c-met
|
|
US11644471B2
(en)
|
2010-09-30 |
2023-05-09 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
PL3279214T3
(pl)
|
2010-10-29 |
2025-03-24 |
Ablynx Nv |
Sposób wytwarzania pojedynczych domen zmiennych immunoglobuliny
|
|
AU2011328246B2
(en)
|
2010-11-08 |
2016-06-30 |
Ablynx N.V. |
CXCR2 binding polypeptides
|
|
PL2643349T3
(pl)
|
2010-11-26 |
2020-03-31 |
Molecular Partners Ag |
Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy
|
|
AU2012234282B2
(en)
|
2011-03-28 |
2015-07-16 |
Ablynx Nv |
Method for producing solid formulations comprising immunoglobulin single variable domains
|
|
CN103917560B
(zh)
|
2011-03-28 |
2017-05-24 |
埃博灵克斯股份有限公司 |
双特异性抗‑cxcr7免疫球蛋白单可变结构域
|
|
MX361242B
(es)
*
|
2011-03-30 |
2018-11-30 |
Ablynx Nv |
Anticuerpos de dominio sencillo contra tnf-alfa y usos de los mismos.
|
|
US20130078247A1
(en)
|
2011-04-01 |
2013-03-28 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to dii4 and ang2
|
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
|
WO2012152823A1
(en)
|
2011-05-09 |
2012-11-15 |
Ablynx Nv |
Method for the production of immunoglobulin single variable domains
|
|
WO2012163887A1
(en)
|
2011-05-27 |
2012-12-06 |
Ablynx Nv |
Inhibition of bone resorption with rankl binding peptides
|
|
EP2723772A1
(en)
|
2011-06-23 |
2014-04-30 |
Ablynx N.V. |
Immunoglobulin single variable domains directed against ige
|
|
SG10201805064SA
(en)
|
2011-06-23 |
2018-07-30 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
RS55775B2
(sr)
|
2011-06-23 |
2022-10-31 |
Ablynx Nv |
Tehnike za predviđanje, otkrivanje i smanjenje nespecifične proteinske interferencije u testovima koji uključuju pojedinačne varijabilne domene imunoglobulina
|
|
EP2723771B1
(en)
*
|
2011-06-23 |
2019-09-11 |
Ablynx NV |
Serum albumin binding proteins
|
|
EP4350345A3
(en)
|
2011-06-23 |
2024-07-24 |
Ablynx N.V. |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
|
|
WO2013041722A1
(en)
|
2011-09-23 |
2013-03-28 |
Ablynx Nv |
Prolonged inhibition of interleukin-6 mediated signaling
|
|
EP2758434A2
(en)
|
2011-09-23 |
2014-07-30 |
Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA |
Anti-tumor necrosis factor-alpha agents and uses thereof
|
|
US9346884B2
(en)
|
2011-09-30 |
2016-05-24 |
Ablynx N.V. |
Biological materials related to c-Met
|
|
JP6219287B2
(ja)
|
2011-09-30 |
2017-10-25 |
アブリンクス エン．ヴェー． |
ｃ−Ｍｅｔに関連する生物学的物質
|
|
PH12021553014A1
(en)
|
2012-02-27 |
2022-09-05 |
Ablynx Nv |
Cx3cr1-binding polypeptides
|
|
SI2831111T1
(sl)
|
2012-03-30 |
2019-06-28 |
Boehringer Ingelheim International Gmbh |
Ang2-vezavne molekule
|
|
EP4151658A1
(en)
|
2012-05-07 |
2023-03-22 |
Elasmogen Limited |
Single domain binding molecule
