MX2015011281A - Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa. - Google Patents

Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.

Info

Publication number
MX2015011281A
MX2015011281A MX2015011281A MX2015011281A MX2015011281A MX 2015011281 A MX2015011281 A MX 2015011281A MX 2015011281 A MX2015011281 A MX 2015011281A MX 2015011281 A MX2015011281 A MX 2015011281A MX 2015011281 A MX2015011281 A MX 2015011281A
Authority
MX
Mexico
Prior art keywords
prevention
treatment
methods
deficency
disorders associated
Prior art date
Application number
MX2015011281A
Other languages
English (en)
Inventor
Cynthia Gallagher
Steven Ruddy
Mark Cornell Manning
Original Assignee
Shire Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51538486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015011281(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shire Viropharma Inc filed Critical Shire Viropharma Inc
Publication of MX2015011281A publication Critical patent/MX2015011281A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors

Abstract

Se divulgan composiciones para el tratamiento y/o prevención de trastornos asociados con la deficiencia del inhibidor de C1 esterasa.
MX2015011281A 2013-03-15 2014-03-17 Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa. MX2015011281A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791399P 2013-03-15 2013-03-15
PCT/US2014/030309 WO2014145519A2 (en) 2013-03-15 2014-03-17 C1-inh compositions and methods for the prevention and treatment of disorders associated with c1 esterase inhibitor deficency

Publications (1)

Publication Number Publication Date
MX2015011281A true MX2015011281A (es) 2016-03-03

Family

ID=51538486

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2020004724A MX2020004724A (es) 2013-03-15 2014-03-17 Composiciones de inh-c1 y métodos para la prevención y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.
MX2015011281A MX2015011281A (es) 2013-03-15 2014-03-17 Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.
MX2021011946A MX2021011946A (es) 2013-03-15 2015-08-28 Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020004724A MX2020004724A (es) 2013-03-15 2014-03-17 Composiciones de inh-c1 y métodos para la prevención y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021011946A MX2021011946A (es) 2013-03-15 2015-08-28 Composiciones de inh-c1 y metodos para la prevencion y el tratamiento de trastornos asociados con la deficiencia del inhibidor de c1 esterasa.

Country Status (30)

Country Link
US (9) US9616111B2 (es)
EP (3) EP3290046B1 (es)
JP (9) JP6184581B2 (es)
KR (4) KR102430453B1 (es)
CN (2) CN111529708A (es)
AU (3) AU2014232912A1 (es)
BR (1) BR112015023207A8 (es)
CA (2) CA3054718A1 (es)
