SG11201903456WA - Piperidine derivatives as inhibitors of ubiquitin specific protease 7 - Google Patents

Piperidine derivatives as inhibitors of ubiquitin specific protease 7

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Publication number
SG11201903456WA
SG11201903456WA SG11201903456WA SG11201903456WA SG11201903456WA SG 11201903456W A SG11201903456W A SG 11201903456WA SG 11201903456W A SG11201903456W A SG 11201903456WA SG 11201903456W A SG11201903456W A SG 11201903456WA SG 11201903456W A SG11201903456W A SG 11201903456WA
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SG
Singapore
Prior art keywords
almac
craigavon
house
seagoe
armagh
Prior art date
Application number
SG11201903456WA
Inventor
Colin O'dowd
Tim Harrison
Peter Hewitt
Shane Rountree
Miel Hugues
Frank Burkamp
Linda Jordan
Matthew Helm
Fabio Broccatelli
James John Crawford
Lewis Gazzard
Ingrid Wertz
Wendy Lee
Original Assignee
Almac Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Discovery Ltd filed Critical Almac Discovery Ltd
Publication of SG11201903456WA publication Critical patent/SG11201903456WA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 April 2018 (26.04.2018) WIPO I PCT omit IIl °nolo olomll oimIE (10) International Publication Number WO 2018/073602 Al (51) International Patent Classification: C07D 401/04 (2006.01) C07D 473/00 (2006.01) C07D 401/06 (2006.01) C07D 487/04 (2006.01) CO7D 401/14 (2006.01) CO7D 491/04 (2006.01) CO7D 403/04 (2006.01) CO7D 513/04 (2006.01) CO7D 471/04 (2006.01) A61K 31/506 (2006.01) CO7D 471/10 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/GB2017/053175 (22) International Filing Date: 20 October 2017 (20.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1617758.6 20 October 2016 (20.10.2016) GB (71) Applicant: ALMAC DISCOVERY LIMITED [GB/GB]; Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). (72) Inventors: O'DOWD, Colin; c/o Almac Discovery Limit- ed, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). HARRISON, Tim; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Es- tate, Craigavon Armagh BT63 5QD (GB). HEWITT, Pe- ter; c/o Almac Discovery Limited, Almac House, 20 Sea- goe Industrial Estate, Craigavon Armagh BT63 5QD (GB). ROUNTREE, Shane; c/o Almac Discovery Limited, Al- mac House, 20 Seagoe Industrial Estate, Craigavon Ar- magh BT63 5QD (GB). HUGUES, Miel; c/o Almac Dis- covery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). BURKAMP, Frank; c/o Almac Discovery Limited, Almac House, 20 Seagoe In- dustrial Estate, Craigavon Armagh BT63 5QD (GB). JOR- DAN, Linda; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). HELM, Matthew; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Ar- magh BT63 5QD (GB). BROCCATELLI, Fabio; c/o Al- mac Discovery Limited, Almac House, 20 Seagoe Indus- trial Estate, Craigavon Armagh BT63 5QD (GB). CRAW- FORD, James John; c/o Almac Discovery Limited, Al- mac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). GAZZARD, Lewis; c/o Almac Discov- ery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). WERTZ, Ingrid; c/ o Almac Discovery Limited, Almac House, 20 Seagoe In- dustrial Estate, Craigavon Armagh BT63 5QD (GB). LEE, O Wendy; c/o Almac Discovery Limited, Almac House, 20 N O Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). (74) Agent: BOULT WADE TENNANT; Verulam Gardens, 70 Gray's Inn Road, London Greater London WC1X 8BT (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) O (57) : The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods 0 of use thereof. (54) Title: PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7
SG11201903456WA 2016-10-20 2017-10-20 Piperidine derivatives as inhibitors of ubiquitin specific protease 7 SG11201903456WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1617758.6A GB201617758D0 (en) 2016-10-20 2016-10-20 Pharmaceutical compounds
PCT/GB2017/053175 WO2018073602A1 (en) 2016-10-20 2017-10-20 Piperidine derivatives as inhibitors of ubiquitin specific protease 7

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SG11201903456WA true SG11201903456WA (en) 2019-05-30

