BR112017005483A2 - materiais e métodos para a produção de animais com pelo curto - Google Patents

materiais e métodos para a produção de animais com pelo curto

Info

Publication number
BR112017005483A2
BR112017005483A2 BR112017005483A BR112017005483A BR112017005483A2 BR 112017005483 A2 BR112017005483 A2 BR 112017005483A2 BR 112017005483 A BR112017005483 A BR 112017005483A BR 112017005483 A BR112017005483 A BR 112017005483A BR 112017005483 A2 BR112017005483 A2 BR 112017005483A2
Authority
BR
Brazil
Prior art keywords
materials
methods
animals
production
protein
Prior art date
Application number
BR112017005483A
Other languages
English (en)
Inventor
West James
Original Assignee
Aggenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aggenetics Inc filed Critical Aggenetics Inc
Publication of BR112017005483A2 publication Critical patent/BR112017005483A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção refere-se a materiais e métodos para a produção de animais com um comprimento de pelo curto. em uma modalidade de preferência, isto é conseguido através da alteração na sequência de nucleotídeos do animal que codifica a proteína receptora da prolactina (prlr) de tal modo que uma versão truncada da proteína é produzida. de forma vantajosa e surpreendente, a proteína truncada produzida de acordo com a presente invenção retém a funcionalidade lactogênica, porém faz com que o animal tenha uma pelagem de pelo curto.
BR112017005483A 2014-09-23 2015-09-23 materiais e métodos para a produção de animais com pelo curto BR112017005483A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462054169P 2014-09-23 2014-09-23
PCT/US2015/051717 WO2016049182A1 (en) 2014-09-23 2015-09-23 Materials and methods for producing animals with short hair

Publications (1)

Publication Number Publication Date
BR112017005483A2 true BR112017005483A2 (pt) 2018-03-06

Family

ID=55524517

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005483A BR112017005483A2 (pt) 2014-09-23 2015-09-23 materiais e métodos para a produção de animais com pelo curto

Country Status (13)

Country Link
US (2) US10716298B2 (pt)
EP (1) EP3197272A4 (pt)
JP (1) JP2017528169A (pt)
KR (1) KR20170058985A (pt)
CN (1) CN106715698A (pt)
AU (2) AU2015320738B2 (pt)
BR (1) BR112017005483A2 (pt)
CA (1) CA2959737A1 (pt)
EA (1) EA201790675A1 (pt)
IL (1) IL251050B (pt)
MX (1) MX2017003770A (pt)
WO (1) WO2016049182A1 (pt)
ZA (1) ZA201701838B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528124B2 (en) 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
MX2016005379A (es) 2013-10-25 2017-02-15 Livestock Improvement Corp Ltd Marcadores geneticos y usos de los mismos.
US10716298B2 (en) 2014-09-23 2020-07-21 Acceligen, Inc. Materials and methods for producing animals with short hair
BR112018005412A2 (pt) * 2015-09-21 2018-10-09 Recombinetics Inc animais geneticamente modificados que possuem tolerância térmica aumentada.
US20240090479A1 (en) * 2021-01-27 2024-03-21 Abs Global, Inc. Hyperprolactinemia or lactation without pregnancy
WO2023196818A1 (en) 2022-04-04 2023-10-12 The Regents Of The University Of California Genetic complementation compositions and methods

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
FR2737497B1 (fr) * 1995-08-02 1997-10-03 Agronomique Inst Nat Rech Utilisation du domaine intra-cytoplasmique du recepteur de la prolactine ou du recepteur de l'hormone de croissance pour obtenir la secretion de proteines
EP0821070A1 (en) 1996-07-22 1998-01-28 Carelli, Claude Marcel Henri Pit-1 gene polymorphism and trait selection in animals
WO2000022098A1 (en) 1998-10-12 2000-04-20 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
WO2000069882A1 (en) * 1999-05-13 2000-11-23 The Penn State Research Foundation Genetic marker for meat quality, growth, carcass and reproductive traits in livestock
AU1100201A (en) 1999-10-28 2001-05-08 Board Of Trustees Of The Leland Stanford Junior University Methods of in vivo gene transfer using a sleeping beauty transposon system
US7645441B2 (en) * 2000-12-22 2010-01-12 Sagres Discovery Inc. Compositions and methods in cancer associated with altered expression of PRLR
BR0307383A (pt) 2002-01-23 2005-04-26 Univ Utah Res Found Mutagênese cromossomica alvo utilizando nucleases de ramificações de zinco
CA2506798C (en) * 2002-11-22 2013-01-22 Institut Clayton De La Recherche Compositions and systems for the regulation of genes
CN104131063A (zh) 2002-12-31 2014-11-05 比浪海威公司 用于推断牛的性状的组合物、方法和系统
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
WO2005040400A2 (en) 2003-10-24 2005-05-06 Mmi Genomics, Inc. Methods and systems for inferring traits to manage non-beef livestock
RU2008102646A (ru) 2005-06-24 2009-07-27 Риджентс Оф Дзе Юниверсити Оф Миннесота (Us) Применение цитозиндезаминаз для уменьшения переноса ретроэлементов от свиней человеку
GB0524110D0 (en) * 2005-11-28 2006-01-04 Univ Cambridge Tech Biomarkers and methods for identification of agents useful in the treatment of affective disorders
US20110023159A1 (en) 2008-12-04 2011-01-27 Sigma-Aldrich Co. Ovine genome editing with zinc finger nucleases
US20110023140A1 (en) 2008-12-04 2011-01-27 Sigma-Aldrich Co. Rabbit genome editing with zinc finger nucleases
KR20100080068A (ko) 2008-12-31 2010-07-08 주식회사 툴젠 신규한 징크 핑거 뉴클레아제 및 이의 용도
US20120192298A1 (en) 2009-07-24 2012-07-26 Sigma Aldrich Co. Llc Method for genome editing
WO2011017315A2 (en) 2009-08-03 2011-02-10 Recombinetics, Inc. Methods and compositions for targeted gene modification
WO2011100505A2 (en) 2010-02-11 2011-08-18 Recombinetics, Inc. Methods and materials for producing transgenic artiodactyls
US9528124B2 (en) * 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
AU2012222144B2 (en) 2011-02-25 2017-04-27 Recombinetics, Inc. Genetically modified animals and methods for making the same
WO2014093595A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
MX2016005379A (es) * 2013-10-25 2017-02-15 Livestock Improvement Corp Ltd Marcadores geneticos y usos de los mismos.
CA2946881A1 (en) 2014-04-28 2015-11-05 Recombinetics, Inc. Multiplex gene editing in swine
US10716298B2 (en) 2014-09-23 2020-07-21 Acceligen, Inc. Materials and methods for producing animals with short hair
BR112018005412A2 (pt) * 2015-09-21 2018-10-09 Recombinetics Inc animais geneticamente modificados que possuem tolerância térmica aumentada.