CY (2) CY1119419T1 (es)
DE (1) DE202014011208U1 (es)
DK (2) DK3290046T3 (es)
EA (1) EA201591278A1 (es)
ES (2) ES2713004T3 (es)
GB (1) GB2530921B (es)
HK (2) HK1220403A1 (es)
HR (2) HRP20171269T1 (es)
HU (2) HUE036224T2 (es)
IL (2) IL241549B (es)
LT (2) LT3290046T (es)
ME (2) ME03326B (es)
MX (3) MX2020004724A (es)
NZ (2) NZ751555A (es)
PL (2) PL2968434T3 (es)
PT (2) PT3290046T (es)
RS (2) RS56285B1 (es)
SG (2) SG11201507616VA (es)
SI (2) SI2968434T1 (es)
TR (1) TR201900319T4 (es)
WO (1) WO2014145519A2 (es)
ZA (3) ZA201507604B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS56285B1 (sr) 2013-03-15 2017-12-29 Shire Viropharma Inc C1-inh kompozicije za upotrebu u prevenciji i lečenju naslednog angioedema (hae)
KR102384814B1 (ko) 2013-11-22 2022-04-08 다케다 야쿠힌 고교 가부시키가이샤 C1-에스테라제 억제제를 사용한 장기 이식 환자에서의 항체-매개성 거부반응의 치료 방법
CN107257683A (zh) * 2015-02-20 2017-10-17 德国杰特贝林生物制品有限公司 C1酯酶抑制剂的药物制剂
EP3302540A4 (en) * 2015-05-28 2018-08-22 Cornell University Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema
BR112018010160A8 (pt) * 2015-11-19 2019-02-26 Shire Human Genetic Therapies inibidor da c1 esterase humana recombinante e usos do mesmo
EP3493832A1 (en) 2016-08-05 2019-06-12 CSL Behring GmbH Pharmaceutical formulations of c1 esterase inhibitor
AU2017316513A1 (en) * 2016-08-23 2019-03-28 Csl Behring Gmbh Method of preventing acute attacks of hereditary angioedema associated with C1 esterase inhibitor deficiency
WO2018210944A1 (en) 2017-05-16 2018-11-22 Octapharma Ag C1-esterase inhibitor preparation
WO2019166572A1 (en) 2018-02-28 2019-09-06 Pharming Intellectual Property B.V. Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor
US20200390872A1 (en) 2018-02-28 2020-12-17 Pharming Intellectual Property B.V. Treatment and prevention of pre-eclampsia
CN112584843A (zh) 2018-06-22 2021-03-30 顺天生化股份有限公司 用于诱发感染性免疫耐受的组合物
CA3104797A1 (en) 2018-06-22 2019-12-26 Junten Bio Co., Ltd. Antibody capable of inducing immune tolerance produced using cell mixture having complexed state, and induced lymphocyte or cell therapeutic agent and cell therapy method each using induced lymphocyte
WO2019245037A1 (ja) 2018-06-22 2019-12-26 株式会社Ｊｕｎｔｅｎ Ｂｉｏ 免疫寛容を誘導する抗体、誘導されたリンパ球、また誘導されたリンパ球を用いる細胞治療剤治療法
US20230041642A1 (en) * 2019-12-16 2023-02-09 Nipro Corporation Aggregation Inhibitory Agent and Medical Composition and Medical Device Including Same
EP3895726A1 (en) 2020-04-17 2021-10-20 Pharming Intellectual Property BV Using c1 esterase inhibitor to treat viral infection-related acute respiratory distress
WO2023280981A1 (en) 2021-07-09 2023-01-12 Pharming Intellectual Property B.V. Using c1 esterase inhibitor to treat viral infection-related symptoms
KR20230046146A (ko) 2021-09-29 2023-04-05 주식회사 엘지에너지솔루션 배터리 제어 시스템 및 방법

