CA2696948C - 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones - Google Patents

1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones Download PDF

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CA2696948C
CA2696948C CA2696948A CA2696948A CA2696948C CA 2696948 C CA2696948 C CA 2696948C CA 2696948 A CA2696948 A CA 2696948A CA 2696948 A CA2696948 A CA 2696948A CA 2696948 C CA2696948 C CA 2696948C
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disorders
disorder
mmol
nervous system
central nervous
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French (fr)
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CA2696948A1 (en
Inventor
Jose Maria Cid-Nunez
Andres Avelino Trabanco-Suarez
Gregor James Macdonald
Guillaume Albert Jacques Duvey
Robert Johannes Luetjens
Terry Patrick Finn
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Addex Pharmaceuticals SA
Janssen Pharmaceuticals Inc
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Addex Pharmaceuticals SA
Ortho McNeil Janssen Pharmaceuticals Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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CA2696948A 2007-09-14 2008-09-12 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones Active CA2696948C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07116390 2007-09-14
EP07116390.1 2007-09-14
PCT/EP2008/007551 WO2009033704A1 (en) 2007-09-14 2008-09-12 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones

Publications (2)

Publication Number Publication Date
CA2696948A1 CA2696948A1 (en) 2009-03-19
CA2696948C true CA2696948C (en) 2013-04-30

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CA2696948A Active CA2696948C (en) 2007-09-14 2008-09-12 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones

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Country Link
US (6) US9114138B2 (enExample)
EP (1) EP2203439B1 (enExample)
JP (1) JP5133416B2 (enExample)
KR (2) KR101533440B1 (enExample)
CN (2) CN101801951B (enExample)
AR (1) AR068511A1 (enExample)
AT (1) ATE496906T1 (enExample)
AU (1) AU2008297878B2 (enExample)
BR (1) BRPI0816767B8 (enExample)
CA (1) CA2696948C (enExample)
CL (1) CL2008002745A1 (enExample)
CY (1) CY1111219T1 (enExample)
DE (1) DE602008004794D1 (enExample)
DK (1) DK2203439T3 (enExample)
EA (1) EA017648B1 (enExample)
ES (1) ES2356032T3 (enExample)
HR (1) HRP20110278T1 (enExample)
IL (2) IL204032A (enExample)
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MY (1) MY152078A (enExample)
NZ (1) NZ584145A (enExample)
PL (1) PL2203439T3 (enExample)
PT (1) PT2203439E (enExample)
RS (1) RS51660B (enExample)
SI (1) SI2203439T1 (enExample)
TW (2) TWI475995B (enExample)
UA (1) UA100126C2 (enExample)
WO (1) WO2009033704A1 (enExample)
ZA (1) ZA201001151B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200922566A (en) * 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
EA017648B1 (ru) 2007-09-14 2013-02-28 Орто-Макнейл-Янссен Фармасьютикалз, Инк. 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
BRPI0816970A2 (pt) 2007-09-14 2015-03-24 Ortho Mcneil Janssen Pharm 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
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CN103342695B (zh) 2015-04-22
US11071729B2 (en) 2021-07-27
KR101533440B1 (ko) 2015-07-03
ZA201001151B (en) 2011-04-28
CN101801951A (zh) 2010-08-11
US9114138B2 (en) 2015-08-25
UA100126C2 (en) 2012-11-26
DK2203439T3 (da) 2011-04-18
MY152078A (en) 2014-08-15
HK1189885A1 (en) 2014-06-20
CY1111219T1 (el) 2015-06-11
CA2696948A1 (en) 2009-03-19
JP2010539121A (ja) 2010-12-16
US20130197019A1 (en) 2013-08-01
EP2203439B1 (en) 2011-01-26
SI2203439T1 (sl) 2011-05-31
NZ584145A (en) 2012-03-30
KR101520086B1 (ko) 2015-05-14
AU2008297878A1 (en) 2009-03-19
BRPI0816767B8 (pt) 2021-05-25
HRP20110278T1 (hr) 2011-05-31
WO2009033704A1 (en) 2009-03-19
IL229304A (en) 2015-08-31
US20130196992A1 (en) 2013-08-01
BRPI0816767A2 (pt) 2017-05-16
ATE496906T1 (de) 2011-02-15
EP2203439A1 (en) 2010-07-07
US20220000856A1 (en) 2022-01-06
US20200038391A1 (en) 2020-02-06

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