SG11201906795SA - Novel plant cells, plants, and seeds - Google Patents
Novel plant cells, plants, and seedsInfo
- Publication number
- SG11201906795SA SG11201906795SA SG11201906795SA SG11201906795SA SG11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA
- Authority
- SG
- Singapore
- Prior art keywords
- inari
- cambridge
- suite
- agriculture
- international
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cultivation Of Plants (AREA)
Abstract
E 20 15 10 5 0 RNP used Treatment InDoti oNRT2.2 Gin1.4 it' . 40 , tr > 0.5 mM KCI 0.5 mM 0 3 A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT 111111Ru o Ellov n °nolo DID MD Imo! iono iflo (10) International Publication Number WO 2018/140899 Al (51) International Patent Classification: (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2018/015793 (22) International Filing Date: 29 January 2018 (29.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,708 28 January 2017 (28.01.2017) US 62/451,710 28 January 2017 (28.01.2017) US 62/452,610 31 January 2017 (31.01.2017) US 62/477,244 27 March 2017 (27.03.2017) US 62/480,989 03 April 2017 (03.04.2017) US 62/510,645 24 May 2017 (24.05.2017) US 62/523,675 22 June 2017 (22.06.2017) US 62/530,495 10 July 2017 (10.07.2017) US 62/530,839 10 July 2017 (10.07.2017) US 62/531,305 11 July 2017 (11.07.2017) US (71) Applicant: INARI AGRICULTURE, INC. [US/US]; 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). (72) Inventors: NIU, Yajie; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). SHULTZ, Randall, William; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). UNSON, Maria Margarita, D.; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). KOCK, Michael, Andreas; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). CASEY, John, P., Jr.; c/o Inari Agriculture, Inc., 200 Sid- ney Street, Suite 340, Cambridge, MA 02139 (US). (74) Agent: ULLSPERGER, Chris, J. et al.; Fenwick & West LLP, Silicon Valley Center, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, AO1H 1/00 (2006.01) C12N 15/09 C12N 5/04 (2006.01) C12N 15/11 C12N 5/10 (2006.01) C12N 15/63 (54) Title: NOVEL PLANT CELLS, PLANTS, AND SEEDS Figure 5 © (57) : The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods C for creating modifications in plant genomes. [Continued on next page] WO 2018/140899 Al MIDEDIMOMMIONER13010MOIIMEHOHMOVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with amended claims and statement (Art. 19(1)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762451710P | 2017-01-28 | 2017-01-28 | |
US201762451708P | 2017-01-28 | 2017-01-28 | |
US201762452610P | 2017-01-31 | 2017-01-31 | |
US201762477244P | 2017-03-27 | 2017-03-27 | |
US201762480989P | 2017-04-03 | 2017-04-03 | |
US201762510645P | 2017-05-24 | 2017-05-24 | |
US201762523675P | 2017-06-22 | 2017-06-22 | |
US201762530839P | 2017-07-10 | 2017-07-10 | |
US201762530495P | 2017-07-10 | 2017-07-10 | |
US201762531305P | 2017-07-11 | 2017-07-11 | |
PCT/US2018/015793 WO2018140899A1 (en) | 2017-01-28 | 2018-01-29 | Novel plant cells, plants, and seeds |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201906795SA true SG11201906795SA (en) | 2019-08-27 |
Family
ID=62979357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201906795SA SG11201906795SA (en) | 2017-01-28 | 2018-01-29 | Novel plant cells, plants, and seeds |
Country Status (7)
Country | Link |
---|---|
US (2) | US11624071B2 (en) |
EP (1) | EP3573448A4 (en) |
AU (1) | AU2018212986A1 (en) |
CA (1) | CA3051585A1 (en) |
SG (1) | SG11201906795SA (en) |
WO (1) | WO2018140899A1 (en) |
ZA (1) | ZA201904927B (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11859219B1 (en) | 2016-12-30 | 2024-01-02 | Flagship Pioneering Innovations V, Inc. | Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA |
AU2018212986A1 (en) | 2017-01-28 | 2019-08-08 | Inari Agriculture Technology, Inc. | Novel plant cells, plants, and seeds |
US11603536B2 (en) | 2017-09-29 | 2023-03-14 | Inari Agriculture Technology, Inc. | Methods for efficient maize genome editing |
