SE370449B
(pt)
|
1970-08-29 |
1974-10-14 |
Philips Nv |
|
JPS5334319B2
(pt)
|
1971-12-28 |
1978-09-20 |
|
|
JPS5717624B2
(pt)
|
1974-04-17 |
1982-04-12 |
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
US5126250A
(en)
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
JPH0341033A
(ja)
|
1989-07-07 |
1991-02-21 |
Kyowa Hakko Kogyo Co Ltd |
安定なモチリン類含有製剤
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
AU649952B2
(en)
|
1989-12-11 |
1994-06-09 |
Immunomedics Inc. |
Method for antibody targeting of diagnostic or therapeutic agents
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
TW212184B
(pt)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
ES2134212T3
(es)
|
1991-04-25 |
1999-10-01 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
US6027725A
(en)
|
1991-11-25 |
2000-02-22 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
EP0627932B1
(en)
|
1992-11-04 |
2002-05-08 |
City Of Hope |
Antibody construct
|
JP3720353B2
(ja)
|
1992-12-04 |
2005-11-24 |
メディカル リサーチ カウンシル |
多価および多重特異性の結合タンパク質、それらの製造および使用
|
ATE187494T1
(de)
|
1992-12-11 |
1999-12-15 |
Dow Chemical Co |
Multivalente einkettige antikörper
|
EP0660937A1
(en)
|
1993-07-01 |
1995-07-05 |
Dade International Inc. |
Process for the preparation of factor x depleted plasma
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
DE122009000068I2
(de)
|
1994-06-03 |
2011-06-16 |
Ascenion Gmbh |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
DK0771216T3
(da)
|
1994-07-11 |
2001-02-05 |
Scripps Research Inst |
Fremgangsmåder og præparater til specifik koagulering af tumorvaskulatur
|
AU3272695A
(en)
|
1994-08-12 |
1996-03-07 |
Immunomedics Inc. |
Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
|
US6451523B1
(en)
|
1994-09-14 |
2002-09-17 |
Interneuron Pharmaceuticals, Inc. |
Detection of a leptin receptor variant and methods for regulating obesity
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
AU700819B2
(en)
|
1994-10-07 |
1999-01-14 |
Chugai Seiyaku Kabushiki Kaisha |
Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
|
PL182089B1
(en)
|
1994-10-21 |
2001-11-30 |
Chugai Pharmaceutical Co Ltd |
Pharmaceutic compositions for treating diseases caused by production of il-6
|
AU4289496A
(en)
|
1994-12-02 |
1996-06-19 |
Chiron Corporation |
Method of promoting an immune response with a bispecific antibody
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
ES2152514T3
(es)
|
1995-02-28 |
2001-02-01 |
Procter & Gamble |
Preparacion de productos de bebidas no carbonatadas que tienen una estabilidad microbiana superior.
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
DE69636015T2
(de)
|
1995-05-03 |
2007-01-04 |
Bioenhancementsments Ltd. |
Bispezifische antikörper in denen die bindungsfähigkeit durch eine mittels licht spaltbare gruppe reversibel inhibiert wird
|
JP3946256B2
(ja)
|
1995-09-11 |
2007-07-18 |
協和醗酵工業株式会社 |
ヒトインターロイキン5受容体α鎖に対する抗体
|
JP2000503204A
(ja)
|
1996-01-08 |
2000-03-21 |
ジェネンテック インコーポレーテッド |
Wsxレセプター及びリガンド類
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
FR2745008A1
(fr)
|
1996-02-20 |
1997-08-22 |
Ass Pour Le Dev De La Rech En |
Recepteur nucleaire de glucocorticoides modifie, fragments d'adn codant pour ledit recepteur et procedes dans lesquels ils sont mis en oeuvre
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
AU720232B2
(en)
|
1996-07-19 |
2000-05-25 |
Amgen, Inc. |
Analogs of cationic proteins
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
US6323000B2
(en)
|
1996-12-20 |
2001-11-27 |
Clark A. Briggs |
Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
|
ES2300122T3
(es)
|
1997-03-20 |
2008-06-01 |
The Government Of The Usa As Represented By The Secretary Of Department Of Health And Human Services |
Anticuerpos recombinantes e inmunoconjugados dirigidos contra celulas y tumores portadores de cd-22.
