ATE232298T1 - Bioluminenztest für agonisten oder antagonisten eines kalzium-gekuppelten-rezeptors - Google Patents
Bioluminenztest für agonisten oder antagonisten eines kalzium-gekuppelten-rezeptorsInfo
- Publication number
- ATE232298T1 ATE232298T1 AT99930956T AT99930956T ATE232298T1 AT E232298 T1 ATE232298 T1 AT E232298T1 AT 99930956 T AT99930956 T AT 99930956T AT 99930956 T AT99930956 T AT 99930956T AT E232298 T1 ATE232298 T1 AT E232298T1
- Authority
- AT
- Austria
- Prior art keywords
- calcium
- coupled receptor
- bioluminence
- agonists
- antagonists
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98870149 | 1998-07-06 | ||
| PCT/BE1999/000087 WO2000002045A2 (en) | 1998-07-06 | 1999-07-06 | Bioluminescent assay for agonists or antagonists of a calcium-coupled receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232298T1 true ATE232298T1 (de) | 2003-02-15 |
Family
ID=8237065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99930956T ATE232298T1 (de) | 1998-07-06 | 1999-07-06 | Bioluminenztest für agonisten oder antagonisten eines kalzium-gekuppelten-rezeptors |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6872538B1 (de) |
| EP (1) | EP1145002B2 (de) |
| JP (1) | JP3495987B2 (de) |
| AT (1) | ATE232298T1 (de) |
| CA (1) | CA2336929C (de) |
| DE (1) | DE69905291T3 (de) |
| DK (1) | DK1145002T4 (de) |
| ES (1) | ES2192060T5 (de) |
| WO (1) | WO2000002045A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6248542B1 (en) | 1997-12-09 | 2001-06-19 | Massachusetts Institute Of Technology | Optoelectronic sensor |
| DE10008373C2 (de) * | 2000-02-23 | 2002-11-28 | Helmut Adelsberger | Verfahren und Vorrichtung zur Bestimmung der Ionenkanalaktivität |
| EP1750129B1 (de) | 2001-02-07 | 2011-04-20 | Massachusetts Institute of Technology | Optoelektronisches Detektionssystem |
| US8216797B2 (en) * | 2001-02-07 | 2012-07-10 | Massachusetts Institute Of Technology | Pathogen detection biosensor |
| US7422860B2 (en) | 2001-02-07 | 2008-09-09 | Massachusetts Institute Of Technology | Optoelectronic detection system |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| AU2002256694A1 (en) * | 2001-03-20 | 2002-10-03 | Euroscreen S.A. | Screening, diagnostic and/or dosage method and device of an agonist and/or antagonist for a calcium-coupled receptor |
| GB0108143D0 (en) * | 2001-03-31 | 2001-05-23 | Univ Dundee | High-throughput screen |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| WO2003057730A1 (en) | 2002-01-07 | 2003-07-17 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| WO2004041862A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| GB0228139D0 (en) * | 2002-12-03 | 2003-01-08 | Kozlova Zwinderman Olga | Fungal biosensor for contaminant detection |
| RU2357974C2 (ru) | 2003-01-10 | 2009-06-10 | Аблинкс Н.В. | Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| CA2559809A1 (en) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10 |
| ITMI20040598A1 (it) * | 2004-03-26 | 2004-06-26 | Carlotta Giorgi | Metodo per la rilevazione di parametri intracellulari con sonde proteiche luminescenti per lo screening di molecole in grado di alterare detti parametri |
| CA2504920C (en) | 2004-05-14 | 2014-04-01 | Euroscreen S.A. | Ligand for g-protein coupled receptor fprl2 and uses thereof |
| RU2464276C2 (ru) | 2005-05-18 | 2012-10-20 | Аблинкс Н.В. | Улучшенные нанотела против фактора некроза опухоли-альфа |
| DK2444424T3 (en) | 2005-05-20 | 2018-12-03 | Ablynx Nv | IMPROVED NANOL BODIES (TM) FOR TREATING AGGREGATED MEDICINAL DISORDERS |
| WO2007100618A2 (en) * | 2006-02-23 | 2007-09-07 | Atto Bioscience | Novel cell-based phosphodiesterase assays |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| WO2011008250A1 (en) | 2009-07-14 | 2011-01-20 | Millipore Corporation | Modified photoproteins with increased affinity for calcium and enhanced bioluminescence and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422266A (en) | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
| JPH01285196A (ja) | 1988-05-11 | 1989-11-16 | Chisso Corp | 発光蛋白エクオリンの製造法 |
| DE68922971T2 (de) † | 1988-12-06 | 1995-10-19 | Chisso Corp | Mit einem Protein mit spezifischer Bindungsaktivität fusioniertes Aequorin, seine Herstellung, Reinigung und Nachweismethode. |
| JPH02253162A (ja) † | 1989-03-27 | 1990-10-11 | Chisso Corp | 特異的結合能を有する物質と結合したエクオリンを用いる検出法 |
| JPH03153700A (ja) † | 1989-11-09 | 1991-07-01 | Chisso Corp | 物理吸着法により担体に固定化されたエクオリン活性を示す蛋白質 |
| US5714666A (en) | 1993-02-09 | 1998-02-03 | Children's Hospital Of Philadelphia | Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells |
| US5744320A (en) † | 1995-06-07 | 1998-04-28 | Promega Corporation | Quenching reagents and assays for enzyme-mediated luminescence |
-
1999
- 1999-07-06 AT AT99930956T patent/ATE232298T1/de active
- 1999-07-06 US US09/743,405 patent/US6872538B1/en not_active Expired - Lifetime
- 1999-07-06 JP JP2000558390A patent/JP3495987B2/ja not_active Expired - Lifetime
- 1999-07-06 DK DK99930956T patent/DK1145002T4/da active
- 1999-07-06 WO PCT/BE1999/000087 patent/WO2000002045A2/en not_active Ceased
- 1999-07-06 DE DE69905291T patent/DE69905291T3/de not_active Expired - Lifetime
- 1999-07-06 CA CA002336929A patent/CA2336929C/en not_active Expired - Lifetime
- 1999-07-06 EP EP99930956A patent/EP1145002B2/de not_active Expired - Lifetime
- 1999-07-06 ES ES99930956T patent/ES2192060T5/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69905291T2 (de) | 2003-11-06 |
| EP1145002B2 (de) | 2008-12-10 |
| EP1145002B1 (de) | 2003-02-05 |
| WO2000002045A2 (en) | 2000-01-13 |
| DE69905291T3 (de) | 2009-06-25 |
| CA2336929A1 (en) | 2000-01-13 |
| DK1145002T3 (da) | 2003-05-05 |
| ES2192060T3 (es) | 2003-09-16 |
| EP1145002A2 (de) | 2001-10-17 |
| WO2000002045A3 (en) | 2001-11-08 |
| ES2192060T5 (es) | 2009-05-01 |
| DK1145002T4 (da) | 2009-03-16 |
| JP2002519699A (ja) | 2002-07-02 |
| DE69905291D1 (de) | 2003-03-13 |
| US6872538B1 (en) | 2005-03-29 |
| CA2336929C (en) | 2005-10-04 |
| JP3495987B2 (ja) | 2004-02-09 |
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