JP2020511113A5 - - Google Patents
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- JP2020511113A5 JP2020511113A5 JP2019530389A JP2019530389A JP2020511113A5 JP 2020511113 A5 JP2020511113 A5 JP 2020511113A5 JP 2019530389 A JP2019530389 A JP 2019530389A JP 2019530389 A JP2019530389 A JP 2019530389A JP 2020511113 A5 JP2020511113 A5 JP 2020511113A5
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- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- polypeptide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023085495A JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430972P | 2016-12-07 | 2016-12-07 | |
| US62/430,972 | 2016-12-07 | ||
| PCT/EP2017/081818 WO2018104444A1 (en) | 2016-12-07 | 2017-12-07 | Improved serum albumin binding immunoglobulin single variable domains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085495A Division JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511113A JP2020511113A (ja) | 2020-04-16 |
| JP2020511113A5 true JP2020511113A5 (https=) | 2020-11-19 |
| JP7417421B2 JP7417421B2 (ja) | 2024-01-18 |
Family
ID=60990745
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530389A Active JP7417421B2 (ja) | 2016-12-07 | 2017-12-07 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2023085495A Pending JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A Pending JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085495A Pending JP2023109939A (ja) | 2016-12-07 | 2023-05-24 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
| JP2025102421A Pending JP2025131869A (ja) | 2016-12-07 | 2025-06-18 | 改善された血清アルブミン結合性免疫グロブリン単一可変ドメイン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11414480B2 (https=) |
| EP (1) | EP3551656A1 (https=) |
| JP (3) | JP7417421B2 (https=) |
| KR (3) | KR20240001271A (https=) |
| CN (2) | CN117164710A (https=) |
| AU (2) | AU2017373746B2 (https=) |
| BR (1) | BR112019011189A2 (https=) |
| CA (1) | CA3045726A1 (https=) |
| IL (2) | IL310340A (https=) |
| MX (3) | MX2019006574A (https=) |
| RU (2) | RU2022101604A (https=) |
| WO (1) | WO2018104444A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| RU2022101604A (ru) * | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| JP7183163B2 (ja) | 2017-01-06 | 2022-12-05 | クレシェンド・バイオロジックス・リミテッド | プログラム細胞死（ｐｄ－１）に対するシングルドメイン抗体 |
| HRP20241501T1 (hr) * | 2017-01-17 | 2025-01-03 | Ablynx Nv | Poboljšana veziva albumina u serumu |
| SG10202108972RA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
| WO2019092452A1 (en) | 2017-11-13 | 2019-05-16 | Crescendo Biologics Limited | Molecules that bind to cd137 and psma |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| CN113508134B (zh) * | 2019-02-22 | 2024-12-03 | 安维达生物科技公司 | 白蛋白结合抗体及其用途 |
| CN113840835B (zh) * | 2019-05-15 | 2024-06-25 | 克雷森多生物制剂有限公司 | 结合分子 |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN112409480B (zh) * | 2019-08-20 | 2024-08-27 | 四川科伦博泰生物医药股份有限公司 | 结合血清白蛋白的蛋白及其用途 |
| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| PH12022551231A1 (en) | 2019-12-06 | 2023-07-31 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting tnfa and ox40l |
| JP7657797B2 (ja) | 2019-12-06 | 2025-04-07 | アブリンクス エン．ヴェー． | ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド |
| WO2021116182A1 (en) | 2019-12-09 | 2021-06-17 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp |
| IL296767A (en) | 2020-03-30 | 2022-11-01 | Ablynx Nv | A method for the production and purification of single variable multivalent immunoglobulin sites |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| MX2023003522A (es) | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| KR20230122084A (ko) | 2020-12-18 | 2023-08-22 | 아블린쓰 엔.브이. | Tcr 알파/베타 반응성에 기초한 t 세포 동원 폴리펩타이드 |
| KR20230123495A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | 글리피칸-3 및 t세포 수용체를 표적으로 하는 면역글로불린단일 가변 도메인을 포함하는 폴리펩티드 |
| KR20230123497A (ko) | 2020-12-18 | 2023-08-23 | 아블린쓰 엔.브이. | IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드 |
| JP2024506145A (ja) * | 2021-02-02 | 2024-02-09 | イーライ リリー アンド カンパニー | 半減期延長部分及びその使用方法 |
| AU2022409733A1 (en) | 2021-12-17 | 2024-08-01 | Ablynx Nv | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123 |
