CA2821906C - Methods for non-invasive prenatal paternity testing - Google Patents
Methods for non-invasive prenatal paternity testing Download PDFInfo
- Publication number
- CA2821906C CA2821906C CA2821906A CA2821906A CA2821906C CA 2821906 C CA2821906 C CA 2821906C CA 2821906 A CA2821906 A CA 2821906A CA 2821906 A CA2821906 A CA 2821906A CA 2821906 C CA2821906 C CA 2821906C
- Authority
- CA
- Canada
- Prior art keywords
- father
- dna
- fetus
- alleged
- fetal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B10/00—ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426208P | 2010-12-22 | 2010-12-22 | |
| US61/426,208 | 2010-12-22 | ||
| US201161462972P | 2011-02-09 | 2011-02-09 | |
| US61/462,972 | 2011-02-09 | ||
| US201161448547P | 2011-03-02 | 2011-03-02 | |
| US61/448,547 | 2011-03-02 | ||
| US201161516996P | 2011-04-12 | 2011-04-12 | |
| US61/516,996 | 2011-04-12 | ||
| US13/110,685 US8825412B2 (en) | 2010-05-18 | 2011-05-18 | Methods for non-invasive prenatal ploidy calling |
| US13/110,685 | 2011-05-18 | ||
| US201161571248P | 2011-06-23 | 2011-06-23 | |
| US61/571,248 | 2011-06-23 | ||
| US201161542508P | 2011-10-03 | 2011-10-03 | |
| US61/542,508 | 2011-10-03 | ||
| US13/300,235 | 2011-11-18 | ||
| US13/300,235 US10017812B2 (en) | 2010-05-18 | 2011-11-18 | Methods for non-invasive prenatal ploidy calling |
| PCT/US2011/066938 WO2012088456A2 (en) | 2010-12-22 | 2011-12-22 | Methods for non-invasive prenatal paternity testing |
| US13/335,043 | 2011-12-22 | ||
| US13/335,043 US10113196B2 (en) | 2010-05-18 | 2011-12-22 | Prenatal paternity testing using maternal blood, free floating fetal DNA and SNP genotyping |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2821906A1 CA2821906A1 (en) | 2012-06-28 |
| CA2821906C true CA2821906C (en) | 2020-08-25 |
Family
ID=46314949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2821906A Active CA2821906C (en) | 2010-12-22 | 2011-12-22 | Methods for non-invasive prenatal paternity testing |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10113196B2 (https=) |
| EP (1) | EP2656263B1 (https=) |
| JP (1) | JP6328934B2 (https=) |
| CN (1) | CN103608466B (https=) |
| AU (1) | AU2011348100B2 (https=) |
| BR (1) | BR112013016193B1 (https=) |
| CA (1) | CA2821906C (https=) |
| ES (1) | ES2770342T3 (https=) |
| RU (1) | RU2620959C2 (https=) |
| WO (1) | WO2012088456A2 (https=) |
Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070178501A1 (en) * | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US20070027636A1 (en) * | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| US8532930B2 (en) * | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US8515679B2 (en) | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| WO2009105531A1 (en) * | 2008-02-19 | 2009-08-27 | Gene Security Network, Inc. | Methods for cell genotyping |
| WO2009146335A1 (en) * | 2008-05-27 | 2009-12-03 | Gene Security Network, Inc. | Methods for embryo characterization and comparison |
| EP2321642B1 (en) | 2008-08-04 | 2017-01-11 | Natera, Inc. | Methods for allele calling and ploidy calling |
| WO2011041485A1 (en) | 2009-09-30 | 2011-04-07 | Gene Security Network, Inc. | Methods for non-invasive prenatal ploidy calling |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| WO2011146632A1 (en) | 2010-05-18 | 2011-11-24 | Gene Security Network Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
| US10131947B2 (en) * | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| ES2986436T3 (es) | 2011-04-15 | 2024-11-11 | Univ Johns Hopkins | Sistema de secuenciación segura |
| US20140235474A1 (en) | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
| WO2013052907A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013059746A1 (en) | 2011-10-19 | 2013-04-25 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| CA2861856C (en) | 2012-01-20 | 2020-06-02 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
| EP2807292B1 (en) | 2012-01-26 | 2019-05-22 | Tecan Genomics, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
| CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| EP2847353B1 (en) | 2012-05-10 | 2022-01-19 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US20150105267A1 (en) * | 2012-05-24 | 2015-04-16 | University Of Washington Through Its Center For Commercialization | Whole genome sequencing of a human fetus |
| CA2877094A1 (en) | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| CA2877493C (en) * | 2012-07-24 | 2020-08-25 | Natera, Inc. | Highly multiplex pcr methods and compositions |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9235808B2 (en) | 2013-03-14 | 2016-01-12 | International Business Machines Corporation | Evaluation of predictions in the absence of a known ground truth |
| US9822408B2 (en) | 2013-03-15 | 2017-11-21 | Nugen Technologies, Inc. | Sequential sequencing |
| WO2014151117A1 (en) | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| US10930368B2 (en) | 2013-04-03 | 2021-02-23 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| KR102665592B1 (ko) | 2013-05-24 | 2024-05-21 | 시쿼넘, 인코포레이티드 | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 |
| ES3037160T3 (en) | 2013-06-21 | 2025-09-29 | Sequenom Inc | Methods and processes for non-invasive assessment of genetic variations |
| KR102758333B1 (ko) | 2013-08-28 | 2025-01-23 | 벡톤 디킨슨 앤드 컴퍼니 | 대량의 동시 단일 세포 분석 |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| KR102384620B1 (ko) | 2013-10-04 | 2022-04-11 | 시쿼넘, 인코포레이티드 | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 |
| CN105874082B (zh) | 2013-10-07 | 2020-06-02 | 塞昆纳姆股份有限公司 | 用于非侵入性评估染色体改变的方法和过程 |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| EP3099820A4 (en) | 2014-01-27 | 2018-01-03 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
| US9745614B2 (en) | 2014-02-28 | 2017-08-29 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| GB2524948A (en) * | 2014-03-07 | 2015-10-14 | Oxford Gene Technology Operations Ltd | Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| EP3169803B1 (en) * | 2014-07-18 | 2019-11-20 | Illumina, Inc. | Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna |
| US11783911B2 (en) | 2014-07-30 | 2023-10-10 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
| EP3192879A4 (en) * | 2014-09-11 | 2017-07-19 | Fujifilm Corporation | Method for detecting presence/absence of fetal chromosomal aneuploidy |
| CN107075730A (zh) | 2014-09-12 | 2017-08-18 | 利兰·斯坦福青年大学托管委员会 | 循环核酸的鉴定及用途 |
| WO2016049878A1 (zh) * | 2014-09-30 | 2016-04-07 | 深圳华大基因科技有限公司 | 一种基于snp分型的亲子鉴定方法及应用 |
| US20180119210A1 (en) * | 2014-11-24 | 2018-05-03 | Shaare Zedek Scientific Ltd. | Fetal haplotype identification |
| EP3239875B1 (en) * | 2014-12-26 | 2019-10-02 | National University Corporation, Tohoku University | Method for determining genotype of particular gene locus group or individual gene locus, determination computer system and determination program |
| WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| EP4582556A3 (en) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Methods and compositions for whole transcriptome amplification |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| CN104946773B (zh) * | 2015-07-06 | 2018-04-13 | 厦门万基生物科技有限公司 | 一种利用snp进行产前亲权关系判定的方法 |
| KR101817785B1 (ko) * | 2015-08-06 | 2018-01-11 | 이원다이애그노믹스(주) | 다양한 플랫폼에서 태아의 성별과 성염색체 이상을 구분할 수 있는 새로운 방법 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
| JP6564053B2 (ja) * | 2015-11-10 | 2019-08-21 | 富士フイルム株式会社 | 細胞間または細胞群間の同一人かどうか、他人かどうか、親子かどうか、または血縁関係かどうかの判定方法 |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US11708574B2 (en) | 2016-06-10 | 2023-07-25 | Myriad Women's Health, Inc. | Nucleic acid sequencing adapters and uses thereof |
| CA3030890A1 (en) | 2016-07-27 | 2018-02-01 | Sequenom, Inc. | Genetic copy number alteration classifications |
| WO2018053365A1 (en) | 2016-09-15 | 2018-03-22 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for analysis of cell-free dna |
| US10704082B2 (en) | 2016-09-15 | 2020-07-07 | ArcherDX, Inc. | Methods of nucleic acid sample preparation |
| CN109791157B (zh) | 2016-09-26 | 2022-06-07 | 贝克顿迪金森公司 | 使用具有条形码化的寡核苷酸序列的试剂测量蛋白质表达 |
| WO2018064486A1 (en) | 2016-09-29 | 2018-04-05 | Counsyl, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CA3207879A1 (en) | 2017-01-24 | 2018-08-02 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| WO2018156418A1 (en) | 2017-02-21 | 2018-08-30 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| JP7370862B2 (ja) | 2017-03-17 | 2023-10-30 | セクエノム, インコーポレイテッド | 遺伝子モザイク症のための方法およびプロセス |
| CA3057589A1 (en) | 2017-03-24 | 2018-09-27 | Myriad Women's Health, Inc. | Copy number variant caller |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| CN107012226A (zh) * | 2017-04-20 | 2017-08-04 | 司法部司法鉴定科学技术研究所 | 一种基于高通量测序的snp位点的检测试剂盒及其检测方法 |
| CN110719959B (zh) | 2017-06-05 | 2021-08-06 | 贝克顿迪金森公司 | 针对单细胞的样品索引 |
| CN107217095B (zh) * | 2017-06-15 | 2021-06-04 | 广东腾飞基因科技股份有限公司 | 人类亲权鉴定用多重pcr引物组及检测方法 |