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304482A (en) 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
WO1992022320A1 (en) 1991-06-14 1992-12-23 Genentech, Inc. C1 inhibitor variants and treating inflammatory response with c1 inhibitor
AU678064B2 (en) 1993-09-01 1997-05-15 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method to reduce myocardial injury during acute myocardial infarction
JP2000507204A (ja) 1995-12-18 2000-06-13 ステイヒテイング・サンキン・ブロードボールジーニング Ｃ１―インヒビターの補体及び血液凝固阻害特性の強化
AT409336B (de) * 1999-12-22 2002-07-25 Baxter Ag Verfahren zur herstellung einer c1-esterase-inhibitor (c1-inh)-hältigen zusammensetzung
US7067713B2 (en) 2000-01-31 2006-06-27 Pharming Intellectual Property B.V. C1 Inhibitor produced in the milk of transgenic non-human mammals
CA2398707C (en) 2000-01-31 2010-10-26 Pharming Intellectual Property B.V. C1 inhibitor produced in the milk of transgenic mammals
EP1324776B2 (en) 2000-10-12 2018-03-21 Genentech, Inc. Reduced-viscosity concentrated protein formulations
DE10112617A1 (de) 2001-03-14 2002-10-02 Aventis Behring Gmbh Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren
AU2003300781A1 (en) 2002-09-25 2004-05-04 The Center For Blood Research, Inc. Methods for treating and preventing sepsis using modified c1 inhibitor or fragments thereof
WO2004110356A2 (en) 2003-05-15 2004-12-23 Cbr Institute For Biomedical Research, Inc. Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity
CN100431604C (zh) 2003-05-16 2008-11-12 法明知识产权股份有限公司 用于瞬时性治疗的具有短半衰期的c1抑制剂
US20060233776A1 (en) 2003-08-19 2006-10-19 Norbert Heimburger C1-inh as a drug for treating viruses pathogenic to humans
US8501705B2 (en) 2003-09-11 2013-08-06 The Board Of Regents Of The University Of Texas System Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
US7897561B2 (en) 2005-06-06 2011-03-01 Girish J. Kotwal Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury
EP1940457B1 (en) 2005-10-21 2012-12-12 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
ES2369522T3 (es) * 2005-12-21 2011-12-01 Pharming Intellectual Property B.V. Uso de un inhibidor c1 para la prevención de lesiones por isquemia-reperfusión.
US8071532B2 (en) 2005-12-21 2011-12-06 Pharming Intellectual Property B.V. Use of C1 inhibitor for the prevention of ischemia-reperfusion injury
US7837992B2 (en) 2006-06-22 2010-11-23 Beth Israel Deaconess Medical Center C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis
DK2109457T3 (en) 2007-02-12 2016-04-11 Csl Behring Gmbh THERAPEUTIC USE OF KAZAL TYPE SERINE PROTEASE INHIBITORS
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
TW200938221A (en) 2007-11-30 2009-09-16 Abbott Lab Protein formulations and methods of making same
US20100143325A1 (en) 2008-12-09 2010-06-10 Vascular Laboratory, Inc. Composition And Methods Involving Thrombolytic Agents
WO2011003098A1 (en) 2009-07-02 2011-01-06 Musc Foundation For Research Development Methods of stimulating liver regeneration
CA2971474C (en) 2009-10-16 2022-11-22 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation
JP6148013B2 (ja) 2010-03-05 2017-06-14 リグショスピタレト 補体活性化のキメラ抑制分子
US20130085111A1 (en) * 2010-03-18 2013-04-04 Thrombolytic Science, Llc Production of human c1 inhibitor in human cells
WO2013013017A2 (en) * 2011-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Compositions and methods for modifying the glycosylation of lysosomal storage disorder therapeutics
CN104010656B (zh) 2011-09-24 2016-02-24 德国杰特贝林生物制品有限公司 使用免疫球蛋白和c1-抑制剂的联合疗法
WO2013093027A1 (en) 2011-12-22 2013-06-27 Csl Behring Gmbh Use of c1-inhibitor for the treatment of secondary edema of the central nervous system
JP2015512370A (ja) 2012-03-16 2015-04-27 ベルローズ ファーマ，インコーポレーテッド Ｃ１−阻害剤のポリマーコンジュゲート
EP2972375A2 (en) 2013-03-13 2016-01-20 Creatics LLC Methods and compositions for detecting pancreatic cancer
RS56285B1 (sr) * 2013-03-15 2017-12-29 Shire Viropharma Inc C1-inh kompozicije za upotrebu u prevenciji i lečenju naslednog angioedema (hae)