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US (1) US10766903B2 (en)
EP (2) EP3529241B1 (en)
JP (2) JP7073359B2 (en)
KR (1) KR20190069529A (en)
CN (1) CN110088096A (en)
AU (1) AU2017346516B2 (en)
BR (1) BR112019007977A2 (en)
CA (1) CA3040805A1 (en)
DK (1) DK3529241T3 (en)
ES (1) ES2914284T3 (en)
GB (1) GB201617758D0 (en)
IL (1) IL266146A (en)
MX (2) MX2019004450A (en)
RU (1) RU2019115115A (en)
SG (1) SG11201903456WA (en)
WO (1) WO2018073602A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201612938D0 (en) * 2016-07-26 2016-09-07 Almac Discovery Ltd Pharmaceutical compounds
CA3072353A1 (en) * 2017-09-26 2019-04-04 Dana-Farber Cancer Institute, Inc. Novel usp7 inhibitors for treating multiple myeloma
GB201801562D0 (en) * 2018-01-31 2018-03-14 Almac Diagnostics Ltd Pharmaceutical compounds
UY38291A (en) * 2018-07-05 2020-06-30 Servier Lab NEW AMINO-PYRIMIDONYL DERIVATIVES A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS
UY38423A (en) * 2018-10-19 2021-02-26 Servier Lab NEW AMINO-PYRIMIDONIL-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN109912598B (en) * 2019-03-27 2022-09-13 四川大学华西医院 Nucleoside derivative for preventing and treating inflammatory reaction and application thereof
CN111808105B (en) * 2019-04-11 2023-09-08 四川科伦博泰生物医药股份有限公司 Pyrimidinone pyrazolo compound containing fused ring group, preparation method and application thereof
CN113423709B (en) * 2019-04-11 2024-02-09 四川科伦博泰生物医药股份有限公司 Triazinone imidazole compound and medical application thereof
CN113087724B (en) * 2020-01-08 2024-01-19 四川科伦博泰生物医药股份有限公司 Isothiazolopyrimidinone compounds, pharmaceutical compositions containing the same and uses thereof
CN112608320B (en) * 2020-01-16 2023-03-17 中国药科大学 Piperidine compound and preparation method and medical application thereof
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
US20230087388A1 (en) 2020-02-28 2023-03-23 Immunologik Gmbh Inhibitors of human deubiquitinases for the treatment of coronaviral infections
CN112047933B (en) * 2020-10-15 2022-06-14 郑州大学 Quinazolinone USP7 inhibitor and preparation method and application thereof
CN113336714A (en) * 2021-06-25 2021-09-03 山东大学 Compound and preparation method and application thereof
WO2022272133A2 (en) * 2021-06-25 2022-12-29 Stablix, Inc. Protein stabilizing compounds containing usp7 ligands
CA3225596A1 (en) * 2021-07-20 2023-01-26 Sara BUHRLAGE Inhibitors targeting ubiquitin specific protease 7 (usp7)
GB202200753D0 (en) 2022-01-21 2022-03-09 Almac Discovery Ltd Pharmaceutical compounds
CN114507278B (en) * 2022-01-27 2023-04-25 苏州大学 UFM1-Lys-TAMRA probe and synthesis method thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO111096A0 (en) 1996-07-18 1996-08-08 Fujisawa Pharmaceutical Co., Ltd. New compound
ZA986594B (en) 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
AU2003301095A1 (en) 2002-12-23 2004-07-22 Merck And Co., Inc. 4(spiropiperidinyl)methyl substituted pyrrolidines as modulators of chemokine receptor activity
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
JP4787529B2 (en) 2004-04-09 2011-10-05 大塚製薬株式会社 Pharmaceutical composition
EP1765348B1 (en) 2004-06-18 2016-08-03 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1915377A1 (en) 2005-07-22 2008-04-30 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
EP1749822B1 (en) 2005-08-05 2008-10-15 Hybrigenics S.A. Novel cysteine protease inhibitors and their therapeutic applications
CA2638787A1 (en) 2006-02-16 2007-08-23 Takeda Pharmaceutical Company Limited Cyclic amine compound and use thereof for the prophylaxis or treatment of hypertension
JP5406722B2 (en) 2006-10-16 2014-02-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Substituted sulfonamide derivatives as bradykinin 1 receptor modulators
