SG11201906795SA - Novel plant cells, plants, and seeds - Google Patents

Novel plant cells, plants, and seeds

Info

Publication number
SG11201906795SA
SG11201906795SA SG11201906795SA SG11201906795SA SG11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA SG 11201906795S A SG11201906795S A SG 11201906795SA
Authority
SG
Singapore
Prior art keywords
inari
cambridge
suite
agriculture
international
Prior art date
Application number
SG11201906795SA
Inventor
Yajie Niu
Randall Shultz
Maria Margarita Unson
Michael Kock
John Casey
Original Assignee
Inari Agriculture Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inari Agriculture Inc filed Critical Inari Agriculture Inc
Publication of SG11201906795SA publication Critical patent/SG11201906795SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cultivation Of Plants (AREA)

Abstract

E 20 15 10 5 0 RNP used Treatment InDoti oNRT2.2 Gin1.4 it' . 40 , tr > 0.5 mM KCI 0.5 mM 0 3 A (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT 111111Ru o Ellov n °nolo DID MD Imo! iono iflo (10) International Publication Number WO 2018/140899 Al (51) International Patent Classification: (2006.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2018/015793 (22) International Filing Date: 29 January 2018 (29.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/451,708 28 January 2017 (28.01.2017) US 62/451,710 28 January 2017 (28.01.2017) US 62/452,610 31 January 2017 (31.01.2017) US 62/477,244 27 March 2017 (27.03.2017) US 62/480,989 03 April 2017 (03.04.2017) US 62/510,645 24 May 2017 (24.05.2017) US 62/523,675 22 June 2017 (22.06.2017) US 62/530,495 10 July 2017 (10.07.2017) US 62/530,839 10 July 2017 (10.07.2017) US 62/531,305 11 July 2017 (11.07.2017) US (71) Applicant: INARI AGRICULTURE, INC. [US/US]; 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). (72) Inventors: NIU, Yajie; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). SHULTZ, Randall, William; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). UNSON, Maria Margarita, D.; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). KOCK, Michael, Andreas; c/o Inari Agriculture, Inc., 200 Sidney Street, Suite 340, Cambridge, MA 02139 (US). CASEY, John, P., Jr.; c/o Inari Agriculture, Inc., 200 Sid- ney Street, Suite 340, Cambridge, MA 02139 (US). (74) Agent: ULLSPERGER, Chris, J. et al.; Fenwick & West LLP, Silicon Valley Center, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, AO1H 1/00 (2006.01) C12N 15/09 C12N 5/04 (2006.01) C12N 15/11 C12N 5/10 (2006.01) C12N 15/63 (54) Title: NOVEL PLANT CELLS, PLANTS, AND SEEDS Figure 5 © (57) : The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods C for creating modifications in plant genomes. [Continued on next page] WO 2018/140899 Al MIDEDIMOMMIONER13010MOIIMEHOHMOVOIMIE SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with amended claims and statement (Art. 19(1)) — with sequence listing part of description (Rule 5.2(a))
SG11201906795SA 2017-01-28 2018-01-29 Novel plant cells, plants, and seeds SG11201906795SA (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762451710P 2017-01-28 2017-01-28
US201762451708P 2017-01-28 2017-01-28
US201762452610P 2017-01-31 2017-01-31
US201762477244P 2017-03-27 2017-03-27
US201762480989P 2017-04-03 2017-04-03
US201762510645P 2017-05-24 2017-05-24
US201762523675P 2017-06-22 2017-06-22
US201762530495P 2017-07-10 2017-07-10
US201762530839P 2017-07-10 2017-07-10
US201762531305P 2017-07-11 2017-07-11
PCT/US2018/015793 WO2018140899A1 (en) 2017-01-28 2018-01-29 Novel plant cells, plants, and seeds

Publications (1)

Publication Number Publication Date
SG11201906795SA true SG11201906795SA (en) 2019-08-27

Family

ID=62979357

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201906795SA SG11201906795SA (en) 2017-01-28 2018-01-29 Novel plant cells, plants, and seeds