| WO2019028462A1 (en) | 2017-08-04 | 2019-02-07 | Billiontoone, Inc. | TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| CN107557458A (zh) * | 2017-10-11 | 2018-01-09 | 华东医药(杭州)基因科技有限公司 | 一种有效检测基因型的方法及装置 |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| CN111526793A (zh) | 2017-10-27 | 2020-08-11 | 朱诺诊断学公司 | 用于超低体积液体活检的设备、系统和方法 |
| CN108048575B (zh) * | 2017-11-03 | 2021-06-15 | 中南大学湘雅医院 | 一种用于产前无创亲子鉴定的试剂盒及方法 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12398389B2 (en) | 2018-02-15 | 2025-08-26 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| US12462935B2 (en) | 2018-03-30 | 2025-11-04 | Nucleix Ltd. | Deep learning-based methods, devices, and systems for prenatal testing |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| WO2019204208A1 (en) * | 2018-04-16 | 2019-10-24 | Memorial Sloan Kettering Cancer Center | SYSTEMS AND METHODS FOR DETECTING CANCER VIA cfDNA SCREENING |
| JP7358388B2 (ja) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | 反対側の転写物末端における分子バーコーディング |
| CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
| CN108875307B (zh) * | 2018-06-29 | 2021-12-03 | 上海欧易生物医学科技有限公司 | 一种基于孕妇外周血中胎儿游离dna的亲子鉴定方法 |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US20210280270A1 (en) * | 2018-09-07 | 2021-09-09 | Illumina, Inc. | Method to determine if a circulating fetal cell isolated from a pregnant mother is from either the current or a historical pregnancy |
| ES2992135T3 (es) | 2018-10-01 | 2024-12-09 | Becton Dickinson Co | Determinar secuencias de transcripción 5 |
| US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| CN110964690A (zh) * | 2019-01-16 | 2020-04-07 | 北京大学深圳医院 | 辅助生殖技术实施过程中防止配子错配的方法 |
| ES2945227T3 (es) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
| WO2020167920A1 (en) | 2019-02-14 | 2020-08-20 | Cellular Research, Inc. | Hybrid targeted and whole transcriptome amplification |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| US12205674B2 (en) | 2019-06-21 | 2025-01-21 | Coopersurgical, Inc. | System and method for determining genetic relationships between a sperm provider, oocyte provider, and the respective conceptus |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| CN112466397A (zh) * | 2019-09-09 | 2021-03-09 | 深圳乐土生物科技有限公司 | 一种用于亲缘关系检测的方法和装置 |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
| CN110724732A (zh) * | 2019-11-12 | 2020-01-24 | 陈洪亮 | 一种产前亲权关系鉴定的方法 |
| WO2021137770A1 (en) * | 2019-12-30 | 2021-07-08 | Geneton S.R.O. | Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| WO2021146219A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Cell capture using du-containing oligonucleotides |
| EP3851542A1 (en) | 2020-01-20 | 2021-07-21 | Tecan Genomics, Inc. | Depletion of abundant uninformative sequences |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| US12059674B2 (en) | 2020-02-03 | 2024-08-13 | Tecan Genomics, Inc. | Reagent storage system |
| EP4103748A4 (en) | 2020-02-14 | 2024-03-13 | The Johns Hopkins University | METHOD AND MATERIALS FOR ASSESSING NUCLEIC ACIDS |
| WO2021173719A1 (en) | 2020-02-25 | 2021-09-02 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| WO2021174079A2 (en) * | 2020-02-28 | 2021-09-02 | Laboratory Corporation Of America Holdings | Compositions, methods, and systems for paternity determination |
| CN111518917B (zh) * | 2020-04-02 | 2022-06-07 | 中山大学 | 一种用于无创产前亲权关系判定的微单倍型遗传标记组合及方法 |
| US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| US12391940B2 (en) | 2020-07-31 | 2025-08-19 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| CN112053743B (zh) * | 2020-08-31 | 2024-11-22 | 济宁医学院 | 一种亲缘关系鉴定方法、系统及设备 |
| EP4247967A1 (en) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profiling of highly expressed and lowly expressed proteins |
| EP4255481A1 (en) | 2020-12-02 | 2023-10-11 | Genentech, Inc. | Methods and compositions for neoadjuvant and adjuvant urothelial carcinoma therapy |
| CN116685850A (zh) | 2020-12-15 | 2023-09-01 | 贝克顿迪金森公司 | 单细胞分泌组分析 |
| EP4266315A4 (en) | 2020-12-16 | 2024-11-20 | Seedna Inc. | METHOD FOR CALCULATING THE RELIABILITY VALUE OF A POLYMORPHISM LOCUS SIGNAL |
| US20240229136A9 (en) * | 2021-02-25 | 2024-07-11 | Natera, Inc. | Methods for detection of donor-derived cell-free dna in transplant recipients of multiple organs |
| EP4301499A4 (en) | 2021-03-05 | 2025-01-22 | Enumerix, Inc. | SYSTEMS AND METHODS FOR GENERATING DROPLETS AND PERFORMING DIGITAL ANALYSES |
| EP4314336A4 (en) * | 2021-03-23 | 2025-02-19 | BillionToOne, Inc. | Fragment analysis for quantitative diagnostics of biological targets |
| CN113549701B (zh) * | 2021-07-21 | 2022-07-01 | 内蒙古农业大学 | 一种山羊亲子鉴定snp分子标记及其应用 |
| EP4381099A1 (en) | 2021-08-02 | 2024-06-12 | Natera, Inc. | Methods for detecting neoplasm in pregnant women |
| CN118613594A (zh) | 2021-09-01 | 2024-09-06 | 纳特拉公司 | 用于非侵入性产前测试的方法 |
| CN113999900B (zh) * | 2021-10-14 | 2024-02-20 | 武汉蓝沙医学检验实验室有限公司 | 以孕妇游离dna评估胎儿dna浓度的方法及应用 |
| CN113981062B (zh) * | 2021-10-14 | 2024-02-20 | 武汉蓝沙医学检验实验室有限公司 | 以非生父和母亲dna评估胎儿dna浓度的方法及应用 |
| CN113889189B (zh) * | 2021-10-14 | 2025-05-16 | 武汉蓝沙医学检验实验室有限公司 | 以生父和母亲dna评估胎儿dna浓度的方法及应用 |
| CN113969310B (zh) * | 2021-10-14 | 2024-02-20 | 武汉蓝沙医学检验实验室有限公司 | 胎儿dna浓度的评估方法及应用 |
| JP7331325B1 (ja) | 2022-08-30 | 2023-08-23 | 株式会社seeDNA | 2種以上の検査を実施可能な遺伝学的解析方法 |
| CN116240274B (zh) * | 2022-11-10 | 2026-04-21 | 武汉蓝沙医学检验实验室有限公司 | 无需父本对妊娠胎儿进行亲子鉴定的方法 |
| CN117116359A (zh) * | 2023-08-07 | 2023-11-24 | 天津大学 | Dna存储中基于最大后验概率的鲁棒多序列重建方法 |
| JP7684727B2 (ja) * | 2023-08-22 | 2025-05-28 | 株式会社seeDNA | 非侵襲的出生前親子鑑定方法 |
| CN117487932B (zh) * | 2023-11-22 | 2024-09-03 | 复旦大学 | 一种用于亲子鉴定的snp位点组合、及其检测引物对和应用 |
Family Cites Families (559)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4040785A (en) | 1976-10-18 | 1977-08-09 | Technicon Instruments Corporation | Lysable blood preservative composition |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4935342A (en) | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
| SU1552642A3 (ru) * | 1987-12-07 | 1994-03-15 | Институт молекулярной генетики РАН | Способ определения родства живых организмов |
| US5153117A (en) * | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5262329A (en) | 1991-06-13 | 1993-11-16 | Carver Jr Edward L | Method for improved multiple species blood analysis |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| US5976790A (en) | 1992-03-04 | 1999-11-02 | The Regents Of The University Of California | Comparative Genomic Hybridization (CGH) |
| GB9305984D0 (en) | 1993-03-23 | 1993-05-12 | Royal Free Hosp School Med | Predictive assay |
| ES2197168T3 (es) | 1993-07-05 | 2004-01-01 | Sheffield Teaching Hospitals National Health Service Trust | Preparacion y estabilizacion de celulas. |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5716776A (en) | 1994-03-04 | 1998-02-10 | Mark H. Bogart | Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample |
| US5891734A (en) | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
| US6025128A (en) | 1994-09-29 | 2000-02-15 | The University Of Tulsa | Prediction of prostate cancer progression by analysis of selected predictive parameters |
| US6479235B1 (en) | 1994-09-30 | 2002-11-12 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| US5648220A (en) | 1995-02-14 | 1997-07-15 | New England Medical Center Hospitals, Inc. | Methods for labeling intracytoplasmic molecules |
| ATE215993T1 (de) | 1995-05-19 | 2002-04-15 | Abbott Lab | Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| AU2324997A (en) | 1996-03-15 | 1997-10-01 | Penn State Research Foundation, The | Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays |
| DE69739909D1 (de) | 1996-03-26 | 2010-07-29 | Michael S Kopreski | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
| US6108635A (en) | 1996-05-22 | 2000-08-22 | Interleukin Genetics, Inc. | Integrated disease information system |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| US5860917A (en) | 1997-01-15 | 1999-01-19 | Chiron Corporation | Method and apparatus for predicting therapeutic outcomes |
| US5824467A (en) | 1997-02-25 | 1998-10-20 | Celtrix Pharmaceuticals | Methods for predicting drug response |
| US20010051341A1 (en) | 1997-03-04 | 2001-12-13 | Isis Innovation Limited | Non-invasive prenatal diagnosis |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| JP2002503954A (ja) | 1997-04-01 | 2002-02-05 | グラクソ、グループ、リミテッド | 核酸増幅法 |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US20020119478A1 (en) | 1997-05-30 | 2002-08-29 | Diagen Corporation | Methods for detection of nucleic acid sequences in urine |
| US5994148A (en) | 1997-06-23 | 1999-11-30 | The Regents Of University Of California | Method of predicting and enhancing success of IVF/ET pregnancy |
| US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| EP1177281B1 (en) | 1999-04-30 | 2009-01-21 | Cyclops Genome Sciences Limited | Isolation of nucleic acid |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| US7058517B1 (en) | 1999-06-25 | 2006-06-06 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