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
AU2013263349B2
(en)
|
2012-05-17 |
2016-09-08 |
Extend Biosciences, Inc |
Carriers for improved drug delivery
|
|
JP6411333B2
(ja)
|
2012-05-24 |
2018-10-24 |
ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ |
腫瘍関連マクロファージのターゲティングおよびｉｎｖｉｖｏイメージング用抗マクロファージマンノース受容体単一可変ドメイン
|
|
RU2530553C2
(ru)
*
|
2012-11-07 |
2014-10-10 |
Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) |
Рекомбинантное однодоменное антитело, способное специфически связывать фактор некроза опухолей человека, и его производные
|
|
US9315280B2
(en)
*
|
2012-11-20 |
2016-04-19 |
Lockheed Martin Corporation |
Heat pipe with axial wick
|
|
WO2014087010A1
(en)
|
2012-12-07 |
2014-06-12 |
Ablynx N.V. |
IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
|
|
WO2017004144A1
(en)
|
2015-07-01 |
2017-01-05 |
Immunomedics, Inc. |
Antibody-sn-38 immunoconjugates with a cl2a linker
|
|
US20160185847A1
(en)
|
2012-12-17 |
2016-06-30 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Use of monoclonal antibodies for the treatment of inflammation and bacterial infections
|
|
WO2014111550A1
(en)
|
2013-01-17 |
2014-07-24 |
Glaxosmithkline Intellectual Property Development Limited |
Modified anti-serum albumin binding proteins
|
|
CN105102478A
(zh)
|
2013-01-30 |
2015-11-25 |
弗拉芒区生物技术研究所 |
用于筛选和药物发现目的的新型嵌合多肽
|
|
US20150368339A1
(en)
|
2013-02-05 |
2015-12-24 |
Vib Vzw |
Muscarinic acetylcholine receptor binding agents and uses thereof
|
|
EP3594230A1
(en)
|
2013-02-13 |
2020-01-15 |
Laboratoire Français du Fractionnement et des Biotechnologies |
Highly galactosylated anti-tnf-alpha antibodies and uses thereof
|
|
WO2014125377A2
(en)
|
2013-02-13 |
2014-08-21 |
Laboratoire Francais Du Fractionnement Et Des Biotechnologies |
Highly galactosylated anti-her2 antibodies and uses thereof
|
|
CN105358577A
(zh)
|
2013-02-13 |
2016-02-24 |
法国化学与生物科技实验室 |
具有经修饰的糖基化的西妥昔单抗及其用途
|
|
US9255262B2
(en)
|
2013-03-06 |
2016-02-09 |
Vision Global Holdings Ltd. |
Albumin-binding arginine deminase and the use thereof
|
|
USRE48805E1
(en)
|
2013-03-06 |
2021-11-02 |
Vision Global Holdings Ltd. |
Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
|
|
JP6457999B2
(ja)
|
2013-03-14 |
2019-01-23 |
ザ チルドレンズ メディカル センター コーポレーション |
処置に関してがんの対象を識別するためのｃｄ３６の使用
|
|
JP6499090B2
(ja)
|
2013-03-15 |
2019-04-10 |
ブイアイビー ブイゼットダブリュＶｉｂ Ｖｚｗ |
心血管疾患において使用するための抗マクロファージマンノース受容体単一可変ドメイン
|
|
JP6616284B2
(ja)
|
2013-04-23 |
2019-12-04 |
ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン |
特異的結合分子の人工ライブラリー
|
|
NL1040254C2
(en)
|
2013-05-17 |
2014-11-24 |
Ablynx Nv |
Stable formulations of immunoglobulin single variable domains and uses thereof.