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
US6183744B1
(en)
|
1997-03-24 |
2001-02-06 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
US6368596B1
(en)
|
1997-07-08 |
2002-04-09 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
AU750453B2
(en)
|
1997-10-03 |
2002-07-18 |
Chugai Seiyaku Kabushiki Kaisha |
Natural human antibody
|
ATE383875T1
(de)
|
1998-03-17 |
2008-02-15 |
Chugai Pharmaceutical Co Ltd |
Prophylaktische oder therapeutische mittel gegen entzündliche erkrankungen des verdauungstraktes enthaltend antagonistische il-6 rezeptor antikörper
|
BR9909382A
(pt)
|
1998-04-03 |
2000-12-05 |
Chugai Pharmaceutical Co Ltd |
Anticorpo humanizado contra o fator tissular humano (tf) e processo de produção de anticorpo humanizado
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
US7081360B2
(en)
|
1998-07-28 |
2006-07-25 |
Cadus Technologies, Inc. |
Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
|
EP1105427A2
(en)
|
1998-08-17 |
2001-06-13 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
WO2000018806A1
(de)
|
1998-09-25 |
2000-04-06 |
Horst Lindhofer |
Bispezifische und trispezifische antikörper, die spezifisch mit induzierbaren oberflächenantigenen als operationelle zielstrukturen reagieren
|
ATE477273T1
(de)
|
1998-12-01 |
2010-08-15 |
Facet Biotech Corp |
Humanisierte antikoerper gegen gamma-interferon
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
PL220113B1
(pl)
|
1999-01-15 |
2015-08-31 |
Genentech Inc |
Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
CO5280147A1
(es)
|
1999-05-18 |
2003-05-30 |
Smithkline Beecham Corp |
Anticuerpo humano monoclonal
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
US20020028178A1
(en)
|
2000-07-12 |
2002-03-07 |
Nabil Hanna |
Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
AU1290001A
(en)
|
1999-11-18 |
2001-05-30 |
Oxford Biomedica (Uk) Limited |
Antibodies
|
CA2390662A1
(en)
|
1999-12-14 |
2001-06-21 |
The Burnham Institute |
Bcl-g polypeptides, encoding nucleic acids and methods of use
|
AU2001256174A1
(en)
|
2000-03-01 |
2001-09-12 |
Christoph Gasche |
Mammalian interleukin-10 (il-10) receptor variants
|
TWI242043B
(en)
|
2000-03-10 |
2005-10-21 |
Chugai Pharmaceutical Co Ltd |
Polypeptide inducing apoptosis
|
AU4778101A
(en)
|
2000-03-22 |
2001-10-03 |
Curagen Corp |
Novel polypeptides, and nucleic acids encoding the same
|
CN1981868A
(zh)
|
2000-03-31 |
2007-06-20 |
拜奥根Idec公司 |
抗细胞因子抗体或拮抗剂与抗-cd20在b细胞淋巴瘤治疗中的联合应用
|
WO2001075454A2
(en)
|
2000-04-03 |
2001-10-11 |
Oxford Glycosciences (Uk) Ltd. |
Diagnosis and treatment of alzheimer's disease
|
WO2001079494A1
(fr)
|
2000-04-17 |
2001-10-25 |
Chugai Seiyaku Kabushiki Kaisha |
Anticorps agonistes
|
AU2001266272B2
(en)
|
2000-05-03 |
2005-09-15 |
Medigene Ag |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
JP2004511430A
(ja)
|
2000-05-24 |
2004-04-15 |
イムクローン システムズ インコーポレイティド |
二重特異性免疫グロブリン様抗原結合蛋白および製造方法
|
WO2001097858A2
(en)
|
2000-06-20 |
2001-12-27 |
Idec Pharmaceuticals Corporation |
Cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination
|
SG136804A1
(en)
|
2000-07-12 |
2007-11-29 |
Idec Pharma Corp |
Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
|
JP4908721B2
(ja)
|
2000-07-17 |
2012-04-04 |
中外製薬株式会社 |
生理活性を有するリガンドのスクリーニング方法
|
MXPA03002262A
(es)
|
2000-09-18 |
2003-10-15 |
Idec Pharma Corp |
Terapia de combinacion para tratamiento de enfermedades autoinmunes usando una combinacion de anticuerpos inmunorreguladores/supresores de celulas b.
