IL179176A - 5 – fluoro-3 – phenyl – 2– [1– (h9– purine – 6 – ellamino) –profile] h – 3– quinazolin – 4 – on and 6 – fluorine – 3 – phenyl – 2– [1– ( h9– Purine – 6 – Ylamino) –ethyl] h – 3– Quinazolin – 4 – On and their use in the preparation of drugs to inhibit the activity of phosphatidylanositol 3 – kinase Delta in leukocytes - Google Patents

5 – fluoro-3 – phenyl – 2– [1– (h9– purine – 6 – ellamino) –profile] h – 3– quinazolin – 4 – on and 6 – fluorine – 3 – phenyl – 2– [1– ( h9– Purine – 6 – Ylamino) –ethyl] h – 3– Quinazolin – 4 – On and their use in the preparation of drugs to inhibit the activity of phosphatidylanositol 3 – kinase Delta in leukocytes

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Publication number
IL179176A
IL179176A IL179176A IL17917606A IL179176A IL 179176 A IL179176 A IL 179176A IL 179176 A IL179176 A IL 179176A IL 17917606 A IL17917606 A IL 17917606A IL 179176 A IL179176 A IL 179176A
Authority
IL
Israel
Prior art keywords
purin
quinazolin
ylamino
fluoro
phenyl
Prior art date
Application number
IL179176A
Other languages
English (en)
Hebrew (he)
Other versions
IL179176A0 (en
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL179176(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of IL179176A0 publication Critical patent/IL179176A0/en
Publication of IL179176A publication Critical patent/IL179176A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
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  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
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IL179176A 2004-05-13 2006-11-09 5 – fluoro-3 – phenyl – 2– [1– (h9– purine – 6 – ellamino) –profile] h – 3– quinazolin – 4 – on and 6 – fluorine – 3 – phenyl – 2– [1– ( h9– Purine – 6 – Ylamino) –ethyl] h – 3– Quinazolin – 4 – On and their use in the preparation of drugs to inhibit the activity of phosphatidylanositol 3 – kinase Delta in leukocytes IL179176A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13
PCT/US2005/016778 WO2005113556A1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Publications (2)

Publication Number Publication Date
IL179176A0 IL179176A0 (en) 2007-03-08
IL179176A true IL179176A (en) 2015-10-29

Family

ID=34969603

Family Applications (4)

Application Number Title Priority Date Filing Date
IL179176A IL179176A (en) 2004-05-13 2006-11-09 5 – fluoro-3 – phenyl – 2– [1– (h9– purine – 6 – ellamino) –profile] h – 3– quinazolin – 4 – on and 6 – fluorine – 3 – phenyl – 2– [1– ( h9– Purine – 6 – Ylamino) –ethyl] h – 3– Quinazolin – 4 – On and their use in the preparation of drugs to inhibit the activity of phosphatidylanositol 3 – kinase Delta in leukocytes
IL24173215A IL241732B (en) 2004-05-13 2015-09-20 2-di-tert-butyloxycarbonylamino-6-bromo-9-(2-trimehylsilylethoxy)methyl-9h-purine
IL269976A IL269976B (en) 2004-05-13 2019-10-15 Intermediate compounds for the preparation of quinazolinones as inhibitors of human phophatidylinositol 3-kinase delta
IL281945A IL281945A (en) 2004-05-13 2021-03-31 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL24173215A IL241732B (en) 2004-05-13 2015-09-20 2-di-tert-butyloxycarbonylamino-6-bromo-9-(2-trimehylsilylethoxy)methyl-9h-purine
IL269976A IL269976B (en) 2004-05-13 2019-10-15 Intermediate compounds for the preparation of quinazolinones as inhibitors of human phophatidylinositol 3-kinase delta
IL281945A IL281945A (en) 2004-05-13 2021-03-31 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Country Status (23)

Country Link
US (14) USRE44638E1 (enEXAMPLES)
EP (4) EP3943494A1 (enEXAMPLES)
JP (1) JP2007537291A (enEXAMPLES)
CN (2) CN101031569B (enEXAMPLES)
AU (2) AU2005245875C1 (enEXAMPLES)
BE (1) BE2017C002I2 (enEXAMPLES)
CA (1) CA2566609C (enEXAMPLES)
CY (3) CY2016046I2 (enEXAMPLES)
DK (2) DK2612862T3 (enEXAMPLES)
ES (3) ES2873875T3 (enEXAMPLES)
FR (1) FR17C1007I2 (enEXAMPLES)
HR (2) HRP20161751T1 (enEXAMPLES)
HU (3) HUE030839T2 (enEXAMPLES)
IL (4) IL179176A (enEXAMPLES)
LT (3) LT1761540T (enEXAMPLES)
LU (1) LUC00005I2 (enEXAMPLES)
ME (2) ME02695B (enEXAMPLES)
NL (1) NL300867I2 (enEXAMPLES)
PL (3) PL3153514T3 (enEXAMPLES)
PT (3) PT1761540T (enEXAMPLES)
RS (2) RS55546B1 (enEXAMPLES)
SI (2) SI3153514T1 (enEXAMPLES)
WO (2) WO2005113556A1 (enEXAMPLES)

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US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
WO2005016348A1 (en) * 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
ES2873875T3 (es) 2004-05-13 2021-11-04 Icos Corp Quinazolinonas como inhibidores de fosfatidilinositol 3-quinasa delta humano
WO2005112935A1 (en) * 2004-05-13 2005-12-01 Vanderbilt University Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
CA2598409A1 (en) * 2005-02-17 2006-08-24 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
GB2431156A (en) * 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
US20080032960A1 (en) 2006-04-04 2008-02-07 Regents Of The University Of California PI3 kinase antagonists
CN101605797A (zh) 2006-11-13 2009-12-16 伊莱利利公司 治疗炎症疾病和癌症的噻吩并嘧啶酮
EP1953163A1 (en) * 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
WO2009002553A1 (en) * 2007-06-25 2008-12-31 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
FR2918668B1 (fr) * 2007-07-09 2009-08-21 Arkema France Procede ameliore de preparation d'alcoxyamines issues de nitroxydes beta-phosphores.
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
EP2220089A4 (en) * 2007-11-13 2011-10-26 Icos Corp HEMMER OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE-DELTA
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
AU2014203687B2 (en) * 2008-01-04 2016-04-14 Intellikine Llc Certain chemical entities, compositions and methods
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