Also Published As

Publication number Publication date
US20190160158A1 (en) 2019-05-30
DE202014011208U1 (de) 2018-08-23
HRP20190270T1 (hr) 2019-04-05
ZA201706929B (en) 2019-05-29
JP2021088599A (ja) 2021-06-10
ZA201507604B (en) 2018-05-30
JP2017105847A (ja) 2017-06-15
LT3290046T (lt) 2019-03-12
EP2968434A2 (en) 2016-01-20
US11364288B2 (en) 2022-06-21
US20160015795A1 (en) 2016-01-21
US11534482B2 (en) 2022-12-27
JP6877471B2 (ja) 2021-05-26
EP2968434A4 (en) 2016-03-02
JP2018119001A (ja) 2018-08-02
WO2014145519A2 (en) 2014-09-18
CY1119419T1 (el) 2018-03-07
JP6473535B2 (ja) 2019-02-20
JP2019073546A (ja) 2019-05-16
JP2019073544A (ja) 2019-05-16
CA3054718A1 (en) 2014-09-18
HUE036224T2 (hu) 2018-06-28
KR20220070049A (ko) 2022-05-27
KR102430453B1 (ko) 2022-08-05
CN105517559A (zh) 2016-04-20
PL3290046T3 (pl) 2019-05-31
GB2530921A (en) 2016-04-06
BR112015023207A2 (pt) 2017-11-21
GB201519921D0 (en) 2015-12-23
CY1121653T1 (el) 2020-07-31
US10080788B2 (en) 2018-09-25
AU2020203183B2 (en) 2022-06-02
JP2018119000A (ja) 2018-08-02
MX2020004724A (es) 2022-01-18
ES2639833T3 (es) 2017-10-30
US20200261556A1 (en) 2020-08-20
JP6877472B2 (ja) 2021-05-26
HRP20171269T1 (hr) 2017-11-03
AU2020203183A1 (en) 2020-06-04
KR20150135242A (ko) 2015-12-02
RS58351B1 (sr) 2019-03-29
RS56285B1 (sr) 2017-12-29
US10201595B2 (en) 2019-02-12
US20180110843A1 (en) 2018-04-26
HK1250912B (zh) 2020-01-10
US20190160157A1 (en) 2019-05-30
LT2968434T (lt) 2017-09-25
US9616111B2 (en) 2017-04-11
GB2530921B (en) 2017-09-20
PT3290046T (pt) 2019-02-18
KR20210021146A (ko) 2021-02-24
SI2968434T1 (sl) 2017-11-30
CA2904543C (en) 2019-10-08
IL276153B (en) 2022-06-01
PL2968434T3 (pl) 2018-01-31
SG10201707598QA (en) 2017-10-30
AU2014232912A1 (en) 2015-09-03
JP6184581B2 (ja) 2017-08-23
AU2018229558B2 (en) 2020-03-05
IL241549B (en) 2020-08-31
CN111529708A (zh) 2020-08-14
SG11201507616VA (en) 2015-10-29
PT2968434T (pt) 2017-09-18
EP2968434B1 (en) 2017-06-28
JP2016516073A (ja) 2016-06-02
JP2019073545A (ja) 2019-05-16
JP6473534B2 (ja) 2019-02-20
DK3290046T3 (en) 2019-03-18
ME03326B (me) 2019-10-20
HUE041837T2 (hu) 2019-05-28
US20180085441A1 (en) 2018-03-29
EA201591278A1 (ru) 2016-03-31
NZ751555A (en) 2021-07-30
US20180153972A1 (en) 2018-06-07
ZA201806793B (en) 2020-01-29
JP6473536B2 (ja) 2019-02-20
KR102579789B1 (ko) 2023-09-15
JP2018119002A (ja) 2018-08-02
US10105423B2 (en) 2018-10-23
IL276153A (en) 2020-09-30
EP3290046B1 (en) 2019-01-02
JP6877470B2 (ja) 2021-05-26
CA2904543A1 (en) 2014-09-18
WO2014145519A3 (en) 2014-12-31
SI3290046T1 (sl) 2019-04-30
BR112015023207A8 (pt) 2018-01-23
KR20210129267A (ko) 2021-10-27
ME02865B (me) 2018-04-20
NZ710730A (en) 2021-07-30
US10130690B2 (en) 2018-11-20
DK2968434T3 (en) 2017-09-11
HK1220403A1 (zh) 2017-05-05
AU2018229558A1 (en) 2018-10-04
MX2021011946A (es) 2021-11-17
ES2713004T3 (es) 2019-05-17
TR201900319T4 (tr) 2019-02-21
EP3508213A1 (en) 2019-07-10
US20170224788A1 (en) 2017-08-10
EP3290046A1 (en) 2018-03-07
US20180110844A1 (en) 2018-04-26
JP6422520B2 (ja) 2018-11-14

Similar Documents

Publication Publication Date Title
IL276153B (en) c1-inh preparations and methods for preventing and treating disorders associated with c1 esterase inhibitor deficiency
MX2019003623A (es) Composiciones y metodos para el tratamiento de afecciones oftalmicas.
MX2019010709A (es) Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
WO2014055996A3 (en) Rho kinase inhibitors
SG10201808940WA (en) Nox inhibitor and nfкb inhibitor containing methoxyflavone
MX2016009590A (es) Composiciones de apilimod y métodos para usar las mismas.
PH12018501279A1 (en) Compositions comprising 15-hepe and methods of using the same
MX2018000715A (es) Metodos para tratar cancer usando apilimod.
MX2018006700A (es) Inhibidores aza-bencimidazol de peptidilarginina desiminasa (pad4).
PH12017501864A1 (en) Compositions and methods for treating autism
MX2017013729A (es) Deteccion especifica de isoformas de clusterina.
AU2015311730A8 (en) CaMKII inhibitors and uses thereof
MX2018000708A (es) Composiciones y metodos para desgomar aceite.
EP3294294A4 (en) Compositions and methods for the treatment or prevention of pulmonary hypertension
IL247616B (en) Centrally acting acetylcholinesterase inhibitors for the prevention/or treatment of chemically induced neurodegenerative diseases and their symptoms, and corresponding compositions, uses, methods and kit

Legal Events

Date Code Title Description
FG Grant or registration