|
PT1324776E
(pt)
|
2000-10-12 |
2009-12-23 |
Genentech Inc |
Formulações de proteína concentradas de viscosidade reduzida
|
EP1327680B1
(en)
|
2000-10-20 |
2008-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
Modified tpo agonist antibody
|
CA2424371A1
(en)
|
2000-10-20 |
2003-04-01 |
Chugai Seiyaku Kabushiki Kaisha |
Agonistic monoclonal antibody fragments
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
CN1308447C
(zh)
|
2000-10-20 |
2007-04-04 |
中外制药株式会社 |
低分子化的激动剂抗体
|
WO2002036165A1
(fr)
|
2000-10-27 |
2002-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Agent à base d'antagoniste d'il-6, faisant baisser le niveau des mmp-3 dans le sang
|
ES2727425T3
(es)
|
2000-12-12 |
2019-10-16 |
Medimmune Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
KR20090010127A
(ko)
|
2001-03-07 |
2009-01-28 |
메르크 파텐트 게엠베하 |
하이브리드 이소타입 항체 부분구조를 포함하는 단백질을 위한 발현 기술
|
AU2002307062A1
(en)
|
2001-04-02 |
2002-10-15 |
Purdue Pharma L.P. |
Thrombopoietin (tpo) synthebody for stimulation of platelet production
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
SK288124B6
(sk)
|
2001-04-13 |
2013-09-03 |
Biogen Idec Ma Inc. |
Anti-VLA-1 antibody, composition comprising such antibodies, isolated nucleic acids sequence, use of composition, in vitro method of determining level of VLA-1 in tissue, cell of cell line hAQC2, haAQC2, hsAQC2 or hybridoma mAQC2 and method for identifying inhibitor of I domain of integrin
|
JP4281869B2
(ja)
|
2001-06-22 |
2009-06-17 |
中外製薬株式会社 |
抗グリピカン3抗体を含む細胞増殖抑制剤
|
AU2002319402B2
(en)
|
2001-06-28 |
2008-09-11 |
Domantis Limited |
Dual-specific ligand and its use
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
BR0213303A
(pt)
|
2001-10-15 |
2005-06-07 |
Immunomedics Inc |
Proteìnas de ligação de alvejamento direto
|
WO2003035835A2
(en)
|
2001-10-25 |
2003-05-01 |
Genentech, Inc. |
Glycoprotein compositions
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
MXPA04007583A
(es)
|
2002-02-11 |
2005-04-25 |
Genentech Inc |
Variantes de anticuerpo con tasas mas rapidas de asociacion a antigeno.
|
US20040002587A1
(en)
|
2002-02-20 |
2004-01-01 |
Watkins Jeffry D. |
Fc region variants
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US7736652B2
(en)
|
2002-03-21 |
2010-06-15 |
The Regents Of The University Of California |
Antibody fusion proteins: effective adjuvants of protein vaccination
|
AU2003227504A1
(en)
|
2002-04-15 |
2003-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
DK1495055T3
(da)
|
2002-04-18 |
2013-11-11 |
Genencor Int |
Produktion af funktionelle antistoffer i filamentøse svampe
|
US7732149B2
(en)
|
2002-04-26 |
2010-06-08 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening agonistic antibodies
|
US20050130224A1
(en)
|
2002-05-31 |
2005-06-16 |
Celestar Lexico- Sciences, Inc. |
Interaction predicting device
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
WO2003104425A2
(en)
|
2002-06-07 |
2003-12-18 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Novel stable anti-cd22 antibodies
|
CA2488836A1
(en)
|
2002-06-12 |
2003-12-24 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
EP2366718A3
(en)
|
2002-06-28 |
2012-05-02 |
Domantis Limited |
Ligand
|
PT2314629E
(pt)
|
2002-07-18 |
2014-01-22 |
Merus B V |
Produção recombinante de misturas de anticorpos
|
CA2492524A1
(en)
|
2002-08-15 |
2004-02-26 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
AU2003257536A1
(en)
|
2002-08-27 |
2004-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Method of stabilizing protein solution preparation
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
EP1561759B9
(en)
|
2002-10-11 |
2009-08-26 |
Chugai Seiyaku Kabushiki Kaisha |
Cell death-inducing agent
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
GB0224082D0
(en)
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
EP2330130B1
(en)
|
2002-10-17 |
2014-08-27 |
Genmab A/S |
Human monoclonal antibodies against CD20
|
NZ540730A
(en)
|