|
|
CA2927695C
(en)
|
2013-10-21 |
2022-03-01 |
Dyax Corp. |
Diagnosis and treatment of autoimmune diseases
|
|
US10233241B2
(en)
|
2014-01-30 |
2019-03-19 |
Vib Vzw |
Opioid receptor binding agents and uses thereof
|
|
JP6832707B2
(ja)
*
|
2014-03-26 |
2021-02-24 |
セル メディカ スイッツァランド アーゲー |
ＴＮＦαに対する結合メンバー
|
|
AU2015249592A1
(en)
|
2014-04-24 |
2016-12-15 |
Immusant, Inc. |
Use of Interleukin-2 for diagnosis of Celiac disease
|
|
EP3143164B1
(en)
|
2014-05-16 |
2021-08-11 |
Children's Hospital Medical Center |
Methods for assessing responsiveness to asthma treatment based on vnn-1 expression and promoter methylation
|
|
EP4707303A2
(en)
|
2014-05-16 |
2026-03-11 |
Ablynx NV |
Improved immunoglobulin variable domains
|
|
US11009511B2
(en)
*
|
2014-05-16 |
2021-05-18 |
Ablynx N.V. |
Methods for detecting and/or measuring anti-drug antibodies, in particular treatment-emergent anti-drug antibodies
|
|
IL318433A
(en)
|
2014-05-16 |
2025-03-01 |
Ablynx Nv |
Improved immunoglobulin variable complexes
|
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
|
DK3194976T3
(da)
|
2014-07-22 |
2020-07-13 |
Vib Vzw |
Fremgangsmåder til udvælgelse af midler, som stabiliserer proteinkomplekser
|
|
EP3207048A4
(en)
|
2014-10-17 |
2018-05-30 |
The Broad Institute, Inc. |
Compositions and methods of treating muscular dystrophy
|
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
|
WO2016065042A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Therapeutic vitamin d conjugates
|
|
US20170267784A1
(en)
|
2014-10-23 |
2017-09-21 |
Singh Molecular Medicine, Llc |
Single domain antibodies directed against intracellular antigens
|
|
US20160115247A1
(en)
|
2014-10-23 |
2016-04-28 |
Singh Biotechnology, Llc |
Single domain antibodies directed against intracellular antigens
|
|
US11897921B2
(en)
|
2014-12-09 |
2024-02-13 |
New York University |
Propeptide fusion comprising a mutated clostridium botulinum neurotoxin and a VHH domain
|
|
AU2015366284B2
(en)
|
2014-12-19 |
2021-07-22 |
Ablynx N.V. |
Cysteine linked nanobody dimers
|
|
SI3242890T1
(sl)
|
2015-01-08 |
2020-01-31 |
BioNTech SE |
Agonistična sredstva, ki vežejo receptorje TNF
|
|
WO2016156468A1
(en)
|
2015-03-31 |
2016-10-06 |
Vhsquared Limited |
Polypeptides
|
|
CA3255406A1
(en)
|
2015-03-31 |
2025-07-03 |
Sorriso Pharmaceuticals, Inc. |
Tnf-alpha binding polypeptides
|
|
SG11201706840WA
(en)
|
2015-03-31 |
2017-09-28 |
Vhsquared Ltd |
Peptide construct having a protease-cleavable linker
|
|
KR102427117B1
(ko)
|
2015-04-02 |
2022-07-29 |
몰리큘라 파트너스 아게 |
혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인
|
|
AU2016252771B2
(en)
|
2015-04-22 |
2021-12-16 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells
|
|
CN114920848B
(zh)
|
2015-05-13 |
2024-10-11 |
埃博灵克斯股份有限公司 |
基于cd3反应性的t细胞募集多肽
|
|
LT3611192T
(lt)
|
2015-05-13 |
2025-06-25 |
Ablynx N.V. |
T ląstelių rekrutingo polipeptidai tcr alfa/beta reaktyvumo pagrindu
|
|