CN109935663B (en) * | 2017-12-15 | 2021-06-22 | Tcl科技集团股份有限公司 | Preparation method of composite material film and QLED device |
US11926835B1 (en) | 2018-01-29 | 2024-03-12 | Inari Agriculture Technology, Inc. | Methods for efficient tomato genome editing |
US11220694B1 (en) | 2018-01-29 | 2022-01-11 | Inari Agriculture, Inc. | Rice cells and rice plants |
US11802288B1 (en) | 2018-01-29 | 2023-10-31 | Inari Agriculture Technology, Inc. | Methods for efficient soybean genome editing |
EP3794130A4 (en) * | 2018-05-16 | 2022-07-27 | Synthego Corporation | Methods and systems for guide rna design and use |
US11866719B1 (en) | 2018-06-04 | 2024-01-09 | Inari Agriculture Technology, Inc. | Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants |
EP3889266A4 (en) * | 2019-11-07 | 2022-08-10 | Qingdao KingAgroot Chemical Compound Co., Ltd. | Method for generating new mutations in organisms, and application thereof |
US20230175001A1 (en) * | 2020-03-30 | 2023-06-08 | Inari Agriculture Technology, Inc. | Improved polynucleotides for expression of rna-guided nucleases and dna binding proteins in soybean |
US11326177B2 (en) | 2020-07-31 | 2022-05-10 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize |
WO2022026566A1 (en) * | 2020-07-31 | 2022-02-03 | Inari Agriculture Technology, Inc. | Inir17 transgenic maize |
US11359210B2 (en) | 2020-07-31 | 2022-06-14 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize |
US11369073B2 (en) | 2020-07-31 | 2022-06-28 | Inari Agriculture Technology, Inc. | INIR12 transgenic maize |
CN116390644A (en) * | 2020-07-31 | 2023-07-04 | 伊纳瑞农业技术有限公司 | Generation of plants with improved transgene loci by genome editing |
US20240011042A1 (en) | 2020-07-31 | 2024-01-11 | Inari Agriculture Technology, Inc. | Excisable plant transgenic loci with signature protospacer adjacent motifs or signature guide rna recognition sites |
US11242534B1 (en) | 2020-07-31 | 2022-02-08 | Inari Agriculture Technology, Inc. | INHT31 transgenic soybean |
US11214811B1 (en) | 2020-07-31 | 2022-01-04 | Inari Agriculture Technology, Inc. | INIR6 transgenic maize |
WO2022046957A2 (en) * | 2020-08-26 | 2022-03-03 | Arcadia Biosciences, Inc. | Cannabis dna constructs and methods of regulating gene expression in plants |
US11976291B2 (en) | 2020-09-28 | 2024-05-07 | Inari Agriculture Technology, Inc. | Genetically enhanced maize plants |
US11198885B1 (en) | 2020-09-28 | 2021-12-14 | Inari Agriculture Technology, Inc. | Genetic regulatory element |
CA3195047A1 (en) * | 2020-10-07 | 2022-04-14 | Nathaniel BUTLER | Delivery of genome editing reagents via chimeric plants |
WO2022226107A1 (en) * | 2021-04-20 | 2022-10-27 | Texas Tech University System | Tissue-culture independent gene editing of cells by a long-distance rna transport system |
AU2022375817A1 (en) | 2021-11-01 | 2024-05-09 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
WO2023081907A1 (en) * | 2021-11-08 | 2023-05-11 | Inari Agriculture Technology, Inc. | Plant genome editing methods |
WO2023136966A1 (en) * | 2022-01-12 | 2023-07-20 | Inari Agriculture Technology, Inc. | Reduced height maize |
WO2023141540A2 (en) | 2022-01-20 | 2023-07-27 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
WO2023183772A2 (en) * | 2022-03-21 | 2023-09-28 | Inari Agriculture Technology, Inc. | Soybean jag1 gene mutations |
WO2023192825A1 (en) * | 2022-03-29 | 2023-10-05 | Inari Agriculture Technology, Inc. | Targeted donor dna insertion and indel editing of plant genes |
WO2024005863A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
EP4299733A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
EP4299739A1 (en) | 2022-06-30 | 2024-01-03 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
WO2024005864A1 (en) | 2022-06-30 | 2024-01-04 | Inari Agriculture Technology, Inc. | Compositions, systems, and methods for genome editing |
WO2024059543A2 (en) * | 2022-09-14 | 2024-03-21 | Monsanto Technology Llc | Methods and compositions for selective regulation of protein expression |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US20020169297A1 (en) | 2000-10-20 | 2002-11-14 | Susheng Gan | Genetic insulator for preventing influence by another gene promoter |