2002-12-24 |
2010-09-30 |
Rinat Neuroscience Corp |
Anti-NGF antibodies and methods using same
|
WO2004060919A1
(ja)
|
2002-12-26 |
2004-07-22 |
Chugai Seiyaku Kabushiki Kaisha |
ヘテロ受容体に対するアゴニスト抗体
|
US8337841B2
(en)
|
2003-01-21 |
2012-12-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening for antibody light chains
|
US7223393B2
(en)
|
2003-02-07 |
2007-05-29 |
Pdl Biopharma, Inc |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
EP1598074B1
(en)
|
2003-02-28 |
2019-01-02 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilized protein-containing formulations
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
JP4739954B2
(ja)
|
2003-03-13 |
2011-08-03 |
中外製薬株式会社 |
変異受容体に対するアゴニスト活性を有するリガンド
|
US20070003556A1
(en)
|
2003-03-31 |
2007-01-04 |
Masayuki Tsuchiya |
Modified antibodies against cd22 and utilization thereof
|
JP2004321100A
(ja)
*
|
2003-04-25 |
2004-11-18 |
Rikogaku Shinkokai |
IgGのFc領域を含むタンパク質の変異体
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
EP2395017A3
(en)
|
2003-05-30 |
2012-12-19 |
Merus B.V. |
Design and use of paired variable regions of specific binding molecules
|
EP1629001A2
(en)
|
2003-06-05 |
2006-03-01 |
Genentech, Inc. |
Blys antagonists and uses thereof
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
EP1636264A2
(en)
|
2003-06-24 |
2006-03-22 |
MERCK PATENT GmbH |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
EP1644416A4
(en)
|
2003-06-30 |
2007-08-29 |
Centocor Inc |
ANTI-TARGET AND GENETICALLY MODIFIED IMMUNOGLOBULIN-DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
WO2005035753A1
(ja)
|
2003-10-10 |
2005-04-21 |
Chugai Seiyaku Kabushiki Kaisha |
機能蛋白質を代替する二重特異性抗体
|
EP2311945A1
(en)
|
2003-10-14 |
2011-04-20 |
Chugai Seiyaku Kabushiki Kaisha |
Bispecific antibodies substituting for functional proteins
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
US20050142133A1
(en)
|
2003-12-03 |
2005-06-30 |
Xencor, Inc. |
Optimized proteins that target the epidermal growth factor receptor
|
EP1711207B1
(en)
|
2003-12-10 |
2012-11-28 |
Medarex, Inc. |
Interferon alpha antibodies and their uses
|
KR20130133302A
(ko)
|
2003-12-10 |
2013-12-06 |
메다렉스, 인코포레이티드 |
Ip―10 항체 및 그의 용도
|
EP1710255A4
(en)
|
2003-12-12 |
2008-09-24 |
Chugai Pharmaceutical Co Ltd |
MODIFIED ANTIBODIES RECOGNIZING A TRIMER OR LARGER RECEPTOR
|
TW200530269A
(en)
|
2003-12-12 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Anti-Mpl antibodies
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
WO2005062916A2
(en)
|
2003-12-22 |
2005-07-14 |
Centocor, Inc. |
Methods for generating multimeric molecules
|
UA93027C2
(ru)
|
2003-12-25 |
2011-01-10 |
Киова Хакко Кирин Ко., Лимитед |
Мутантное антитело, которое специфически связывается с cd40
|
DE602004013372T2
(de)
|
2003-12-30 |
2009-07-02 |
Merck Patent Gmbh |
Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
CA2552523C
(en)
|
2004-01-09 |
2019-11-26 |
Pfizer Inc. |
Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam)
|
AU2005227326B2
(en)
|
2004-03-24 |
2009-12-03 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
TW200605906A
(en)
|
2004-05-11 |
2006-02-16 |
Chugai Pharmaceutical Co Ltd |
Remedy for thrombopenia
|
AU2005250499B2
(en)
|
2004-06-03 |
2011-12-08 |
Novimmune S.A. |
Anti-CD3 antibodies and methods of use thereof
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
AU2005259992A1
(en)
|
2004-06-25 |
2006-01-12 |
Medimmune, Llc |
Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis
|
PL1674111T3
(pl)
|
2004-07-09 |
2011-04-29 |
Chugai Pharmaceutical Co Ltd |
Przeciwciała anty-glipikan 3
|
EP1919950A1
(en)
|
2004-07-15 |
2008-05-14 |
Xencor, Inc. |
Optimized fc variants
|
WO2006020114A2
(en)
|
2004-08-04 |
2006-02-23 |
Applied Molecular Evolution, Inc. |
Variant fc regions
|
CA2577082A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
MX2007002883A
(es)
|
2004-09-13 |
2007-06-15 |
Macrogenics Inc |
Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo.