US9708412B2
(en)
|
2015-05-21 |
2017-07-18 |
Harpoon Therapeutics, Inc. |
Trispecific binding proteins and methods of use
|
|
GB201510758D0
(en)
|
2015-06-18 |
2015-08-05 |
Ucb Biopharma Sprl |
Novel TNFa structure for use in therapy
|
|
WO2017004142A1
(en)
|
2015-06-29 |
2017-01-05 |
Children's Medical Center Corporation |
Treatment for myopathy
|
|
CA2998611A1
(en)
|
2015-09-14 |
2017-03-23 |
Leukemia Therapeutics, LLC |
Identification of novel diagnostics and therapeutics by modulating rhoh
|
|
TWI746473B
(zh)
|
2015-11-02 |
2021-11-21 |
美商辛分子醫藥有限公司 |
針對細胞內抗原之單域抗體
|
|
NO2768984T3
(https=)
*
|
2015-11-12 |
2018-06-09 |
|
|
|
LT3374392T
(lt)
|
2015-11-13 |
2022-01-25 |
Ablynx Nv |
Patobulinti serumo albuminą surišantys imunoglobulino kintami domenai
|
|
CN108473575B
(zh)
*
|
2015-11-13 |
2022-04-19 |
美国卫生和人力服务部 |
抗-bcma多肽和蛋白质
|
|
IL300122A
(en)
|
2015-11-18 |
2023-03-01 |
Merck Sharp ַ& Dohme Llc |
Substances that bind to PD1 and/or LAG3
|
|
AU2016357460B2
(en)
*
|
2015-11-18 |
2023-07-27 |
Ablynx Nv |
Improved serum albumin binders
|
|
CA3003777A1
(en)
|
2015-11-18 |
2017-05-26 |
Merck Sharp & Dohme Corp. |
Pd1/ctla4 binders
|
|
AU2016355569B2
(en)
|
2015-11-18 |
2020-01-02 |
Merck Sharp & Dohme Llc |
CTLA4 binders
|
|
KR20180080337A
(ko)
|
2015-11-27 |
2018-07-11 |
아블린쓰 엔.브이. |
Ｃｄ40ｌ을 억제하는 폴리펩티드
|
|
UA122079C2
(uk)
|
2015-12-04 |
2020-09-10 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Поліпептид, що специфічно зв'язується з lrp5 і lrp6
|
|
GB201522394D0
(en)
*
|
2015-12-18 |
2016-02-03 |
Ucb Biopharma Sprl |
Antibodies
|
|
CN116769054A
(zh)
|
2016-02-05 |
2023-09-19 |
奥里尼斯生物科学私人有限公司 |
双特异性信号传导剂及其用途
|
|
US10465003B2
(en)
*
|
2016-02-05 |
2019-11-05 |
Janssen Biotech, Inc. |
Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
|
|
EP3426278B1
(en)
|
2016-03-07 |
2024-01-03 |
Vib Vzw |
Cd20 binding single domain antibodies
|
|
CN109311968A
(zh)
|
2016-05-02 |
2019-02-05 |
埃博灵克斯股份有限公司 |
治疗rsv感染
|
|
EP3455245A2
(en)
|
2016-05-13 |
2019-03-20 |
Orionis Biosciences NV |
Therapeutic targeting of non-cellular structures
|
|
EP3493844A4
(en)
|
2016-05-20 |
2021-03-24 |
Harpoon Therapeutics Inc. |
SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
|
|
WO2017201493A1
(en)
|
2016-05-20 |
2017-11-23 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment cd3 binding proteins
|
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
|
AU2017281421B2
(en)
|
2016-06-23 |
2024-07-25 |
Ablynx N.V. |
Improved pharmacokinetic assays for immunoglobulin single variable domains
|
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
|
US11098113B2
(en)
|
2016-09-15 |
2021-08-24 |
Vib Vzw |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
|
EP3519438A1
(en)
|
2016-09-30 |
2019-08-07 |
VHsquared Limited |
Compositions
|
|
BR112019010061A2
(pt)
*
|
2016-11-16 |
2019-08-13 |
Ablynx Nv |
polipeptídeos de recrutamento de células t capazes de se ligarem ao cd123 e tcr alfa/beta
|
|
