ATE469176T1 - Modifizierter anti-tnf antikörper - Google Patents

Modifizierter anti-tnf antikörper

Info

Publication number
ATE469176T1
ATE469176T1 AT02787636T AT02787636T ATE469176T1 AT E469176 T1 ATE469176 T1 AT E469176T1 AT 02787636 T AT02787636 T AT 02787636T AT 02787636 T AT02787636 T AT 02787636T AT E469176 T1 ATE469176 T1 AT E469176T1
Authority
AT
Austria
Prior art keywords
chain variable
light chain
variable region
modified
heavy
Prior art date
Application number
AT02787636T
Other languages
English (en)
Inventor
Koen Hellendoorn
Matthew Baker
Francis J Carr
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE469176T1 publication Critical patent/ATE469176T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02787636T 2001-11-12 2002-11-11 Modifizierter anti-tnf antikörper ATE469176T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01126858 2001-11-12
PCT/EP2002/012566 WO2003042247A2 (en) 2001-11-12 2002-11-11 Modified anti-tnf alpha antibody

Publications (1)

Publication Number Publication Date
ATE469176T1 true ATE469176T1 (de) 2010-06-15

Family

ID=8179220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02787636T ATE469176T1 (de) 2001-11-12 2002-11-11 Modifizierter anti-tnf antikörper

Country Status (17)

Country Link
US (2) US7524502B2 (de)
EP (1) EP1448602B1 (de)
JP (1) JP4304073B2 (de)
KR (1) KR20050044405A (de)
CN (1) CN1585778A (de)
AT (1) ATE469176T1 (de)
AU (1) AU2002351957B2 (de)
BR (1) BR0213565A (de)
CA (1) CA2466592A1 (de)
DE (1) DE60236536D1 (de)
ES (1) ES2346517T3 (de)
HU (1) HUP0402333A3 (de)
MX (1) MXPA04004417A (de)
PL (1) PL369739A1 (de)
RU (1) RU2004117915A (de)
WO (1) WO2003042247A2 (de)
ZA (1) ZA200404626B (de)

