CY2007019I2 - Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη ή προληψη του διαβητη - Google Patents

Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη ή προληψη του διαβητη

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Publication number
CY2007019I2
CY2007019I2 CY2007019C CY2007019C CY2007019I2 CY 2007019 I2 CY2007019 I2 CY 2007019I2 CY 2007019 C CY2007019 C CY 2007019C CY 2007019 C CY2007019 C CY 2007019C CY 2007019 I2 CY2007019 I2 CY 2007019I2
Authority
CY
Cyprus
Prior art keywords
pyrasines
tetrahydrotriazole
tetrahydroimidazo
diabetes
induction
Prior art date
Application number
CY2007019C
Other languages
Greek (el)
English (en)
Other versions
CY2007019I1 (el
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2007019(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY2007019I1 publication Critical patent/CY2007019I1/el
Publication of CY2007019I2 publication Critical patent/CY2007019I2/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/12—Antihypertensives

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
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  • Immunology (AREA)
  • Obesity (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Communicable Diseases (AREA)
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  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
CY2007019C 2001-07-06 2007-08-23 Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη ή προληψη του διαβητη CY2007019I2 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number Publication Date
CY2007019I1 CY2007019I1 (el) 2009-11-04
CY2007019I2 true CY2007019I2 (el) 2017-07-12

Family

ID=23172273

Family Applications (3)

Application Number Title Priority Date Filing Date
CY2007019C CY2007019I2 (el) 2001-07-06 2007-08-23 Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη ή προληψη του διαβητη
CY200800014C CY2008014I1 (el) 2001-07-06 2008-09-09 Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη η προληψη του διαβητη
CY20101100836T CY1110784T1 (el) 2001-07-06 2010-09-15 Ιατρικη χρηση της τετρα-υδροτριαζολο[4,3-α]πυραζινης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY200800014C CY2008014I1 (el) 2001-07-06 2008-09-09 Β-αμινο-τετραϋδροϊμιδαζο-(1,2-α)-πυραζινες και τετραϋδροτριαζολο-(4,3-α)-πυραζινες ως αναστολεις της διπεπτιδυλο πεπτιδασης για την αγωγη η προληψη του διαβητη
CY20101100836T CY1110784T1 (el) 2001-07-06 2010-09-15 Ιατρικη χρηση της τετρα-υδροτριαζολο[4,3-α]πυραζινης

Country Status (45)

Country Link
US (9) US7125873B2 (instruction)
EP (4) EP2226324A1 (instruction)
JP (1) JP3762407B2 (instruction)
KR (1) KR100606871B1 (instruction)
CN (2) CN1861077A (instruction)
AR (1) AR036114A1 (instruction)
AT (2) ATE321048T1 (instruction)
AU (1) AU2002320303B2 (instruction)
BE (1) BE2007C047I2 (instruction)
BG (1) BG108493A (instruction)
BR (1) BRPI0210866B8 (instruction)
CA (1) CA2450740C (instruction)
CR (1) CR7235A (instruction)
CY (3) CY2007019I2 (instruction)
DE (4) DE122007000056I1 (instruction)
DK (2) DK1625847T3 (instruction)
DO (1) DOP2002000438A (instruction)
EA (2) EA012701B1 (instruction)
EC (1) ECSP044935A (instruction)
ES (2) ES2344846T3 (instruction)
FR (2) FR07C0041I2 (instruction)
GE (2) GEP20053734B (instruction)
HR (1) HRP20031098B1 (instruction)
HU (2) HU225695B1 (instruction)
IL (3) IL159109A0 (instruction)
IS (2) IS2218B (instruction)
JO (1) JO2230B1 (instruction)
LT (1) LTC1412357I2 (instruction)
LU (2) LUC91360I2 (instruction)
MA (1) MA27053A1 (instruction)
ME (1) ME00439B (instruction)
MX (1) MXPA04000018A (instruction)
MY (1) MY127961A (instruction)
NL (2) NL300287I2 (instruction)
NO (4) NO321999B1 (instruction)
NZ (1) NZ529833A (instruction)
PE (1) PE20030654A1 (instruction)
PL (1) PL196278B6 (instruction)
PT (2) PT1625847E (instruction)
RS (1) RS50737B (instruction)
SI (1) SI1412357T1 (instruction)
TW (1) TWI226331B (instruction)
UA (1) UA74912C2 (instruction)
WO (1) WO2003004498A1 (instruction)
ZA (1) ZA200309294B (instruction)

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DE60209348T2 (de) 2001-06-20 2006-10-12 Merck & Co., Inc. Dipeptidylpeptidase-hemmer zur behandlung von diabetes
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UA74912C2 (en) * 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
AU2003219787A1 (en) * 2002-02-14 2003-09-04 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
EP1490335B1 (en) * 2002-03-25 2007-09-19 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
AU2003251869A1 (en) * 2002-07-15 2004-02-02 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
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ME00439B (me) 2011-12-20
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ES2344846T3 (es) 2010-09-08
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PL196278B6 (pl) 2023-02-13
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IS2964B (is) 2017-02-15
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BE2007C047I2 (instruction) 2021-06-04
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