AU2017363300A1
(en)
|
2016-11-23 |
2019-06-20 |
Harpoon Therapeutics, Inc. |
Prostate specific membrane antigen binding protein
|
|
WO2018098356A1
(en)
|
2016-11-23 |
2018-05-31 |
Harpoon Therapeutics, Inc. |
Psma targeting trispecific proteins and methods of use
|
|
WO2018099968A1
(en)
|
2016-11-29 |
2018-06-07 |
Ablynx N.V. |
Treatment of infection by respiratory syncytial virus (rsv)
|
|
RU2022101604A
(ru)
*
|
2016-12-07 |
2022-03-29 |
Аблинкс Нв |
Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином
|
|
GB201621907D0
(en)
|
2016-12-21 |
2017-02-01 |
Ucb Biopharma Sprl And Sanofi |
Antibody epitope
|
|
CN107674122A
(zh)
*
|
2016-12-28 |
2018-02-09 |
天津天锐生物科技有限公司 |
一种识别人血清白蛋白的单域抗体
|
|
IL267897B2
(en)
|
2017-01-17 |
2025-02-01 |
Ablynx Nv |
Improved serum albumin binders
|
|
JP7219220B2
(ja)
|
2017-01-17 |
2023-02-07 |
アブリンクス エン．ヴェー． |
改善された血清アルブミン結合剤
|
|
KR102642385B1
(ko)
|
2017-02-06 |
2024-03-04 |
오리오니스 바이오사이언시스 엔브이 |
표적화된 키메라 단백질 및 이의 용도
|
|
HUE070957T2
(hu)
|
2017-02-16 |
2025-07-28 |
Sonnet Biotherapeutics Inc |
Albuminkötõ domén fúziós fehérjék
|
|
US11535668B2
(en)
|
2017-02-28 |
2022-12-27 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
|
JP7186401B2
(ja)
|
2017-02-28 |
2022-12-09 |
フエー・イー・ベー・フエー・ゼツト・ウエー |
タンパク質の経口送達のための手段及び方法
|
|
US12480957B2
(en)
|
2017-03-31 |
2025-11-25 |
Ablynx N.V. |
Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs
|
|
KR20200005635A
(ko)
|
2017-05-11 |
2020-01-15 |
브이아이비 브이지더블유 |
가변 면역글로불린 도메인의 글리코실화
|
|
EP3621994A4
(en)
|
2017-05-12 |
2020-12-30 |
Harpoon Therapeutics, Inc. |
MESOTHELIN BINDING PROTEINS
|
|
WO2018209304A1
(en)
|
2017-05-12 |
2018-11-15 |
Harpoon Therapeutics, Inc. |
Msln targeting trispecific proteins and methods of use
|
|
EP3630816B1
(en)
|
2017-05-31 |
2024-03-20 |
Boehringer Ingelheim International GmbH |
Polypeptides antagonizing wnt signaling in tumor cells
|
|
NZ759601A
(en)
|
2017-06-02 |
2023-06-30 |
Merck Patent Gmbh |
Aggrecan binding immunoglobulins
|
|
JP7249961B2
(ja)
|
2017-06-02 |
2023-03-31 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ａｄａｍｔｓ５、ｍｍｐ１３およびアグリカンに結合するポリペプチド
|
|
CN118894939A
(zh)
|
2017-06-02 |
2024-11-05 |
默克专利股份有限公司 |
结合adamts的免疫球蛋白
|
|
TW202417517A
(zh)
|
2017-06-02 |
2024-05-01 |
德商麥克專利有限公司 |
與ｍｍｐ１３結合之免疫球蛋白
|
|
US11198726B2
(en)
|
2017-06-02 |
2021-12-14 |
Boerhinger Ingelheim International Gmbh |
Anti-cancer combination therapy
|
|
GB201710973D0
(en)
|
2017-07-07 |
2017-08-23 |
Avacta Life Sciences Ltd |
Scaffold proteins
|
|
CA3070253A1
(en)
|
2017-07-19 |
2019-01-24 |
Vib Vzw |
Serum albumin binding agents
|
|
SG11202000198QA
(en)
|
2017-08-04 |
2020-02-27 |
Genmab As |
Binding agents binding to pd-l1 and cd137 and use thereof
|
|
IL315737A
(en)
|
2017-10-13 |
2024-11-01 |
Harpoon Therapeutics Inc |
B-cell maturation antigen-binding proteins
|
|
MX2020003915A
(es)
|
2017-10-13 |
2020-10-08 |
Harpoon Therapeutics Inc |
Proteinas trispecificas y metodos de uso.