Country Status (7)

Country Link
US (2) US11624071B2 (en)
EP (1) EP3573448A4 (en)
AU (1) AU2018212986B2 (en)
CA (1) CA3051585A1 (en)
SG (1) SG11201906795SA (en)
WO (1) WO2018140899A1 (en)
ZA (1) ZA201904927B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11859219B1 (en) 2016-12-30 2024-01-02 Flagship Pioneering Innovations V, Inc. Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
US11624071B2 (en) 2017-01-28 2023-04-11 Inari Agriculture Technology, Inc. Method of creating a plurality of targeted insertions in a plant cell
US11603536B2 (en) 2017-09-29 2023-03-14 Inari Agriculture Technology, Inc. Methods for efficient maize genome editing
CN109935663B (en) * 2017-12-15 2021-06-22 Tcl科技集团股份有限公司 Preparation method of composite material film and QLED device
US11220694B1 (en) 2018-01-29 2022-01-11 Inari Agriculture, Inc. Rice cells and rice plants
US11802288B1 (en) 2018-01-29 2023-10-31 Inari Agriculture Technology, Inc. Methods for efficient soybean genome editing
US11926835B1 (en) 2018-01-29 2024-03-12 Inari Agriculture Technology, Inc. Methods for efficient tomato genome editing
KR20210045360A (en) * 2018-05-16 2021-04-26 신테고 코포레이션 Methods and systems for guide RNA design and use
US11866719B1 (en) 2018-06-04 2024-01-09 Inari Agriculture Technology, Inc. Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
CA3159682A1 (en) * 2019-11-07 2021-05-14 Qingdao Kingagroot Chemical Compound Co., Ltd. Method for generating new mutations in organisms, and application thereof
CN115484815A (en) * 2020-03-30 2022-12-16 伊纳瑞农业技术有限公司 Improved polynucleotides for expressing RNA-guided nucleases and DNA binding proteins in soybean
US20240011042A1 (en) 2020-07-31 2024-01-11 Inari Agriculture Technology, Inc. Excisable plant transgenic loci with signature protospacer adjacent motifs or signature guide rna recognition sites
BR112023001853A2 (en) * 2020-07-31 2023-02-23 Inari Agriculture Tech Inc TRANSGENIC CORN PLANT CELL, TRANSGENIC CORN PLANT SEED, TRANSGENIC CORN PLANT, METHOD FOR OBTAINING A BULK POPULATION OF SEEDS, METHOD FOR OBTAINING A HYBRID CORN SEED, DNA MOLECULE, PROCESSED TRANSGENIC CORN PLANT PRODUCT, BIOLOGICAL SAMPLE, NUCLEIC ACID MOLECULE ADAPTED FOR DETECTION OF GENOMIC DNA, METHOD FOR DETECTING A CORN PLANT CELL COMPRISING THE TRANSGENIC LOCUUS, METHOD FOR EXCITING A TRANSGENIC LOCIUS, METHODS FOR MODIFYING AND PRODUCING A TRANSGENIC CORN PLANT CELL AND TRANSGENIC CALLUS TRANSGENIC CORN PLANT
US11359210B2 (en) 2020-07-31 2022-06-14 Inari Agriculture Technology, Inc. INIR12 transgenic maize
US11369073B2 (en) 2020-07-31 2022-06-28 Inari Agriculture Technology, Inc. INIR12 transgenic maize
US11242534B1 (en) 2020-07-31 2022-02-08 Inari Agriculture Technology, Inc. INHT31 transgenic soybean
US11214811B1 (en) 2020-07-31 2022-01-04 Inari Agriculture Technology, Inc. INIR6 transgenic maize
WO2022026390A1 (en) * 2020-07-31 2022-02-03 Inari Agriculture Technology, Inc. Generation of plants with improved transgenic loci by genome editing
US11326177B2 (en) 2020-07-31 2022-05-10 Inari Agriculture Technology, Inc. INIR12 transgenic maize
WO2022046957A2 (en) * 2020-08-26 2022-03-03 Arcadia Biosciences, Inc. Cannabis dna constructs and methods of regulating gene expression in plants
US11198885B1 (en) 2020-09-28 2021-12-14 Inari Agriculture Technology, Inc. Genetic regulatory element
US11976291B2 (en) 2020-09-28 2024-05-07 Inari Agriculture Technology, Inc. Genetically enhanced maize plants
CN117320546A (en) * 2020-10-07 2023-12-29 希博斯国际有限合伙公司 Delivery of genome editing agents via chimeric plants
WO2022226107A1 (en) * 2021-04-20 2022-10-27 Texas Tech University System Tissue-culture independent gene editing of cells by a long-distance rna transport system
AU2022375817A1 (en) 2021-11-01 2024-05-09 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
WO2023081907A1 (en) * 2021-11-08 2023-05-11 Inari Agriculture Technology, Inc. Plant genome editing methods
AU2022434057A1 (en) * 2022-01-12 2024-07-11 Inari Agriculture Technology, Inc. Reduced height maize
IL314307A (en) 2022-01-20 2024-09-01 Flagship Pioneering Innovations Vii Llc Polynucleotides for modifying organisms
WO2023183772A2 (en) * 2022-03-21 2023-09-28 Inari Agriculture Technology, Inc. Soybean jag1 gene mutations
WO2023192825A1 (en) * 2022-03-29 2023-10-05 Inari Agriculture Technology, Inc. Targeted donor dna insertion and indel editing of plant genes
EP4299739A1 (en) 2022-06-30 2024-01-03 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
WO2024005864A1 (en) 2022-06-30 2024-01-04 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
WO2024005863A1 (en) 2022-06-30 2024-01-04 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
EP4299733A1 (en) 2022-06-30 2024-01-03 Inari Agriculture Technology, Inc. Compositions, systems, and methods for genome editing
WO2024059543A2 (en) * 2022-09-14 2024-03-21 Monsanto Technology Llc Methods and compositions for selective regulation of protein expression

