ME00439B - Beta-amino tetrahidromidazo (1,2-a) pirazini i tetrahidrotriazolo (4,3-a) pirazini kao inhibitori dipeptidil peptidaze u liječenju ili prevenciji dijabetesa - Google Patents

Beta-amino tetrahidromidazo (1,2-a) pirazini i tetrahidrotriazolo (4,3-a) pirazini kao inhibitori dipeptidil peptidaze u liječenju ili prevenciji dijabetesa

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Publication number
ME00439B
ME00439B MEP-2008-667A MEP66708A ME00439B ME 00439 B ME00439 B ME 00439B ME P66708 A MEP66708 A ME P66708A ME 00439 B ME00439 B ME 00439B
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ME
Montenegro
Prior art keywords
compound
treatment
group
patient
effective amount
Prior art date
Application number
MEP-2008-667A
Other languages
English (en)
Unknown language (me)
Inventor
Scott D Edmondson
Michael H Fisher
Dooseop Kim
Malcolm Maccoss
Emma R Parmee
Ann E Weber
Jinyou Xu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00439(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ME00439B publication Critical patent/ME00439B/me

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/06Antihyperlipidemics
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    • A61P31/12Antivirals
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
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    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
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    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
MEP-2008-667A 2001-07-06 2002-07-05 Beta-amino tetrahidromidazo (1,2-a) pirazini i tetrahidrotriazolo (4,3-a) pirazini kao inhibitori dipeptidil peptidaze u liječenju ili prevenciji dijabetesa ME00439B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
ME00439B true ME00439B (me) 2011-12-20

Family

ID=23172273

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-667A ME00439B (me) 2001-07-06 2002-07-05 Beta-amino tetrahidromidazo (1,2-a) pirazini i tetrahidrotriazolo (4,3-a) pirazini kao inhibitori dipeptidil peptidaze u liječenju ili prevenciji dijabetesa

Country Status (45)

Country Link
US (9) US6699871B2 (instruction)
EP (4) EP2292232B1 (instruction)
JP (1) JP3762407B2 (instruction)
KR (1) KR100606871B1 (instruction)
CN (2) CN1861077A (instruction)
AR (1) AR036114A1 (instruction)
AT (2) ATE471148T1 (instruction)
AU (1) AU2002320303B2 (instruction)
BE (1) BE2007C047I2 (instruction)
BG (1) BG108493A (instruction)
BR (1) BRPI0210866B8 (instruction)
CA (1) CA2450740C (instruction)
CR (1) CR7235A (instruction)
CY (3) CY2007019I2 (instruction)
DE (4) DE122008000046I1 (instruction)
DK (2) DK1625847T3 (instruction)
DO (1) DOP2002000438A (instruction)
EA (2) EA012701B1 (instruction)
EC (1) ECSP044935A (instruction)
ES (2) ES2259713T3 (instruction)
FR (2) FR07C0041I2 (instruction)
GE (2) GEP20063734B (instruction)
HR (1) HRP20031098B1 (instruction)
HU (2) HU225695B1 (instruction)
IL (3) IL159109A0 (instruction)
IS (2) IS2218B (instruction)
JO (1) JO2230B1 (instruction)
LT (1) LTC1412357I2 (instruction)
LU (2) LUC91360I2 (instruction)
MA (1) MA27053A1 (instruction)
ME (1) ME00439B (instruction)
MX (1) MXPA04000018A (instruction)
MY (1) MY127961A (instruction)
NL (2) NL300287I2 (instruction)
NO (4) NO321999B1 (instruction)
NZ (1) NZ529833A (instruction)
PE (1) PE20030654A1 (instruction)
PL (1) PL196278B6 (instruction)
PT (2) PT1625847E (instruction)
RS (1) RS50737B (instruction)
SI (1) SI1412357T1 (instruction)
TW (1) TWI226331B (instruction)
UA (1) UA74912C2 (instruction)
WO (1) WO2003004498A1 (instruction)
ZA (1) ZA200309294B (instruction)

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