IL184048A0 - Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists - Google Patents

Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists

Info

Publication number
IL184048A0
IL184048A0 IL184048A IL18404807A IL184048A0 IL 184048 A0 IL184048 A0 IL 184048A0 IL 184048 A IL184048 A IL 184048A IL 18404807 A IL18404807 A IL 18404807A IL 184048 A0 IL184048 A0 IL 184048A0
Authority
IL
Israel
Prior art keywords
tetrazolone
triazolone
alpha
adrenoreceptor antagonists
imidazolone derivatives
Prior art date
Application number
IL184048A
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL184048A0 publication Critical patent/IL184048A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
IL184048A 2004-12-21 2007-06-19 Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists IL184048A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04106817 2004-12-21
EP05104873 2005-06-03
PCT/EP2005/056951 WO2006067139A1 (en) 2004-12-21 2005-12-20 Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists

Publications (1)

Publication Number Publication Date
IL184048A0 true IL184048A0 (en) 2007-10-31

Family

ID=36013649

Family Applications (1)

Application Number Title Priority Date Filing Date
IL184048A IL184048A0 (en) 2004-12-21 2007-06-19 Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists

Country Status (15)

Country Link
US (1) US20100029620A1 (en)
EP (1) EP1831185A1 (en)
JP (1) JP2008524312A (en)
KR (1) KR20070090941A (en)
AR (1) AR052342A1 (en)
AU (1) AU2005318188A1 (en)
BR (1) BRPI0516380A (en)
CA (1) CA2588028A1 (en)
EA (1) EA011514B1 (en)
IL (1) IL184048A0 (en)
MX (1) MX2007007472A (en)
NO (1) NO20073760L (en)
PA (1) PA8657301A1 (en)
TW (1) TW200635906A (en)
WO (1) WO2006067139A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008083124A1 (en) 2006-12-28 2008-07-10 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
CA2798330A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
SI2623499T1 (en) * 2010-10-01 2015-10-30 Taisho Pharmaceutical Co., Ltd. 1,2,4-triazolone derivative
FR2976287B1 (en) 2011-06-09 2013-07-05 Pf Medicament BENZOQUINOLIZIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
WO2013062027A1 (en) * 2011-10-27 2013-05-02 大正製薬株式会社 Azole derivative
BR112014028991A2 (en) 2012-05-22 2017-06-27 Autifony Therapeutics Ltd triazoles as kv3 inhibitors
WO2014198592A1 (en) * 2013-06-11 2014-12-18 F. Hoffmann-La Roche Ag Novel tetrazolone derivatives
JP2016523918A (en) 2013-06-27 2016-08-12 シーダーズ−サイナイ メディカル センター Adrenergic receptor antagonists for the prevention and treatment of neurodegenerative conditions
BR112019000569A2 (en) 2016-07-12 2019-04-24 Bayer Cropscience Aktiengesellschaft bicyclic compounds as pesticides
WO2019089066A1 (en) * 2017-11-06 2019-05-09 Acelot, Inc. SMALL MOLECULE DRUGS AND RELATED METHODS FOR TREATMENT OF DISEASES RELATED TO Aβ42 OLIGOMER FORMATION

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355457A (en) * 1965-05-21 1967-11-28 American Cyanamid Co Substituted 2-imidazolinones
DE2725148A1 (en) * 1977-06-03 1978-12-14 Hoechst Ag 1-ARYL-4-ALKYL-1,2,4-TRIAZOL-5-ONE AND METHOD FOR THE PRODUCTION THEREOF
CZ288544B6 (en) * 1994-01-24 2001-07-11 Janssen Pharmaceutica N. V. Azoles, process and intermediates for their preparation and pharmaceutical preparations based thereon
JPH0899975A (en) * 1994-08-05 1996-04-16 Nippon Bayeragrochem Kk Five-membered heterocyclic ring substituted tetrazolinone derivative and herbicide
JPH09183770A (en) * 1995-10-31 1997-07-15 Nippon Bayeragrochem Kk Derivative of 1-azine-tetrazolinon and herbicide
WO1998025912A1 (en) * 1996-12-13 1998-06-18 E.I. Du Pont De Nemours And Company Herbicidal heterocyclic amides
WO1998051683A1 (en) * 1997-05-15 1998-11-19 E.I. Du Pont De Nemours And Company Herbicidal tetrazolinones
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
WO2000010984A1 (en) * 1998-08-19 2000-03-02 Hokko Chemical Industry Co., Ltd. Triazolinone derivatives and herbicide compositions
JP3837242B2 (en) * 1998-08-25 2006-10-25 北興化学工業株式会社 Triazolinone derivatives and herbicides

Also Published As

Publication number Publication date
NO20073760L (en) 2007-07-19
MX2007007472A (en) 2007-07-20
AR052342A1 (en) 2007-03-14
PA8657301A1 (en) 2007-01-17
AU2005318188A1 (en) 2006-06-29
JP2008524312A (en) 2008-07-10
US20100029620A1 (en) 2010-02-04
KR20070090941A (en) 2007-09-06
BRPI0516380A (en) 2008-09-02
TW200635906A (en) 2006-10-16
WO2006067139A1 (en) 2006-06-29
EP1831185A1 (en) 2007-09-12
EA200701345A1 (en) 2007-10-26
EA011514B1 (en) 2009-04-28
CA2588028A1 (en) 2006-06-29

Similar Documents

Publication Publication Date Title
IL184048A0 (en) Triazolone, tetrazolone and imidazolone derivatives for use as alpha-2c adrenoreceptor antagonists
EP1827326A4 (en) Dynamic hand splints
HK1100326A1 (en) Guanidine compounds, and use thereof as binding partners for 5-ht5 receptors 5-ht5
AP2007004218A0 (en) NPY antagonists, preparation and use
IL180257A0 (en) Heterocycle-substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
ME01643B (en) Benzimidazole derivative and use as aii receptor antagonist
ZA200606678B (en) 2-Pyridinylethylcarboxamide derivatives and their use as fungicides
ZA200409333B (en) 4-substituted imidazole-2-thiones and imidazol-2-ones as agonists of the alpha-2B and alpha-2C adrenergic receptors.
IL186112A0 (en) SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND Pak INHIBITORS
IL189679A0 (en) Imidazole derivatives functionally selective alpha2c adrenoreceptor agonists
EP1717231A4 (en) Substituted azole compounds and thereof preparation and application
IL184901A0 (en) 2,4-diamino-pyridopyrimidine derivatives and their use as mtor inhibitors
IL202293A0 (en) 1,(,3)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
IL180682A0 (en) N-hydroxamide derivatives, their preparation and use
IL196671A0 (en) Substituted imidazolone derivatives, preparation and uses
IL178989A0 (en) Guanidine based composition and system for same
IL177366A0 (en) Substituted azetidine compounds as cyclooxygease-1-cyclooxygenase-2 inhibitors, and their preparation and use as medicaments
IL178765A0 (en) 2-pyridinylcycloalkylbenzamide derivatives and their use as fungicides
IL176630A0 (en) Benzimidazole derivatives
ZA200702596B (en) Novel bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors
IL185726A0 (en) Benzimidazole derivative and use as angiotensin ii antagonist
EP1961753A4 (en) Pyrazolopyrimidinone derivatives, their preparation and their use
HK1104823A1 (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i
ZA200706672B (en) 2,4-Diamino-pyridopyrimidine derivatives and their use as mTOR inhibitors
HK1113686A1 (en) Biotinylated hexadecasaccharides, preparation and use thereof