US7875613B2 (en) 2006-10-30 2011-01-25 Hybrigenics Sa Tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
FR2911138B1 (en) 2007-01-05 2009-02-20 Sanofi Aventis Sa NOVEL N, N'-2,4-DIANILINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS INHIBITORS OF IKK
WO2009074487A1 (en) 2007-12-11 2009-06-18 F. Hoffmann-La Roche Ag Inhibitors of stearoyl-coa desaturase
ES2531398T3 (en) 2008-02-22 2015-03-13 Msd Kk New aminopyridine derivatives that have a selective inhibitory action on Aurora A
AU2009272486A1 (en) 2008-07-18 2010-01-21 Takeda Pharmaceutical Company Limited. Benzazepine derivatives and their use as hstamine H3 antagonists
RU2011105768A (en) 2008-08-01 2012-09-10 Биокрист Фармасьютикалз, Инк. (Us) PIPERIDINE DERIVATIVES AS JAKЗ INHIBITORS
EP2331518A1 (en) 2008-08-22 2011-06-15 Evotec AG New bradykinin b1 antagonists
EP2208725A1 (en) 2009-01-13 2010-07-21 Hybrigenics S.A. Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications
WO2010114881A1 (en) 2009-04-01 2010-10-07 Progenra Inc. Anti-neoplastic compounds, compositions and methods
US20120264735A1 (en) 2009-12-21 2012-10-18 Jonathan Young Tyrosine kinase inhibitors
US20110177105A1 (en) 2010-01-15 2011-07-21 Roman Lopez Novel Selective Inhibitors of Ubiquitin Specific Protease 7, the Pharmaceutical Compositions Thereof and Their Therapeutic Applications
TWI503323B (en) 2010-03-29 2015-10-11 Oncotherapy Science Inc Tricyclic compounds and pbk inhibitors containing the same
CN103025725B (en) 2010-08-10 2015-09-16 安斯泰来制药有限公司 Heterogeneous ring compound
JP2012072067A (en) 2010-09-28 2012-04-12 Astellas Pharma Inc Nitrogen containing aromatic heterocyclic compound
GB201114448D0 (en) 2011-08-22 2011-10-05 Takeda Pharmaceutical Compounds and their use
EP2565186A1 (en) * 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
GEP201706608B (en) 2011-10-07 2017-01-25 Takeda Pharmaceuticals Co 1 - arylcarbonyl - 4 - oxy – piperidine compounds useful for the treatment of neurodegenerative diseases
US8969341B2 (en) 2011-11-29 2015-03-03 Novartis Ag Pyrazolopyrrolidine compounds
MX347917B (en) 2012-03-09 2017-05-17 Lexicon Pharmaceuticals Inc Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof.
WO2014045101A1 (en) * 2012-09-21 2014-03-27 Cellzome Gmbh Tetrazolo quinoxaline derivatives as tankyrase inhibitors
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9763957B2 (en) 2013-07-18 2017-09-19 Novartis Ag Autotaxin inhibitors
JPWO2015046193A1 (en) 2013-09-25 2017-03-09 塩野義製薬株式会社 Aromatic heterocyclic amine derivatives having TRPV4 inhibitory activity
RU2021102805A (en) 2014-12-05 2021-02-12 Эррэй Биофарма Инк. 4,6-SUBSTITUTED PYRAZOLO [1,5-a] PYRAZINES AS INHIBITORS OF JANUS KINASE
MA41291A (en) 2014-12-30 2017-11-07 Forma Therapeutics Inc PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUE-SPECIFIC PROTEASE INHIBITORS No. 7 (USP7) FOR THE TREATMENT OF CANCER
TWI770525B (en) 2014-12-30 2022-07-11 美商瓦洛健康公司 Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors
US9938300B2 (en) * 2015-02-05 2018-04-10 Forma Therapeutics, Inc. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016126926A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
WO2016126929A1 (en) * 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016150800A1 (en) 2015-03-20 2016-09-29 F. Hoffmann-La Roche Ag Usp7 inhibitor compounds and methods of use
GB201604638D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
GB201604647D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
GB201612938D0 (en) 2016-07-26 2016-09-07 Almac Discovery Ltd Pharmaceutical compounds
JP7466308B2 (en) 2016-09-20 2024-04-12 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Compositions and methods for identifying, evaluating, preventing, and treating AML using USP10 biomarkers and modulators - Patents.com

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