| KR20250023503A (ko) | 2022-06-14 | 2025-02-18 | 아블린쓰 | T 세포 수용체를 표적화하는 면역글로불린 단일 가변 도메인 |
| MA71603A (fr) | 2022-07-27 | 2025-05-30 | Ablynx Nv | Polypeptides se liant à un épitope spécifique du récepteur fc néonatal |
| WO2024097639A1 (en) * | 2022-10-31 | 2024-05-10 | Modernatx, Inc. | Hsa-binding antibodies and binding proteins and uses thereof |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| JP2026506075A (ja) | 2023-02-17 | 2026-02-20 | アブリンクス エン．ヴェー． | 新生児型ｆｃ受容体に結合するポリペプチド |
| WO2024192065A1 (en) | 2023-03-14 | 2024-09-19 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| CN121002685A (zh) | 2023-05-12 | 2025-11-21 | 株式会社Lg新能源 | 包括用于固定堆叠件的外部的带的电极组件和包括该电极组件的二次电池 |
| CN121511255A (zh) | 2023-05-17 | 2026-02-10 | 奥德赛治疗股份有限公司 | 经修饰的单结构域抗体 |
| CN116655805B (zh) * | 2023-05-31 | 2024-03-08 | 四川大学华西医院 | 一种靶向her2阳性肿瘤的新型car-t细胞及制备方法和应用 |
| KR20260030116A (ko) * | 2023-06-22 | 2026-03-05 | 아블린쓰 엔.브이. | Pd-l1을 표적화하는 면역글로불린 단일 가변 도메인 |
| KR20260028051A (ko) | 2023-06-22 | 2026-03-03 | 아블린쓰 엔.브이. | 사이토카인의 수용체-활성을 조절하기 위한 키메라 단백질 |
| IL325291A (en) | 2023-06-29 | 2026-02-01 | Odyssey Therapeutics Inc | Anti-TRAILR2 antigen-binding proteins and their uses |
| AR133188A1 (es) | 2023-07-05 | 2025-09-03 | Ablynx Nv | ANTAGONISTAS DE FcRn MEJORADOS PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON IgG |
| WO2025051767A1 (en) | 2023-09-04 | 2025-03-13 | Sanofi | Polypeptides for use in the treatment of glypican-3-expressing tumours |
| US20250129145A1 (en) | 2023-09-22 | 2025-04-24 | Ablynx N.V. | Bi- and multivalent albumin binders |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| WO2025080751A2 (en) | 2023-10-13 | 2025-04-17 | Odyssey Therapeutics, Inc. | Anti-cdh17 antigen-binding proteins and uses thereof |
| AR134267A1 (es) | 2023-11-08 | 2025-12-17 | Sanofi Sa | Degradador lisosómico basado en cd25 y usos del mismo |
| TW202540188A (zh) | 2023-12-01 | 2025-10-16 | 比利時商艾伯霖克斯公司 | 精準活化的多肽 |
| TW202543670A (zh) | 2023-12-22 | 2025-11-16 | 比利時商艾伯霖克斯公司 | 用於核內投予之基於蛋白質的接合載劑 |
| US20250236673A1 (en) | 2023-12-22 | 2025-07-24 | Ablynx N.V. | Protein-based carriers for site-specific amine conjugation |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
| WO2026006708A2 (en) | 2024-06-27 | 2026-01-02 | Odyssey Therapeutics, Inc. | Anti-cd25 antigen-binding proteins and uses thereof |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
| WO2026052756A1 (en) | 2024-09-05 | 2026-03-12 | Ablynx Nv | Her2 binding immunoglobulin single variable domains, constructs comprising the same and uses thereof |
| WO2026078159A1 (en) | 2024-10-10 | 2026-04-16 | Ablynx Nv | Immune cell engagers and methods comprising the same |
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| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| BR9813276A (pt) | 1997-10-27 | 2000-08-22 | Unilever Nv | Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma |
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| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| ES2263984T3 (es) | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| CA2505316C (en) | 2002-11-08 | 2014-08-05 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| CA2588892A1 (en) | 2004-12-02 | 2006-06-08 | Dormantis Limited | Anti-il-1r1 single domain antibodies and therapeutic uses |
| WO2006122787A1 (en) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Serum albumin binding proteins |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| EA200801166A1 (ru) | 2005-12-01 | 2008-12-30 | Домантис Лимитед | Форматы конкурентного доменного антитела, которые связываются с рецептором интерлейкина 1 первого типа |
| CA2632866A1 (en) | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| WO2007085814A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Fusion proteins that contain natural junctions |
| EP2057191A1 (en) | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| CN101646689A (zh) * | 2006-09-08 | 2010-02-10 | 埃博灵克斯股份有限公司 | 具有长半衰期的血清清蛋白结合蛋白 |
| CN101796072B (zh) | 2007-05-24 | 2014-09-24 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