| US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
| EP1196623B8 (en) | 1999-07-23 | 2008-05-21 | Forensic Science Service Ltd | Method for detecting single nucleotide polymorphisms |
| GB9917307D0 (en) | 1999-07-23 | 1999-09-22 | Sec Dep Of The Home Department | Improvements in and relating to analysis of DNA |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6251604B1 (en) | 1999-08-13 | 2001-06-26 | Genopsys, Inc. | Random mutagenesis and amplification of nucleic acid |
| EP1244811A1 (en) | 1999-11-10 | 2002-10-02 | Ligochem Inc. | Method for isolating dna from a proteinaceous medium and kit for performing method |
| US20030148301A1 (en) | 1999-12-10 | 2003-08-07 | Toshiya Aono | Method of detecting nucleotide polymorphism |
| US6221603B1 (en) | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
| DK1259643T3 (da) | 2000-02-07 | 2009-02-23 | Illumina Inc | Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming |
| US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| GB0009179D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Non-invasive prenatal diagnosis |
| US7510834B2 (en) | 2000-04-13 | 2009-03-31 | Hidetoshi Inoko | Gene mapping method using microsatellite genetic polymorphism markers |
| EP1290225A4 (en) | 2000-05-20 | 2004-09-15 | Univ Michigan | METHOD FOR PRODUCING A DNA BANK BY POSITIONAL REPRODUCTION |
| JP2004511210A (ja) | 2000-05-23 | 2004-04-15 | バリアジェニックス インコーポレーテッド | 配列変動を検出する、dnaを遺伝分析するための方法 |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| US7087414B2 (en) | 2000-06-06 | 2006-08-08 | Applera Corporation | Methods and devices for multiplexing amplification reactions |
| JP2004500867A (ja) | 2000-06-07 | 2004-01-15 | ベイラー カレッジ オブ メディシン | アレイ利用型核酸ハイブリダイゼーションのための新規な組成物および方法 |
| US7058616B1 (en) | 2000-06-08 | 2006-06-06 | Virco Bvba | Method and system for predicting resistance of a disease to a therapeutic agent using a neural network |
| GB0016742D0 (en) | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| US6664056B2 (en) | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
| DE60131903T2 (de) | 2000-10-24 | 2008-11-27 | The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto | Direkte multiplex charakterisierung von genomischer dna |
| US20020107640A1 (en) | 2000-11-14 | 2002-08-08 | Ideker Trey E. | Methods for determining the true signal of an analyte |
| CA2428757A1 (en) | 2000-11-15 | 2002-07-18 | Roche Diagnostics Corporation | Methods and reagents for identifying rare fetal cells in the maternal circulation |
| WO2002044411A1 (en) | 2000-12-01 | 2002-06-06 | Rosetta Inpharmatics, Inc. | Use of profiling for detecting aneuploidy |
| US7218764B2 (en) | 2000-12-04 | 2007-05-15 | Cytokinetics, Inc. | Ploidy classification method |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| US20020182622A1 (en) | 2001-02-01 | 2002-12-05 | Yusuke Nakamura | Method for SNP (single nucleotide polymorphism) typing |
| JP2002300894A (ja) | 2001-02-01 | 2002-10-15 | Inst Of Physical & Chemical Res | 一塩基多型タイピング方法 |
| CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| WO2002073504A1 (en) | 2001-03-14 | 2002-09-19 | Gene Logic, Inc. | A system and method for retrieving and using gene expression data from multiple sources |
| WO2002076377A2 (en) | 2001-03-23 | 2002-10-03 | Yoshiyuki Kanai | Mononucleosome and process for producing the same, method of assaying antibody specific to nucleosome, method of diagnosing autoimmune disease, process for producing nucleosome dna, dna plate, process for producing dna plate and method of assaying anti-dna antibody |
| US20020197630A1 (en) | 2001-04-12 | 2002-12-26 | Knapp Michael R. | Systems and methods for high throughput genetic analysis |
| US6489135B1 (en) | 2001-04-17 | 2002-12-03 | Atairgintechnologies, Inc. | Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media |
| FR2824144B1 (fr) | 2001-04-30 | 2004-09-17 | Metagenex S A R L | Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel |
| US7392199B2 (en) | 2001-05-01 | 2008-06-24 | Quest Diagnostics Investments Incorporated | Diagnosing inapparent diseases from common clinical tests using Bayesian analysis |
| US7262030B2 (en) | 2001-05-09 | 2007-08-28 | Virginia Commonwealth University | Multiple sequencible and ligatible structures for genomic analysis |
| US20040126760A1 (en) | 2001-05-17 | 2004-07-01 | Natalia Broude | Novel compositions and methods for carrying out multple pcr reactions on a single sample |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| IL159482A0 (en) | 2001-06-22 | 2004-06-01 | Univ Geneve | Method for detecting diseases caused by chromosomal imbalances |
| WO2003010537A1 (en) | 2001-07-24 | 2003-02-06 | Curagen Corporation | Family based tests of association using pooled dna and snp markers |
| CA2455731C (en) | 2001-07-25 | 2012-02-07 | Oncomedx, Inc. | Methods for evaluating pathologic conditions using extracellular rna |
| US7297778B2 (en) | 2001-07-25 | 2007-11-20 | Affymetrix, Inc. | Complexity management of genomic DNA |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| WO2003019141A2 (en) | 2001-08-23 | 2003-03-06 | Immunivest Corporation | Analysis of circulating tumor cells, fragments, and debris |
| US6807491B2 (en) | 2001-08-30 | 2004-10-19 | Hewlett-Packard Development Company, L.P. | Method and apparatus for combining gene predictions using bayesian networks |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| AUPR749901A0 (en) | 2001-09-06 | 2001-09-27 | Monash University | Method of identifying chromosomal abnormalities and prenatal diagnosis |
| US7153656B2 (en) | 2001-09-11 | 2006-12-26 | Los Alamos National Security, Llc | Nucleic acid sequence detection using multiplexed oligonucleotide PCR |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| WO2003031646A1 (en) | 2001-10-12 | 2003-04-17 | The University Of Queensland | Multiple genetic marker selection and amplification |
| US20040014067A1 (en) | 2001-10-12 | 2004-01-22 | Third Wave Technologies, Inc. | Amplification methods and compositions |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| JP4229237B2 (ja) | 2001-12-11 | 2009-02-25 | 株式会社ネーテック | 血液細胞分離システム |
| US7198897B2 (en) | 2001-12-19 | 2007-04-03 | Brandeis University | Late-PCR |
| EP1325963B1 (en) | 2001-12-24 | 2006-09-27 | Wolfgang Prof. Holzgreve | Method for non-invasive diagnosis of transplantations and transfusions |
| US20040115629A1 (en) | 2002-01-09 | 2004-06-17 | Panzer Scott R | Molecules for diagnostics and therapeutics |
| US20030211522A1 (en) | 2002-01-18 | 2003-11-13 | Landes Gregory M. | Methods for fetal DNA detection and allele quantitation |
| CA2474982A1 (en) | 2002-02-01 | 2003-08-07 | Rosetta Inpharmatics Llc | Computer systems and methods for identifying genes and determining pathways associated with traits |
| IL163600A0 (en) | 2002-03-01 | 2005-12-18 | Ravgen Inc | Methods for detection of genetic disorders |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US20060229823A1 (en) | 2002-03-28 | 2006-10-12 | Affymetrix, Inc. | Methods and computer software products for analyzing genotyping data |
| US20030235848A1 (en) | 2002-04-11 | 2003-12-25 | Matt Neville | Characterization of CYP 2D6 alleles |
| US20040096874A1 (en) | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
| IL164687A0 (en) | 2002-05-02 | 2005-12-18 | Univ North Carolina | Cellular libraries and methods for the preparationthereof |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20070178478A1 (en) | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
| US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040009518A1 (en) | 2002-05-14 | 2004-01-15 | The Chinese University Of Hong Kong | Methods for evaluating a disease condition by nucleic acid detection and fractionation |
| US20040229231A1 (en) | 2002-05-28 | 2004-11-18 | Frudakis Tony N. | Compositions and methods for inferring ancestry |
| EP1532453B1 (en) | 2002-05-31 | 2013-08-21 | Genetic Technologies Limited | Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood |
| WO2003106623A2 (en) | 2002-06-13 | 2003-12-24 | New York University | Early noninvasive prenatal test for aneuploidies and heritable conditions |
| US7108976B2 (en) | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| US7097976B2 (en) | 2002-06-17 | 2006-08-29 | Affymetrix, Inc. | Methods of analysis of allelic imbalance |
| US20050009069A1 (en) | 2002-06-25 | 2005-01-13 | Affymetrix, Inc. | Computer software products for analyzing genotyping |
| CN100354298C (zh) | 2002-06-28 | 2007-12-12 | 兰华生物科技公司 | 使用单核苷酸多态性组分析受损样品的方法和组合物 |
| EP1388812A1 (en) | 2002-07-04 | 2004-02-11 | Ronald E. Dr. Kates | Method for training a learning-capable system |
| US20040117346A1 (en) | 2002-09-20 | 2004-06-17 | Kilian Stoffel | Computer-based method and apparatus for repurposing an ontology |