|
|
KR20200091400A
(ko)
|
2017-10-31 |
2020-07-30 |
브이아이비 브이지더블유 |
신규한 항원-결합 키메라 단백질 및 이의 방법 및 용도
|
|
WO2019133827A1
(en)
*
|
2017-12-29 |
2019-07-04 |
Board Of Regents, The University Of Texas System |
Antimicrobial nanobodies
|
|
EP3743448A4
(en)
|
2018-01-26 |
2021-11-03 |
Orionis Biosciences, Inc. |
XCR1 BINDING AGENTS AND USES THEREOF
|
|
KR102877915B1
(ko)
|
2018-02-05 |
2025-10-29 |
오리오니스 바이오사이언시즈 인코포레이티드 |
섬유아세포 결합제 및 이의 용도
|
|
WO2019155041A1
(en)
|
2018-02-12 |
2019-08-15 |
Vib Vzw |
Gβγ COMPLEX ANTIBODIES AND USES THEREOF
|
|
WO2019165105A1
(en)
*
|
2018-02-26 |
2019-08-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Ligands of the urokinase receptor and their use in treating, detecting, and imaging cancer
|
|
CA3092421A1
(en)
|
2018-03-01 |
2019-09-06 |
Vrije Universiteit Brussel |
Human pd-l1-binding immunoglobulins
|
|
US12123881B2
(en)
|
2018-04-20 |
2024-10-22 |
Unm Rainforest Innovations |
Rap1-Gtp, Rac1-GTP and FMS-like tyrosine kinase 3 ligand (FLT3-L) as biomarkers for early detection of sepsis
|
|
BR112020023330A2
(pt)
|
2018-05-14 |
2021-04-20 |
Harpoon Therapeutics, Inc. |
porção de ligação para ativação condicional de moléculas de imunoglobulina
|
|
CN110613838A
(zh)
*
|
2018-06-19 |
2019-12-27 |
姜石松 |
增强细胞通透性的多肽及其应用
|
|
DE102018122275A1
(de)
*
|
2018-09-12 |
2020-03-12 |
Osram Opto Semiconductors Gmbh |
Lichtemittierendes bauteil und verfahren zum betreiben eines lichtemittierenden bauteils
|
|
US12195544B2
(en)
|
2018-09-21 |
2025-01-14 |
Harpoon Therapeutics, Inc. |
EGFR binding proteins and methods of use
|
|
US10815311B2
(en)
|
2018-09-25 |
2020-10-27 |
Harpoon Therapeutics, Inc. |
DLL3 binding proteins and methods of use
|
|
EP3636657A1
(en)
|
2018-10-08 |
2020-04-15 |
Ablynx N.V. |
Chromatography-free antibody purification method
|
|
CN111138536B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
抗人血清白蛋白单域抗体的制备及其应用
|
|
CN111138537B
(zh)
*
|
2018-11-06 |
2021-07-09 |
瑞阳(苏州)生物科技有限公司 |
一种抗人血清白蛋白抗体片段、制备方法和应用
|
|
US12410225B2
(en)
|
2018-11-08 |
2025-09-09 |
Orionis Biosciences, Inc |
Modulation of dendritic cell lineages
|
|
GB201818460D0
(en)
*
|
2018-11-13 |
2018-12-26 |
Crescendo Biologics Ltd |
Single domain antibodies that bind human serum albumin
|
|
CN112830967B
(zh)
*
|
2019-01-10 |
2022-06-24 |
瑞阳(苏州)生物科技有限公司 |
抗hsa单域抗体及其融合蛋白的亲和层析纯化方法
|
|
CN109627334B
(zh)
*
|
2019-01-29 |
2020-07-17 |
康元医疗科技(大连)有限公司 |
一种纳米抗体、以该纳米抗体为配基的吸附剂及其用途
|
|
GB201901306D0
(en)
|
2019-01-30 |
2019-03-20 |
Immunocore Ltd |
Multi-domain binding molecules
|
|
JP7773372B2
(ja)
|
2019-03-28 |
2025-11-19 |
オリオニス バイオサイエンシズ，インコーポレイテッド |
線維芽細胞活性化タンパク質結合物質およびその使用
|
|
MX2021011854A
(es)
|
2019-03-29 |
2021-10-22 |
Boehringer Ingelheim Int |
Tratamiento conjunto antineoplasico.
