CO6251277A2 - Inhibidor de la dpp-iv combinado con mas de un agente antidiabetico, comprimidos que comprenden tales formulaciones, su uso y procedimientos para su preparación. - Google Patents

Inhibidor de la dpp-iv combinado con mas de un agente antidiabetico, comprimidos que comprenden tales formulaciones, su uso y procedimientos para su preparación.

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Publication number
CO6251277A2
CO6251277A2 CO10121097A CO10121097A CO6251277A2 CO 6251277 A2 CO6251277 A2 CO 6251277A2 CO 10121097 A CO10121097 A CO 10121097A CO 10121097 A CO10121097 A CO 10121097A CO 6251277 A2 CO6251277 A2 CO 6251277A2
Authority
CO
Colombia
Prior art keywords
pharmaceutical composition
dpp4 inhibitor
composition according
inhibitor
drug
Prior art date
Application number
CO10121097A
Other languages
English (en)
Inventor
Thomas Friedl
Michael Braun
Hikaru Fujita
Takaaki Nishioka
Megumi Maruyama
Kenji Egusa
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39714040&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251277(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO6251277A2 publication Critical patent/CO6251277A2/es

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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
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  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

La presente invención se refiere a composiciones farmacéuticas que comprenden combinaciones en dosis fijas de un fármaco inhibidor de la DPP4 y un fármaco acompañante, procedimientos para la preparación de las mismas y su uso para tratar determinadas enfermedades. 1.- Una composición farmacéutica que comprende o está hecha de un inhibidor de la DPP4, un fármaco acompañante y uno o más excipientes farmacéuticos y un agente nucleófilo y/o básico para estabilizar dicho inhibidor de la DPP4 frente a la degradación. 2.- Una composición farmacéutica de acuerdo con la reivindicación 1, que comprende un inhibidor de la DPP4, un fármaco acompañante, uno o más excipientes farmacéuticos y una sustancia tamponante para estabilizar dicho inhibidor de la DPP4 frente a la degradación. 3.- La composición farmacéutica de acuerdo con la reivindicación 1 o 2, en la que dicho inhibidor de la DPP4 está estabilizado frente a la degradación química. 4.- La composición farmacéutica según cualquiera de las reivindicaciones 1, 2 o 3, en la que el fármaco acompañante se selecciona del grupo que consiste en biguanidas que incluyen clorhidrato de metformina, tiazolidinonas que incluyen clorhidrato de pioglitazona, estatinas que incluyen atorvastatina, y BRAs que incluyen telmisartán. 5.- La composición farmacéutica según cualquiera de las reivindicaciones 1 a 4, en la que el agente nucleófilo y/o básico o la sustancia tamponante es un aminoácido básico que tiene un grupo amino intramolecular y características alcalinas, que incluyen Larginina, L-lisina y L-histidina. 6.- La composición farmacéutica según cualquiera de las reivindicaciones 1 a 5, en la que el inhibidor de la DPP4 tiene un grupo amino intramolecular primario o secundario libre. 7.- La composición farmacéutica según cualquiera de las reivindicaciones 1 a 6, en la que el inhibidor de la DPP4 se selecciona entre vildagliptina, saxagliptina y alogliptina. 8.- La composición farmacéutica según cualquiera de las reivindicaciones 1 a 6, en la que el inhibidor de la DPP4 es la base libre de la 1-[(4-metil-quinazolin-2- il)metill-3-metil-7-(2-butin-1-il)-8-(3-(R)-amino-piperidin-1- il)-xantina.
CO10121097A 2008-04-03 2010-09-30 Inhibidor de la dpp-iv combinado con mas de un agente antidiabetico, comprimidos que comprenden tales formulaciones, su uso y procedimientos para su preparación. CO6251277A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08154039 2008-04-03
US8734308P 2008-08-08 2008-08-08

Publications (1)

Publication Number Publication Date
CO6251277A2 true CO6251277A2 (es) 2011-02-21

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CO10121097A CO6251277A2 (es) 2008-04-03 2010-09-30 Inhibidor de la dpp-iv combinado con mas de un agente antidiabetico, comprimidos que comprenden tales formulaciones, su uso y procedimientos para su preparación.

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US (10) US9155705B2 (es)
EP (3) EP2285410B1 (es)
JP (2) JP5588428B2 (es)
KR (3) KR20170056021A (es)
CN (4) CN106215190A (es)
AR (1) AR071175A1 (es)
AU (1) AU2009232043B2 (es)
BR (1) BRPI0911273B8 (es)
CA (1) CA2720450C (es)
CO (1) CO6251277A2 (es)
DK (1) DK2285410T3 (es)
EA (2) EA038435B1 (es)
EC (1) ECSP10010489A (es)
ES (1) ES2696124T3 (es)
HK (1) HK1149485A1 (es)
IL (2) IL207497A0 (es)
MA (1) MA32200B1 (es)
MX (2) MX2010010819A (es)
NZ (1) NZ587747A (es)
PE (2) PE20091730A1 (es)
PL (1) PL2285410T3 (es)
TW (2) TWI527816B (es)
UA (1) UA104136C2 (es)
UY (1) UY31747A (es)
WO (1) WO2009121945A2 (es)
ZA (1) ZA201005664B (es)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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