EE03697B1 - Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm - Google Patents

Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Info

Publication number
EE03697B1
EE03697B1 EE9700090A EE9700090A EE03697B1 EE 03697 B1 EE03697 B1 EE 03697B1 EE 9700090 A EE9700090 A EE 9700090A EE 9700090 A EE9700090 A EE 9700090A EE 03697 B1 EE03697 B1 EE 03697B1
Authority
EE
Estonia
Prior art keywords
interleukin
antagonist
receptor antagonist
new
intracellular isoform
Prior art date
Application number
EE9700090A
Other languages
English (en)
Other versions
EE9700090A (et
Inventor
Colotta Francesco
Muzio Marta
Mantovani Alberto
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of EE9700090A publication Critical patent/EE9700090A/et
Publication of EE03697B1 publication Critical patent/EE03697B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
EE9700090A 1994-10-13 1995-10-12 Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm EE03697B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942097A IT1270662B (it) 1994-10-13 1994-10-13 Antagonista della interleuchina-1
PCT/EP1995/004023 WO1996012022A1 (en) 1994-10-13 1995-10-12 Intracellular isoform of the interleukin-1 receptor antagonist

Publications (2)

Publication Number Publication Date
EE9700090A EE9700090A (et) 1997-10-15
EE03697B1 true EE03697B1 (et) 2002-04-15

Family

ID=11369705

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700090A EE03697B1 (et) 1994-10-13 1995-10-12 Interleukiin-1 retseptori antagonisti intratsellulaarne isovorm

Country Status (19)

Country Link
US (1) US5739282A (et)
EP (1) EP0786002B1 (et)
JP (1) JPH10509306A (et)
KR (1) KR100237936B1 (et)
CN (2) CN100363053C (et)
AT (1) ATE303439T1 (et)
BR (1) BR9509317A (et)
CA (1) CA2202470C (et)
DE (1) DE69534419T2 (et)
EE (1) EE03697B1 (et)
ES (1) ES2243942T3 (et)
HK (2) HK1002659A1 (et)
IT (1) IT1270662B (et)
MX (1) MX9702616A (et)
NO (1) NO320494B1 (et)
PT (1) PT786002E (et)
RU (1) RU2193064C2 (et)
UA (1) UA65522C2 (et)
WO (1) WO1996012022A1 (et)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075222A (en) * 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
US5872095A (en) * 1990-05-01 1999-02-16 Chiron Corporation IL-1 receptor antagonists medicaments
PT938500E (pt) 1996-10-31 2005-02-28 Applied Research Systems Peptidos inibidores da ice
DE69738948D1 (de) * 1996-12-06 2008-10-09 Amgen Inc Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
IL126562A0 (en) * 1998-10-14 1999-08-17 Interpharm Lab Ltd Expression and secretion of icil-1 receptor antagonist type ii
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US7166712B2 (en) * 2000-07-12 2007-01-23 Philadelphia, Health And Education Corporation Mammalian MDM2 binding proteins and uses thereof
ES2533084T3 (es) * 2003-12-23 2015-04-07 Genentech, Inc. Tratamiento del cáncer con anticuerpos monoclonales anti-IL 13 novedosos
EP2327413A1 (en) 2004-07-06 2011-06-01 ZymoGenetics, Inc. Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use
WO2009062339A1 (en) 2007-11-14 2009-05-22 General Regeneratives, Ltd. Methods of using interleukin-1 receptor antagonist as a myeloprotective agent
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
CA2828504A1 (en) 2011-03-14 2012-09-20 Serodus Asa Antagonists of the interleukin-1 receptor
DK2859015T3 (en) 2012-06-08 2018-06-18 Alkermes Inc LIGANDS MODIFIED BY CIRCULAR MODIFICATION AS AGONISTS AND ANTAGONISTS
WO2015191783A2 (en) 2014-06-10 2015-12-17 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148009B1 (ko) * 1988-05-27 1998-08-01 그래고리 비. 아보트 인터루킨-1 억제제
ES2103305T3 (es) * 1989-11-29 1997-09-16 Amgen Boulder Inc Produccion de inhibidor de interleuquina-1 humana recombinada.
AU649245B2 (en) * 1990-04-02 1994-05-19 Amgen, Inc. Methods for treating interleukin-1 mediated diseases
WO1991017184A1 (en) * 1990-04-27 1991-11-14 The Upjohn Company Modified interleukin-1 inhibitors
WO1991017249A1 (en) * 1990-05-01 1991-11-14 Cetus Corporation Interleukin-1 antagonist and uses thereof