| JP4116856B2 (ja) | 2002-10-02 | 2008-07-09 | 富士フイルム株式会社 | 1塩基多型の検出方法 |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| AU2003285861A1 (en) | 2002-10-07 | 2004-05-04 | University Of Medicine And Dentistry Of New Jersey | High throughput multiplex dna sequence amplifications |
| EP1578994A2 (en) | 2002-11-11 | 2005-09-28 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
| EP2031070B1 (en) | 2002-12-04 | 2013-07-17 | Life Technologies Corporation | Multiplex amplification of polynucleotides |
| ES2440218T3 (es) | 2003-01-02 | 2014-01-28 | Wobben Properties Gmbh | Pala de rotor de turbina eólica con emisión de ruido reducida |
| US20040224331A1 (en) | 2003-01-17 | 2004-11-11 | The Trustees Of Boston University | Haplotype analysis |
| WO2004065628A1 (en) | 2003-01-21 | 2004-08-05 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| CA2513899C (en) | 2003-01-29 | 2013-03-26 | 454 Corporation | Methods of amplifying and sequencing nucleic acids |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| US20040209299A1 (en) | 2003-03-07 | 2004-10-21 | Rubicon Genomics, Inc. | In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA |
| US20040197832A1 (en) | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| US20070059700A1 (en) | 2003-05-09 | 2007-03-15 | Shengce Tao | Methods and compositions for optimizing multiplex pcr primers |
| JP2004348437A (ja) | 2003-05-22 | 2004-12-09 | Matsushita Electric Ind Co Ltd | リソース管理装置、リソース管理方法及び記録媒体 |
| EP1626621A4 (en) | 2003-05-28 | 2009-10-21 | Pioneer Hi Bred Int | PLANT SELECTION METHOD |
| US20040259100A1 (en) | 2003-06-20 | 2004-12-23 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| EP2107129B1 (en) | 2003-07-31 | 2012-08-22 | Sequenom, Inc. | Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorhisms |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| WO2005021793A1 (en) | 2003-08-29 | 2005-03-10 | Pantarhei Bioscience B.V. | Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood |
| WO2005023091A2 (en) | 2003-09-05 | 2005-03-17 | The Trustees Of Boston University | Method for non-invasive prenatal diagnosis |
| US20050053950A1 (en) | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
| WO2005028645A1 (ja) | 2003-09-24 | 2005-03-31 | Kyushu Tlo Company, Limited | MDR1遺伝子の5’制御領域におけるSNPs |
| WO2005030999A1 (en) | 2003-09-25 | 2005-04-07 | Dana-Farber Cancer Institute, Inc | Methods to detect lineage-specific cells |
| EP1689884A4 (en) | 2003-10-08 | 2007-04-04 | Univ Boston | PROCESS FOR THE PRENATAL DIAGNOSIS OF CHROMOSOMAL ABNORMALITIES |
| CA2482097C (en) | 2003-10-13 | 2012-02-21 | F. Hoffmann-La Roche Ag | Methods for isolating nucleic acids |
| ATE435301T1 (de) * | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
| US20050221341A1 (en) | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
| EP1678329A4 (en) | 2003-10-30 | 2008-07-02 | Tufts New England Medical Ct | PRENATAL DIAGNOSIS USING CELL-FREE FEDERAL DNA IN FRUIT WATER |
| US20050164252A1 (en) | 2003-12-04 | 2005-07-28 | Yeung Wah Hin A. | Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell |
| WO2005071078A1 (en) | 2004-01-12 | 2005-08-04 | Nimblegen Systems Inc. | Method of performing pcr amplification on a microarray |
| US20100216151A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| EP2380993B1 (en) | 2004-03-08 | 2015-12-23 | Rubicon Genomics, Inc. | Method for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation |
| US7035740B2 (en) | 2004-03-24 | 2006-04-25 | Illumina, Inc. | Artificial intelligence and global normalization methods for genotyping |
| JP4437050B2 (ja) | 2004-03-26 | 2010-03-24 | 株式会社日立製作所 | 診断支援システム、診断支援方法および診断支援サービスの提供方法 |
| US7805282B2 (en) | 2004-03-30 | 2010-09-28 | New York University | Process, software arrangement and computer-accessible medium for obtaining information associated with a haplotype |
| CA2561830C (en) | 2004-03-31 | 2013-05-21 | Adnagen Ag | Monoclonal antibodies with specificity for fetal erythroid cells |
| US7414118B1 (en) | 2004-04-14 | 2008-08-19 | Applied Biosystems Inc. | Modified oligonucleotides and applications thereof |
| US7468249B2 (en) | 2004-05-05 | 2008-12-23 | Biocept, Inc. | Detection of chromosomal disorders |
| US20060014179A1 (en) | 2004-06-02 | 2006-01-19 | New England Biolabs, Inc. | Inferring function from shotgun sequencing data |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| JP2008506637A (ja) | 2004-06-14 | 2008-03-06 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 胎児起源の細胞に対する抗体 |
| WO2006002491A1 (en) | 2004-07-06 | 2006-01-12 | Genera Biosystems Pty Ltd | Method of detecting aneuploidy |
| WO2006019804A2 (en) | 2004-07-14 | 2006-02-23 | Wyeth | Compositions and methods of purifying myelin-associated glycoprotein (mag) |
| DE102004036285A1 (de) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe |
| JP5249581B2 (ja) | 2004-08-09 | 2013-07-31 | ジェネレイション バイオテック リミテッド ライアビリティ カンパニー | 核酸の単離および増幅方法 |
| CA2577741A1 (en) | 2004-08-18 | 2006-03-02 | Abbott Molecular, Inc. | Determining data quality and/or segmental aneusomy using a computer system |
| JP4810164B2 (ja) | 2004-09-03 | 2011-11-09 | 富士フイルム株式会社 | 核酸分離精製方法 |
| US8024128B2 (en) | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
| US20060088574A1 (en) | 2004-10-25 | 2006-04-27 | Manning Paul B | Nutritional supplements |
| CA2584723A1 (en) | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US20060134662A1 (en) | 2004-10-25 | 2006-06-22 | Pratt Mark R | Method and system for genotyping samples in a normalized allelic space |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| US20060141499A1 (en) | 2004-11-17 | 2006-06-29 | Geoffrey Sher | Methods of determining human egg competency |
| EP2623099A1 (en) | 2004-11-24 | 2013-08-07 | Neuromolecular Pharmaceuticals, Inc | Composition and method for treating neurological disease |
| US20070042384A1 (en) | 2004-12-01 | 2007-02-22 | Weiwei Li | Method for isolating and modifying DNA from blood and body fluids |
| WO2006091979A2 (en) | 2005-02-25 | 2006-08-31 | The Regents Of The University Of California | Full karyotype single cell chromosome analysis |
| US20060234264A1 (en) | 2005-03-14 | 2006-10-19 | Affymetrix, Inc. | Multiplex polynucleotide synthesis |
| US7618777B2 (en) | 2005-03-16 | 2009-11-17 | Agilent Technologies, Inc. | Composition and method for array hybridization |
| US7645576B2 (en) | 2005-03-18 | 2010-01-12 | The Chinese University Of Hong Kong | Method for the detection of chromosomal aneuploidies |
| CA3007182A1 (en) | 2005-03-18 | 2006-09-21 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis, monitoring or predicting preeclampsia |
| ES2404311T3 (es) | 2005-04-12 | 2013-05-27 | 454 Life Sciences Corporation | Métodos para determinar variantes de secuencias usando secuenciación ultraprofunda |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
| JP2008545418A (ja) | 2005-05-27 | 2008-12-18 | ジョン ウェイン キャンサー インスティチュート | 癌の診断、予後診断、および治療のための遊離循環dnaの使用 |
| JP4879975B2 (ja) | 2005-05-31 | 2012-02-22 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | 短い核酸のマルチプレックス増幅 |
| WO2007044091A2 (en) | 2005-06-02 | 2007-04-19 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| CA2615323A1 (en) | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
| EP3257949A1 (en) | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| EP2308990B1 (en) | 2005-07-15 | 2012-09-26 | Life Technologies Corporation | Analyzing messenger RNA and micro RNA in the same reaction mixture |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| RU2290078C1 (ru) | 2005-07-25 | 2006-12-27 | Евгений Владимирович Новичков | Способ прогнозирования рецидива серозного рака яичников |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070178501A1 (en) | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US20070027636A1 (en) | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| US8515679B2 (en) | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| WO2007018601A1 (en) | 2005-08-02 | 2007-02-15 | Rubicon Genomics, Inc. | Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction |
| US7884119B2 (en) | 2005-09-07 | 2011-02-08 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as Axl inhibitors |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US20090228299A1 (en) | 2005-11-09 | 2009-09-10 | The Regents Of The University Of California | Methods and apparatus for context-sensitive telemedicine |
| GB0523276D0 (en) | 2005-11-15 | 2005-12-21 | London Bridge Fertility | Chromosomal analysis by molecular karyotyping |
| ES2634665T3 (es) | 2005-11-26 | 2017-09-28 | Natera, Inc. | Método y sistema para detectar anormalidades cromosómicas |
| WO2007070280A2 (en) | 2005-12-02 | 2007-06-21 | The General Hospital Corporation | Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility |
| WO2007070482A2 (en) | 2005-12-14 | 2007-06-21 | Xueliang Xia | Microarray-based preimplantation genetic diagnosis of chromosomal abnormalities |
