BR112015023207A2 - uso de c1-inh no tratamento de desordens associadas à deficiência de inibidor de c1 esterase - Google Patents

uso de c1-inh no tratamento de desordens associadas à deficiência de inibidor de c1 esterase

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Publication number
BR112015023207A2
BR112015023207A2 BR112015023207A BR112015023207A BR112015023207A2 BR 112015023207 A2 BR112015023207 A2 BR 112015023207A2 BR 112015023207 A BR112015023207 A BR 112015023207A BR 112015023207 A BR112015023207 A BR 112015023207A BR 112015023207 A2 BR112015023207 A2 BR 112015023207A2
Authority
BR
Brazil
Prior art keywords
inh
esterase inhibitor
disorders associated
inhibitor deficiency
treating disorders
Prior art date
Application number
BR112015023207A
Other languages
English (en)
Other versions
BR112015023207A8 (pt
Inventor
Gallagher Cynthia
Cornell Manning Mark
Ruddy Steven
Original Assignee
Shire Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51538486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015023207(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Viropharma Inc filed Critical Shire Viropharma Inc
Publication of BR112015023207A2 publication Critical patent/BR112015023207A2/pt
Publication of BR112015023207A8 publication Critical patent/BR112015023207A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo composições de cl-inh e métodos para prevenção e tratamento de desordens associadas à deficiência de inibidor de c1 esterase composições e métodos para o tratamento e/ou prevenção de desordens associadas a deficiência de inibidor de c1 esterase são divulgados.
BR112015023207A 2013-03-15 2014-03-17 composições de ci-inh e métodos para prevenção e tratamento de desordens associadas à deficiência de inibidor de c1 esterase. BR112015023207A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791399P 2013-03-15 2013-03-15
PCT/US2014/030309 WO2014145519A2 (en) 2013-03-15 2014-03-17 C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency

Publications (2)

Publication Number Publication Date
BR112015023207A2 true BR112015023207A2 (pt) 2017-11-21
BR112015023207A8 BR112015023207A8 (pt) 2018-01-23

Family

ID=51538486

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023207A BR112015023207A8 (pt) 2013-03-15 2014-03-17 composições de ci-inh e métodos para prevenção e tratamento de desordens associadas à deficiência de inibidor de c1 esterase.

Country Status (30)

Country Link
US (9) US9616111B2 (pt)
EP (3) EP2968434B1 (pt)
JP (9) JP6184581B2 (pt)
KR (4) KR102579789B1 (pt)
CN (2) CN105517559A (pt)
AU (3) AU2014232912A1 (pt)
BR (1) BR112015023207A8 (pt)
CA (2) CA3054718A1 (pt)
CY (2) CY1119419T1 (pt)
DE (1) DE202014011208U1 (pt)
DK (2) DK2968434T3 (pt)
EA (1) EA201591278A1 (pt)
ES (2) ES2639833T3 (pt)
GB (1) GB2530921B (pt)
HK (2) HK1220403A1 (pt)
HR (2) HRP20171269T1 (pt)
HU (2) HUE036224T2 (pt)
IL (2) IL241549B (pt)
LT (2) LT2968434T (pt)
ME (2) ME03326B (pt)
MX (3) MX2015011281A (pt)
NZ (2) NZ710730A (pt)
PL (2) PL2968434T3 (pt)
PT (2) PT2968434T (pt)
RS (2) RS56285B1 (pt)
SG (2) SG10201707598QA (pt)
SI (2) SI3290046T1 (pt)
TR (1) TR201900319T4 (pt)
WO (1) WO2014145519A2 (pt)
ZA (3) ZA201507604B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME03326B (me) 2013-03-15 2019-10-20 Shire Viropharma Inc C1-inh kompozicije i postupci za prevenciju i liječenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze
HUE041809T2 (hu) * 2013-11-22 2019-05-28 Shire Viropharma Inc Eljárások antitest által közvetített kilökõdés kezelésére szervbeültetéses páciensekben C1-észteráz inhibitorral
CA2977090A1 (en) * 2015-02-20 2016-08-25 Wolfram Schaefer Pharmaceutical formulations of c1 esterase inhibitor
CN113999875A (zh) * 2015-05-28 2022-02-01 康奈尔大学 腺相关病毒介导的c1ei递送作为用于血管性水肿的疗法
ES2927271T3 (es) * 2015-11-19 2022-11-03 Takeda Pharmaceuticals Co Inhibidor de esterasa C1 humana recombinante y usos del mismo
US20190175683A1 (en) 2016-08-05 2019-06-13 Csl Behring Gmbh Pharmaceutical formulations of c1 esterase inhibitor
AU2017316513A1 (en) * 2016-08-23 2019-03-28 Csl Behring Gmbh Method of preventing acute attacks of hereditary angioedema associated with C1 esterase inhibitor deficiency
EP3624833A1 (en) * 2017-05-16 2020-03-25 Octapharma AG C1-esterase inhibitor preparation
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
MA52121A (fr) 2018-02-28 2021-06-02 Pharming Intellectual Property Bv Traitement et prévention de pré-éclampsie
JP6999809B2 (ja) 2018-06-22 2022-02-04 株式会社Junten Bio 免疫寛容を誘導する抗体、誘導されたリンパ球、また誘導されたリンパ球を用いる細胞治療剤治療法
JPWO2019245039A1 (ja) 2018-06-22 2021-06-24 株式会社Ｊｕｎｔｅｎ Ｂｉｏ 感染性免疫寛容を惹起するための組成物
EP3811952A4 (en) 2018-06-22 2022-06-01 JUNTEN BIO Co., Ltd. IMMUNTOLERANCE-INDUCING ANTIBODIES PRODUCED USING A COMPLEX CONDITION CELL MIXTURE AND INDUCED LYMPHOCYTE OR CELL THERAPEUTIC MEDICATION AND CELL THERAPY METHODS EACH USING THE INDUCED LYMPHOCYTE
EP4079325A1 (en) * 2019-12-16 2022-10-26 Nipro Corporation Aggregation inhibitory agent and medical composition and medical device including same
EP3895726A1 (en) 2020-04-17 2021-10-20 Pharming Intellectual Property BV Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress
EP4366761A1 (en) 2021-07-09 2024-05-15 Pharming Intellectual Property B.V. Using c1 esterase inhibitor to treat viral infection-related symptoms
KR20230046146A (ko) 2021-09-29 2023-04-05 주식회사 엘지에너지솔루션 배터리 제어 시스템 및 방법

