MXPA05007853A - Antagonistas de il-1 beta humana. - Google Patents

Antagonistas de il-1 beta humana.

Info

Publication number
MXPA05007853A
MXPA05007853A MXPA05007853A MXPA05007853A MXPA05007853A MX PA05007853 A MXPA05007853 A MX PA05007853A MX PA05007853 A MXPA05007853 A MX PA05007853A MX PA05007853 A MXPA05007853 A MX PA05007853A MX PA05007853 A MXPA05007853 A MX PA05007853A
Authority
MX
Mexico
Prior art keywords
antigen
human
binding portions
antibodies
beta
Prior art date
Application number
MXPA05007853A
Other languages
English (en)
Inventor
Jirong Lu
Original Assignee
Applied Molecular Evolution
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Molecular Evolution filed Critical Applied Molecular Evolution
Publication of MXPA05007853A publication Critical patent/MXPA05007853A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Abstract

La presente invencion abarca anticuerpos aislados, o sus porciones de union a antigeno, que especificamente unen IL-1 beta humano maduro. Estos anticuerpos, o sus porciones de union a antigeno, generalmente exhiben altas afinidades de union (valores de Kooff bajos), desamidacion reducida, comparado con el anticuerpo nativo, y se pueden utilizar para tratar varios trastornos tales como artritis reumatoide, osteoartritis, o neuroinflamacion.
MXPA05007853A 2003-01-24 2004-01-21 Antagonistas de il-1 beta humana. MXPA05007853A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44279803P 2003-01-24 2003-01-24
PCT/US2004/000019 WO2004067568A2 (en) 2003-01-24 2004-01-21 Human il-1 beta antagonists

Publications (1)

Publication Number Publication Date
MXPA05007853A true MXPA05007853A (es) 2006-02-10

Family

ID=32825261

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05007853A MXPA05007853A (es) 2003-01-24 2004-01-21 Antagonistas de il-1 beta humana.

Country Status (9)

Country Link
US (2) US7541033B2 (es)
EP (1) EP1590369B1 (es)
JP (2) JP4538461B2 (es)
CN (1) CN1780855B (es)
AU (1) AU2004207741B2 (es)
CA (1) CA2509136C (es)
ES (1) ES2567198T3 (es)
MX (1) MXPA05007853A (es)
WO (1) WO2004067568A2 (es)

