HRP20040684B1 - Spojevi 2,4-pirimidindiamina i njihova upotreba - Google Patents
Spojevi 2,4-pirimidindiamina i njihova upotrebaInfo
- Publication number
- HRP20040684B1 HRP20040684B1 HRP20040684AA HRP20040684A HRP20040684B1 HR P20040684 B1 HRP20040684 B1 HR P20040684B1 HR P20040684A A HRP20040684A A HR P20040684AA HR P20040684 A HRP20040684 A HR P20040684A HR P20040684 B1 HRP20040684 B1 HR P20040684B1
- Authority
- HR
- Croatia
- Prior art keywords
- compounds
- release
- methods
- pyrimidinediamine compounds
- receptor signaling
- Prior art date
Links
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 102000009438 IgE Receptors Human genes 0.000 abstract 2
- 108010073816 IgE Receptors Proteins 0.000 abstract 2
- 102000009490 IgG Receptors Human genes 0.000 abstract 2
- 108010073807 IgG Receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000019491 signal transduction Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
Ovaj izum omogućuje spojeve 2,4-pirimidindiamina koji inhibiraju IgE i/ili IgG receptor signalizirajuće kaskade koji vode oslobađanju kemijskih posrednika, međuproizvode i metode sinteziranja spojeva i metode korištenja spojeva u različitim kontekstima, uključujući i liječenje i prevenciju bolesti karakteriziranih, prouzročenih ili vezanih za oslobađanje kemijskih posrednika putem degranulacije i drugih procesa na koje utječe aktiviranje IgE i/ili IgG receptora signalizirajućih kaskada.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US35333302P | 2002-02-01 | 2002-02-01 | |
US35326702P | 2002-02-01 | 2002-02-01 | |
US39967302P | 2002-07-29 | 2002-07-29 | |
US43427702P | 2002-12-17 | 2002-12-17 | |
PCT/US2003/003022 WO2003063794A2 (en) | 2002-02-01 | 2003-01-31 | 2,4-pyrimidinediamine compounds and their uses |
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HRP20040684A2 HRP20040684A2 (hr) | 2008-12-31 |
HRP20040684B1 true HRP20040684B1 (hr) | 2014-07-04 |
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HRP20040684AA HRP20040684B1 (hr) | 2002-02-01 | 2004-07-23 | Spojevi 2,4-pirimidindiamina i njihova upotreba |
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US (41) | US7557210B2 (hr) |
EP (2) | EP2281563B1 (hr) |
JP (2) | JP4658477B2 (hr) |
KR (1) | KR101037856B1 (hr) |
CN (2) | CN1625400B (hr) |
AT (1) | ATE524184T1 (hr) |
AU (2) | AU2003208931C1 (hr) |
BR (1) | BRPI0307355C1 (hr) |
CA (1) | CA2474277C (hr) |
CY (1) | CY1112516T1 (hr) |
DK (2) | DK2281563T3 (hr) |
ES (2) | ES2373646T3 (hr) |
HK (2) | HK1069538A1 (hr) |
HR (1) | HRP20040684B1 (hr) |
IL (1) | IL221381A (hr) |
MX (2) | MXPA04007386A (hr) |
NO (1) | NO328071B1 (hr) |
NZ (1) | NZ534361A (hr) |
PL (1) | PL214988B1 (hr) |
PT (2) | PT2281563E (hr) |
RS (2) | RS53367B (hr) |
SG (1) | SG167664A1 (hr) |
SI (2) | SI2281563T1 (hr) |
TW (1) | TWI329105B (hr) |
WO (1) | WO2003063794A2 (hr) |
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