BRPI0816767A2 - 1'3'-dissubstituída-4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'-onas - Google Patents

1'3'-dissubstituída-4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'-onas

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Publication number
BRPI0816767A2
BRPI0816767A2 BRPI0816767A BRPI0816767A BRPI0816767A2 BR PI0816767 A2 BRPI0816767 A2 BR PI0816767A2 BR PI0816767 A BRPI0816767 A BR PI0816767A BR PI0816767 A BRPI0816767 A BR PI0816767A BR PI0816767 A2 BRPI0816767 A2 BR PI0816767A2
Authority
BR
Brazil
Prior art keywords
bipyridinyl
disubstituted
tetrahydro
ones
phenyl
Prior art date
Application number
BRPI0816767A
Other languages
English (en)
Inventor
Avelino Trabanco-Suárez Andrés
James Macdonald Gregor
Albert Jacques Duvey Guillaume
Maria Cid-Núnez José
Johannes Lütjens Robert
Patrick Finn Terry
Original Assignee
Addex Pharmaceuticals Sa
Ortho-Mcneil-Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39930548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0816767(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Addex Pharmaceuticals Sa, Ortho-Mcneil-Janssen Pharmaceuticals Inc filed Critical Addex Pharmaceuticals Sa
Publication of BRPI0816767A2 publication Critical patent/BRPI0816767A2/pt
Publication of BRPI0816767B1 publication Critical patent/BRPI0816767B1/pt
Publication of BRPI0816767B8 publication Critical patent/BRPI0816767B8/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Diabetes (AREA)
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  • Obesity (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0816767A 2007-09-14 2008-09-12 composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos BRPI0816767B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07116390 2007-09-14
EP07116390.1 2007-09-14
PCT/EP2008/007551 WO2009033704A1 (en) 2007-09-14 2008-09-12 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones

Publications (3)

Publication Number Publication Date
BRPI0816767A2 true BRPI0816767A2 (pt) 2017-05-16
BRPI0816767B1 BRPI0816767B1 (pt) 2021-03-09
BRPI0816767B8 BRPI0816767B8 (pt) 2021-05-25

Family

ID=39930548

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816767A BRPI0816767B8 (pt) 2007-09-14 2008-09-12 composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos

Country Status (30)

Country Link
US (6) US9114138B2 (pt)
EP (1) EP2203439B1 (pt)
JP (1) JP5133416B2 (pt)
KR (2) KR101520086B1 (pt)
CN (2) CN103342695B (pt)
AR (1) AR068511A1 (pt)
AT (1) ATE496906T1 (pt)
AU (1) AU2008297878B2 (pt)
BR (1) BRPI0816767B8 (pt)
CA (1) CA2696948C (pt)
CL (1) CL2008002745A1 (pt)
CY (1) CY1111219T1 (pt)
DE (1) DE602008004794D1 (pt)
DK (1) DK2203439T3 (pt)
EA (1) EA017648B1 (pt)
ES (1) ES2356032T3 (pt)
HK (2) HK1143820A1 (pt)
HR (1) HRP20110278T1 (pt)
IL (2) IL204032A (pt)
MX (1) MX2010002536A (pt)
MY (1) MY152078A (pt)
NZ (1) NZ584145A (pt)
PL (1) PL2203439T3 (pt)
PT (1) PT2203439E (pt)
RS (1) RS51660B (pt)
SI (1) SI2203439T1 (pt)
TW (2) TWI475995B (pt)
UA (1) UA100126C2 (pt)
WO (1) WO2009033704A1 (pt)
ZA (1) ZA201001151B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CN101801930B (zh) 2007-09-14 2013-01-30 奥梅-杨森制药有限公司 1,3-二取代的-4-苯基-1h-吡啶-2-酮
BRPI0816767B8 (pt) 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
ES2637794T3 (es) 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
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