JP2024522092A5 - - Google Patents
Info
- Publication number
- JP2024522092A5 JP2024522092A5 JP2023572758A JP2023572758A JP2024522092A5 JP 2024522092 A5 JP2024522092 A5 JP 2024522092A5 JP 2023572758 A JP2023572758 A JP 2023572758A JP 2023572758 A JP2023572758 A JP 2023572758A JP 2024522092 A5 JP2024522092 A5 JP 2024522092A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid position
- polypeptide
- effector
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163193665P | 2021-05-27 | 2021-05-27 | |
| US63/193,665 | 2021-05-27 | ||
| EP21315127 | 2021-07-15 | ||
| EP21315127.7 | 2021-07-15 | ||
| PCT/IB2022/055019 WO2022249146A1 (en) | 2021-05-27 | 2022-05-27 | Fc VARIANT WITH ENHANCED AFFINITY TO Fc RECEPTORS AND IMPROVED THERMAL STABILITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024522092A JP2024522092A (ja) | 2024-06-11 |
| JP2024522092A5 true JP2024522092A5 (https=) | 2025-06-03 |
Family
ID=82358573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023572758A Pending JP2024522092A (ja) | 2021-05-27 | 2022-05-27 | Ｆｃ受容体に対する親和性の増強および熱安定性の改善を伴うＦｃバリアント |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12297273B2 (https=) |
| EP (1) | EP4347640A1 (https=) |
| JP (1) | JP2024522092A (https=) |
| KR (1) | KR20240015093A (https=) |
| AU (1) | AU2022282666A1 (https=) |
| BR (1) | BR112023022584A2 (https=) |
| CA (1) | CA3216005A1 (https=) |
| CO (1) | CO2023016432A2 (https=) |
| IL (1) | IL308733A (https=) |
| MX (1) | MX2023014100A (https=) |
| TW (1) | TW202306584A (https=) |
| WO (1) | WO2022249146A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12286475B2 (en) | 2023-07-31 | 2025-04-29 | Sanofi | Anti-GPRC5D antibodies and compositions |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627932B1 (en) | 1992-11-04 | 2002-05-08 | City Of Hope | Antibody construct |
| BR9606706A (pt) | 1995-10-16 | 1999-04-06 | Unilever Nv | Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo |
| GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
| CA2410551A1 (en) | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| US7312181B2 (en) | 2005-04-08 | 2007-12-25 | Cropsolution, Inc. | Acylated thiosemicarbazides as herbicides |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| JP5898082B2 (ja) * | 2009-10-07 | 2016-04-06 | マクロジェニクス，インコーポレーテッド | フコシル化程度の変更により改良されたエフェクター機能を示すＦｃ領域含有ポリペプチドおよびその使用法 |
| TWI743461B (zh) | 2011-03-28 | 2021-10-21 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| EP2825557B1 (en) * | 2012-03-16 | 2017-06-28 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Soluble engineered monomeric fc |
| US10011660B2 (en) | 2012-04-30 | 2018-07-03 | Medimmune, Llc | Molecules with reduced effector function and extended half-lives, compositions, and uses thereof |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| CN120988137A (zh) | 2015-01-23 | 2025-11-21 | 赛诺菲 | 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体 |
| EA201891753A1 (ru) * | 2016-02-03 | 2019-01-31 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкции антител к psma и cd3, вовлекающие т-клетки |
| CA3020633A1 (en) | 2016-04-13 | 2017-10-19 | Sanofi | Trispecific and/or trivalent binding proteins |
| AR108963A1 (es) | 2016-04-13 | 2018-10-17 | Merial Inc | Dispositivo de inyección con mecanismo de accionamiento para administrar múltiples formulaciones líquidas, tales como vacunas |
| CN108218998A (zh) * | 2017-12-31 | 2018-06-29 | 武汉班科生物技术股份有限公司 | 一种突变型人源IgG的Fc片段及其制备方法与应用 |
| IL276286B2 (en) | 2018-01-26 | 2025-07-01 | Genzyme Corp | FC variants with improved binding to FCRN and extended half-life |
| WO2019185164A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Holdings Pte. Ltd. | Her3 antigen-binding molecules |
| JP7792330B2 (ja) * | 2019-09-03 | 2025-12-25 | アムジエン・インコーポレーテツド | Ｉｌ－２２の経口、直腸内、又は他の消化管関連の組成物及びそれを使用する方法 |
-
2022
- 2022-05-27 EP EP22726534.5A patent/EP4347640A1/en active Pending
- 2022-05-27 BR BR112023022584A patent/BR112023022584A2/pt unknown
- 2022-05-27 JP JP2023572758A patent/JP2024522092A/ja active Pending
- 2022-05-27 IL IL308733A patent/IL308733A/en unknown
- 2022-05-27 US US17/826,295 patent/US12297273B2/en active Active
- 2022-05-27 KR KR1020237044602A patent/KR20240015093A/ko active Pending
- 2022-05-27 MX MX2023014100A patent/MX2023014100A/es unknown
- 2022-05-27 AU AU2022282666A patent/AU2022282666A1/en active Pending
- 2022-05-27 WO PCT/IB2022/055019 patent/WO2022249146A1/en not_active Ceased
- 2022-05-27 TW TW111119900A patent/TW202306584A/zh unknown
- 2022-05-27 CA CA3216005A patent/CA3216005A1/en active Pending
-
2023
- 2023-11-29 CO CONC2023/0016432A patent/CO2023016432A2/es unknown
-
2025
- 2025-03-26 US US19/091,594 patent/US20250376526A1/en active Pending
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