| CN101365803B (zh) | 2005-12-22 | 2013-03-20 | 关键基因股份有限公司 | 采用高通量测序技术的改进的转录谱描述策略 |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| EP3591068A1 (en) | 2006-02-02 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| ATE514775T1 (de) | 2006-02-08 | 2011-07-15 | Illumina Cambridge Ltd | Endenmodifikation zur verhinderung einer überrepräsentierung von fragmenten |
| US20100184043A1 (en) | 2006-02-28 | 2010-07-22 | University Of Louisville Research Foundation | Detecting Genetic Abnormalities |
| EP2351858B1 (en) | 2006-02-28 | 2014-12-31 | University of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| US8609338B2 (en) | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2007106523A2 (en) | 2006-03-13 | 2007-09-20 | Veridex, Llc | Propagation of primary cells |
| WO2007111937A1 (en) | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
| WO2007112418A2 (en) | 2006-03-28 | 2007-10-04 | Baylor College Of Medicine | Screening for down syndrome |
| JP2009072062A (ja) | 2006-04-07 | 2009-04-09 | Institute Of Physical & Chemical Research | 核酸の5’末端を単離するための方法およびその適用 |
| WO2007121276A2 (en) | 2006-04-12 | 2007-10-25 | Biocept, Inc. | Enrichment of circulating fetal dna |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US7901884B2 (en) | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| EP3617321B1 (en) | 2006-05-31 | 2024-10-23 | Sequenom, Inc. | Kit for the extraction and amplification of nucleic acid from a sample |
| US7981609B2 (en) | 2006-06-09 | 2011-07-19 | The Brigham And Women's Hospital, Inc. | Methods for identifying and using SNP panels |
| EP4170042A1 (en) | 2006-06-14 | 2023-04-26 | Verinata Health, Inc. | Methods for the diagnosis of fetal abnormalities |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| WO2009035447A1 (en) | 2006-06-14 | 2009-03-19 | Living Microsystems, Inc. | Diagnosis of fetal abnormalities by comparative genomic hybridization analysis |
| WO2007147079A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Rare cell analysis using sample splitting and dna tags |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| DK2029778T3 (en) | 2006-06-14 | 2018-08-20 | Verinata Health Inc | DIAGNOSIS OF Fetal ABNORMITIES |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US20080090239A1 (en) | 2006-06-14 | 2008-04-17 | Daniel Shoemaker | Rare cell analysis using sample splitting and dna tags |
| JP2009540868A (ja) | 2006-06-15 | 2009-11-26 | ストラタジーン カリフォルニア | 生体分子を試料から単離するシステム |
| JP2009540802A (ja) | 2006-06-16 | 2009-11-26 | セクエノム, インコーポレイテッド | サンプルからの核酸を増幅、検出および定量するための方法および組成物 |
| US20080182244A1 (en) | 2006-08-04 | 2008-07-31 | Ikonisys, Inc. | Pre-Implantation Genetic Diagnosis Test |
| WO2008024473A2 (en) | 2006-08-24 | 2008-02-28 | University Of Massachusetts Medical School | Mapping of genomic interactions |
| US9149473B2 (en) | 2006-09-14 | 2015-10-06 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US20080085836A1 (en) | 2006-09-22 | 2008-04-10 | Kearns William G | Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy |
| WO2008048931A1 (en) | 2006-10-16 | 2008-04-24 | Celula Inc. | Methods and compositions for differential expansion of fetal cells in maternal blood and their use |
| US20100184152A1 (en) | 2006-10-23 | 2010-07-22 | Vladislav Sandler | Target-oriented whole genome amplification of nucleic acids |
| KR100825367B1 (ko) | 2006-11-07 | 2008-04-28 | 전남대학교산학협력단 | 표지자로서 미토콘드리아 유전자 과변이부위를 이용하는조혈모세포이식 후 생착능 평가방법 및 키트 |
| WO2008069906A2 (en) | 2006-11-14 | 2008-06-12 | The Regents Of The University Of California | Digital expression of gene analysis |
| WO2008059578A1 (en) | 2006-11-16 | 2008-05-22 | Olympus Corporation | Multiplex pcr method |
| CA2667851A1 (en) | 2006-11-16 | 2008-05-22 | Genentech, Inc. | Genetic variations associated with tumors |
| WO2008079374A2 (en) | 2006-12-21 | 2008-07-03 | Wang Eric T | Methods and compositions for selecting and using single nucleotide polymorphisms |
| WO2008081451A2 (en) * | 2007-01-03 | 2008-07-10 | Monaliza Medical Ltd. | Methods and kits for analyzing genetic material of a fetus |
| PT2121977T (pt) | 2007-01-11 | 2017-08-18 | Erasmus Univ Medical Center | Captura da conformação cromossómica circular (4c) |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| US20100129792A1 (en) | 2007-02-06 | 2010-05-27 | Gerassimos Makrigiorgos | Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions |
| AU2008213634B2 (en) | 2007-02-08 | 2013-09-05 | Sequenom, Inc. | Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification |
| WO2008115497A2 (en) | 2007-03-16 | 2008-09-25 | Gene Security Network | System and method for cleaning noisy genetic data and determining chromsome copy number |
| US8617816B2 (en) | 2007-03-16 | 2013-12-31 | 454 Life Sciences, A Roche Company | System and method for detection of HIV drug resistant variants |
| US8652780B2 (en) | 2007-03-26 | 2014-02-18 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| JP5262230B2 (ja) | 2007-03-28 | 2013-08-14 | 独立行政法人理化学研究所 | 新規多型検出法 |
| ITTO20070307A1 (it) | 2007-05-04 | 2008-11-05 | Silicon Biosystems Spa | Metodo e dispositivo per la diagnosi prenatale non-invasiva |
| US20080293589A1 (en) | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
| CA2688155C (en) | 2007-05-31 | 2020-02-11 | The Regents Of The University Of California | High specificity and high sensitivity detection based on steric hindrance & enzyme-related signal amplification |
| JP2010528608A (ja) | 2007-06-01 | 2010-08-26 | 454 ライフ サイエンシーズ コーポレイション | 複合的な混合物から個々の試料を特定するためのシステムおよび方法 |
| WO2008151110A2 (en) | 2007-06-01 | 2008-12-11 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| WO2008157264A2 (en) | 2007-06-15 | 2008-12-24 | Sequenom, Inc. | Combined methods for the detection of chromosomal aneuploidy |
| US20090023190A1 (en) | 2007-06-20 | 2009-01-22 | Kai Qin Lao | Sequence amplification with loopable primers |
| WO2008155599A1 (en) | 2007-06-20 | 2008-12-24 | Taag-Genetics Sa | Nested multiplex amplification method for identification of multiple biological entities |
| CA2691942C (en) | 2007-07-03 | 2017-12-05 | Genaphora Ltd. | Methods and kits using chimeric probes for reducing or eliminating formation of artifacts and non-specific amplification products |
| WO2009009769A2 (en) | 2007-07-11 | 2009-01-15 | Artemis Health, Inc. | Diagnosis of fetal abnormalities using nucleated red blood cells |
| PL2557520T3 (pl) | 2007-07-23 | 2021-10-11 | The Chinese University Of Hong Kong | Określanie zaburzenia równowagi sekwencji kwasu nukleinowego |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| JP5531367B2 (ja) | 2007-08-01 | 2014-06-25 | ダナ−ファーバー キャンサー インスチテュート | 標的配列の濃縮 |
| WO2009019215A1 (en) | 2007-08-03 | 2009-02-12 | Dkfz Deutsches Krebsforschungszentrum | Method for prenatal diagnosis using exosomes and cd24 as a marker |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| WO2009032781A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| WO2009032779A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for the size-specific seperation of nucleic acid from a sample |
| US8748100B2 (en) | 2007-08-30 | 2014-06-10 | The Chinese University Of Hong Kong | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences |
| WO2009033178A1 (en) | 2007-09-07 | 2009-03-12 | Fluidigm Corporation | Copy number variation determination, methods and systems |
| EP2201143B2 (en) | 2007-09-21 | 2016-08-24 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| US20090081678A1 (en) | 2007-09-21 | 2009-03-26 | Streck, Inc. | Nucleic acid isolation in preserved whole blood |
| CN102124125A (zh) | 2007-10-16 | 2011-07-13 | 霍夫曼-拉罗奇有限公司 | 通过克隆性测序的高分辨率、高通量hla基因分型 |
| US20100086914A1 (en) | 2008-10-03 | 2010-04-08 | Roche Molecular Systems, Inc. | High resolution, high throughput hla genotyping by clonal sequencing |
| WO2009064897A2 (en) | 2007-11-14 | 2009-05-22 | Chronix Biomedical | Detection of nucleic acid sequence variations in circulating nucleic acid in bovine spongiform encephalopathy |
| CN101878304B (zh) | 2007-11-30 | 2015-01-07 | 通用电气医疗集团生物科学公司 | 用于从单个样品中分离基因组dna、rna和蛋白质的方法 |
| US20100216145A1 (en) | 2007-12-10 | 2010-08-26 | Mor Research Application Ltd. | Assay for Detecting Circulating Free Nucleic Acids |
| FR2925480B1 (fr) | 2007-12-21 | 2011-07-01 | Gervais Danone Sa | Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations |
| EP2077337A1 (en) | 2007-12-26 | 2009-07-08 | Eppendorf Array Technologies SA | Amplification and detection composition, method and kit |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| WO2009091934A1 (en) | 2008-01-17 | 2009-07-23 | Sequenom, Inc. | Single molecule nucleic acid sequence analysis processes and compositions |
| KR101810799B1 (ko) | 2008-02-01 | 2017-12-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| EP2245198A1 (en) | 2008-02-04 | 2010-11-03 | Massachusetts Institute of Technology | Selection of nucleic acids by solution hybridization to oligonucleotide baits |
| WO2009105531A1 (en) | 2008-02-19 | 2009-08-27 | Gene Security Network, Inc. | Methods for cell genotyping |