| EP2220120A2 (en) | 2007-11-27 | 2010-08-25 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| NZ589036A (en) | 2008-05-16 | 2012-07-27 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| HRP20170374T1 (hr) | 2008-09-26 | 2017-05-05 | Ucb Biopharma Sprl | Biološki proizvodi |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| JP2012532620A (ja) * | 2009-07-16 | 2012-12-20 | グラクソ グループ リミテッド | 改良型抗血清アルブミン結合単一可変ドメイン |
| MX2012003939A (es) * | 2009-09-30 | 2012-07-30 | Glaxo Group Ltd | Fusiones y conjugados de farmaco. |
| JP2013538566A (ja) | 2010-08-13 | 2013-10-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 改良された抗血清アルブミン結合変異体 |
| JP2013537421A (ja) * | 2010-08-20 | 2013-10-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 改良された抗血清アルブミン結合変異体 |
| US20130266567A1 (en) * | 2010-12-01 | 2013-10-10 | Haren Arulanantham | Anti-serum albumin binding single variable domains |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| CN106046168A (zh) * | 2011-06-23 | 2016-10-26 | 埃博灵克斯股份有限公司 | 结合血清白蛋白的蛋白 |
| IN2014CN00437A (https=) * | 2011-06-23 | 2015-04-03 | Ablynx Nv | |
| WO2012174741A1 (en) | 2011-06-24 | 2012-12-27 | Google Inc. | Determining cross-language query suggestion based on query translations |
| SG2014010482A (en) | 2011-08-17 | 2014-04-28 | Glaxo Group Ltd | Modified proteins and peptides |
| US20130129727A1 (en) | 2011-11-17 | 2013-05-23 | Nanjingjinsirui Science & Technology Biology Corporation | Methods and systems for increasing protein stability |
| WO2014037419A1 (en) | 2012-09-04 | 2014-03-13 | Vib Vzw | Immunoglobulin single variable domains directed against cd74 and uses derived thereof |
| US20140186365A1 (en) | 2013-01-03 | 2014-07-03 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Antibodies that specifically bind to serum albumin without interfering with albumin's capability to interact with the fcrn |
| WO2014111550A1 (en) * | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
| PL3248986T3 (pl) * | 2014-05-16 | 2022-05-16 | Ablynx Nv | Domeny zmienne immunoglobuliny |
| JP7001474B2 (ja) | 2015-01-21 | 2022-01-19 | インヒブルクス，インコーポレイティド | 非免疫原性単一ドメイン抗体 |
| PT3294768T (pt) * | 2015-05-13 | 2019-11-05 | Ablynx Nv | Polipétidos de recrutamento de células t com base na reatividade do tcr alfa/beta |
| WO2017089618A1 (en) | 2015-11-27 | 2017-06-01 | Ablynx Nv | Polypeptides inhibiting cd40l |
| RU2022101604A (ru) * | 2016-12-07 | 2022-03-29 | Аблинкс Нв | Улучшенные отдельные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| HRP20241501T1 (hr) * | 2017-01-17 | 2025-01-03 | Ablynx Nv | Poboljšana veziva albumina u serumu |
| SG10202108972RA (en) | 2017-01-17 | 2021-09-29 | Ablynx Nv | Improved serum albumin binders |
-
2017
- 2017-12-07 RU RU2022101604A patent/RU2022101604A/ru unknown
- 2017-12-07 US US16/465,188 patent/US11414480B2/en active Active
- 2017-12-07 CN CN202311111034.3A patent/CN117164710A/zh active Pending
- 2017-12-07 IL IL310340A patent/IL310340A/en unknown
- 2017-12-07 RU RU2019120720A patent/RU2765384C2/ru active
- 2017-12-07 MX MX2019006574A patent/MX2019006574A/es unknown
- 2017-12-07 EP EP17829610.9A patent/EP3551656A1/en active Pending
- 2017-12-07 CA CA3045726A patent/CA3045726A1/en active Pending
- 2017-12-07 BR BR112019011189A patent/BR112019011189A2/pt unknown
- 2017-12-07 KR KR1020237043751A patent/KR20240001271A/ko not_active Ceased
- 2017-12-07 AU AU2017373746A patent/AU2017373746B2/en active Active
- 2017-12-07 IL IL266907A patent/IL266907B2/en unknown
- 2017-12-07 KR KR1020197019686A patent/KR102616835B1/ko active Active
- 2017-12-07 KR KR1020237014486A patent/KR20230061582A/ko not_active Ceased
- 2017-12-07 WO PCT/EP2017/081818 patent/WO2018104444A1/en not_active Ceased
- 2017-12-07 CN CN201780076027.0A patent/CN110049997B/zh active Active
- 2017-12-07 JP JP2019530389A patent/JP7417421B2/ja active Active
-
2019
- 2019-06-05 MX MX2023007520A patent/MX2023007520A/es unknown
- 2019-06-05 MX MX2023003630A patent/MX2023003630A/es unknown
-
2022
- 2022-06-29 US US17/852,474 patent/US20230050615A1/en active Pending
-
2023
- 2023-05-24 JP JP2023085495A patent/JP2023109939A/ja active Pending
-
2025
- 2025-01-13 AU AU2025200245A patent/AU2025200245A1/en active Pending
- 2025-06-18 JP JP2025102421A patent/JP2025131869A/ja active Pending
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