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
CA2580319A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
WO2006033386A1
(ja)
|
2004-09-22 |
2006-03-30 |
Kirin Beer Kabushiki Kaisha |
安定化されたヒトIgG4抗体
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
CA2584211C
(en)
|
2004-10-22 |
2014-07-08 |
Amgen Inc. |
Methods for refolding of recombinant antibodies
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
AU2005317279C1
(en)
|
2004-12-14 |
2014-07-17 |
Cytiva Bioprocess R&D Ab |
Purification of immunoglobulins
|
WO2006067847A1
(ja)
|
2004-12-22 |
2006-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
CA2592015A1
(en)
|
2004-12-27 |
2006-07-06 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
HUE026107T2
(en)
|
2004-12-28 |
2016-05-30 |
Innate Pharma |
Monoclonal antibody to NKG2A
|
CA2595169A1
(en)
|
2005-01-12 |
2006-07-20 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
US8716451B2
(en)
|
2005-01-12 |
2014-05-06 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human IgG2 and IgG3 antibodies
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
EP1870458B1
(en)
|
2005-03-31 |
2018-05-09 |
Chugai Seiyaku Kabushiki Kaisha |
sc(Fv)2 STRUCTURAL ISOMERS
|
DK3050963T3
(da)
|
2005-03-31 |
2019-12-09 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåde til fremstilling af polypeptid ved regulering af arrangement
|
EP1871808A2
(en)
|
2005-03-31 |
2008-01-02 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
EP1876236B9
(en)
|
2005-04-08 |
2015-02-25 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody substituting for function of blood coagulation factor viii
|
SG161281A1
(en)
|
2005-04-15 |
2010-05-27 |
Genentech Inc |
Hgf beta chain variants
|
JP5255435B2
(ja)
|
2005-04-26 |
2013-08-07 |
メディミューン,エルエルシー |
ヒンジドメイン操作による抗体エフェクター機能の調節
|
EP2221316A1
(en)
|
2005-05-05 |
2010-08-25 |
Duke University |
Anti-CD19 antibody therapy for autoimmune disease
|
AU2006256041B2
(en)
|
2005-06-10 |
2012-03-29 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
EP3348639A3
(en)
|
2005-06-10 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Sc(fv)2 site-directed mutant
|
CA2613512A1
(en)
|
2005-06-23 |
2007-01-04 |
Medimmune, Inc. |
Antibody formulations having optimized aggregation and fragmentation profiles
|
CN101627054A
(zh)
|
2005-07-11 |
2010-01-13 |
马克罗基因公司 |
用人源化抗cd16a抗体治疗自身免疫疾病的方法
|
WO2007021841A2
(en)
|
2005-08-10 |
2007-02-22 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
PL2407486T3
(pl)
|
2005-08-19 |
2018-05-30 |
Wyeth Llc |
Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
|
JP2009510102A
(ja)
|
2005-09-29 |
2009-03-12 |
ヴァイラル ロジック システムズ テクノロジー コーポレーション |
免疫調節組成物およびその使用
|
RU2446826C2
(ru)
|
2005-10-14 |
2012-04-10 |
Фукуока Юниверсити |
Агенты для подавления повреждения трансплантированных островков после трансплантации островков
|
EP1941908B1
(en)
|
2005-10-21 |
2015-08-19 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agent for heart disease
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
EP1820513A1
(en)
|
2006-02-15 |
2007-08-22 |
Trion Pharma Gmbh |
Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
JP4294082B2
(ja)
|
2006-03-23 |
2009-07-08 |
協和発酵キリン株式会社 |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
EP1999154B1
(en)
|
2006-03-24 |
2012-10-24 |
Merck Patent GmbH |
Engineered heterodimeric protein domains
|
EP3345616A1
(en)
|
2006-03-31 |
2018-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
US11046784B2
(en)
|
2006-03-31 |
2021-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
EP2025346B1
(en)
|
2006-04-07 |
2016-08-10 |
Osaka University |
Muscle regeneration promoter
|
EP2374818B1
(en)
|
2006-06-02 |
2012-12-19 |
Regeneron Pharmaceuticals, Inc. |
High affinity antibodies to human IL-6 receptor
|
JP2009539841A
(ja)
|
2006-06-06 |
2009-11-19 |
トラークス,インコーポレイテッド |
自己免疫疾患の治療における抗cd3抗体の投与
|
CL2007001665A1
(es)
|
2006-06-08 |
2008-01-18 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo o fragmento del mismo con actividad neutralizante de la proteina nr 10; agente que lo comprende; y su uso para prevenir o tratar una enfermedad inflamatoria.