| US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| EP2271772B1 (en) | 2008-03-11 | 2014-07-16 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| US20090307180A1 (en) | 2008-03-19 | 2009-12-10 | Brandon Colby | Genetic analysis |
| WO2009120808A2 (en) | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| PT2271767T (pt) | 2008-04-03 | 2016-08-18 | Cb Biotechnologies Inc | Reação em cadeia de polimerase para captura de amplicões em multiplexo para amplificação de alvos múltiplos |
| WO2009146335A1 (en) | 2008-05-27 | 2009-12-03 | Gene Security Network, Inc. | Methods for embryo characterization and comparison |
| EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| EP2321642B1 (en) | 2008-08-04 | 2017-01-11 | Natera, Inc. | Methods for allele calling and ploidy calling |
| WO2010019588A1 (en) | 2008-08-11 | 2010-02-18 | Ieo Istituto Europeo De Oncologica | Method for detecting or diagnosing genomic instability |
| EP2326732A4 (en) | 2008-08-26 | 2012-11-14 | Fluidigm Corp | TEST METHODS FOR INCREASED SURPLUS OF SAMPLES AND / OR TARGETS |
| DE102008045705A1 (de) | 2008-09-04 | 2010-04-22 | Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft | Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| EP3103871B1 (en) | 2008-09-16 | 2020-07-29 | Sequenom, Inc. | Processes for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for fetal nucleic acid quantification |
| JP2012502632A (ja) | 2008-09-17 | 2012-02-02 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | スモールrnaの単離法 |
| CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US20110301221A1 (en) | 2008-10-10 | 2011-12-08 | Swedish Health Services | Diagnosis, prognosis and treatment of glioblastoma multiforme |
| WO2010045617A2 (en) | 2008-10-17 | 2010-04-22 | University Of Louisville Research Foundation | Detecting genetic abnormalities |
| EP2364368B1 (en) | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| KR101781147B1 (ko) | 2008-12-22 | 2017-10-10 | 셀루라 인코포레이티드 | 대립유전자, 게놈 및 전사체 검출을 위한 방법 및 유전자형 분석 패널 |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| US8450063B2 (en) | 2009-01-28 | 2013-05-28 | Fluidigm Corporation | Determination of copy number differences by amplification |
| NO2398912T3 (https=) | 2009-02-18 | 2018-02-10 | ||
| EP2411543B1 (en) | 2009-03-27 | 2017-04-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| SG174617A1 (en) | 2009-04-02 | 2011-10-28 | Fluidigm Corp | Multi-primer amplification method for barcoding of target nucleic acids |
| US20100285537A1 (en) | 2009-04-02 | 2010-11-11 | Fluidigm Corporation | Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation |
| EP3514244B1 (en) | 2009-04-03 | 2021-07-07 | Sequenom, Inc. | Nucleic acid preparation methods |
| EP2417270B1 (en) | 2009-04-06 | 2017-09-20 | The Johns Hopkins University | Digital quantification of dna methylation |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| KR20110006112A (ko) | 2009-07-13 | 2011-01-20 | 삼성전자주식회사 | 카메라 시스템에서 디스플레이 패널의 백라이트를 제어하는 장치 및 그 방법 |
| US8481699B2 (en) | 2009-07-14 | 2013-07-09 | Academia Sinica | Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| US8563242B2 (en) | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| CN101643904B (zh) | 2009-08-27 | 2011-04-27 | 北京北方微电子基地设备工艺研究中心有限责任公司 | 深硅刻蚀装置和深硅刻蚀设备的进气系统 |
| WO2011032078A1 (en) | 2009-09-11 | 2011-03-17 | Health Reseach Inc. | Detection of x4 strains of hiv-1 by heteroduplex tracking assay |
| ES2661055T3 (es) | 2009-09-22 | 2018-03-27 | Roche Diagniostics Gmbh | Determinación de haplotipos de KIR por amplificación de exones |
| EP2480666B1 (en) | 2009-09-24 | 2017-03-08 | QIAGEN Gaithersburg, Inc. | Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material |
| WO2011041485A1 (en) | 2009-09-30 | 2011-04-07 | Gene Security Network, Inc. | Methods for non-invasive prenatal ploidy calling |
| AU2010311535B2 (en) | 2009-10-26 | 2015-05-21 | Lifecodexx Ag | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
| EP3783110B1 (en) | 2009-11-05 | 2022-11-23 | The Chinese University Of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| JP2013511991A (ja) | 2009-11-25 | 2013-04-11 | クアンタライフ, インコーポレイテッド | 遺伝子材料を検出する方法および組成物 |
| WO2011072086A1 (en) | 2009-12-08 | 2011-06-16 | Hemaquest Pharmaceuticals, Inc. | Methods and low dose regimens for treating red blood cell disorders |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8574842B2 (en) | 2009-12-22 | 2013-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Direct molecular diagnosis of fetal aneuploidy |
| ES2577017T3 (es) | 2009-12-22 | 2016-07-12 | Sequenom, Inc. | Procedimientos y kits para identificar la aneuploidia |
| CA2817990A1 (en) | 2009-12-23 | 2011-06-30 | Genetic Technologies Limited | Methods of enriching and detecting fetal nucleic acids |
| US20130022973A1 (en) | 2010-01-15 | 2013-01-24 | Hansen Carl L G | Multiplex Amplification for the Detection of Nucleic Acid Variations |
| US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
| US20120270739A1 (en) | 2010-01-19 | 2012-10-25 | Verinata Health, Inc. | Method for sample analysis of aneuploidies in maternal samples |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| EP2370599B1 (en) | 2010-01-19 | 2015-01-21 | Verinata Health, Inc | Method for determining copy number variations |
| EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| WO2011094646A1 (en) | 2010-01-28 | 2011-08-04 | Medical College Of Wisconsin, Inc. | Methods and compositions for high yield, specific amplification |
| US8574832B2 (en) | 2010-02-03 | 2013-11-05 | Massachusetts Institute Of Technology | Methods for preparing sequencing libraries |
| US8940487B2 (en) | 2010-02-09 | 2015-01-27 | UmiTaq Bio | Methods and compositions for universal detection of nucleic acids |
| EP2539472B1 (en) | 2010-02-26 | 2015-05-20 | Life Technologies Corporation | Fast pcr for str genotyping |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
| JP5842811B2 (ja) | 2010-03-24 | 2016-01-13 | 凸版印刷株式会社 | 競合プライマーによる標的塩基配列の検出方法 |
| PL2558854T3 (pl) | 2010-04-16 | 2019-04-30 | Chronix Biomedical | Biomarkery będące krążącymi kwasami nukleinowymi związanymi z rakiem piersi |
| US9255291B2 (en) | 2010-05-06 | 2016-02-09 | Bioo Scientific Corporation | Oligonucleotide ligation methods for improving data quality and throughput using massively parallel sequencing |
| WO2011140433A2 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| EP2569447A4 (en) | 2010-05-14 | 2013-11-27 | Fluidigm Corp | ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY |
| WO2011143659A2 (en) | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Nucleic acid isolation methods |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20130196862A1 (en) | 2010-05-18 | 2013-08-01 | Natera, Inc. | Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2011146632A1 (en) | 2010-05-18 | 2011-11-24 | Gene Security Network Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190309358A1 (en) | 2010-05-18 | 2019-10-10 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20140206552A1 (en) | 2010-05-18 | 2014-07-24 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| WO2013052557A2 (en) | 2011-10-03 | 2013-04-11 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20130123120A1 (en) | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| US20190284623A1 (en) | 2010-05-18 | 2019-09-19 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2011146942A1 (en) | 2010-05-21 | 2011-11-24 | The Translational Genomics Research Institute | Methods and kits to analyze microrna by nucleic acid sequencing |
| EP2576837B1 (en) | 2010-06-04 | 2017-09-06 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| US20110301854A1 (en) | 2010-06-08 | 2011-12-08 | Curry Bo U | Method of Determining Allele-Specific Copy Number of a SNP |
| US9080210B2 (en) | 2010-06-09 | 2015-07-14 | Keygene N.V. | High throughput screening using combinatorial sequence barcodes |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20120190557A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
| JP2012085556A (ja) | 2010-10-18 | 2012-05-10 | Shinya Watanabe | 乳がんの診断方法 |
| US9267174B2 (en) | 2010-10-26 | 2016-02-23 | Stanford University | Method of simultaneously screening for multiple genotypes and/or mutations |
| EP2633071B1 (en) | 2010-10-27 | 2016-10-12 | President and Fellows of Harvard College | Compositions of toehold primer duplexes and methods of use |
| CN105243295B (zh) | 2010-11-30 | 2018-08-17 | 香港中文大学 | 与癌症相关的遗传或分子畸变的检测 |
| CN103620055A (zh) | 2010-12-07 | 2014-03-05 | 利兰·斯坦福青年大学托管委员会 | 在全基因组规模非侵入性确定亲本单倍型的胎儿遗传 |
| US20150064695A1 (en) | 2010-12-17 | 2015-03-05 | Celula Inc. | Methods for screening and diagnosing genetic conditions |
| CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
| KR102759126B1 (ko) | 2010-12-30 | 2025-01-24 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| US20120190020A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Detection of genetic abnormalities |