|
|
JP2022526166A
(ja)
|
2019-03-29 |
2022-05-23 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗癌併用療法
|
|
WO2020221769A1
(en)
|
2019-04-29 |
2020-11-05 |
Confo Therapeutics N.V. |
Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
|
|
EP3962599A1
(en)
|
2019-04-30 |
2022-03-09 |
Vib Vzw |
Cystic fibrosis transmembrane conductance regulator stabilizing agents
|
|
AU2020275002A1
(en)
|
2019-05-14 |
2021-12-23 |
Harpoon Therapeutics, Inc. |
EpCAM binding proteins and methods of use
|
|
WO2020239945A1
(en)
|
2019-05-28 |
2020-12-03 |
Vib Vzw |
Cancer treatment by targeting plexins in the immune compartment
|
|
EP3976067A1
(en)
|
2019-05-28 |
2022-04-06 |
Vib Vzw |
Cd8+ t-cells lacking plexins and their application in cancer treatment
|
|
CA3138805A1
(en)
|
2019-06-04 |
2020-12-10 |
Johannes Schilling |
Designed ankyrin repeat domain with improved stability
|
|
KR20220063148A
(ko)
|
2019-06-21 |
2022-05-17 |
소리소 파마슈티컬스 인크. |
조성물
|
|
US12559552B2
(en)
|
2019-06-21 |
2026-02-24 |
Sorriso Pharmaceuticals, Inc. |
IL-23 and TNF-alpha binding bi-specific heavy chain polypeptides
|
|
CA3144567A1
(en)
|
2019-06-21 |
2020-12-24 |
Scott Crowe |
Polypeptides
|
|
TWI844709B
(zh)
|
2019-07-31 |
2024-06-11 |
美商美國禮來大藥廠 |
鬆弛素(relaxin)類似物及其使用方法
|
|
CN112409480B
(zh)
*
|
2019-08-20 |
2024-08-27 |
四川科伦博泰生物医药股份有限公司 |
结合血清白蛋白的蛋白及其用途
|
|
WO2021039574A1
(ja)
*
|
2019-08-23 |
2021-03-04 |
株式会社カネカ |
Ｏ結合型糖鎖修飾が抑制された重鎖抗体
|
|
CN115947846A
(zh)
|
2019-09-12 |
2023-04-11 |
普米斯生物技术(珠海)有限公司 |
一种抗pd-l1纳米抗体及其衍生物和用途
|
|
CN110642946A
(zh)
*
|
2019-09-30 |
2020-01-03 |
中国药科大学 |
一种人源化纳米抗体及其制备方法
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021078786A1
(en)
|
2019-10-21 |
2021-04-29 |
Vib Vzw |
Nanodisc-specific antigen-binding chimeric proteins
|
|
CN112746331A
(zh)
*
|
2019-10-29 |
2021-05-04 |
安升（上海）医药科技有限公司 |
半衰期延长的药物及其文库、以及制备方法和应用
|
|
CA3160506A1
(en)
|
2019-11-11 |
2021-05-20 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Insect control nanobodies and uses thereof
|
|
US20220411495A1
(en)
|
2019-11-27 |
2022-12-29 |
Vib Vzw |
Positive allosteric modulators of the calcium-sensing receptor
|
|
KR20220111313A
(ko)
*
|
2019-12-06 |
2022-08-09 |
아블린쓰 엔.브이. |
TNFα 및 OX40L을 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩티드
|
|
IL293561A
(en)
|
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|
|
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|
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|
|
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|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
*
|
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|
|
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(zh)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ja)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
*
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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(zh)
|
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|
|
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|
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|
|
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|
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|
|
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(zh)
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
*
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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2025-12-25 |
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|
|
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(en)
|
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|
|
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(ko)
|
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|
|
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(en)
|
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|
|
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(en)
|
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2025-10-08 |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(es)
|
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|
|
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(ja)
|
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|
|
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(en)
*
|
2023-01-18 |
2024-07-25 |
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Liquid pharmaceutical compositions of fusion polypeptides and methods of uses thereof
|
|
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(en)
|
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2026-03-11 |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(fr)
|
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Avacta Life Sciences Limited |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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Slc4a4/nbce1 inhibitors
|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(ko)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(en)
*
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
|
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|
|
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(zh)
|
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|
|
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(en)
|
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2024-11-05 |
Sonnet BioTherapeutics, Inc. |
Interleukin 18 (IL-18) variants and fusion proteins comprising same
|
|
WO2025147862A1
(zh)
*
|
2024-01-09 |
2025-07-17 |
上海洛启生物医药技术有限公司 |
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|
|
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(en)
|
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|
|
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(en)
|
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Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect cda nanobodies and uses thereof
|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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