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
WO2002034035A1 (en) 2000-10-20 2002-05-02 University Of Kentucky Research Foundation Genetic insulator for preventing influence by another gene promoter
CA2921821A1 (en) 2001-07-12 2003-01-23 University Of Massachusetts In vivo production of small interfering rnas that mediate gene silencing
US7422889B2 (en) 2004-10-29 2008-09-09 Stowers Institute For Medical Research Dre recombinase and recombinase systems employing Dre recombinase
US20060200878A1 (en) 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
US8314290B2 (en) 2004-12-21 2012-11-20 Monsanto Technology Llc Temporal regulation of gene expression by MicroRNAs
EP1838144B1 (en) 2005-01-07 2016-08-31 Oregon State University Method to trigger rna interference
US9085774B2 (en) 2005-04-19 2015-07-21 Basf Plant Science Gmbh Methods controlling gene expression
AR053279A1 (en) 2005-05-19 2007-04-25 Monsanto Technology Llc POST-TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION
EP3339441A1 (en) 2005-10-13 2018-06-27 Monsanto Technology LLC Methods for producing hybrid seed
AU2007290367B2 (en) 2006-08-31 2013-10-31 Monsanto Technology, Llc Phased small RNAs
ES2633352T3 (en) 2006-10-12 2017-09-20 Monsanto Technology Llc plant microRNA and procedures for their use
US8410334B2 (en) 2007-02-20 2013-04-02 Monsanto Technology Llc Invertebrate microRNAs
BRPI0913657A2 (en) 2008-07-01 2020-08-04 Monsanto Technology Llc recombinant DNA constructs and methods for modulating the expression of a target gene
US8816153B2 (en) 2010-08-27 2014-08-26 Monsanto Technology Llc Recombinant DNA constructs employing site-specific recombination
WO2013006472A1 (en) 2011-07-01 2013-01-10 Monsanto Technology Llc Methods and compositions for selective regulation of protein expression
CN104471067B (en) 2012-05-07 2020-08-14 桑格摩生物治疗股份有限公司 Methods and compositions for nuclease-mediated targeted integration of transgenes
DK2800811T3 (en) 2012-05-25 2017-07-17 Univ Vienna METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION
SG11201503059XA (en) 2012-10-23 2015-06-29 Toolgen Inc Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
KR20150105633A (en) 2012-12-12 2015-09-17 더 브로드 인스티튜트, 인코퍼레이티드 Engineering of systems, methods and optimized guide compositions for sequence manipulation
DK3064585T3 (en) 2012-12-12 2020-04-27 Broad Inst Inc DESIGN AND OPTIMIZATION OF IMPROVED SYSTEMS, PROCEDURES AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
EP4286402A3 (en) 2012-12-12 2024-02-14 The Broad Institute, Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
WO2014093655A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
US10351867B2 (en) 2013-03-01 2019-07-16 The Regents Of The University Of California Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