| EP3187597B1 (en) | 2011-02-09 | 2020-06-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| CA2827873C (en) | 2011-02-24 | 2022-08-16 | The Chinese University Of Hong Kong | Molecular testing of multiple pregnancies |
| GB2488358A (en) | 2011-02-25 | 2012-08-29 | Univ Plymouth | Enrichment of foetal DNA in maternal plasma |
| WO2012122374A2 (en) | 2011-03-08 | 2012-09-13 | Children's Medical Center Corporation | Non-invasive methods for diagnosing chronic organ transplant rejection |
| WO2012125848A2 (en) | 2011-03-16 | 2012-09-20 | Baylor College Of Medicine | A method for comprehensive sequence analysis using deep sequencing technology |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| RS57837B1 (sr) | 2011-04-12 | 2018-12-31 | Verinata Health Inc | Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama |
| EP2754078A4 (en) | 2011-04-14 | 2015-12-02 | Complete Genomics Inc | PROCESSING AND ANALYSIS OF COMPLEX NUCLEIC ACID SEQUENCE DATA |
| US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| ES2986436T3 (es) | 2011-04-15 | 2024-11-11 | Univ Johns Hopkins | Sistema de secuenciación segura |
| WO2014014498A1 (en) | 2012-07-20 | 2014-01-23 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
| EP3495497B1 (en) | 2011-04-28 | 2021-03-24 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| AU2012249531B2 (en) | 2011-04-29 | 2017-06-29 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| EP2546361B1 (en) | 2011-07-11 | 2015-06-03 | Samsung Electronics Co., Ltd. | Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample |
| US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| AU2012304328B2 (en) | 2011-09-09 | 2017-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for obtaining a sequence |
| US20130073214A1 (en) | 2011-09-20 | 2013-03-21 | Life Technologies Corporation | Systems and methods for identifying sequence variation |
| JP5536729B2 (ja) | 2011-09-20 | 2014-07-02 | 株式会社ソニー・コンピュータエンタテインメント | 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法 |
| CN113355321A (zh) | 2011-09-26 | 2021-09-07 | 凯杰有限公司 | 用于分离细胞外核酸的快速方法 |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US20140234273A1 (en) | 2011-10-07 | 2014-08-21 | Muroch Children Research Institute | Diagnostic assay for tissue transplantation status |
| WO2013078470A2 (en) | 2011-11-22 | 2013-05-30 | MOTIF, Active | Multiplex isolation of protein-associated nucleic acids |
| WO2013086464A1 (en) | 2011-12-07 | 2013-06-13 | The Broad Institute, Inc. | Markers associated with chronic lymphocytic leukemia prognosis and progression |
| US20130190653A1 (en) | 2012-01-25 | 2013-07-25 | Angel Gabriel Alvarez Ramos | Device for blood collection from the placenta and the umbilical cord |
| SG11201404899VA (en) | 2012-02-14 | 2014-10-30 | Univ Cornell | Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions |
| WO2013128281A1 (en) | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
| WO2013130848A1 (en) | 2012-02-29 | 2013-09-06 | Natera, Inc. | Informatics enhanced analysis of fetal samples subject to maternal contamination |
| WO2013138510A1 (en) | 2012-03-13 | 2013-09-19 | Patel Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| EP3741871A3 (en) | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| EP2847353B1 (en) | 2012-05-10 | 2022-01-19 | The General Hospital Corporation | Methods for determining a nucleotide sequence |
| EP4148142B1 (en) | 2012-05-21 | 2025-08-13 | The Scripps Research Institute | Methods of sample preparation |
| US20150105267A1 (en) | 2012-05-24 | 2015-04-16 | University Of Washington Through Its Center For Commercialization | Whole genome sequencing of a human fetus |
| WO2013181651A1 (en) | 2012-06-01 | 2013-12-05 | Omega Bio-Tek, Inc. | Selective nucleic acid fragment recovery |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
| CA2877493C (en) | 2012-07-24 | 2020-08-25 | Natera, Inc. | Highly multiplex pcr methods and compositions |
| US10988803B2 (en) | 2014-12-29 | 2021-04-27 | Life Genetics Lab, Llc | Multiplexed assay for quantitating and assessing integrity of cell-free DNA in biological fluids for cancer diagnosis, prognosis and surveillance |
| US10993418B2 (en) | 2012-08-13 | 2021-05-04 | Life Genetics Lab, Llc | Method for measuring tumor burden in patient derived xenograft (PDX) mice |
| US20140051585A1 (en) | 2012-08-15 | 2014-02-20 | Natera, Inc. | Methods and compositions for reducing genetic library contamination |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CN108103057B (zh) | 2012-08-28 | 2021-09-03 | 阿科尼生物系统公司 | 用于纯化核酸的方法和试剂盒 |
| US20140065621A1 (en) | 2012-09-04 | 2014-03-06 | Natera, Inc. | Methods for increasing fetal fraction in maternal blood |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CA3120521A1 (en) | 2012-10-04 | 2014-04-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| GB201217888D0 (en) | 2012-10-05 | 2012-11-21 | Univ Leuven Kath | High-throughput genotyping by sequencing of single cell |
| EP2728014B1 (en) | 2012-10-31 | 2015-10-07 | Genesupport SA | Non-invasive method for detecting a fetal chromosomal aneuploidy |
| EP2943590A4 (en) | 2013-01-13 | 2017-02-15 | Unitaq Bio | Methods and compositions for pcr using blocked and universal primers |
| US10745686B2 (en) | 2013-02-08 | 2020-08-18 | Qiagen Gmbh | Method for separating DNA by size |
| US9982255B2 (en) | 2013-03-11 | 2018-05-29 | Kailos Genetics, Inc. | Capture methodologies for circulating cell free DNA |
| CN105229175A (zh) | 2013-03-15 | 2016-01-06 | 雅培分子公司 | 用于扩增和测定rna融合基因变体的方法、区分它们的方法以及有关的引物、探针和试剂盒 |
| US10385394B2 (en) | 2013-03-15 | 2019-08-20 | The Translational Genomics Research Institute | Processes of identifying and characterizing X-linked disorders |
| WO2014151117A1 (en) | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| MX2015012733A (es) | 2013-03-15 | 2016-06-21 | Immucor Gti Diagnostics Inc | Metodos y composiciones para evaluar el estado renal usando adn libre de celulas de la orina. |
| CN114574581A (zh) | 2013-03-15 | 2022-06-03 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| WO2014145078A1 (en) | 2013-03-15 | 2014-09-18 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| US10072298B2 (en) | 2013-04-17 | 2018-09-11 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| WO2014194113A2 (en) | 2013-05-29 | 2014-12-04 | Chronix Biomedical | Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| WO2015048595A1 (en) | 2013-09-27 | 2015-04-02 | Jay Shendure | Methods and systems for large scale scaffolding of genome assemblies |
| US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| ES2693217T3 (es) | 2013-12-02 | 2018-12-10 | Personal Genome Diagnostics Inc. | Método para evaluar variantes minoritarias en una muestra |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| DK3089822T3 (da) | 2013-12-30 | 2022-05-02 | Atreca Inc | Analyse af nukleinsyrer associeret med enkelte celler under anvendelse af nukleinsyrestregkoder |
| EP3099820A4 (en) | 2014-01-27 | 2018-01-03 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
| CN106029962A (zh) | 2014-02-11 | 2016-10-12 | 豪夫迈·罗氏有限公司 | 靶向测序和uid过滤 |
| EP3114231B1 (en) | 2014-03-03 | 2019-01-02 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| TR201907106T4 (tr) | 2014-03-14 | 2019-06-21 | Caredx Inc | Bir transplant alıcısında immünosüpresif terapileri izleme yöntemleri. |
| CN106462669A (zh) | 2014-03-25 | 2017-02-22 | 奎斯特诊断投资股份有限公司 | 通过使用平均循环阈值的基因内差异表达(ide)检测基因融合 |
| CA2945962C (en) | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| WO2015164432A1 (en) | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| ES2815349T3 (es) | 2014-06-27 | 2021-03-29 | Inst Nat Sante Rech Med | Métodos que emplean ADN y miARN circulantes como biomarcadores para la infertilidad femenina |
| WO2016004368A2 (en) | 2014-07-03 | 2016-01-07 | Rhodx, Inc. | Tagging and assessing a target sequence |
| US10954507B2 (en) | 2014-07-17 | 2021-03-23 | Qiagen Gmbh | Method for isolating RNA with high yield |
| GB201412834D0 (en) | 2014-07-18 | 2014-09-03 | Cancer Rec Tech Ltd | A method for detecting a genetic variant |
| EP3169803B1 (en) | 2014-07-18 | 2019-11-20 | Illumina, Inc. | Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna |
| PT3204520T (pt) | 2014-10-08 | 2020-04-16 | Univ Cornell | Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação |
| US10704104B2 (en) | 2014-10-20 | 2020-07-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for screening a subject for a cancer |
| CA2965500A1 (en) | 2014-10-24 | 2016-04-28 | Abbott Molecular Inc. | Enrichment of small nucleic acids |
| WO2016077313A1 (en) | 2014-11-11 | 2016-05-19 | Bgi Shenzhen | Multi-pass sequencing |
| WO2016089920A1 (en) | 2014-12-01 | 2016-06-09 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
| US9632862B2 (en) | 2014-12-20 | 2017-04-25 | Intel Corporation | Error handling in transactional buffered memory |
| GB201501907D0 (en) | 2015-02-05 | 2015-03-25 | Technion Res & Dev Foundation | System and method for single cell genetic analysis |