Also Published As

Publication number Publication date
CA2959737A1 (en) 2016-03-31
EP3197272A1 (en) 2017-08-02
IL251050A0 (en) 2017-04-30
AU2015320738B2 (en) 2021-12-02
AU2022201249A1 (en) 2022-03-17
US20160081313A1 (en) 2016-03-24
AU2015320738A1 (en) 2017-03-30
EP3197272A4 (en) 2018-05-23
KR20170058985A (ko) 2017-05-29
JP2017528169A (ja) 2017-09-28
WO2016049182A1 (en) 2016-03-31
US10716298B2 (en) 2020-07-21
EA201790675A1 (ru) 2017-08-31
US20200296941A1 (en) 2020-09-24
MX2017003770A (es) 2017-06-30
IL251050B (en) 2021-02-28
ZA201701838B (en) 2018-05-30
CN106715698A (zh) 2017-05-24

Similar Documents

Publication Publication Date Title
BR112017005483A2 (pt) materiais e métodos para a produção de animais com pelo curto
BR112017014346A2 (pt) pó de besouro
BR112019000718A2 (pt) processo para a produção de geopolímero ou compósito de geopolímero
BR112016010175A2 (pt) Repressor genético, seus usos, e composição farmacêutica
BR112017027567A2 (pt) proteínas de fusão para inibir a angiogênese
CL2018000451A1 (es) Composiciones de micropartículas que comprenden saflufenacil
MX2016004035A (es) Formulaciones de espiro-isoxazolina de accion prolongada.
BR112016013485A2 (pt) Método para preparar um produto lácteo tendo teor estável de galacto-oligossacarídeo(s)
BR112015031155A2 (pt) derivados de sulfureto de arila e derivados de aril sulfóxido como acaricidas e inseticidas
BR112018003741A2 (pt) composições biofarmacêuticas
BR112016019825A2 (pt) anticorpos do fator bb do complemento
BR112017017122A2 (pt) 2-tioimidazolilcarboxamidas substituídas como agente controlador de pestes
BR112017023059A2 (pt) processo para preparar um produto de ração úmida esterilizada
MX2016014144A (es) Composiciones de proteina concentrada y metodos para su elaboracion y uso.
BR112017011556A2 (pt) métodos para gerar um anticorpo sintético, prevenir ou tratar uma doença, tratar um sujeito de infecção por um patógeno e um sujeito com câncer, produto, molécula de ácido nucleico, e, composição.
BR112017001679A2 (pt) processo para preparar uma poliamida, um sal de náilon a ser usado na mesma e um processo para produzir o sal
BR112017014598A2 (pt) métodos e usos para hidrólise de queratina
BR112017008707A2 (pt) ração de pré-mistura para aquacultura encapsulada
CL2020001137A1 (es) Anticuerpos anti-apoc3 y métodos de uso de estos.
BR112017009162A2 (pt) métodos para aperfeiçoamento de planta
BR112017000878A2 (pt) emulsão em pó para alimentos do animal
BR112018003778A2 (pt) animal transgênico para produção de anticorpos que apresenta uma cadeia leve comum
UY36435A (es) Supresión del arni parental del gen kruppel para controlar plagas de coleópteros
UY36952A (es) N-acetil-l-metionina bioderivada y uso de la misma
BR112018072697A2 (pt) composição, e, método para tratar uma doença em um sujeito

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]