CN105517579B (en) * 2013-07-10 2019-11-15 哈佛大学校长及研究员协会 For the Gene regulation of guide RNA and the orthogonal Cas9 albumen of editor
US11208628B2 (en) 2013-08-09 2021-12-28 Massachusetts Institute Of Technology Nanobionic engineering of organelles and photosynthetic organisms
MX2016002306A (en) 2013-08-22 2016-07-08 Du Pont A soybean u6 polymerase iii promoter and methods of use.
CN104450745A (en) * 2013-09-12 2015-03-25 北京大学 Method for acquiring specific rice gene mutant and application thereof
US11186843B2 (en) 2014-02-27 2021-11-30 Monsanto Technology Llc Compositions and methods for site directed genomic modification
EP3136842A4 (en) * 2014-04-28 2017-11-29 Dow AgroSciences LLC Haploid maize transformation
BR112017000621B1 (en) * 2014-07-11 2024-03-12 Pioneer Hi-Bred International, Inc Method for improving an agronomic trait of a corn or soybean plant
AU2015288157A1 (en) 2014-07-11 2017-01-19 E. I. Du Pont De Nemours And Company Compositions and methods for producing plants resistant to glyphosate herbicide
EP3194427A1 (en) 2014-08-26 2017-07-26 The Regents of The University of California Hypersensitive aba receptors
WO2016044698A1 (en) 2014-09-19 2016-03-24 Massachusetts Institute Of Technology Ratiometric and multiplexed sensors from single chirality carbon nanotubes
WO2016061481A1 (en) 2014-10-17 2016-04-21 The Penn State Research Foundation Methods and compositions for multiplex rna guided genome editing and other rna technologies
US10787523B2 (en) 2015-01-29 2020-09-29 University Of Massachusetts Nanoparticle-protein complex for intracellular protein delivery
PT3285566T (en) 2015-04-20 2021-04-14 Monsanto Technology Llc Compositions and methods for altering flowering and plant architecture to improve yield potential
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
US9580727B1 (en) 2015-08-07 2017-02-28 Caribou Biosciences, Inc. Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
US20170175140A1 (en) 2015-12-16 2017-06-22 Regents Of The University Of Minnesota Methods for using a 5'-exonuclease to increase homologous recombination in eukaryotic cells
CA3042259A1 (en) 2016-11-04 2018-05-11 Flagship Pioneering Innovations V. Inc. Novel plant cells, plants, and seeds
US11624071B2 (en) 2017-01-28 2023-04-11 Inari Agriculture Technology, Inc. Method of creating a plurality of targeted insertions in a plant cell
US11220694B1 (en) * 2018-01-29 2022-01-11 Inari Agriculture, Inc. Rice cells and rice plants

Also Published As

Publication number Publication date
CA3051585A1 (en) 2018-08-02
AU2018212986A1 (en) 2019-08-08
US20230242927A1 (en) 2023-08-03
EP3573448A4 (en) 2020-09-02
EP3573448A1 (en) 2019-12-04
AU2018212986B2 (en) 2024-07-25
WO2018140899A1 (en) 2018-08-02
ZA201904927B (en) 2023-03-29
US20190352655A1 (en) 2019-11-21
US11624071B2 (en) 2023-04-11

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