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US20040009166A1 (en) * 1997-04-30 2004-01-15 Filpula David R. Single chain antigen-binding polypeptides for polymer conjugation
JP2002505574A (ja) * 1997-04-30 2002-02-19 エンゾン，インコーポレイテッド ポリアルキレンオキシド修飾された単鎖ポリペプチド
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US8147832B2 (en) * 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
DK1694706T3 (da) * 2003-11-01 2012-07-16 Merck Patent Gmbh Modificeret anti-CD52-antistof
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
GB0425713D0 (en) 2004-11-23 2004-12-22 Baker Matthew Immunogencity testing and antibody selection methods
ES2417133T3 (es) 2005-02-03 2013-08-06 Antitope Limited Anticuerpos y proteínas humanas
WO2006102095A2 (en) * 2005-03-18 2006-09-28 Medimmune, Inc. Framework-shuffling of antibodies
CA2608332A1 (en) * 2005-05-12 2006-11-23 Attenuon, Llc Treatment of inflammatory bowel disease (ibd) with anti-angiogenic compounds
EP3613767A1 (de) 2005-05-18 2020-02-26 Ablynx N.V. Verbesserte nanokörper gegen tumor-nekrose-faktor-alpha
DK1919951T3 (en) * 2005-08-04 2015-02-16 Janssen Biotech Inc Anti-tnf-alpha antibodies and methods of use
CN107011431B (zh) * 2007-01-30 2020-11-06 埃皮瓦克斯公司 调节性t细胞表位、组合物及其用途
US20090010966A1 (en) 2007-06-21 2009-01-08 Angelica Therapeutics, Inc. Modified diphtheria toxins
WO2009110944A1 (en) 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
US8926976B2 (en) 2009-09-25 2015-01-06 Xoma Technology Ltd. Modulators
JP5885664B2 (ja) 2009-09-25 2016-03-15 ゾーマ テクノロジー リミテッド スクリーニング法
CN104634955B (zh) 2009-10-26 2016-09-14 雀巢产品技术援助有限公司 检测抗-tnf药物和自身抗体的试验
SG188987A1 (en) * 2010-09-30 2013-05-31 Chengdu Kanghong Biotechnologies Co Ltd HUMANIZED ANTI-a ANTIBODY AND ANTIGEN-BINDING FRAGMENT (FAB) THEREOF AND USE OF THE SAME
CA2814040C (en) 2010-10-08 2021-03-23 Joshua Michael Donaldson A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
US8962804B2 (en) 2010-10-08 2015-02-24 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
BR112013009376A2 (pt) 2010-10-18 2016-07-26 Nestec Sa métodos para determinar isótipos de anticorpos antifármacos
US8658171B2 (en) 2011-02-28 2014-02-25 Livzon Mabpharm Inc. Humanized anti-TNFα antibodies
CN102675460B (zh) * 2011-02-28 2015-08-19 珠海市丽珠单抗生物技术有限公司 抗肿瘤坏死因子α的人源化抗体
EP3130921B1 (de) 2011-07-06 2018-09-12 Nestec S.A. Tests für den nachweis neutralisierender autoantikörper gegen biologische therapie mit tnf-alpha
US9428553B2 (en) 2012-02-10 2016-08-30 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
JP2016519651A (ja) 2013-03-15 2016-07-07 アンジェリカ セラピューティックス，インク． 改質された毒素
JP6545666B2 (ja) * 2013-05-28 2019-07-17 ディーシービー−ユーエスエー エルエルシーＤｃｂ−Ｕｓａ Ｌｌｃ タンパク質薬物の不活性化のための抗体ロッカー
RU2556816C1 (ru) * 2014-03-12 2015-07-20 Открытое акционерное общество "Фармацевтический импорт, экспорт" (ОАО "Фармимэкс") Штамм клеток яичников китайского хомячка - продуцент рекомбинантного антитела против фактора некроза опухоли альфа человека
AU2015356613A1 (en) 2014-12-05 2017-06-15 Société des Produits Nestlé S.A. Indirect homogeneous mobility shift assays for the detection of biologics in patient samples
CN105820246A (zh) * 2015-01-07 2016-08-03 上海张江生物技术有限公司 一种新型重组抗TNFα嵌合单克隆抗体制备方法及用途
US10947305B2 (en) 2015-03-20 2021-03-16 Full Spectrum Genetics, Inc. Anti-TNFα binding compounds and uses thereof
PE20190622A1 (es) 2016-06-02 2019-04-26 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados del mismo
CA3058156C (en) 2017-03-30 2025-05-06 Blonder Tongue Laboratories, Inc. ENTERPRISE CONTENT GATEWAY
HUE054428T2 (hu) 2017-12-01 2021-09-28 Abbvie Inc Glükokortikoid receptor agonista és annak immunkonjugátumai
WO2020206149A2 (en) * 2019-04-05 2020-10-08 The Regents Of The University Of California Methods and compositions involving chimeric binding polypeptides
CN111909267B (zh) * 2019-05-07 2022-03-25 北京天成新脉生物技术有限公司 低免疫原性抗TNF-α人源化单克隆抗体TCX063及其应用
GB202004916D0 (en) * 2020-04-02 2020-05-20 Univ Oxford Innovation Ltd Antibodies
EP4232063A4 (de) * 2020-10-23 2025-01-01 HAN, Hq Bifunktionelle antagonisten des tumornekrosefaktors-alpha und transformierenden wachstumsfaktor-beta und deren verwendungen
WO2024254381A2 (en) * 2023-06-08 2024-12-12 Xentria, Inc. Methods for detecting a neutralizing antibody (nab) against an anti-tnf alpha antibody

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IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
DE10199067I2 (de) * 1991-03-18 2006-03-16 Univ New York Fuer Menschlichen Tumornekrose-Faktor spezifische Monoklonale und Chimaere Antikoerper
US6277969B1 (en) * 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5919452A (en) * 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
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CU22615A1 (es) * 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
ATE319745T1 (de) * 1997-05-21 2006-03-15 Biovation Ltd Verfahren zur herstellung von nicht-immunogenen proteinen
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UA81743C2 (uk) * 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
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Also Published As

Publication number Publication date
RU2004117915A (ru) 2005-05-10
ZA200404626B (en) 2005-10-26
CA2466592A1 (en) 2003-05-22
US20040260069A1 (en) 2004-12-23
JP2005510216A (ja) 2005-04-21
US7524502B2 (en) 2009-04-28
KR20050044405A (ko) 2005-05-12
US7754853B2 (en) 2010-07-13
EP1448602B1 (de) 2010-05-26
BR0213565A (pt) 2004-10-26
ES2346517T3 (es) 2010-10-18
DE60236536D1 (de) 2010-07-08
WO2003042247A3 (en) 2004-03-11
US20060018903A1 (en) 2006-01-26
PL369739A1 (en) 2005-05-02
HUP0402333A3 (en) 2007-05-02
AU2002351957B2 (en) 2009-09-03
JP4304073B2 (ja) 2009-07-29
WO2003042247A2 (en) 2003-05-22
MXPA04004417A (es) 2004-08-11
EP1448602A2 (de) 2004-08-25
HUP0402333A2 (hu) 2005-02-28
CN1585778A (zh) 2005-02-23

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