Also Published As

Publication number Publication date
NO971624D0 (no) 1997-04-09
EE9700090A (et) 1997-10-15
DE69534419D1 (de) 2005-10-06
NO971624L (no) 1997-05-30
CA2202470A1 (en) 1996-04-25
RU2193064C2 (ru) 2002-11-20
BR9509317A (pt) 1997-10-14
CN100363053C (zh) 2008-01-23
EP0786002B1 (en) 2005-08-31
IT1270662B (it) 1997-05-07
ATE303439T1 (de) 2005-09-15
KR970706391A (ko) 1997-11-03
KR100237936B1 (ko) 2000-01-15
AU701471B2 (en) 1999-01-28
ITMI942097A0 (it) 1994-10-13
DE69534419T2 (de) 2006-06-14
WO1996012022A1 (en) 1996-04-25
UA65522C2 (en) 2004-04-15
MX9702616A (es) 1998-04-30
CN1224707C (zh) 2005-10-26
US5739282A (en) 1998-04-14
ITMI942097A1 (it) 1996-04-13
JPH10509306A (ja) 1998-09-14
CN1679919A (zh) 2005-10-12
EP0786002A1 (en) 1997-07-30
CN1161058A (zh) 1997-10-01
CA2202470C (en) 2008-09-16
HK1002659A1 (en) 1998-09-11
PT786002E (pt) 2005-11-30
ES2243942T3 (es) 2005-12-01
HK1081124A1 (en) 2006-05-12
NO320494B1 (no) 2005-12-12
AU3841795A (en) 1996-05-06

Similar Documents

Publication Publication Date Title
HK1081124A1 (en) Intracellular isoform of the interleukin-1 receptor antagonist
PT735818E (pt) Proteinas inflamatorias de macrofagos pim-3 pim-4 e pim-1y
NO960630D0 (no) Heterocykler anvendelige som neurokinin antagonister
DE69839992D1 (de) Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff
FI963101A0 (fi) Anti-TNF-vasta-aineiden käyttö lääkkeenä sellaisten sairauksien hoitoon, joissa seerumin interleukiini-6-taso on kohonnut
NO900227L (no) Ekstruderbar elastisk gel for anvendelse som baerer for terapeutisk middel.
DK0793714T3 (da) Anvendelse af stamcellefaktor og opløselig interleukin-6-receptor til ex vivo ekspansion af hæmatopoietiske multipotentielle celler
ATE306549T1 (de) C-c ckr-1, ein c-c chemokin rezeptor
DE69432951D1 (de) Regulierung der fruchtbarkeit mit transformierendem wachstumfaktor beta
BR0113213A (pt) Método para diagnosticar uma doença auto-imune, anticorpo, composição de diagnóstico, e, uso do anticorpo
TR199700956T1 (xx) Indazolkarboksamidler.
IT1090154B (it) Dispositivo vibratore per sedie poltrone letti e simili
IT8020274A0 (it) Poltrona anatomica asimmetrica, particolarmente per uso odontoiatrico.
TR200103448T2 (tr) IL-8 reseptör antagonistleri.
IT8430790V0 (it) Dispositivo orientabile per i comandi di movimento delle poltrone particolarmente per dentisti.
IT8430791V0 (it) Dispositivo per la sincronizzazione dello schienale particolarmente per poltrone di dentisti.
KR970017323U (ko) 에스, 알, 에스 자기 진단장치의 방전구조
KR900020697U (ko) 초음파 가습기의 진동자용 고무링
IT8921151A0 (it) Dispositivo per la determinazione della regolazione di altezza ottimale dello schienale di una sedia per ufficio, in funzione della statura dell'utilizzatore.
ITRM930679A0 (it) Strumento per la misura diretta del tempo di riverberazione di un ambiente, e procedimento per detto.
IT8920658A0 (it) Dispositivo per la determinazione della regolazione di altezza ottimale di una sedia per ufficio in funzione della statura dell'utilizzazione.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

MM4A Lapsed by not paying the annual fees

Effective date: 20091012