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US7541033B2 (en) * 2003-01-24 2009-06-02 Applied Molecular Evolution, Inc. Humanized anti-IL-1β antibodies
US7566772B2 (en) 2005-01-26 2009-07-28 Amgen Fremont Inc. Antibodies against interleukin-1β
EP2322552B1 (en) 2005-06-21 2016-02-10 Xoma (Us) Llc IL-1beta binding antibodies and fragments thereof
SI1940465T1 (sl) * 2005-10-26 2012-10-30 Novartis Ag Nova uporaba protiteles proti IL-1 beta
WO2008061160A1 (en) * 2006-11-14 2008-05-22 Pharmacyclics, Inc. Uses of selective inhibitors of hdac8 for treatment of inflammatory conditions
CN103405768A (zh) 2006-12-20 2013-11-27 爱克索马技术有限公司 用于治疗IL-1β相关疾病的方法
DK2391650T3 (en) 2007-12-20 2015-01-12 Xoma Us Llc Methods of treating gout
CA2735939A1 (en) 2008-09-05 2010-03-11 Xoma Technology Ltd. Methods for improvement of beta cell function
US8383778B2 (en) * 2009-01-29 2013-02-26 Abbvie Inc. IL-1 binding proteins
EP2455097B1 (en) 2009-07-16 2016-02-17 Sunstar Inc. Proteoglycan-containing material
IN2015DN02826A (es) 2009-09-03 2015-09-11 Merck Sharp & Dohme
MX2012004412A (es) * 2009-10-15 2012-05-08 Abbott Lab Proteinas de union a il-1.
BR112012010707B1 (pt) * 2009-11-04 2022-08-30 Merck Sharp & Dohme Corp Anticorpo ou fragmento de ligação ao antígeno do mesmo, composição, e, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo
CN102883748A (zh) 2010-05-07 2013-01-16 爱克索马技术有限公司 治疗IL-1β相关状况的方法
EP2614085B1 (en) * 2010-09-10 2016-04-20 Apexigen, Inc. Anti-il-1 beta antibodies and methods of use
JP6071558B2 (ja) 2011-01-19 2017-02-01 国立大学法人弘前大学 プロテオグリカンの大量調製法
TW201527322A (zh) * 2011-02-08 2015-07-16 Abbvie Inc 骨關節炎及疼痛之治療
EP3150632B1 (en) * 2011-06-10 2020-04-08 Her Majesty The Queen in right of Canada, as represented by the Minister of National Defence Anti-ricin antibodies and uses thereof
EP3050900A1 (en) 2011-12-19 2016-08-03 Xoma (Us) Llc Methods for treating acne
CN105431452B (zh) 2012-02-13 2019-12-31 新加坡科技研究局 中和IL-1β的人单克隆抗体
ES2769850T3 (es) * 2012-07-25 2020-06-29 Univ Hirosaki Composición para prevenir o tratar la osteoartrosis
CN103588878A (zh) * 2012-08-15 2014-02-19 江苏泰康生物医药有限公司 一种人源化抗人白细胞介素1 β单克隆抗体及其制备与应用
US9404930B2 (en) * 2012-11-05 2016-08-02 Delenex Therapeutics Ag Antibody to human IL-1 beta
ES2895848T3 (es) * 2012-12-17 2022-02-22 Cell Medica Inc Anticuerpos contra IL-1 beta
WO2016008851A1 (en) * 2014-07-14 2016-01-21 Boehringer Ingelheim International Gmbh Anti-il-1b antibodies
CN107074942A (zh) * 2014-11-10 2017-08-18 豪夫迈·罗氏有限公司 抗‑IL‑1β抗体和使用方法
BR112017009764A2 (pt) 2014-11-10 2018-02-20 Hoffmann La Roche anticorpos biespecíficos e métodos de uso em oftalmologia
AU2015345322A1 (en) 2014-11-10 2017-04-06 F. Hoffmann-La Roche Ag Anti-PDGF-B antibodies and methods of use
CN107001456A (zh) 2014-11-10 2017-08-01 豪夫迈·罗氏有限公司 抗ang2 抗体及使用方法
JOP20180021A1 (ar) * 2017-03-16 2019-01-30 Janssen Biotech Inc الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
CN110818793A (zh) * 2018-08-14 2020-02-21 中山康方生物医药有限公司 抗IL-1β的抗体、其药物组合物及其用途
CN111217912B (zh) * 2018-11-26 2022-11-08 东莞市朋志生物科技有限公司 一种抗pgⅱ的抗体及其应用
TWI793503B (zh) 2020-01-20 2023-02-21 美商美國禮來大藥廠 抗IL-1β抗體
WO2022167916A1 (en) * 2021-02-03 2022-08-11 Novartis Ag Use of il-1b binding antibodies for treating neuroinflammatory disorders
US20230227545A1 (en) * 2022-01-07 2023-07-20 Johnson & Johnson Enterprise Innovation Inc. Materials and methods of il-1beta binding proteins

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EP0569687B1 (en) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins
US5484887A (en) * 1984-06-19 1996-01-16 Immunex Corporation Homogeneous interleukin 1
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4935343A (en) * 1986-08-08 1990-06-19 Syntex (U.S.A.) Inc. Monoclonal antibodies for interleukin-1β
WO1990005144A1 (en) * 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
WO1995001997A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
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EP2289550A3 (en) * 2000-01-27 2012-02-15 MedImmune, LLC Ultra high affinity neutralizing antibodies
AU2001240020B9 (en) * 2000-03-01 2008-12-04 Medimmune, Llc High potency recombinant antibodies and method for producing them
GB0020685D0 (en) * 2000-08-22 2000-10-11 Novartis Ag Organic compounds
EP1423432A4 (en) 2001-07-26 2006-01-11 Lilly Co Eli ANTIBODIES TO INTERLEUKIN 1 BETA (IL-1BETA)
AU2003208946A1 (en) * 2002-02-28 2003-09-16 Eli Lilly And Company Anti-interleukin-1 beta analogs
US7541033B2 (en) * 2003-01-24 2009-06-02 Applied Molecular Evolution, Inc. Humanized anti-IL-1β antibodies

Also Published As

Publication number Publication date
WO2004067568A3 (en) 2004-10-07
US20090209004A1 (en) 2009-08-20
US20060140932A1 (en) 2006-06-29
AU2004207741B2 (en) 2011-02-10
JP2010143929A (ja) 2010-07-01
EP1590369B1 (en) 2016-03-16
ES2567198T3 (es) 2016-04-20
CA2509136C (en) 2013-10-29
AU2004207741A1 (en) 2004-08-12
CN1780855B (zh) 2011-03-30
US7714120B2 (en) 2010-05-11
US7541033B2 (en) 2009-06-02
JP2007531509A (ja) 2007-11-08
CA2509136A1 (en) 2004-08-12
JP4538461B2 (ja) 2010-09-08
WO2004067568A2 (en) 2004-08-12
CN1780855A (zh) 2006-05-31
EP1590369A2 (en) 2005-11-02

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