ES2566561T3 (en) | 2001-07-12 | 2016-04-13 | University Of Massachusetts | In vivo production of small interfering RNAs that mediate gene silencing |
US7422889B2 (en) | 2004-10-29 | 2008-09-09 | Stowers Institute For Medical Research | Dre recombinase and recombinase systems employing Dre recombinase |
US20070199095A1 (en) | 2005-10-13 | 2007-08-23 | Edwards Allen | Methods for producing hybrid seed |
US8314290B2 (en) | 2004-12-21 | 2012-11-20 | Monsanto Technology Llc | Temporal regulation of gene expression by MicroRNAs |
US20060200878A1 (en) | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
WO2006074400A2 (en) | 2005-01-07 | 2006-07-13 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Method to trigger rna interference |
US9085774B2 (en) | 2005-04-19 | 2015-07-21 | Basf Plant Science Gmbh | Methods controlling gene expression |
AR053279A1 (en) | 2005-05-19 | 2007-04-25 | Monsanto Technology Llc | POST-TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION |
ES2655700T3 (en) | 2006-08-31 | 2018-02-21 | Monsanto Technology, Llc | Small RNAs in phase |
EP2985353A1 (en) | 2006-10-12 | 2016-02-17 | Monsanto Technology LLC | Plant micrornas and methods of use thereof |
AU2008218813B2 (en) | 2007-02-20 | 2014-04-17 | Monsanto Technology, Llc | Invertebrate microRNAs |
WO2010002984A1 (en) | 2008-07-01 | 2010-01-07 | Monsanto Technology, Llc | Recombinant dna constructs and methods for modulating expression of a target gene |
US8816153B2 (en) | 2010-08-27 | 2014-08-26 | Monsanto Technology Llc | Recombinant DNA constructs employing site-specific recombination |
PE20141518A1 (en) | 2011-07-01 | 2014-11-17 | Monsanto Technology Llc | METHODS AND COMPOSITIONS FOR THE SELECTIVE REGULATION OF PROTEIN EXPRESSION |
CN104471067B (en) | 2012-05-07 | 2020-08-14 | 桑格摩生物治疗股份有限公司 | Methods and compositions for nuclease-mediated targeted integration of transgenes |
PT2800811T (en) | 2012-05-25 | 2017-08-17 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
CN110643600A (en) | 2012-10-23 | 2020-01-03 | 基因工具股份有限公司 | System for cutting target DNA and use thereof |
WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
SG10201912327SA (en) | 2012-12-12 | 2020-02-27 | Broad Inst Inc | Engineering and Optimization of Improved Systems, Methods and Enzyme Compositions for Sequence Manipulation |
EP3825401A1 (en) | 2012-12-12 | 2021-05-26 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
EP4279588A3 (en) | 2012-12-12 | 2024-01-17 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
BR112015021210B8 (en) | 2013-03-01 | 2022-11-16 | Univ California | METHOD FOR REDUCING THE EXPRESSION OF A TARGET NUCLEIC ACID IN A PLANT AND RECOMBINANT NUCLEIC ACID |
BR112016000571B1 (en) * | 2013-07-10 | 2023-12-26 | President And Fellows Of Harvard College | IN VITRO METHODS FOR MODULATING EXPRESSION AND FOR ALTERING ONE OR MORE TARGET NUCLEIC ACIDS IN A CELL SIMULTANEOUSLY WITH REGULATING THE EXPRESSION OF ONE OR MORE TARGET NUCLEIC ACIDS IN A CELL AS WELL AS A YEAST OR BACTERIAL CELL COMPRISING NUCLEIC ACIDS |
US11208628B2 (en) | 2013-08-09 | 2021-12-28 | Massachusetts Institute Of Technology | Nanobionic engineering of organelles and photosynthetic organisms |
MX2016002118A (en) | 2013-08-22 | 2016-06-28 | Du Pont | Plant genome modification using guide rna/cas endonuclease systems and methods of use. |
CN104450745A (en) * | 2013-09-12 | 2015-03-25 | 北京大学 | Method for acquiring specific rice gene mutant and application thereof |
WO2015131101A1 (en) | 2014-02-27 | 2015-09-03 | Monsanto Technology Llc | Compositions and methods for site directed genomic modification |
EP3136842A4 (en) * | 2014-04-28 | 2017-11-29 | Dow AgroSciences LLC | Haploid maize transformation |
AU2015288157A1 (en) | 2014-07-11 | 2017-01-19 | E. I. Du Pont De Nemours And Company | Compositions and methods for producing plants resistant to glyphosate herbicide |
CN106795524A (en) | 2014-07-11 | 2017-05-31 | 先锋国际良种公司 | Change agronomy character and its application method using guide RNA/CAS endonuclease systems |