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304482A (en) 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
WO1992022320A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. C1 inhibitor variants and treating inflammatory response with c1 inhibitor
US6090777A (en) * 1993-09-01 2000-07-18 Stiching Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method to reduce myocardial injury during acute myocardial infarction
AU1042597A (en) 1995-12-18 1997-07-14 Stichting Sanquin Bloedvoorziening Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.
AT409336B (de) 1999-12-22 2002-07-25 Baxter Ag Verfahren zur herstellung einer c1-esterase-inhibitor (c1-inh)-hältigen zusammensetzung
JP2003521914A (ja) 2000-01-31 2003-07-22 ファーミング インテレクチュアル プロパティー ベー．フェー． トランスジェニック哺乳動物の乳汁に産生されるｃ１インヒビター
US7067713B2 (en) 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
JP4340062B2 (ja) 2000-10-12 2009-10-07 ジェネンテック・インコーポレーテッド 粘度の減少した濃縮タンパク質製剤
DE10112617A1 (de) 2001-03-14 2002-10-02 Aventis Behring Gmbh Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren
WO2004034971A2 (en) 2002-09-25 2004-04-29 The Center For Blood Research, Inc. Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof
WO2004110356A2 (en) 2003-05-15 2004-12-23 Cbr Institute For Biomedical Research, Inc. Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity
SI1626736T1 (sl) 2003-05-16 2021-04-30 Pharming Intellectual Property B.V. C1 inhibitor s kratko razpolovno dobo za prehodno zdravljenje
US20060233776A1 (en) 2003-08-19 2006-10-19 Norbert Heimburger C1-inh as a drug for treating viruses pathogenic to humans
US8501705B2 (en) 2003-09-11 2013-08-06 The Board Of Regents Of The University Of Texas System Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
US8652477B2 (en) 2009-10-16 2014-02-18 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting MASP-2 dependent complement activation
EP2529746A1 (en) 2005-06-06 2012-12-05 Girish J. Kotwal Methods for treatment or prophylaxis of reperfusion injury
EP1940457B1 (en) 2005-10-21 2012-12-12 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
SI2380587T1 (en) 2005-12-21 2018-03-30 Pharming Intellectual Property B.V. Use of a C1 inhibitor to prevent ischemic reperfusion injury
PT2380587T (pt) * 2005-12-21 2018-01-19 Pharming Intellectual Property B V Resumo
US7837992B2 (en) 2006-06-22 2010-11-23 Beth Israel Deaconess Medical Center C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis
EP2526962B1 (en) 2007-02-12 2019-08-14 CSL Behring GmbH Therapeutic application of Kazal-type serine protease inhibitors
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US8420081B2 (en) 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
US20100143325A1 (en) 2008-12-09 2010-06-10 Vascular Laboratory, Inc. Composition And Methods Involving Thrombolytic Agents
EP2453906A4 (en) 2009-07-02 2014-01-15 Musc Found For Res Dev METHOD FOR STIMULATING THE LIVER REGENERATION
AU2011222883B2 (en) 2010-03-05 2016-05-26 Omeros Corporation Chimeric inhibitor molecules of complement activation
WO2011116291A1 (en) * 2010-03-18 2011-09-22 Thrombolytic Science International Production of human c1 inhibitor in human cells
WO2013013017A2 (en) * 2011-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Compositions and methods for modifying the glycosylation of lysosomal storage disorder therapeutics
KR101956585B1 (ko) 2011-09-24 2019-03-11 체에스엘 베링 게엠베하 면역글로불린과 ｃ1-억제제를 사용하는 병용 치료요법
US9452203B2 (en) 2011-12-22 2016-09-27 Csl Behring Gmbh Use of C1-inhibitor for the treatment of secondary edema of the central nervous system
WO2013138731A1 (en) 2012-03-16 2013-09-19 Enzon Pharmaceuticals, Inc. Polymeric conjugates of c1-inhibitors
AU2014243704A1 (en) 2013-03-13 2015-09-10 Creatics Llc Methods and compositions for detecting pancreatic cancer
ME03326B (me) 2013-03-15 2019-10-20 Shire Viropharma Inc C1-inh kompozicije i postupci za prevenciju i liječenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze

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JP2018119002A (ja) 2018-08-02
JP2018119001A (ja) 2018-08-02
JP6473535B2 (ja) 2019-02-20
CN105517559A (zh) 2016-04-20
PL3290046T3 (pl) 2019-05-31
JP6184581B2 (ja) 2017-08-23
WO2014145519A2 (en) 2014-09-18
EP3508213A1 (en) 2019-07-10
KR20150135242A (ko) 2015-12-02
JP2019073544A (ja) 2019-05-16
TR201900319T4 (tr) 2019-02-21
KR20210129267A (ko) 2021-10-27
ZA201507604B (en) 2018-05-30
US20180110844A1 (en) 2018-04-26
IL276153B (en) 2022-06-01
KR20220070049A (ko) 2022-05-27
RS58351B1 (sr) 2019-03-29
JP2018119000A (ja) 2018-08-02
NZ751555A (en) 2021-07-30
EP2968434B1 (en) 2017-06-28
JP2019073545A (ja) 2019-05-16
LT3290046T (lt) 2019-03-12
IL276153A (en) 2020-09-30
JP6422520B2 (ja) 2018-11-14
KR102430453B1 (ko) 2022-08-05
MX2020004724A (es) 2022-01-18
DK2968434T3 (en) 2017-09-11
US20170224788A1 (en) 2017-08-10
GB201519921D0 (en) 2015-12-23
ES2713004T3 (es) 2019-05-17
HUE041837T2 (hu) 2019-05-28
CY1119419T1 (el) 2018-03-07
ZA201706929B (en) 2019-05-29
HRP20190270T1 (hr) 2019-04-05
DK3290046T3 (en) 2019-03-18
US10105423B2 (en) 2018-10-23
JP2016516073A (ja) 2016-06-02
SG10201707598QA (en) 2017-10-30
NZ710730A (en) 2021-07-30
US10130690B2 (en) 2018-11-20
CA2904543A1 (en) 2014-09-18
SI2968434T1 (sl) 2017-11-30
JP6877471B2 (ja) 2021-05-26
JP2021088599A (ja) 2021-06-10
US20180153972A1 (en) 2018-06-07
WO2014145519A3 (en) 2014-12-31
PT2968434T (pt) 2017-09-18
PL2968434T3 (pl) 2018-01-31
US20180085441A1 (en) 2018-03-29
EP3290046B1 (en) 2019-01-02
EA201591278A1 (ru) 2016-03-31
HRP20171269T1 (hr) 2017-11-03
JP6473534B2 (ja) 2019-02-20
US20200261556A1 (en) 2020-08-20
MX2021011946A (es) 2021-11-17
CN111529708A (zh) 2020-08-14
JP6877470B2 (ja) 2021-05-26
SI3290046T1 (sl) 2019-04-30
IL241549B (en) 2020-08-31
US20190160158A1 (en) 2019-05-30
AU2014232912A1 (en) 2015-09-03
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EP2968434A4 (en) 2016-03-02
US9616111B2 (en) 2017-04-11
KR102579789B1 (ko) 2023-09-15
CA3054718A1 (en) 2014-09-18
SG11201507616VA (en) 2015-10-29
CY1121653T1 (el) 2020-07-31
JP2019073546A (ja) 2019-05-16
AU2018229558A1 (en) 2018-10-04
KR20210021146A (ko) 2021-02-24
US11364288B2 (en) 2022-06-21
RS56285B1 (sr) 2017-12-29
US10201595B2 (en) 2019-02-12
US20180110843A1 (en) 2018-04-26
MX2015011281A (es) 2016-03-03
GB2530921B (en) 2017-09-20
ZA201806793B (en) 2020-01-29
DE202014011208U1 (de) 2018-08-23
ME03326B (me) 2019-10-20
HK1250912B (zh) 2020-01-10
ME02865B (me) 2018-04-20
LT2968434T (lt) 2017-09-25
GB2530921A (en) 2016-04-06
ES2639833T3 (es) 2017-10-30
US11534482B2 (en) 2022-12-27
BR112015023207A8 (pt) 2018-01-23
EP2968434A2 (en) 2016-01-20
HK1220403A1 (zh) 2017-05-05
CA2904543C (en) 2019-10-08
JP6473536B2 (ja) 2019-02-20
JP6877472B2 (ja) 2021-05-26
AU2020203183A1 (en) 2020-06-04
AU2018229558B2 (en) 2020-03-05
US20190160157A1 (en) 2019-05-30
PT3290046T (pt) 2019-02-18
HUE036224T2 (hu) 2018-06-28
EP3290046A1 (en) 2018-03-07
AU2020203183B2 (en) 2022-06-02
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US20160015795A1 (en) 2016-01-21

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