|
JP2009541275A
(ja)
|
2006-06-22 |
2009-11-26 |
ノボ・ノルデイスク・エー/エス |
二重特異性抗体の生産
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
JPWO2008090960A1
(ja)
|
2007-01-24 |
2010-05-20 |
協和発酵キリン株式会社 |
ガングリオシドgm2に特異的に結合する遺伝子組換え抗体組成物
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
CN101802015B
(zh)
|
2007-03-29 |
2015-05-06 |
根马布股份公司 |
双特异性抗体及其制造方法
|
EP4119579A1
(en)
|
2007-05-31 |
2023-01-18 |
Genmab A/S |
Stable igg4 antibodies
|
US20100291023A1
(en)
|
2007-05-31 |
2010-11-18 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
CN101802011A
(zh)
|
2007-06-29 |
2010-08-11 |
先灵公司 |
Mdl-1应用
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
CA2698809C
(en)
|
2007-09-14 |
2023-10-17 |
Amgen Inc. |
Homogeneous antibody populations
|
CA2700394C
(en)
|
2007-09-26 |
2017-10-24 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant region
|
WO2009041621A1
(ja)
|
2007-09-26 |
2009-04-02 |
Chugai Seiyaku Kabushiki Kaisha |
抗il-6レセプター抗体
|
MX369784B
(es)
|
2007-09-26 |
2019-11-21 |
Chugai Pharmaceutical Co Ltd |
Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
DK2196541T3
(da)
|
2007-09-28 |
2012-11-26 |
Chugai Pharmaceutical Co Ltd |
Anti-glypican-3-antistof med forbedret kinetik i plasmaet
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
ES2400107T3
(es)
|
2007-10-22 |
2013-04-05 |
Merck Serono S.A. |
IFN-beta sencillo fusionado a un fragmento Fc de lgG mutado
|
AU2008332271C1
(en)
|
2007-12-05 |
2014-04-24 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-NR10 antibody and use thereof
|
CA2706502C
(en)
|
2007-12-18 |
2018-08-07 |
Bioalliance C.V. |
Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
US20110059078A1
(en)
|
2008-02-08 |
2011-03-10 |
Medimmune, Llc |
Anti-ifnar1 antibodies with reduced fc ligand affinity
|
EP2274008B1
(en)
|
2008-03-27 |
2014-02-26 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting pdgfrbeta and vegf-a
|
CN107551270A
(zh)
|
2008-04-11 |
2018-01-09 |
中外制药株式会社 |
与多个分子的抗原反复结合的抗原结合分子
|
MX2010011955A
(es)
|
2008-04-29 |
2011-01-21 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
MX2010011717A
(es)
|
2008-05-01 |
2010-11-30 |
Amgen Inc |
Anticuerpos anti-hepcidina y metodos de uso.
|
BRPI0919382A2
(pt)
|
2008-09-26 |
2016-01-05 |
Roche Glycart Ag |
anticorpos bi-específicos anti-egfr/anti-igf-1r
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
BRPI0920572A8
(pt)
*
|
2008-10-20 |
2015-10-27 |
Abbott Lab |
Inativação viral durante a purificação dos anticorpos
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
DE202008016028U1
(de)
|
2008-12-04 |
2010-04-15 |
Melitta Haushaltsprodukte Gmbh & Co. Kg |
Behälter zur Aufbewahrung von Gegenständen
|
CN102272145B
(zh)
|
2009-01-12 |
2014-07-30 |
通用电气健康护理生物科学股份公司 |
亲和色谱基质
|
CA2750533A1
(en)
|
2009-01-23 |
2010-07-29 |
Biogen Idec Ma Inc. |
Stabilized fc polypeptides with reduced effector function and methods of use
|
JP5836807B2
(ja)
|
2009-03-05 |
2015-12-24 |
アッヴィ・インコーポレイテッド |
Il−17結合タンパク質
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
TWI646193B
(zh)
|
2009-03-19 |
2019-01-01 |
中外製藥股份有限公司 |
抗體恆定區域改變體
|
WO2010107110A1
(ja)
|
2009-03-19 |
2010-09-23 |
中外製薬株式会社 |
抗体定常領域改変体
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
PE20120878A1
(es)
|
2009-04-01 |
2012-08-06 |
Genentech Inc |
ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS
|
BRPI1010297A2
(pt)
|
2009-04-07 |
2017-06-06 |
Roche Glycart Ag |
anticorpos biespecíficos trivalentes.