CA2958767A1 (en) | 2014-08-26 | 2016-03-03 | The Regents Of The University Of California | Hypersensitive aba receptors |
US11002741B2 (en) | 2014-09-19 | 2021-05-11 | Massachusetts Institute Of Technology | Ratiometric and multiplexed sensors from single chirality carbon nanotubes |
CN107027313B (en) | 2014-10-17 | 2021-09-07 | 宾州研究基金会 | Methods and compositions for multiplex RNA-guided genome editing and other RNA techniques |
US10787523B2 (en) | 2015-01-29 | 2020-09-29 | University Of Massachusetts | Nanoparticle-protein complex for intracellular protein delivery |
CN113957080A (en) | 2015-04-20 | 2022-01-21 | 孟山都技术有限公司 | Compositions and methods for modifying flowering and plant architecture to increase yield potential |
US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
US20170175140A1 (en) | 2015-12-16 | 2017-06-22 | Regents Of The University Of Minnesota | Methods for using a 5'-exonuclease to increase homologous recombination in eukaryotic cells |
WO2018085693A1 (en) | 2016-11-04 | 2018-05-11 | Inari Agriculture, Inc. | Novel plant cells, plants, and seeds |
AU2018212986A1 (en) | 2017-01-28 | 2019-08-08 | Inari Agriculture Technology, Inc. | Novel plant cells, plants, and seeds |
US11220694B1 (en) * | 2018-01-29 | 2022-01-11 | Inari Agriculture, Inc. | Rice cells and rice plants |
-
2018
- 2018-01-29 AU AU2018212986A patent/AU2018212986A1/en active Pending
- 2018-01-29 SG SG11201906795SA patent/SG11201906795SA/en unknown
- 2018-01-29 US US16/480,992 patent/US11624071B2/en active Active
- 2018-01-29 CA CA3051585A patent/CA3051585A1/en active Pending
- 2018-01-29 WO PCT/US2018/015793 patent/WO2018140899A1/en unknown
- 2018-01-29 EP EP18744149.8A patent/EP3573448A4/en active Pending
-
2019
- 2019-07-26 ZA ZA2019/04927A patent/ZA201904927B/en unknown
-
2023
- 2023-02-10 US US18/167,581 patent/US20230242927A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11624071B2 (en) | 2023-04-11 |
CA3051585A1 (en) | 2018-08-02 |
US20190352655A1 (en) | 2019-11-21 |
EP3573448A4 (en) | 2020-09-02 |
ZA201904927B (en) | 2023-03-29 |
EP3573448A1 (en) | 2019-12-04 |
AU2018212986A1 (en) | 2019-08-08 |
WO2018140899A1 (en) | 2018-08-02 |
US20230242927A1 (en) | 2023-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201906795SA (en) | Novel plant cells, plants, and seeds | |
SG11201809857TA (en) | Anti-CTLA-4 Antibodies | |
SG11201807252QA (en) | Anti-lag-3 antibodies | |
SG11201810003UA (en) | Using programmable dna binding proteins to enhance targeted genome modification | |
SG11201807279QA (en) | Binding proteins and methods of use thereof | |
SG11201903514VA (en) | Novel cd47 monoclonal antibodies and uses thereof | |
SG11201809344QA (en) | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde | |
SG11201810423XA (en) | Pd-1 / pd-l1 inhibitors for cancer treatment | |
SG11201901996UA (en) | Formulations of ( r)-2-amino-3-phenylpropyl carbamate | |
SG11201908813QA (en) | Anti-sirp alpha antibodies | |
SG11201907650RA (en) | Personal therapy and exercise monitoring and oversight devices, systems, and related methods | |
SG11201805888SA (en) | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer | |
SG11201807998WA (en) | Treatment Of Inflammatory Diseases With Inhibitors Of C5a Activity | |
SG11201909963YA (en) | Methods for treating dravet syndrome | |
SG11201903456WA (en) | Piperidine derivatives as inhibitors of ubiquitin specific protease 7 | |
SG11201811363YA (en) | Anti-zika virus antibodies and methods of use | |
SG11201900501RA (en) | Cannabis composition | |
SG11201900554YA (en) | Spiro-lactam nmda modulators and methods of using same | |
SG11201900551WA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
SG11201807593TA (en) | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers | |
SG11201805001UA (en) | Method of treating influenza a | |
SG11201908114UA (en) | Pyrimidopyrimidinones useful as wee-1 kinase inhibitors | |
SG11201809594WA (en) | Nicotine particles and compositions | |
SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same |