CN114634950A - 用于序列操纵的crispr-cas组分系统、方法以及组合物 - Google Patents

用于序列操纵的crispr-cas组分系统、方法以及组合物 Download PDF

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Publication number
CN114634950A
CN114634950A CN202111233527.5A CN202111233527A CN114634950A CN 114634950 A CN114634950 A CN 114634950A CN 202111233527 A CN202111233527 A CN 202111233527A CN 114634950 A CN114634950 A CN 114634950A
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sequence
crispr
cas9
cells
target
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CN202111233527.5A
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Chinese (zh)
Inventor
张锋
D·O·比卡德
丛乐
D·B·T·科克斯
P·徐
W·蒋
林帅亮
L·马拉菲尼
R·J·普拉特
然霏
N·E·桑加纳
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Rockefeller University
Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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Rockefeller University
Massachusetts Institute of Technology
Broad Institute Inc
Harvard University
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Application filed by Rockefeller University, Massachusetts Institute of Technology, Broad Institute Inc, Harvard University filed Critical Rockefeller University
Publication of CN114634950A publication Critical patent/CN114634950A/zh
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CN202111233527.5A 2012-12-12 2013-12-12 用于序列操纵的crispr-cas组分系统、方法以及组合物 Pending CN114634950A (zh)

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US201261736527P 2012-12-12 2012-12-12
US61/736,527 2012-12-12
US201361748427P 2013-01-02 2013-01-02
US61/748,427 2013-01-02
US201361768959P 2013-02-25 2013-02-25
US61/768,959 2013-02-25
US201361791409P 2013-03-15 2013-03-15
US61/791,409 2013-03-15
US201361835931P 2013-06-17 2013-06-17
US61/835,931 2013-06-17
CN201380072868.6A CN105658796B (zh) 2012-12-12 2013-12-12 用于序列操纵的crispr-cas组分系统、方法以及组合物
PCT/US2013/074611 WO2014093595A1 (en) 2012-12-12 2013-12-12 Crispr-cas component systems, methods and compositions for sequence manipulation

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US (26) US20140189896A1 (enExample)
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EP2449112A1 (en) 2009-07-01 2012-05-09 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (scid)
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
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AU2013359262A1 (en) 2015-07-30
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JP2023093658A (ja) 2023-07-04
KR20150105635A (ko) 2015-09-17
AU2022203763B2 (en) 2025-02-27
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BR112015013786B1 (pt) 2022-03-15
EP2840140B1 (en) 2016-11-16
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