IL159109A0 - Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Info

Publication number
IL159109A0
IL159109A0 IL15910902A IL15910902A IL159109A0 IL 159109 A0 IL159109 A0 IL 159109A0 IL 15910902 A IL15910902 A IL 15910902A IL 15910902 A IL15910902 A IL 15910902A IL 159109 A0 IL159109 A0 IL 159109A0
Authority
IL
Israel
Prior art keywords
pyrazines
tetrahydrotriazolo
diabetes
beta
prevention
Prior art date
Application number
IL15910902A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL159109(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL159109A0 publication Critical patent/IL159109A0/xx

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
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    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
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    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
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    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
IL15910902A 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes IL159109A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
IL159109A0 true IL159109A0 (en) 2004-05-12

Family

ID=23172273

Family Applications (3)

Application Number Title Priority Date Filing Date
IL15910902A IL159109A0 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotriazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
IL159109A IL159109A (en) 2001-07-06 2003-11-27 Derivatives of 7- (3-amino-4-arylbutanoil) tetrahydroimidazole (A-2,1) pyrazine and tetrahydrotriazolo (3,4-A) pyrazine as inhibitors of dipeptidyl peptides and pharmaceutical preparations containing them
IL178307A IL178307A (en) 2001-07-06 2006-09-26 A medical composition comprising tetrahydrotriazolo [3,4–] a pyrazine

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL159109A IL159109A (en) 2001-07-06 2003-11-27 Derivatives of 7- (3-amino-4-arylbutanoil) tetrahydroimidazole (A-2,1) pyrazine and tetrahydrotriazolo (3,4-A) pyrazine as inhibitors of dipeptidyl peptides and pharmaceutical preparations containing them
IL178307A IL178307A (en) 2001-07-06 2006-09-26 A medical composition comprising tetrahydrotriazolo [3,4–] a pyrazine

Country Status (45)

Country Link
US (9) US6699871B2 (instruction)
EP (4) EP2292232B1 (instruction)
JP (1) JP3762407B2 (instruction)
KR (1) KR100606871B1 (instruction)
CN (2) CN1861077A (instruction)
AR (1) AR036114A1 (instruction)
AT (2) ATE321048T1 (instruction)
AU (1) AU2002320303B2 (instruction)
BE (1) BE2007C047I2 (instruction)
BG (1) BG108493A (instruction)
BR (1) BRPI0210866B8 (instruction)
CA (1) CA2450740C (instruction)
CR (1) CR7235A (instruction)
CY (3) CY2007019I2 (instruction)
DE (4) DE60210093T2 (instruction)
DK (2) DK1625847T3 (instruction)
DO (1) DOP2002000438A (instruction)
EA (2) EA006845B1 (instruction)
EC (1) ECSP044935A (instruction)
ES (2) ES2259713T3 (instruction)
FR (2) FR07C0041I2 (instruction)
GE (2) GEP20053734B (instruction)
HR (1) HRP20031098B1 (instruction)
HU (2) HU225695B1 (instruction)
IL (3) IL159109A0 (instruction)
IS (2) IS2218B (instruction)
JO (1) JO2230B1 (instruction)
LT (1) LTC1412357I2 (instruction)
LU (2) LUC91360I2 (instruction)
MA (1) MA27053A1 (instruction)
ME (1) ME00439B (instruction)
MX (1) MXPA04000018A (instruction)
MY (1) MY127961A (instruction)
NL (2) NL300287I2 (instruction)
NO (4) NO321999B1 (instruction)
NZ (1) NZ529833A (instruction)
PE (1) PE20030654A1 (instruction)
PL (1) PL196278B6 (instruction)
PT (2) PT1625847E (instruction)
RS (1) RS50737B (instruction)
SI (1) SI1412357T1 (instruction)
TW (1) TWI226331B (instruction)
UA (1) UA74912C2 (instruction)
WO (1) WO2003004498A1 (instruction)
ZA (1) ZA200309294B (instruction)

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CA2499586A1 (en) * 2002-10-07 2004-04-22 Merck & Co., Inc. Antidiabetic beta-amino heterocyclic dipeptidyl peptidase inhibitors
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JP2006510630A (ja) * 2002-12-04 2006-03-30 メルク エンド カムパニー インコーポレーテッド 糖尿病を治療又は予防するためのジペプチジルペプチダーゼ阻害剤としてのフェニルアラニン誘導体
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IL178307A (en) 2010-04-15
PE20030654A1 (es) 2003-07-29
IL159109A (en) 2007-06-03
LUC91360I1 (instruction) 2020-04-23
NL300287I1 (nl) 2007-10-01
US20100130504A1 (en) 2010-05-27
US20130217695A1 (en) 2013-08-22
ZA200309294B (en) 2004-07-22
AU2002320303B2 (en) 2004-10-14
LTPA2007006I1 (lt) 2020-04-27
IS7062A (is) 2003-11-28
ME00439B (me) 2011-12-20
PT1625847E (pt) 2010-08-20
DOP2002000438A (es) 2003-01-31
DE60210093T2 (de) 2006-11-23
PL196278B1 (pl) 2007-12-31
BR0210866A (pt) 2004-06-29
EA200501805A1 (ru) 2006-06-30
HUP0401104A2 (hu) 2004-09-28
NL300357I1 (nl) 2008-10-01
US20110190308A1 (en) 2011-08-04
MXPA04000018A (es) 2004-05-21
US20030100563A1 (en) 2003-05-29
EP1625847B1 (en) 2010-06-16
BRPI0210866B1 (pt) 2016-07-05

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