|
EP2424567B1
(en)
|
2009-04-27 |
2018-11-21 |
OncoMed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
KR101747103B1
(ko)
|
2009-06-26 |
2017-06-14 |
리제너론 파마슈티칼스 인코포레이티드 |
천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
US10053513B2
(en)
|
2009-11-30 |
2018-08-21 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
KR101856792B1
(ko)
|
2009-12-25 |
2018-05-11 |
추가이 세이야쿠 가부시키가이샤 |
폴리펩티드 다량체를 정제하기 위한 폴리펩티드의 개변방법
|
US20130089554A1
(en)
|
2009-12-29 |
2013-04-11 |
Emergent Product Development Seattle, Llc |
RON Binding Constructs and Methods of Use Thereof
|
TWI505838B
(zh)
|
2010-01-20 |
2015-11-01 |
Chugai Pharmaceutical Co Ltd |
Stabilized antibody solution containing
|
EP2525822B1
(en)
|
2010-01-20 |
2017-05-10 |
Merck Sharp & Dohme Corp. |
Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
|
EP2525813B1
(en)
|
2010-01-20 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Anti-ilt5 antibodies and ilt5-binding antibody fragments
|
ES2602971T3
(es)
|
2010-03-02 |
2017-02-23 |
Kyowa Hakko Kirin Co., Ltd. |
Composición de anticuerpo modificado
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
KR20150002894A
(ko)
|
2010-03-11 |
2015-01-07 |
리나트 뉴로사이언스 코프. |
pH 의존성 항원 결합을 갖는 항체
|
WO2011125674A1
(ja)
*
|
2010-03-31 |
2011-10-13 |
Jsr株式会社 |
アフィニティークロマトグラフィー用充填剤
|
SG10201800757TA
(en)
|
2010-04-20 |
2018-02-27 |
Genmab As |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
TWI586806B
(zh)
|
2010-04-23 |
2017-06-11 |
建南德克公司 |
異多聚體蛋白質之製造
|
CA2797981C
(en)
|
2010-05-14 |
2019-04-23 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
JP6320753B2
(ja)
|
2010-05-27 |
2018-05-09 |
ゲンマブ エー/エス |
Her2に対するモノクローナル抗体
|
AU2011283694B2
(en)
|
2010-07-29 |
2017-04-13 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
JP2013537416A
(ja)
|
2010-08-13 |
2013-10-03 |
メディミューン リミテッド |
変異型Fc領域を含むモノマーポリペプチド及び使用方法
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
RU2620071C2
(ru)
|
2010-11-17 |
2017-05-22 |
Чугаи Сеияку Кабушики Каиша |
Мультиспецифическая связывающая антиген молекула, которая обладает альтернативной функцией к функции фактора свертывания крови viii
|
JP6278598B2
(ja)
|
2010-11-30 |
2018-02-14 |
中外製薬株式会社 |
細胞傷害誘導治療剤
|
AU2012233313C1
(en)
|
2011-03-30 |
2017-08-03 |
Chugai Seiyaku Kabushiki Kaisha |
Method for altering plasma retention and immunogenicity of antigen-binding molecule
|
EP2699263A4
(en)
|
2011-04-20 |
2014-12-24 |
Liquidating Trust |
METHOD FOR REDUCING AN UNWANTED IMMUNE RESPONSE TO A FOREIGN-LIKE IN A HUMAN PATIENT WITH ANTI-CD4 ANTIBODIES OR CD4-BINDING FRAGMENTS THEREOF OR CD4-BINDING MOLECULES
|
SG10201805291TA
(en)
|
2011-10-27 |
2018-08-30 |
Genmab As |
Production of heterodimeric proteins
|
KR102168733B1
(ko)
|
2011-10-31 |
2020-10-23 |
추가이 세이야쿠 가부시키가이샤 |
중쇄와 경쇄의 회합이 제어된 항원 결합 분자
|
CA2854233C
(en)
|
2011-11-04 |
2020-05-12 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
WO2014067011A1
(en)
|
2012-11-02 |
2014-05-08 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
CA2860543C
(en)
|
2012-03-08 |
2018-04-24 |
F. Hoffmann-La Roche Ag |
Abeta antibody formulation
|
ES2728301T3
(es)
|
2012-03-13 |
2019-10-23 |
Novimmune Sa |
Anticuerpos biespecíficos fácilmente aislados con formato de inmunoglobulina nativa
|
WO2013147153A1
(ja)
|
2012-03-29 |
2013-10-03 |
株式会社未来創薬研究所 |
抗lamp5抗体およびその利用
|
MX360109B
(es)
|
2012-04-20 |
2018-10-23 |
Merus Nv |
Metodos y medios para la produccion de moleculas de tipo ig.