| WO2016123698A1 (en) | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
| US10557134B2 (en) | 2015-02-24 | 2020-02-11 | Trustees Of Boston University | Protection of barcodes during DNA amplification using molecular hairpins |
| WO2016138500A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Methods and compositions for barcoding nucleic acids for sequencing |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| KR101850437B1 (ko) | 2015-04-14 | 2018-04-20 | 이원다이애그노믹스(주) | 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법 |
| EP4582556A3 (en) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Methods and compositions for whole transcriptome amplification |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| WO2016176662A1 (en) | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| JP7007197B2 (ja) | 2015-06-05 | 2022-01-24 | キアゲン ゲーエムベーハー | サイズによってdnaを分離する方法 |
| US20160371428A1 (en) | 2015-06-19 | 2016-12-22 | Natera, Inc. | Systems and methods for determining aneuploidy risk using sample fetal fraction |
| US12018314B2 (en) | 2015-07-02 | 2024-06-25 | Arima Genomics, Inc. | Accurate molecular deconvolution of mixture samples |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| WO2017058784A1 (en) | 2015-09-29 | 2017-04-06 | Ludwig Institute For Cancer Research Ltd | Typing and assembling discontinuous genomic elements |
| CA3002740A1 (en) | 2015-10-19 | 2017-04-27 | Dovetail Genomics, Llc | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| CN105986030A (zh) | 2016-02-03 | 2016-10-05 | 广州市基准医疗有限责任公司 | 甲基化dna检测方法 |
| CA3016077A1 (en) | 2016-03-22 | 2017-09-28 | Counsyl, Inc. | Combinatorial dna screening |
| WO2017173039A1 (en) | 2016-03-30 | 2017-10-05 | Covaris, Inc. | Extraction of cfdna from biological samples |
| ES3002715T3 (en) | 2016-04-14 | 2025-03-07 | Guardant Health Inc | Methods for early detection of cancer |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2017190106A1 (en) | 2016-04-29 | 2017-11-02 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-target number |
| ES2870626T3 (es) | 2016-05-24 | 2021-10-27 | Translational Genomics Res Inst | Métodos de marcado molecular y bibliotecas de secuenciación |
| EP4043581A1 (en) | 2016-05-27 | 2022-08-17 | Sequenom, Inc. | Method for generating a paralog assay system |
| JP2019526230A (ja) | 2016-07-01 | 2019-09-19 | ナテラ, インコーポレイテッド | 核酸突然変異検出のための組成物及び方法 |
| WO2018009723A1 (en) | 2016-07-06 | 2018-01-11 | Guardant Health, Inc. | Methods for fragmentome profiling of cell-free nucleic acids |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| JP2019534016A (ja) | 2016-11-02 | 2019-11-28 | ザ メディカル カレッジ オブ ウィスコンシン,インコーポレイテッドThe Medical College of Wisconsin, Inc. | 全および特異的な無細胞dnaを使用しリスクを評価するための方法 |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| JP7228510B2 (ja) | 2016-11-08 | 2023-02-24 | ベクトン・ディキンソン・アンド・カンパニー | 細胞標識分類の方法 |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CN110249060A (zh) | 2017-01-17 | 2019-09-17 | 生命技术公司 | 用于免疫组库测序的组合物和方法 |
| WO2018156418A1 (en) | 2017-02-21 | 2018-08-30 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| US20210139988A1 (en) | 2017-06-20 | 2021-05-13 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| CA3067635A1 (en) | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| WO2019046817A1 (en) | 2017-09-01 | 2019-03-07 | Life Technologies Corporation | COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING |
| US11091800B2 (en) | 2017-09-20 | 2021-08-17 | University Of Utah Research Foundation | Size-selection of cell-free DNA for increasing family size during next-generation sequencing |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| WO2019140298A1 (en) | 2018-01-12 | 2019-07-18 | Natera, Inc. | Novel primers and uses thereof |
| US12398389B2 (en) | 2018-02-15 | 2025-08-26 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| WO2019241349A1 (en) | 2018-06-12 | 2019-12-19 | Natera, Inc. | Methods and systems for calling mutations |
| EP3818177A1 (en) | 2018-07-03 | 2021-05-12 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| JP2021530231A (ja) | 2018-07-17 | 2021-11-11 | ナテラ, インコーポレイテッド | ニューラルネットワークを使用して倍数性状態を呼び出すための方法およびシステム |
| WO2020041449A1 (en) | 2018-08-21 | 2020-02-27 | Zymo Research Corporation | Methods and compositions for tracking sample quality |
| WO2020076957A1 (en) | 2018-10-09 | 2020-04-16 | Tai Diagnostics, Inc. | Cell lysis assay for cell-free dna analysis |
| CN121575489A (zh) | 2018-11-21 | 2026-02-27 | 卡里乌斯公司 | 感染性疾病的检测和预测 |
| JP2022519159A (ja) | 2018-12-17 | 2022-03-22 | ナテラ, インコーポレイテッド | 循環細胞の分析方法 |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| EP3956466A1 (en) | 2019-04-15 | 2022-02-23 | Natera, Inc. | Improved liquid biopsy using size selection |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| WO2021055968A1 (en) | 2019-09-20 | 2021-03-25 | Natera Inc. | Methods for assessing graft suitability for transplantation |
| US20230203573A1 (en) | 2020-05-29 | 2023-06-29 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| US20220009866A1 (en) | 2020-06-23 | 2022-01-13 | Antares Agriculture Group, LLC | Systems and methods for extracting and isolating bio-oils and powders from biomass using hydraulic hammering |
| WO2022015676A1 (en) | 2020-07-13 | 2022-01-20 | The Medical College Of Wisconsin, Inc. | Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values |
| JP2025533814A (ja) | 2022-10-06 | 2025-10-09 | ナテラ, インコーポレイテッド | 妊娠中の移植レシピエントにおける移植拒絶反応を評価する非侵襲的方法 |
-
2011
- 2011-12-22 CN CN201180068305.0A patent/CN103608466B/zh active Active
- 2011-12-22 CA CA2821906A patent/CA2821906C/en active Active
- 2011-12-22 BR BR112013016193-0A patent/BR112013016193B1/pt active IP Right Grant
- 2011-12-22 US US13/335,043 patent/US10113196B2/en active Active
- 2011-12-22 ES ES11851621T patent/ES2770342T3/es active Active
- 2011-12-22 JP JP2013546434A patent/JP6328934B2/ja active Active
- 2011-12-22 RU RU2013133413A patent/RU2620959C2/ru active
- 2011-12-22 EP EP11851621.0A patent/EP2656263B1/en active Active
- 2011-12-22 WO PCT/US2011/066938 patent/WO2012088456A2/en not_active Ceased
- 2011-12-22 AU AU2011348100A patent/AU2011348100B2/en active Active
-
2013
- 2013-03-18 US US13/846,160 patent/US20130261004A1/en not_active Abandoned
-
2019
- 2019-02-27 US US16/287,662 patent/US10774380B2/en active Active
- 2019-04-30 US US16/399,957 patent/US10590482B2/en active Active
-
2020
- 2020-09-11 US US17/018,831 patent/US12553083B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011348100A2 (en) | 2013-08-15 |
| US20190194743A1 (en) | 2019-06-27 |
| US20120122701A1 (en) | 2012-05-17 |
| CN103608466A (zh) | 2014-02-26 |
| CN103608466B (zh) | 2020-09-18 |
| WO2012088456A2 (en) | 2012-06-28 |
| RU2013133413A (ru) | 2015-01-27 |
| US20130261004A1 (en) | 2013-10-03 |
| ES2770342T3 (es) | 2020-07-01 |
| US10590482B2 (en) | 2020-03-17 |
| EP2656263A4 (en) | 2015-06-24 |
| US10774380B2 (en) | 2020-09-15 |
| RU2620959C2 (ru) | 2017-05-30 |
| US20200407788A1 (en) | 2020-12-31 |
| EP2656263B1 (en) | 2019-11-06 |
| CA2821906A1 (en) | 2012-06-28 |
| BR112013016193A2 (en) | 2018-06-19 |
| JP2014502845A (ja) | 2014-02-06 |
| US10113196B2 (en) | 2018-10-30 |
| US12553083B2 (en) | 2026-02-17 |
| JP6328934B2 (ja) | 2018-05-23 |
| BR112013016193B1 (pt) | 2019-10-22 |
| WO2012088456A3 (en) | 2013-10-24 |
| US20190256907A1 (en) | 2019-08-22 |
| AU2011348100B2 (en) | 2016-08-25 |
| EP2656263A2 (en) | 2013-10-30 |
| AU2011348100A1 (en) | 2013-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12553083B2 (en) | Methods for enriching and sequencing nucleic acids for non-invasive cancer testing | |
| US20240060124A1 (en) | Methods for amplification of cell-free dna using ligated adaptors and universal and inner target-specific primers for multiplexed nested pcr | |
| US11326208B2 (en) | Methods for nested PCR amplification of cell-free DNA | |
| US20210222230A1 (en) | Methods for simultaneous amplification of target loci | |
| AU2012385961B9 (en) | Highly multiplex PCR methods and compositions | |
| US20190256908A1 (en) | Methods for non-invasive prenatal ploidy calling | |
| US20130196862A1 (en) | Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination | |
| US20140094373A1 (en) | Highly multiplex pcr methods and compositions | |
| WO2013130848A1 (en) | Informatics enhanced analysis of fetal samples subject to maternal contamination | |
| EP2847347B1 (en) | Highly multiplex pcr methods and compositions | |
| HK1195104B (zh) | 非侵入性产前亲子鉴定方法 | |
| HK1195104A (en) | Methods for non-invasive prenatal paternity testing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161216 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD Year of fee payment: 13 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241205 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241205 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20241205 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251208 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251208 |