CN102079743B - 二肽基肽酶抑制剂 - Google Patents

二肽基肽酶抑制剂 Download PDF

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Publication number
CN102079743B
CN102079743B CN201110004223.1A CN201110004223A CN102079743B CN 102079743 B CN102079743 B CN 102079743B CN 201110004223 A CN201110004223 A CN 201110004223A CN 102079743 B CN102079743 B CN 102079743B
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alkyl
phenyl
amino
group
compound
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Chinese (zh)
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CN102079743A (zh
Inventor
冯军
S·L·格沃特尼
J·A·斯塔福德
张志远
B·埃尔德
P·伊斯贝斯特
G·帕默尔
J·萨尔斯贝里
L·尤利塞
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority claimed from CN 200480042457 external-priority patent/CN1926128A/zh
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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CN201110004223.1A 2004-03-15 2004-12-15 二肽基肽酶抑制剂 Active CN102079743B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55357104P 2004-03-15 2004-03-15
US60/553,571 2004-03-15
US62952404P 2004-11-18 2004-11-18
US60/629,524 2004-11-18
CN 200480042457 CN1926128A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN 200480042457 Division CN1926128A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂

Publications (2)

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CN102079743A CN102079743A (zh) 2011-06-01
CN102079743B true CN102079743B (zh) 2020-08-25

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ID=34930979

Family Applications (7)

Application Number Title Priority Date Filing Date
CN2011100052676A Pending CN102127053A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN2011100098843A Pending CN102140090A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110005788.1A Active CN102134229B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN2011100052892A Pending CN102127057A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110006009.XA Active CN102134230B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110006939.5A Active CN102134231B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110004223.1A Active CN102079743B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂

Family Applications Before (6)

Application Number Title Priority Date Filing Date
CN2011100052676A Pending CN102127053A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN2011100098843A Pending CN102140090A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110005788.1A Active CN102134229B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN2011100052892A Pending CN102127057A (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110006009.XA Active CN102134230B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂
CN201110006939.5A Active CN102134231B (zh) 2004-03-15 2004-12-15 二肽基肽酶抑制剂

Country Status (35)

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EP (1) EP1586571B3 (US07906523-20110315-C00033.png)
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WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
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KR20090004950A (ko) 2006-04-12 2009-01-12 프로비오드룩 아게 효소 억제제
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