|
US20140154270A1
(en)
*
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
EA028244B1
(ru)
|
2012-08-13 |
2017-10-31 |
Ридженерон Фармасьютикалз, Инк. |
АНТИТЕЛА К PCSK9 C pH-ЗАВИСИМЫМИ ХАРАКТЕРИСТИКАМИ СВЯЗЫВАНИЯ
|
US20150297820A1
(en)
*
|
2012-09-10 |
2015-10-22 |
Kaneka Corporation |
Adsorbent
|
US9714291B2
(en)
|
2012-10-05 |
2017-07-25 |
Kyowa Hakko Kirin Co., Ltd |
Heterodimer protein composition
|
JP6449229B2
(ja)
|
2013-03-15 |
2019-01-09 |
アッヴィ・バイオセラピューティクス・インコーポレイテッド |
Fc変異体
|
US11124576B2
(en)
|
2013-09-27 |
2021-09-21 |
Chungai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
CA2929256C
(en)
*
|
2013-11-04 |
2022-04-26 |
Glenmark Pharmaceuticals S.A. |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
TWI831106B
(zh)
|
2014-06-20 |
2024-02-01 |
日商中外製藥股份有限公司 |
用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
|
AR101262A1
(es)
*
|
2014-07-26 |
2016-12-07 |
Regeneron Pharma |
Plataforma de purificación para anticuerpos biespecíficos
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
SG10201907215QA
(en)
|
2015-02-05 |
2019-09-27 |
Chugai Pharmaceutical Co Ltd |
Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof
|
EP3279216A4
(en)
|
2015-04-01 |
2019-06-19 |
Chugai Seiyaku Kabushiki Kaisha |
PROCESS FOR PREPARING POLYPEPTIDE HETERO OLIGOMER
|
JP6962819B2
(ja)
|
2015-04-10 |
2021-11-05 |
アディマブ, エルエルシー |
親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法
|
CN107454906B
(zh)
|
2015-04-17 |
2022-05-27 |
豪夫迈·罗氏有限公司 |
使用凝固因子和多特异性抗体的联合治疗
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物
|
CA3004288A1
(en)
|
2015-12-28 |
2017-07-06 |
Nobuyuki Tanaka |
Method for promoting efficiency of purification of fc region-containing polypeptide
|
TWI797073B
(zh)
|
2016-01-25 |
2023-04-01 |
德商安美基研究(慕尼黑)公司 |
包含雙特異性抗體建構物之醫藥組合物
|
TW202402326A
(zh)
|
2016-04-28 |
2024-01-16 |
日商中外製藥股份有限公司 |
含抗體製劑
|
US20210107994A1
(en)
|
2017-03-31 |
2021-04-15 |
Public University Corporation Nara Medical University |
Medicinal composition usable for preventing and/or treating blood coagulation factor ix abnormality, comprising multispecific antigen binding molecule replacing function of blood coagulation factor viii
|
WO2018203567A1
(en)
|
2017-05-02 |
2018-11-08 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
US10246642B2
(en)
|
2017-08-25 |
2019-04-02 |
Saudi Arabian Oil Company |
Process to produce blown asphalt
|
AR113142A1
(es)
|
2017-09-29 |
2020-01-29 |
Chugai Pharmaceutical Co Ltd |
Moléculas de unión al antígeno multiespecíficas que tienen actividad de sustitución de la función de cofactor del factor viii de coagulación de sangre (fviii), y formulaciones farmacéuticas que contienen dicha molécula como ingrediente activo
|
PE20210553A1
(es)
|
2017-11-01 |
2021-03-17 |
Chugai Pharmaceutical Co Ltd |
Variantes e isoformas de anticuerpos con actividad biologica reducida
|
JOP20200292A1
(ar)
|
2018-05-16 |
2020-11-15 |
Stichting Vumc |
Bcma / cd3 و gprdc5d / cd3 مضادات غير محددة للاستخدام في علاج السرطان
|
WO2021201202A1
(ja)
|
2020-04-02 |
2021-10-07 |
中外製薬株式会社 |
多重特異性抗原結合分子を含む組成物における不純物分子の分析方法
|